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Statements

Subject Item
dbr:Active_zone
rdf:type
owl:Thing yago:Abstraction100002137 yago:LifeScience106037298 yago:NaturalScience106000400 yago:Content105809192 yago:Biology106037666 yago:PsychologicalFeature100023100 yago:Cognition100023271 yago:Morphology106078327 yago:Science105999797 yago:Anatomy106057539 yago:KnowledgeDomain105999266 yago:Discipline105996646
rdfs:label
Active zone
rdfs:comment
The active zone or synaptic active zone is a term first used by Couteaux and Pecot-Dechavassinein in 1970 to define the site of neurotransmitter release. Two neurons make near contact through structures called synapses allowing them to communicate with each other. As shown in the adjacent diagram, a synapse consists of the presynaptic bouton of one neuron which stores vesicles containing neurotransmitter (uppermost in the picture), and a second, postsynaptic neuron which bears receptors for the neurotransmitter (at the bottom), together with a gap between the two called the synaptic cleft (with synaptic adhesion molecules, SAMs, holding the two together). When an action potential reaches the presynaptic bouton, the contents of the vesicles are released into the synaptic cleft and the relea
dbp:name
Active zone
foaf:depiction
n11:Exocytosis-machinery.jpg n11:AZ_detail.png n11:Active_zone3.jpg n11:Membrane_capacitance.jpg n11:Neuron_synapse.svg
dcterms:subject
dbc:Cell_signaling dbc:Signal_transduction dbc:Cellular_neuroscience dbc:Neurophysiology dbc:Molecular_neuroscience
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31153340
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1123202196
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dbt:Nervous_tissue dbt:Vesicular_transport_proteins dbt:Authority_control dbt:Infobox_microanatomy dbt:Main dbt:Reflist
dbo:thumbnail
n11:Neuron_synapse.svg?width=300
dbp:caption
A diagram of a typical central nervous system synapse. The proteins of the active zone are represented as dark brown pyramids on the upper neuron terminal
dbo:abstract
The active zone or synaptic active zone is a term first used by Couteaux and Pecot-Dechavassinein in 1970 to define the site of neurotransmitter release. Two neurons make near contact through structures called synapses allowing them to communicate with each other. As shown in the adjacent diagram, a synapse consists of the presynaptic bouton of one neuron which stores vesicles containing neurotransmitter (uppermost in the picture), and a second, postsynaptic neuron which bears receptors for the neurotransmitter (at the bottom), together with a gap between the two called the synaptic cleft (with synaptic adhesion molecules, SAMs, holding the two together). When an action potential reaches the presynaptic bouton, the contents of the vesicles are released into the synaptic cleft and the released neurotransmitter travels across the cleft to the postsynaptic neuron (the lower structure in the picture) and activates the receptors on the postsynaptic membrane. The active zone is the region in the presynaptic bouton that mediates neurotransmitter release and is composed of the presynaptic membrane and a dense collection of proteins called the cytomatrix at the active zone (CAZ). The CAZ is seen under the electron microscope to be a dark (electron dense) area close to the membrane. Proteins within the CAZ tether synaptic vesicles to the presynaptic membrane and mediate synaptic vesicle fusion, thereby allowing neurotransmitter to be released reliably and rapidly when an action potential arrives.
dbp:latin
zona activa
gold:hypernym
dbr:Term
prov:wasDerivedFrom
wikipedia-en:Active_zone?oldid=1123202196&ns=0
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22590
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wikipedia-en:Active_zone