This HTML5 document contains 57 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
dbohttp://dbpedia.org/ontology/
foafhttp://xmlns.com/foaf/0.1/
n18https://global.dbpedia.org/id/
dbthttp://dbpedia.org/resource/Template:
dbpedia-ukhttp://uk.dbpedia.org/resource/
n19http://arz.dbpedia.org/resource/
rdfshttp://www.w3.org/2000/01/rdf-schema#
freebasehttp://rdf.freebase.com/ns/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
dbpedia-arhttp://ar.dbpedia.org/resource/
owlhttp://www.w3.org/2002/07/owl#
n16http://bs.dbpedia.org/resource/
n21http://tt.dbpedia.org/resource/
wikipedia-enhttp://en.wikipedia.org/wiki/
dbphttp://dbpedia.org/property/
provhttp://www.w3.org/ns/prov#
dbchttp://dbpedia.org/resource/Category:
xsdhhttp://www.w3.org/2001/XMLSchema#
goldhttp://purl.org/linguistics/gold/
wikidatahttp://www.wikidata.org/entity/
dbrhttp://dbpedia.org/resource/

Statements

Subject Item
dbr:CMTM2
rdf:type
dbo:Gene dbo:HumanGene owl:Thing dbo:Biomolecule wikidata:Q7187 wikidata:Q206229 dbo:Protein
rdfs:label
CMTM2 CMTM2 CMTM2
rdfs:comment
CKLF-like MARVEL transmembrane domain-containing protein 2 (i.e. CMTM2), previously termed chemokine-like factor superfamily 2 ( i.e. CKLFSF2), is a member of the CKLF-like MARVEL transmembrane domain-containing family (CMTM) of proteins. In humans, it is encoded by the CMTM2 gene located in band 22 on the long (i.e. "q") arm of chromosome 16. CMTM2 protein is expressed in the bone marrow and various circulating blood cells. It is also highly expressed in testicular tissues: The CMTM2 gene and CMTM2 protein, it is suggested, may play an important role in testicular development. CMTM2 (англ. CKLF like MARVEL transmembrane domain containing 2) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 16-ї хромосоми. Довжина поліпептидного ланцюга білка становить 248 амінокислот, а молекулярна маса — 27 496. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин CMTM2‏ (CKLF like MARVEL transmembrane domain containing 2) هوَ بروتين يُشَفر بواسطة جين CMTM2 في الإنسان.
dcterms:subject
dbc:Human_proteins dbc:Gene_expression
dbo:wikiPageID
16846511
dbo:wikiPageRevisionID
1118758935
dbo:wikiPageWikiLink
dbr:Gastric_cancer dbr:Locus_(genetics) dbr:Testicular dbr:Tumor_suppressor dbr:CKLF-like_MARVEL_transmembrane_domain-containing_family dbr:Bone_marrow dbc:Human_proteins dbr:Adenoid_cystic_carcinoma dbc:Gene_expression dbr:Gene dbr:Chromosome_16 dbr:Hepatocellular_carcinoma dbr:Salivary_gland dbr:Karyotype dbr:Linitis_plastica dbr:Blood_cells dbr:Biological_target
owl:sameAs
dbpedia-ar:CMTM2 freebase:m.04084mq n16:CMTM2 dbpedia-uk:CMTM2 wikidata:Q18051443 n18:kJ3e n19:CMTM2 n21:CMTM2
dbp:wikiPageUsesTemplate
dbt:Refbegin dbt:Cite_journal dbt:Reflist dbt:Refend dbt:Short_description dbt:Infobox_gene dbt:Clear dbt:UCSC_gene_info
dbo:abstract
CKLF-like MARVEL transmembrane domain-containing protein 2 (i.e. CMTM2), previously termed chemokine-like factor superfamily 2 ( i.e. CKLFSF2), is a member of the CKLF-like MARVEL transmembrane domain-containing family (CMTM) of proteins. In humans, it is encoded by the CMTM2 gene located in band 22 on the long (i.e. "q") arm of chromosome 16. CMTM2 protein is expressed in the bone marrow and various circulating blood cells. It is also highly expressed in testicular tissues: The CMTM2 gene and CMTM2 protein, it is suggested, may play an important role in testicular development. Studies find that the levels of CMTM2 protein in hepatocellular carcinoma tissues of patients are lower higher than their levels in normal liver tissues. CMTM2 protein levels were also lower in the hepatocellular carcinoma tissues that had a more aggressive pathology and therefore a possible poorer prognosis. Finally, the forced overexpression of CMTM2 protein in cultured hepatocellular tumor cells inhibited their invasiveness and migration. These findings suggest that CMTM2 protein suppresses the development and/or progression of hepatocellular carcinoma and therefore that the CMTM2 gene acts as a tumor suppressor in this cancer. Patients with higher CMTM2 levels in their linitis plastica stomach cancer (i.e. a type of gastric cancer also termed diffuse-type gastric cancer or diffuse type adenocarcinoma of the stomach) tissues had better prognoses than patients with lower CMTM2 levels in their linitis plastica tissues. And, the CMTM2 gene has been found to be more highly expressed in the salivary gland adenoid cystic carcinoma tissues of patients who did not develop tumor recurrences or perineural invasion of their carcinomas compared to the expression of this gene in patients whose adenoid cystic carcinoma tissues went on to develop these complications. These findings suggest that the CMTM2 gene may act as a tumor suppressor not only in hepatocellular carcinoma but also in linitis plastica and salivary gland adenoid cystic carcinoma. Further studies are needed to confirm these findings and determine if CMTM2 protein can serve as a marker for the severity of these three cancers and/or as a therapeutic target for treating them. CMTM2 (англ. CKLF like MARVEL transmembrane domain containing 2) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 16-ї хромосоми. Довжина поліпептидного ланцюга білка становить 248 амінокислот, а молекулярна маса — 27 496. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функцією належить до цитокінів. Задіяний у таких біологічних процесах, як хемотаксис, альтернативний сплайсинг. Локалізований у мембрані. CMTM2‏ (CKLF like MARVEL transmembrane domain containing 2) هوَ بروتين يُشَفر بواسطة جين CMTM2 في الإنسان.
gold:hypernym
dbr:Protein
prov:wasDerivedFrom
wikipedia-en:CMTM2?oldid=1118758935&ns=0
dbo:wikiPageLength
7382
foaf:isPrimaryTopicOf
wikipedia-en:CMTM2