Highway 38 is a major road on St. Thomas, U.S. Virgin Islands. Starting at Highway 35 in the eastern part of Charlotte Amalie, the road runs in an east–west direction. Along its path, Highway 38 serves as the southern terminus of Highway 39 and Highway 42, and the northern terminus of Highway 32. Past Highway 42, the road turns south and runs along the eastern coast of St. Thomas. Finally, as the road turns back west near Red Hook, its designation changes to Highway 32.