Villa Constitución is a city in the province of Santa Fe, Argentina, and the head town of the Constitución Department. It is located on the south-western banks of the Paraná River between the courses of the and the Arroyo del Medio, about 214 km south from the provincial capital, the city of Santa Fe, and 50 km from Rosario. It has a population of more than 47,374 inhabitants as per the 2010 census [INDEC].