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Subject Item
dbr:ADP-ribosylation
rdf:type
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rdfs:label
ADP-ribosylering ADP-ribosilazione ADP-리보실화 二磷酸腺苷核糖基化 АДФ-рибозилирование ADP-ribosylation ADPリボース化 ADP-ribosylation
rdfs:comment
La ADP-ribosilazione è l'aggiunta di uno o più molecole di ADP ribosio a una proteina.L'ADP ribosio proviene da una molecole di NAD+ che viene tagliata rilasciando una molecola di Nicotinamide ad opera di enzimi eucariotici della famiglia di ADP-ribosil-transferasi (ADPRT) che possono essere Poli-ADPRT (come la Poli ADP-ribosio polimerasi (PARP) che catalizzano reazioni di Poli-ADP-ribosilazione oppure ad opera della mono-ADPRT che catalizza una reazione di mono-ADP ribosilazione. Queste reazioni sono reversibili, mentre esistono varie tossine batteriche (tossine della pertosse, colerica, botulinica e difterica) che sono Mono-ADPRT ma catalizzano reazioni irreversibili.Queste reazioni sono coinvolte nella segnalazione cellulare e il controllo di processi cellulari, tra cui la riparazione d АДФ-рибозили́рование (англ. ADP-ribosylation) — химическая реакция присоединения одного или нескольких остатков АДФ-рибозы к белку. Это обратимая посттрансляционная модификация, которая играет важную роль во многих клеточных процессах, таких как передача сигнала, репарация ДНК, регуляция экспрессии генов и апоптоз. Неправильное АДФ-рибозилирование наблюдается при некоторых формах рака. Многие бактериальные токсины, такие как холерный токсин и , влияют на АДФ-рибозилирование. 二磷酸腺苷核糖基化（英語：ADP-ribosylation，ADP-核糖基化）是将额外的单个或多个二磷酸腺苷核糖（ADP核糖）基团添加到蛋白质的氨基酸残基上的轉譯后修饰过程。这一过程可逆，涉及许多细胞中的过程，包括细胞信号传送、DNA修復、基因表达调控和细胞凋亡。 异常的ADP-核糖基化已被证明和一些癌症相关。它也是來自细菌的毒素之致病机理，如、等。 ADP-ribosylering is de koppeling van een aan een eiwit. Het is een posttranslationele modificatie: een covalente wijziging van een nieuw gesynthetiseerd eiwit. ADP-ribosylering van eiwitten is van belang bij diverse cellulaire processen, waaronder celcommunicatie, genregulatie, sturing van apoptose en reparatie van beschadigd DNA. Defecten in het ADP-ribosyleringsproces is in verband gebracht met bepaalde vormen van kanker. Naast de cellulaire functies is ADP-ribosylering ook het achterliggende mechanisme van bacteriële toxische verbindingen. ADPリボース化（ADP-ribosylation）はタンパク質の翻訳後修飾の一つで、1つまたはそれ以上のアデノシン二リン酸（ADP）リボースを付加する反応である。この反応は細胞間の情報伝達やDNA修復、アポトーシスなど多くの細胞機能に関わっている。 ADP-리보실화(영어: ADP-ribosylation)는 단백질에 하나 이상의 ADP-리보스 부분을 참가하는 것이다. ADP-리보실화는 세포 신호전달, DNA 복구, 유전자 발현의 조절 및 세포 사멸을 포함한 다양한 세포 과정에 관여하는 가역적인 번역 후 변형 과정이다. 부적절한 ADP-리보실화는 암의 일부 형태와 관련이 있다. 또한 , 등과 같은 세균성 화합물의 독성과 관련이 있다. L'ADP-ribosylation est une modification post-traductionnelle de certaines protéines consistant à leur adjoindre une ou plusieurs unités ADP-ribose. Il s'agit d'une modification réversible intervenant dans de nombreux processus des cellules vivantes, notamment la signalisation cellulaire, la réparation de l'ADN, la régulation de l'expression génétique (épigénétique) et l'apoptose. Certaines formes de cancer ont été associées à une ADP-ribosylation incorrecte. Cette modification est également à la base du mécanisme d'action de certaines toxines bactériennes telles que la toxine cholérique et la toxine diphtérique. ADP-ribosylation is the addition of one or more ADP-ribose moieties to a protein. It is a reversible post-translational modification that is involved in many cellular processes, including cell signaling, DNA repair, gene regulation and apoptosis.Improper ADP-ribosylation has been implicated in some forms of cancer. It is also the basis for the toxicity of bacterial compounds such as cholera toxin, diphtheria toxin, and others.
