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Statements

Subject Item
dbr:Cutamesine
rdf:type
n10:ChemicalObject dbo:ChemicalSubstance owl:Thing dbo:ChemicalCompound wikidata:Q11173
rdfs:label
Cutamesine
rdfs:comment
Cutamesine (SA 4503) is a synthetic sigma receptor agonist which is selective for the σ1 receptor, a chaperone protein mainly found in the endoplasmic reticulum of cells in the central nervous system. These σ1 receptors play a key role in the modulation of Ca2+ release and apoptosis. Cutamesine's activation of the σ1 receptor is tied to a variety of physiological phenomena in the CNS, including activation of dopamine-releasing neurons and repression of the MAPK/ERK pathway.
foaf:depiction
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dct:subject
dbc:Catechol_ethers dbc:Sigma_agonists dbc:Phenethylamines dbc:Piperazines
dbo:wikiPageID
11805180
dbo:wikiPageRevisionID
1117600644
dbo:wikiPageWikiLink
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dbo:wikiPageExternalLink
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owl:sameAs
dbpedia-sr:SA_4503 wikidata:Q6589967 n19:اس‌ای-۴۵۰۳ dbpedia-fa:اس‌ای-۴۵۰۳ dbpedia-sh:SA_4503 n22:4qK6r
dbp:wikiPageUsesTemplate
dbt:Chembox dbt:Chembox_Properties dbt:MeshName dbt:Sigma_receptor_modulators dbt:Fdacite dbt:Cascite dbt:Chembox_Hazards dbt:Chembox_Identifiers
dbo:thumbnail
n7:SA_4503.png?width=300
dbp:imagefile
SA 4503.png
dbp:imagesize
250
dbp:pin
1
dbp:verifiedfields
changed
dbp:verifiedrevid
426718453
dbo:abstract
Cutamesine (SA 4503) is a synthetic sigma receptor agonist which is selective for the σ1 receptor, a chaperone protein mainly found in the endoplasmic reticulum of cells in the central nervous system. These σ1 receptors play a key role in the modulation of Ca2+ release and apoptosis. Cutamesine's activation of the σ1 receptor is tied to a variety of physiological phenomena in the CNS, including activation of dopamine-releasing neurons and repression of the MAPK/ERK pathway.
prov:wasDerivedFrom
wikipedia-en:Cutamesine?oldid=1117600644&ns=0
dbo:wikiPageLength
14919
dbo:iupacName
1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine
foaf:isPrimaryTopicOf
wikipedia-en:Cutamesine