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Statements

Subject Item
dbr:Deubiquitinating_enzyme
rdf:type
yago:Abstraction100002137 dbo:Band yago:Unit108189659 dbo:Protein yago:Organization108008335 wikidata:Q8054 yago:Family108078020 dbo:Biomolecule yago:YagoLegalActor yago:YagoLegalActorGeo yago:YagoPermanentlyLocatedEntity yago:SocialGroup107950920 wikidata:Q206229 owl:Thing yago:Group100031264
rdfs:label
脱ユビキチン化酵素 Deubiquitinating enzyme
rdfs:comment
脱ユビキチン化酵素（だつユビキチンかこうそ、英: deubiquitinating enzyme、略称: DUB）は、タンパク質からユビキチンを切断除去するプロテアーゼのグループである。他にdeubiquitinating peptidase、deubiquitinating isopeptidase、deubiquitinase、ubiquitin protease、ubiquitin hydrolase、ubiquitin isopeptidaseなどとも呼ばれる。ユビキチンは、プロテアソームとリソソームを介したタンパク質分解の調節や、タンパク質の細胞内局在の調整、タンパク質の活性化や不活性化、タンパク質間相互作用の調節のためにタンパク質に付加される。DUBはユビキチンと基質の間のペプチド結合またはを切断することで、ユビキチン化による効果を逆転させる。ヒトには約100種類のDUBの遺伝子が存在し、システインプロテアーゼとメタロプロテアーゼという2つの主要なクラスに分類される。システインプロテアーゼグループのDUBは、USP（ubiquitin-specific protease）、UCH（ubiquitin C-terminal hydrolase）、MJD（Machado-Josephin domain protease）、OTU（ovarian tumour protease）ファミリーなどからなる。メタロプロテアーゼグループのDUBは、JAMM（Jab1/Mov34/Mpr1 Pad1 N-terminal+）ドメインプロテアーゼのみが含まれる。 Deubiquitinating enzymes (DUBs), also known as deubiquitinating peptidases, deubiquitinating isopeptidases, deubiquitinases, ubiquitin proteases, ubiquitin hydrolases, ubiquitin isopeptidases, are a large group of proteases that cleave ubiquitin from proteins. Ubiquitin is attached to proteins in order to regulate the degradation of proteins via the proteasome and lysosome; coordinate the cellular localisation of proteins; activate and inactivate proteins; and modulate protein-protein interactions. DUBs can reverse these effects by cleaving the peptide or isopeptide bond between ubiquitin and its substrate protein. In humans there are nearly 100 DUB genes, which can be classified into two main classes: cysteine proteases and metalloproteases. The cysteine proteases comprise ubiquitin-speci
dbp:name
DUSP domain UCH
foaf:depiction
n9:Ub_AMC.jpeg n9:Ubiquitin_and_USP21.png n9:PDB_2hd5_EBI.jpg n9:Role_of_USP7_in_p53-dependent_path.png n9:PDB_1w6v_EBI.jpg n9:DUBs.png n9:DUBs_in_the_cell_cycle.png n9:Catalytic_domain_of_USP7.png
dct:subject
dbc:Enzymes dbc:Protein_domains
dbo:wikiPageID
3247517
dbo:wikiPageRevisionID
1081624875
dbo:wikiPageWikiLink
dbr:Isoleucine dbr:Isopeptide_bond dbr:Protein_interaction dbr:USP40 dbr:OTUB2 dbr:Metalloprotease n4:Ub_AMC.jpeg n4:Ubiquitin_and_USP21.png dbr:Ubiquitin_C dbr:Polyamine dbr:Ribosome dbr:MINDY4 dbr:USP11 dbr:Ubiquitin-like_protein dbr:Ubiquitin_ligase dbr:Amino_acids dbr:Proteasome dbr:USP20 dbr:Catalytic dbr:FAM63A dbr:USP18 dbr:USP2 dbr:USP10 dbr:C-jun dbr:Protein_domain dbr:USP24 dbr:USP36 dbr:USP42 dbc:Enzymes dbr:Aspartate dbr:USP9X dbr:Glutathione dbr:USP14 dbr:Alpha_helix dbr:UCHL5 dbr:USP37 dbr:Cancer dbr:OTU1 dbr:USP16 dbr:UBB+1 dbr:NEDD8 dbr:USP25 dbr:UCHL1 dbr:USP39 dbr:Protein_motif dbr:Beta-sheet dbr:OTUB1 dbr:Proteolysis dbr:USP44 dbc:Protein_domains dbr:VCPIP1 dbr:USP13 dbr:USP33 dbr:FAM63B dbr:ATXN3 dbr:Protein_folding dbr:UCHL3 dbr:Papain-like_protease dbr:Ubiquitin dbr:Amide_bond dbr:USP1 dbr:Conserved_sequence dbr:Cysteine dbr:Ubiquitin-activating_enzyme dbr:Cysteine_protease dbr:ATXN3L dbr:Serine dbr:Proline dbr:USP12 dbr:USP17 dbr:USP17L2 dbr:Nucleophilic_attack dbr:USP17L3 dbr:USP17L4 dbr:USP17L5 dbr:Zinc dbr:USP9Y