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Statements

Subject Item
dbr:E-64
rdf:type
yago:Medicine103740161 yago:Formula106816935 yago:ProteaseInhibitor104013993 yago:CausalAgent100007347 dbo:ChemicalCompound n11:ChemicalObject dbo:ChemicalSubstance yago:Matter100020827 owl:Thing yago:MolecularFormula106817173 yago:WikicatMolecularFormulas wikidata:Q11173 yago:Communication100033020 yago:WikicatProteaseInhibitors yago:Antiviral102725367 yago:Message106598915 yago:Statement106722453 yago:Agent114778436 yago:Drug103247620 yago:Substance100020090 yago:PhysicalEntity100001930 yago:Abstraction100002137
rdfs:label
E-64
rdfs:comment
E-64 is an epoxide which can irreversibly inhibit a wide range of cysteine peptidases. The compound was first isolated and identified from Aspergillus japonicus in 1978. It has since been shown to inhibit many cysteine peptidases such as papain, cathepsin B, cathepsin L, calpain and staphopain. The low toxic effects of the inhibitor, in addition to its effective mechanism of action, makes E-64 a potential template for drugs to treat diseases where high levels of a cysteine proteases are the primary cause.
foaf:depiction
n10:E_64.png n10:E-64mech.jpg n10:E-64spheres.png
dct:subject
dbc:Protease_inhibitors dbc:Epoxides dbc:Carboxamides dbc:Carboxylic_acids dbc:Guanidines dbc:Dipeptides
dbo:wikiPageID
28444024
dbo:wikiPageRevisionID
1113224581
dbo:wikiPageWikiLink
dbr:Papain dbc:Protease_inhibitors dbc:Epoxides dbr:Epoxide dbr:Calpain dbr:Aspergillus_japonicus dbr:Cysteine dbr:Cysteine_protease dbc:Carboxamides dbc:Carboxylic_acids dbr:Thiol dbc:Guanidines dbr:Dipeptide dbr:Staphopain n23:E-64mech.jpg dbr:Cathepsin_L_(disambiguation) dbr:Cathepsin_B dbc:Dipeptides dbr:Aloxistatin
owl:sameAs
dbpedia-sr:E-64 yago-res:E-64 n16:4jAbv freebase:m.0crd36m dbpedia-sh:E-64 wikidata:Q5321373
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dbo:thumbnail
n10:E-64spheres.png?width=300
dbp:imagefile
E-64spheres.png E 64.png
dbp:iupacname
-2
dbp:othernames
E 64; Proteinase Inhibitor E 64; N-[N--(L)-leucyl]-agmatine; [1-[N-[-(L)-leucyl]amino]-4-guanidinobutane]
dbp:verifiedrevid
445994617
dbp:watchedfields
changed
dbo:abstract
E-64 is an epoxide which can irreversibly inhibit a wide range of cysteine peptidases. The compound was first isolated and identified from Aspergillus japonicus in 1978. It has since been shown to inhibit many cysteine peptidases such as papain, cathepsin B, cathepsin L, calpain and staphopain. The low toxic effects of the inhibitor, in addition to its effective mechanism of action, makes E-64 a potential template for drugs to treat diseases where high levels of a cysteine proteases are the primary cause.
gold:hypernym
dbr:Epoxide
prov:wasDerivedFrom
wikipedia-en:E-64?oldid=1113224581&ns=0
dbo:wikiPageLength
4180
dbo:alternativeName
E 64; Proteinase Inhibitor E 64; N-[N-((L)-3-trans-carboxyirane-2-carbonyl)-(L)-leucyl]-agmatine;[1-[N-[((L)-3-trans-carboxyoxirane-2-carbonyl)-(L)-leucyl]amino]-4-guanidinobutane]
dbo:iupacName
(1S,2S)-2-(((S)-1-((4-Guanidinobutyl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)cyclopropanecarboxylic acid
foaf:isPrimaryTopicOf
wikipedia-en:E-64