Unlikely Prescription is the fifteenth studio album by Twiztid. Released on September 10, 2021, the album marked a stylistic change in the duo's music. Previously, Twiztid had performed mainly rap with only certain rock elements thrown in (such as horrorcore); however, on Unlikely Prescription, they ventured into a purely rock-oriented direction. The album featured rock and metal guests such as Spencer Charnas (Ice Nine Kills), Dani Filth (Cradle of Filth), Rich Ward (Fozzy), and Matt Brandyberry (From Ashes to New).