USS Upshur (DD–144) was a Wickes-class destroyer in the United States Navy before and during World War II. She was the first ship named for Rear Admiral John Henry Upshur. Upshur was laid down on 19 February 1918 at Philadelphia by William Cramp & Sons' shipyards. The ship is launched on 4 July 1918, sponsored by Mrs. Alexander Gustavus Brown, the granddaughter of Rear Admiral Upshur. The destroyer commissioned at the Philadelphia Navy Yard on 23 December 1918.