Zabelle Panosian (June 7, 1891 – January 26, 1986) was an Armenian-American soprano. She was born Takouhi Der Mesrobian in a Western Armenian-speaking town, (now , Turkey). She emigrated to the United States in the spring of 1907 and was married to the photo-engraver Aram Sarkis Panosian, in Somerville, Massachusetts, with whom she had a daughter in 1908, the dancer Adrina Otero (later Adriana Joyce).