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Statements

Subject Item
dbr:Cocaine_esterase
rdf:type
yago:Thing100002452 dbo:Enzyme wikidata:Q206229 dbo:Biomolecule yago:Macromolecule114944888 yago:Compound114818238 yago:Chemical114806838 yago:Activator114723079 yago:Protein114728724 yago:Substance100019613 yago:Unit109465459 yago:OrganicCompound114727670 yago:Material114580897 yago:Relation100031921 yago:Molecule114682133 yago:PhysicalEntity100001930 yago:Matter100020827 yago:Enzyme114732946 yago:Part113809207 yago:Catalyst114723628 owl:Thing wikidata:Q8047 yago:Abstraction100002137
rdfs:label
コカインエステラーゼ Cocaine esterase Esterase cocaína
rdfs:comment
The enzyme cocaine esterase (EC 3.1.1.84, CocE, hCE2, hCE-2, human carboxylesterase 2; systematic name cocaine benzoylhydrolase) catalyses the reaction cocaine + H2O ecgonine methyl ester + benzoate Rhodococcus sp. strain MB1 and Pseudomonas maltophilia strain MB11L can utilize cocaine as sole source of carbon and energy. The theoretical molecular mass is 62,128 Da. This enzyme and redesigned versions of it have been studied as a potential treatment for cocaine addiction in humans. コカインエステラーゼ(Cocaine esterase、EC 3.1.1.84)は、コカイン ベンゾイルヒドロラーゼ(cocaine benzoylhydrolase)という系統名を持つ酵素である。この酵素は、以下の化学反応を触媒する。 コカイン + 水エクゴニンメチルエステル + 安息香酸 ロドコッカス属のMB1株やのMB1 1L株はコカインを唯一の炭素源、エネルギー源として用いることができる。 Esterase cocaína (EC 3.1.1.84, CocE, hCE2, hCE-2, carboxilesterase humana 2) é uma enzima que metaboliza a cocaína (COC) por hidrólise benzoica. Esta enzima catalisa a seguinte reação química: cocaína + H2O éster metílico de ecgonina + ácido benzoico Em alguns microorganismos, como na cepa MB1 de Rhodococcus sp. e na cepa MB11L de Pseudomonas maltophilia, a cocaína é utilizada como a única fonte de carbono e energia.
foaf:name
Cocaine esterase
dbp:name
Cocaine esterase
dcterms:subject
dbc:EC_3.1.1
dbo:wikiPageID
39003392
dbo:wikiPageRevisionID
1105066610
dbo:wikiPageWikiLink
dbc:EC_3.1.1 dbr:Cocaine dbr:Cocaine_addiction dbr:Rhodococcus dbr:Bioremediation dbr:Catalysis dbr:Pseudomonas_maltophilia dbr:Energy dbr:Benzoate dbr:Carbon
dbo:wikiPageExternalLink
n20:16968810
owl:sameAs
dbpedia-ja:コカインエステラーゼ dbpedia-sr:Kokainska_estaraza dbpedia-sh:Kokainska_estaraza n16:7L9Z freebase:m.0sghmsx dbpedia-pt:Esterase_cocaína wikidata:Q10324630
dbp:wikiPageUsesTemplate
dbt:Enzymes dbt:MeshName dbt:Infobox_enzyme dbt:Portal_bar dbt:Reflist dbt:Esterases
dbp:ecNumber
3.1
dbp:iubmbEcNumber
3
dbp:molecularWeight
62128
dbo:abstract
The enzyme cocaine esterase (EC 3.1.1.84, CocE, hCE2, hCE-2, human carboxylesterase 2; systematic name cocaine benzoylhydrolase) catalyses the reaction cocaine + H2O ecgonine methyl ester + benzoate Rhodococcus sp. strain MB1 and Pseudomonas maltophilia strain MB11L can utilize cocaine as sole source of carbon and energy. The theoretical molecular mass is 62,128 Da. This enzyme and redesigned versions of it have been studied as a potential treatment for cocaine addiction in humans. TNX-1300 (T172R/G173Q double-mutant cocaine esterase 200 mg, i.v. solution) is being developed under an Investigational New Drug application (IND) for the treatment of cocaine intoxication. TNX-1300 (formerly known as RBP-8000) is a recombinant protein enzyme produced through rDNA technology in a non-disease-producing strain of E. coli bacteria. Cocaine Esterase (CocE) was identified in bacteria (Rhodococcus) that use cocaine as its sole source of carbon and nitrogen and that grow in soil surrounding coca plants. The gene encoding CocE was identified and the protein was extensively characterized. CoCE catalyzes the breakdown of cocaine into metabolite ecgonine methyl ester and benzoic acid. Wild-type CocE is unstable at body temperature, so targeted mutations were introduced in the CocE gene and resulted in the T172R/G173Q Double-Mutant CocE, which is active for approximately 6 hours at body temperature. In a Phase 2 study, TNX-1300 at 100 mg or 200 mg i.v. doses was well tolerated and interrupted cocaine effects after cocaine 50 mg i.v. challenge. The enzyme is important in bioremediation, levels of cocaine in European ocean water were cited at 20 ng/L, similar levels in which swollen muscles, and in some cases broken muscle fibers of eels were reported in a controlled study. Esterase cocaína (EC 3.1.1.84, CocE, hCE2, hCE-2, carboxilesterase humana 2) é uma enzima que metaboliza a cocaína (COC) por hidrólise benzoica. Esta enzima catalisa a seguinte reação química: cocaína + H2O éster metílico de ecgonina + ácido benzoico Em alguns microorganismos, como na cepa MB1 de Rhodococcus sp. e na cepa MB11L de Pseudomonas maltophilia, a cocaína é utilizada como a única fonte de carbono e energia. コカインエステラーゼ(Cocaine esterase、EC 3.1.1.84)は、コカイン ベンゾイルヒドロラーゼ(cocaine benzoylhydrolase)という系統名を持つ酵素である。この酵素は、以下の化学反応を触媒する。 コカイン + 水エクゴニンメチルエステル + 安息香酸 ロドコッカス属のMB1株やのMB1 1L株はコカインを唯一の炭素源、エネルギー源として用いることができる。
prov:wasDerivedFrom
wikipedia-en:Cocaine_esterase?oldid=1105066610&ns=0
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7210
dbo:ecNumber
3.1.1.84
foaf:isPrimaryTopicOf
wikipedia-en:Cocaine_esterase