The Upper Klamath National Wildlife Refuge is a wildlife refuge in southwestern Klamath County on the shores of Upper Klamath Lake in Oregon. It was established in 1928 and contains some 14,400 acres (5,800 ha) of freshwater marshes. It is accessible only by boat from and , Malone springs, and a few neighboring ramps. The refuge is part of the Klamath Basin National Wildlife Refuge Complex and is administered along with the other refuges of the complex from common offices in Tulelake, California.