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Statements

Subject Item
dbr:DAPT_(chemical)
rdf:type
dbo:ChemicalSubstance owl:Thing wikidata:Q11173 dbo:ChemicalCompound n16:ChemicalObject
rdfs:label
DAPT (chemical)
rdfs:comment
DAPT is a chemical compound used in the study of the Notch signaling pathway. DAPT is a γ-secretase inhibitor. It indirectly inhibits Notch, which is a substrate for γ-secretase. In a mouse model of Alzheimer's disease, DAPT reduces the levels of beta-amyloid.
foaf:name
DAPT
dbp:name
DAPT
foaf:depiction
n11:DAPT.svg
dcterms:subject
dbc:Dipeptides dbc:Enzyme_inhibitors dbc:Fluoroarenes dbc:Gamma_secretase_inhibitors
dbo:wikiPageID
60114732
dbo:wikiPageRevisionID
1030539227
dbo:wikiPageWikiLink
dbr:Beta-amyloid dbc:Gamma_secretase_inhibitors dbc:Enzyme_inhibitors dbr:Mouse_model dbc:Fluoroarenes dbr:Alzheimer's_disease dbr:Gamma_secretase dbr:Notch_signaling_pathway dbr:Chemical_compound dbr:Enzyme_inhibitor dbc:Dipeptides
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dbo:thumbnail
n11:DAPT.svg?width=300
dbp:imagefile
DAPT.svg
dbp:imagesize
200
dbp:othernames
gamma-Secretase Inhibitor IX; GSI-IX; LY-374973; N-[N--(L)-alanyl]-S-phenylglycine t-butyl ester
dbp:pin
tert-Butyl -{-2-[2-acetamido]propanamido}phenylacetate
dbo:abstract
DAPT is a chemical compound used in the study of the Notch signaling pathway. DAPT is a γ-secretase inhibitor. It indirectly inhibits Notch, which is a substrate for γ-secretase. In a mouse model of Alzheimer's disease, DAPT reduces the levels of beta-amyloid.
prov:wasDerivedFrom
wikipedia-en:DAPT_(chemical)?oldid=1030539227&ns=0
dbo:wikiPageLength
3439
dbo:alternativeName
gamma-Secretase Inhibitor IX; GSI-IX; LY-374973; N-[N-(3,5-Difluorophenacetyl)-(L)-alanyl]-S-phenylglycine t-butyl ester
dbo:iupacName
tert-Butyl (S)-{(2S)-2-[2-(3,5-difluorophenyl)acetamido]propanamido}phenylacetate
foaf:isPrimaryTopicOf
wikipedia-en:DAPT_(chemical)