dbr:USP26 n4:Role_of_USP7_in_p53-dependent_path.png dbr:Ubiquitin-conjugating_enzyme dbr:Protease dbr:Hydrolysis dbr:Asparagine dbr:BAP1 dbr:Thioester dbr:USP8 dbr:Lysine dbr:USP19 dbr:USP27X dbr:TP63 dbr:C-Myc dbr:Amide dbr:Post_translational_modification dbr:USP15 dbr:Protein-protein_interaction n4:Catalytic_domain_of_USP7.png dbr:Fam188a dbr:USP31 dbr:USP5 dbr:USP32 dbr:USP35 dbr:USP38 dbr:USP41 dbr:USP43 dbr:USP45 dbr:USP46 dbr:USP17L7 dbr:Nucleophile dbr:USP17L8 dbr:Glycine dbr:USP21 dbr:USP23 dbr:USP28 dbr:N-terminus dbr:USP29 dbr:USP34 dbr:USP3 dbr:Ubiquitin_A-52_residue_ribosomal_protein_fusion_product_1 dbr:USP30 dbr:Lysosome dbr:Histidine dbr:Ubiquitin_B dbr:SUMO_protein dbr:USP4 dbr:USP6 dbr:USP7 dbr:C-terminus dbr:USP22 dbr:Catalytic_triad n4:DUBs.png n4:DUBs_in_the_cell_cycle.png dbr:RPS27A dbr:Notch_1 dbr:Subcellular_localization
owl:sameAs
n13:4iacB wikidata:Q5266092 freebase:m.0912jh dbpedia-ja:脱ユビキチン化酵素
dbp:wikiPageUsesTemplate
dbt:Reflist dbt:Posttranslational_modification dbt:Infobox_protein_family dbt:InterPro_content dbt:Circular_reference
dbo:thumbnail
n9:Ubiquitin_and_USP21.png?width=300
dbp:prosite
PDOC00750
dbp:scop
1
dbp:caption
USP2 in complex with ubiquitin. Solution structure of the DUSP domain of HUSP15.
dbp:interpro
IPR006615 IPR001394
dbp:pfam
PF00443 PF06337
dbp:pfamClan
CL0125
dbp:symbol
DUSP UCH
dbo:abstract
脱ユビキチン化酵素（だつユビキチンかこうそ、英: deubiquitinating enzyme、略称: DUB）は、タンパク質からユビキチンを切断除去するプロテアーゼのグループである。他にdeubiquitinating peptidase、deubiquitinating isopeptidase、deubiquitinase、ubiquitin protease、ubiquitin hydrolase、ubiquitin isopeptidaseなどとも呼ばれる。ユビキチンは、プロテアソームとリソソームを介したタンパク質分解の調節や、タンパク質の細胞内局在の調整、タンパク質の活性化や不活性化、タンパク質間相互作用の調節のためにタンパク質に付加される。DUBはユビキチンと基質の間のペプチド結合またはを切断することで、ユビキチン化による効果を逆転させる。ヒトには約100種類のDUBの遺伝子が存在し、システインプロテアーゼとメタロプロテアーゼという2つの主要なクラスに分類される。システインプロテアーゼグループのDUBは、USP（ubiquitin-specific protease）、UCH（ubiquitin C-terminal hydrolase）、MJD（Machado-Josephin domain protease）、OTU（ovarian tumour protease）ファミリーなどからなる。メタロプロテアーゼグループのDUBは、JAMM（Jab1/Mov34/Mpr1 Pad1 N-terminal+）ドメインプロテアーゼのみが含まれる。 Deubiquitinating enzymes (DUBs), also known as deubiquitinating peptidases, deubiquitinating isopeptidases, deubiquitinases, ubiquitin proteases, ubiquitin hydrolases, ubiquitin isopeptidases, are a large group of proteases that cleave ubiquitin from proteins. Ubiquitin is attached to proteins in order to regulate the degradation of proteins via the proteasome and lysosome; coordinate the cellular localisation of proteins; activate and inactivate proteins; and modulate protein-protein interactions. DUBs can reverse these effects by cleaving the peptide or isopeptide bond between ubiquitin and its substrate protein. In humans there are nearly 100 DUB genes, which can be classified into two main classes: cysteine proteases and metalloproteases. The cysteine proteases comprise ubiquitin-specific proteases (USPs), ubiquitin C-terminal hydrolases (UCHs), Machado-Josephin domain proteases (MJDs) and ovarian tumour proteases (OTU). The metalloprotease group contains only the Jab1/Mov34/Mpr1 Pad1 N-terminal+ (MPN+) (JAMM) domain proteases.
dbp:merops
19.0
gold:hypernym
dbr:Group
skos:closeMatch
n11:deubiquitylating-enzymes
prov:wasDerivedFrom
wikipedia-en:Deubiquitinating_enzyme?oldid=1081624875&ns=0
dbo:wikiPageLength
38140
dbo:symbol
UCH DUSP
foaf:isPrimaryTopicOf
wikipedia-en:Deubiquitinating_enzyme