Van Nest Polglase (August 25, 1898 – December 20, 1968) was an American art director. He was nominated for six Academy Awards in the category Best Art Direction. Best remembered as head of the design department at RKO Pictures, he worked on 333 films between 1925 and 1957. He was born in Brooklyn, New York and died in Los Angeles, California. His death notice noted that he was "survived by his son Dr. Van Nest Polglase and 2 grandchildren", his wife, Helen, having predeceased him six months earlier.