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Statements

Subject Item
dbr:Collagenase_clostridium_histolyticum
rdf:type
dbo:Protein yago:Drug103247620 n11:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug yago:PhysicalEntity100001930 yago:WikicatDrugsActingOnTheMusculoskeletalSystem yago:Substance100020090 yago:CausalAgent100007347 owl:Thing yago:Agent114778436 yago:Matter100020827
rdfs:label
Collagenase clostridium histolyticum
rdfs:comment
Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum that dismantles collagen. It is used as a powder-and-solvent injection kit for the treatment of Dupuytren's contracture, a condition where the fingers bend towards the palm and cannot be fully straightened, and Peyronie's disease, a connective tissue disorder involving the growth of fibrous plaques in the soft tissue of the penis. BioSpecifics Technologies developed the preparation, which is manufactured and marketed by Endo Pharmaceuticals as Xiaflex in the US and by Sobi as Xiapex in Europe.
foaf:name
Collagenase clostridium histolyticum
foaf:depiction
n19:Xiaflex_(Collagenase)_for_Dupuytrens.jpg
dcterms:subject
dbc:Drugs_acting_on_the_musculoskeletal_system dbc:Orphan_drugs dbc:EC_3.4.24
dbo:wikiPageID
26270435
dbo:wikiPageRevisionID
1106435897
dbo:wikiPageWikiLink
dbr:Peyronie's_disease dbr:Clostridium_histolyticum dbr:Tetracyclines dbr:Endo_Pharmaceuticals dbr:Oedema dbr:Injection_(medicine) dbc:Drugs_acting_on_the_musculoskeletal_system dbr:C-terminus dbr:Bruise dbr:Anaerobic_fermentation dbr:Quinolones dbc:Orphan_drugs dbr:Ecchymoses dbr:Synergistic dbc:EC_3.4.24 dbr:Tropocollagen dbr:Strain_(biology) dbr:Lymph_node dbr:Allergic_reaction dbr:Lesion dbr:Collagen dbr:Santyl dbr:Committee_for_Medicinal_Products_for_Human_Use dbr:Lipoma dbr:Lymphadenopathy dbr:Amino_acid_sequence n20:Xiaflex_(Collagenase)_for_Dupuytrens.jpg dbr:Swedish_Orphan_Biovitrum dbr:Matrix_metalloproteinase dbr:Frozen_shoulder dbr:Collagenase dbr:Palmar_fascia dbr:N-termini dbr:Enzyme dbr:Dupuytren's_contracture dbr:Food_and_Drug_Administration dbr:Protease dbr:Anthracyclines dbr:Anthraquinone
dbo:wikiPageExternalLink
n7:collagenase%20clostridium%20histolyticum n14:
owl:sameAs
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dbp:wikiPageUsesTemplate
dbt:Fdacite dbt:Enzymes dbt:Medcn dbt:Portal_bar dbt:Cascite dbt:Cite_web dbt:Chemspidercite dbt:Reflist dbt:Metalloendopeptidases dbt:Drugs.com dbt:Short_description dbt:Drugbankcite dbt:Citation_needed dbt:Other_drugs_for_disorders_of_the_musculo-skeletal_system dbt:Drugbox
dbo:thumbnail
n19:Xiaflex_(Collagenase)_for_Dupuytrens.jpg?width=300
dbp:atcSuffix
AB02
dbp:atcPrefix
M09
dbp:casNumber
9001-12-01
dbp:chemspiderid
none
dbp:drugName
Collagenase clostridium histolyticum
dbp:drugbank
DB00048
dbp:kegg
816.0
dbp:legalStatus
Rx-only
dbp:legalUs
Rx-only
dbp:medlineplus
a612029
dbp:molecularWeight
114 113
dbp:pregnancyUs
B
dbp:routesOfAdministration
Intralesional injection
dbp:synonyms
AA-4500, collagenase clostridium histolyticum-aaes
dbp:tradename
Xiaflex, Xiapex, Qwo
dbp:unii
9
dbp:verifiedfields
changed
dbp:verifiedrevid
460106587
dbp:watchedfields
changed
dbo:abstract
Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum that dismantles collagen. It is used as a powder-and-solvent injection kit for the treatment of Dupuytren's contracture, a condition where the fingers bend towards the palm and cannot be fully straightened, and Peyronie's disease, a connective tissue disorder involving the growth of fibrous plaques in the soft tissue of the penis. BioSpecifics Technologies developed the preparation, which is manufactured and marketed by Endo Pharmaceuticals as Xiaflex in the US and by Sobi as Xiapex in Europe. Biochemically, it is a mixture of two C. histolyticum collagenases, ColH and ColG. A similar ointment preparation called Santyl contains one or many collagenases from the same bacterium, but it is unclear which.
dbp:dailymedid
Collagenase_clostridium_histolyticum
dbp:innEma
Collagenase clostridium histolyticum
dbp:licenceEu
yes
dbp:pubchemsubstance
138909
gold:hypernym
dbr:Enzyme
prov:wasDerivedFrom
wikipedia-en:Collagenase_clostridium_histolyticum?oldid=1106435897&ns=0
dbo:wikiPageLength
9624
dbo:alternativeName
Xiaflex, Xiapex, Qwo
dbo:casNumber
9001-12-1
dbo:drugbank
DB00048
dbo:fdaUniiCode
9X7O8V25IT
dbo:kegg
C00816
dbo:medlinePlus
a612029
foaf:isPrimaryTopicOf
wikipedia-en:Collagenase_clostridium_histolyticum