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Statements

Subject Item

dbr:Conserved_signature_indels

rdfs:label

Conserved Signature Indel Conserved signature indels

rdfs:comment

Conserved signature inserts and deletions (CSIs) in protein sequences provide an important category of molecular markers for understanding phylogenetic relationships. CSIs, brought about by rare genetic changes, provide useful phylogenetic markers that are generally of defined size and they are flanked on both sides by conserved regions to ensure their reliability. While indels can be arbitrary inserts or deletions, CSIs are defined as only those protein indels that are present within conserved regions of the protein. Conserved signature inserts and deletions (zu Deutsch ‚konservierte charakteristische Indels‘, CSI) sind Indels in konservierten proteincodierenden DNA-Sequenzen. Sie werden in der Biochemie und Genetik als Marker zur Bestimmung von Verwandtschaftsgraden zwischen verschiedenen Arten verwendet.

foaf:depiction

n16:Group_indel_picture.png n16:Archea_phylogeny_CSI.png n16:Pastureles_phylogeny_CSI.png n16:Mainline_indel_picture.png n16:Thermotogae_phlogeny_CSI_summary.png

dct:subject

dbc:Molecular_biology

dbo:wikiPageID

35155103

dbo:wikiPageRevisionID

1086347579

dbo:wikiPageWikiLink

dbr:Deinococcota dbr:Pseudomonadota dbr:Fungi dbr:Nitrososphaerota n9:Group_indel_picture.png dbr:Enolase dbr:Dictyoglomota dbr:Thermotogota dbr:Fusobacteriota dbr:Phosphoribosylaminoimidazolecarboxamide_formyltransferase dbr:Nitrosopumilus_maritimus dbr:Ribosomal_protein dbr:Thiotrichales dbr:Horizontal_gene_transfer dbr:Taxon dbr:Animals dbr:Francisella_tularensis dbr:16s_rRNA dbc:Molecular_biology dbr:Molecular_markers dbr:Xanthomonadales dbr:Methylococcales dbr:Clade n9:Thermotogae_phlogeny_CSI_summary.png dbr:RNA_polymerase dbr:Sulfolobales dbr:Eukaryotes dbr:Eukaryotic dbr:Cenarchaeum_symbiosum dbr:Oceanospirillales dbr:Haemophilus_influenzae dbr:Enterobacteriales dbr:Monophyly dbr:Thermoproteota dbr:Haemophilus_ducreyi dbr:Aggregatibacter dbr:Planctomycetota dbr:Convergent_evolution dbr:Pasteurella dbr:Gammaproteobacteria dbr:Chlorobiota dbr:Pseudomonadales dbr:Thermoproteales dbr:Cardiobacteriales dbr:Leucyl-tRNA_synthetase dbr:Class_(biology) n9:Pastureles_phylogeny_CSI.png dbr:Phylogenetic_tree dbr:Eukaryotic_translation_elongation_factor_1_alpha_1 dbr:Chloroflexota dbr:Plants dbr:Indel dbr:Chromatiales dbr:Pasteurellales n9:Mainline_indel_picture.png dbr:Aeromonadales dbr:Chlamydiota dbr:Order_(biology) dbr:Bacteroidota n9:Archea_phylogeny_CSI.png dbr:Vibrionales dbr:Legionellales dbr:Bacillota dbr:Parallel_evolution dbr:Aquificota dbr:Archaea dbr:RpoB dbr:Synapomorphy dbr:Alteromonadales dbr:Type_II_topoisomerase dbr:Desulfurococcales dbr:16S_ribosomal_RNA

owl:sameAs

dbpedia-gl:Indel_sinatura_conservado n10:4iN8D wikidata:Q5163163 dbpedia-de:Conserved_Signature_Indel yago-res:Conserved_signature_indels freebase:m.0jt48z4

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dbo:thumbnail

n16:Group_indel_picture.png?width=300

dbo:abstract

Conserved signature inserts and deletions (zu Deutsch ‚konservierte charakteristische Indels‘, CSI) sind Indels in konservierten proteincodierenden DNA-Sequenzen. Sie werden in der Biochemie und Genetik als Marker zur Bestimmung von Verwandtschaftsgraden zwischen verschiedenen Arten verwendet. Conserved signature inserts and deletions (CSIs) in protein sequences provide an important category of molecular markers for understanding phylogenetic relationships. CSIs, brought about by rare genetic changes, provide useful phylogenetic markers that are generally of defined size and they are flanked on both sides by conserved regions to ensure their reliability. While indels can be arbitrary inserts or deletions, CSIs are defined as only those protein indels that are present within conserved regions of the protein. The CSIs that are restricted to a particular clade or group of species, generally provide good phylogenetic markers of common evolutionary descent. Due to the rarity and highly specific nature of such changes, it is less likely that they could arise independently by either convergent or parallel evolution (i.e. homoplasy) and therefore are likely to represent synapomorphy. Other confounding factors such as differences in evolutionary rates at different sites or among different species also generally do not affect the interpretation of a CSI. By determining the presence or absence of CSIs in an out-group species, one can infer whether the ancestral form of the CSI was an insert or deletion and this can be used to develop a rooted phylogenetic relationship among organisms. Most CSIs that have been identified have been found to exhibit high predictive value and they generally retain the specificity for the originally identified clades of species. Therefore, based upon their presence or absence, it should be possible to identify both known and even previously unknown species belonging to these groups in different environments.

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wikipedia-en:Conserved_signature_indels?oldid=1086347579&ns=0

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20597

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wikipedia-en:Conserved_signature_indels