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Statements

Subject Item
dbr:Autologous_matrix-induced_chondrogenesis
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rdfs:label
Autologe Matrixinduzierte Chondrogenese Autologous matrix-induced chondrogenesis
rdfs:comment
Die Autologe Matrixinduzierte Chondrogenese (AMIC) (syn. Autogene Matrixinduzierte Chondrogenese) ist ein biologisches Operationsverfahren zur Behandlung und Reparatur von geschädigtem Gelenkknorpel. Hierbei handelt sich um eine Modifikation der , einer Technik zur Behandlung kleiner Knorpeldefekte, bei der zusätzlich eine zweischichtige Kollagen-I/III-Membran aufgetragen wird. Das Akronym AMIC ist ein Markenname, an dem die Ed. Geistlich Söhne AG die Rechte besitzt. Autologous matrix-induced chondrogenesis (AMIC) is a treatment for articular cartilage damage. It combines microfracture surgery with the application of a bi-layer collagen I/III membrane.There is tentative short to medium term benefits as of 2017. The initialism AMIC, often used as a genericized trademark, is a registered trademark of Ed. Geistlich Söhne AG, protected by German Registration No. 30255356 and international Registration No. 840373.
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dbr:Knee_cartilage_replacement_therapy
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dbo:abstract
Die Autologe Matrixinduzierte Chondrogenese (AMIC) (syn. Autogene Matrixinduzierte Chondrogenese) ist ein biologisches Operationsverfahren zur Behandlung und Reparatur von geschädigtem Gelenkknorpel. Hierbei handelt sich um eine Modifikation der , einer Technik zur Behandlung kleiner Knorpeldefekte, bei der zusätzlich eine zweischichtige Kollagen-I/III-Membran aufgetragen wird. Das Akronym AMIC ist ein Markenname, an dem die Ed. Geistlich Söhne AG die Rechte besitzt. AMIC bewirkt eine Schmerzlinderung und Wiederherstellung der Gelenkfunktion und soll letztlich eine vollkommene Wiedererlangung der Beweglichkeit ermöglichen, so dass eine Rückkehr zum gewohnten Lebensstil und Aktivitätsniveau möglich wird. Es verlangsamt den Verschleiß des Gelenkknorpels mit dem Ziel, auf einen teilweisen oder vollständigen Ersatz des Kniegelenks (Knieprothese) verzichten oder diesen hinauszögern zu können. Autologous matrix-induced chondrogenesis (AMIC) is a treatment for articular cartilage damage. It combines microfracture surgery with the application of a bi-layer collagen I/III membrane.There is tentative short to medium term benefits as of 2017. The initialism AMIC, often used as a genericized trademark, is a registered trademark of Ed. Geistlich Söhne AG, protected by German Registration No. 30255356 and international Registration No. 840373. The procedure described below relates specifically to the use of a collagen membrane, but recent advances now allow the use, using the same surgical procedure of non woven bio degradable materials that were initially developed for cell culturing of chondrocytes to be employed. These purely synthetic materials ( contain no animal derived products) are often further enhanced by impregnation of the material with high concentrations of Hyaluronic acid, which has been shown to be required to stimulate the differentiation of stem cells migrating from the bone marrow into chondrocytes (the true cartilage cell) and the resultant synthesis of type 2 collagen, the same native collagen found in the undamaged cartilage tissue. These enhanced synthetic biodegradable materials have been used to treat lesions in the knee, ankle, hip and great toe.
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