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Statements

Subject Item
dbr:3H_domain
rdf:type
yago:Abstraction100002137 wikidata:Q206229 dbo:Protein yago:YagoPermanentlyLocatedEntity wikidata:Q8054 yago:Organization108008335 yago:YagoLegalActor yago:YagoLegalActorGeo dbo:Biomolecule yago:Family108078020 yago:Unit108189659 yago:SocialGroup107950920 yago:WikicatProteinFamilies yago:Group100031264 owl:Thing
rdfs:label
3H domain
rdfs:comment
In molecular biology, the 3H domain is a protein domain named after its three highly conserved histidine residues. The 3H domain appears to be a smarr molecure-binding domain, based on its occurrence with other domains. Several proteins carrying this domain are transcriptional regulators from the biotin repressor family. The transcription regulator TM1602 from Thermotoga maritima is a DNA-binding protein thought to belong to a family of de novo NAD synthesis pathway regulators. TM1602 has an N-terminal DNA-binding domain and a C-terminal 3H regulatory domain. The N-terminal domain appears to bind to the NAD promoter region and repress the de novo NAD biosynthesis operon, while the C-terminal 3H domain may bind to nicotinamide, nicotinic acid, or other substrate/products. The 3H domain has
dbp:name
3.0
foaf:depiction
n15:PDB_1j5y_EBI.jpg
dct:subject
dbc:Protein_families
dbo:wikiPageID
31732429
dbo:wikiPageRevisionID
1077024676
dbo:wikiPageWikiLink
dbr:Transcription_(genetics) dbr:Promotor_(biology) dbc:Protein_families dbr:Conservation_(genetics) dbr:Biosynthesis dbr:Protein_family dbr:Domain_(biology) dbr:Histidine dbr:Gene_regulation dbr:Repressor dbr:Nicotinamide dbr:Proteins dbr:Protein_domain dbr:Protein_folding dbr:Transcriptional_regulation
owl:sameAs
freebase:m.0gty9q_ wikidata:Q24771004 yago-res:3H_domain n19:2L6MR
dbp:wikiPageUsesTemplate
dbt:Infobox_protein_family dbt:InterPro_content dbt:Orphan dbt:Short_description dbt:Reflist
dbo:thumbnail
n15:PDB_1j5y_EBI.jpg?width=300
dbp:prosite
PDOC00449
dbp:scop
1.57788E8
dbp:caption
crystal structure of transcriptional regulator from thermotoga maritima at 2.3 a resolution
dbp:interpro
IPR004173
dbp:pfam
PF02829
dbp:symbol
3.0
dbo:abstract
In molecular biology, the 3H domain is a protein domain named after its three highly conserved histidine residues. The 3H domain appears to be a smarr molecure-binding domain, based on its occurrence with other domains. Several proteins carrying this domain are transcriptional regulators from the biotin repressor family. The transcription regulator TM1602 from Thermotoga maritima is a DNA-binding protein thought to belong to a family of de novo NAD synthesis pathway regulators. TM1602 has an N-terminal DNA-binding domain and a C-terminal 3H regulatory domain. The N-terminal domain appears to bind to the NAD promoter region and repress the de novo NAD biosynthesis operon, while the C-terminal 3H domain may bind to nicotinamide, nicotinic acid, or other substrate/products. The 3H domain has a 2-layer alpha/beta sandwich fold.
gold:hypernym
dbr:Domain
prov:wasDerivedFrom
wikipedia-en:3H_domain?oldid=1077024676&ns=0
dbo:wikiPageLength
2589
dbo:symbol
3H
foaf:isPrimaryTopicOf
wikipedia-en:3H_domain