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dbo:abstract
ADP-리보실화(영어: ADP-ribosylation)는 단백질에 하나 이상의 ADP-리보스 부분을 참가하는 것이다. ADP-리보실화는 세포 신호전달, DNA 복구, 유전자 발현의 조절 및 세포 사멸을 포함한 다양한 세포 과정에 관여하는 가역적인 번역 후 변형 과정이다. 부적절한 ADP-리보실화는 암의 일부 형태와 관련이 있다. 또한 , 등과 같은 세균성 화합물의 독성과 관련이 있다. ADP-ribosylation is the addition of one or more ADP-ribose moieties to a protein. It is a reversible post-translational modification that is involved in many cellular processes, including cell signaling, DNA repair, gene regulation and apoptosis.Improper ADP-ribosylation has been implicated in some forms of cancer. It is also the basis for the toxicity of bacterial compounds such as cholera toxin, diphtheria toxin, and others. L'ADP-ribosylation est une modification post-traductionnelle de certaines protéines consistant à leur adjoindre une ou plusieurs unités ADP-ribose. Il s'agit d'une modification réversible intervenant dans de nombreux processus des cellules vivantes, notamment la signalisation cellulaire, la réparation de l'ADN, la régulation de l'expression génétique (épigénétique) et l'apoptose. Certaines formes de cancer ont été associées à une ADP-ribosylation incorrecte. Cette modification est également à la base du mécanisme d'action de certaines toxines bactériennes telles que la toxine cholérique et la toxine diphtérique. ADP-ribosylering is de koppeling van een aan een eiwit. Het is een posttranslationele modificatie: een covalente wijziging van een nieuw gesynthetiseerd eiwit. ADP-ribosylering van eiwitten is van belang bij diverse cellulaire processen, waaronder celcommunicatie, genregulatie, sturing van apoptose en reparatie van beschadigd DNA. Defecten in het ADP-ribosyleringsproces is in verband gebracht met bepaalde vormen van kanker. Naast de cellulaire functies is ADP-ribosylering ook het achterliggende mechanisme van bacteriële toxische verbindingen. De meeste enzymen die ADP-ribosylering uitvoeren halen ADP-ribose uit het co-enzym NAD+. In deze splitsingsreactie wordt de glycosidische binding tussen het ADP-ribose en de nicotinamide verbroken. Een nucleofiel aminozuur valt vervolgens de vrijgekomen ADP-ribose aan, zodat deze aan het enzym wordt gebonden. Nu kan het worden overgedragen aan het betreffende eiwit. ADP-ribosyltransferasen kunnen twee typen modificaties uitvoeren: mono-ADP-ribosylering and poly-ADP-ribosylering. 二磷酸腺苷核糖基化（英語：ADP-ribosylation，ADP-核糖基化）是将额外的单个或多个二磷酸腺苷核糖（ADP核糖）基团添加到蛋白质的氨基酸残基上的轉譯后修饰过程。这一过程可逆，涉及许多细胞中的过程，包括细胞信号传送、DNA修復、基因表达调控和细胞凋亡。 异常的ADP-核糖基化已被证明和一些癌症相关。它也是來自细菌的毒素之致病机理，如、等。 ADPリボース化（ADP-ribosylation）はタンパク質の翻訳後修飾の一つで、1つまたはそれ以上のアデノシン二リン酸（ADP）リボースを付加する反応である。この反応は細胞間の情報伝達やDNA修復、アポトーシスなど多くの細胞機能に関わっている。 АДФ-рибозили́рование (англ. ADP-ribosylation) — химическая реакция присоединения одного или нескольких остатков АДФ-рибозы к белку. Это обратимая посттрансляционная модификация, которая играет важную роль во многих клеточных процессах, таких как передача сигнала, репарация ДНК, регуляция экспрессии генов и апоптоз. Неправильное АДФ-рибозилирование наблюдается при некоторых формах рака. Многие бактериальные токсины, такие как холерный токсин и , влияют на АДФ-рибозилирование. La ADP-ribosilazione è l'aggiunta di uno o più molecole di ADP ribosio a una proteina.L'ADP ribosio proviene da una molecole di NAD+ che viene tagliata rilasciando una molecola di Nicotinamide ad opera di enzimi eucariotici della famiglia di ADP-ribosil-transferasi (ADPRT) che possono essere Poli-ADPRT (come la Poli ADP-ribosio polimerasi (PARP) che catalizzano reazioni di Poli-ADP-ribosilazione oppure ad opera della mono-ADPRT che catalizza una reazione di mono-ADP ribosilazione. Queste reazioni sono reversibili, mentre esistono varie tossine batteriche (tossine della pertosse, colerica, botulinica e difterica) che sono Mono-ADPRT ma catalizzano reazioni irreversibili.Queste reazioni sono coinvolte nella segnalazione cellulare e il controllo di processi cellulari, tra cui la riparazione del DNA e l'apoptosi.
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