USCGC Seneca, or before 1915 USRC Seneca, was a United States Coast Guard cutter built and commissioned as a "derelict destroyer" with the specific mission of locating and then destroying abandoned shipwrecks that were still afloat and were a menace to navigation. She was designed with excellent sea-keeping qualities, a long cruising range, good towing capabilities, and by necessity the capacity to store a large amount of munitions. She was one of five Coast Guard cutters serving with the U.S. Navy in European waters during World War I.