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Statements

Subject Item
dbr:Kedarcidin
rdf:type
yago:WikicatAntibiotics wikidata:Q11173 yago:PhysicalEntity100001930 owl:Thing yago:Substance100020090 n21:ChemicalObject yago:Drug103247620 dbo:ChemicalSubstance yago:CausalAgent100007347 dbo:ChemicalCompound yago:Antibiotic102716866 yago:Matter100020827 yago:Antibacterial102716205 yago:Agent114778436 yago:Medicine103740161
rdfs:label
Кедарцидін Kedarcidin
rdfs:comment
Кедарцидін — хромопротеїн протипухлинний препарат вперше виділений з актиноміцетів у 1992 році. Кедарцидін, ймовірно, виробляється мікроорганізмами для вбивства конкурентних бактерій. Оскільки це досягається шляхом пошкодження ДНК кедарцидін здатний також завдавати шкоди пухлинним клітинам. Кедарцидін є предметом наукових досліджень, як з точки зору його структурної складності, так і його протипухлинних властивостей. Kedarcidin is a chromoprotein antitumor antibiotic first isolated from an Actinomycete in 1992, comprising an ansa-bridged enediyne chromophore (shown) as well as an apoprotein that serves to stabilize the toxin in the Actinomycete. Like other members of the enediyne class of drugs—so named for the nine-or-ten-membered core structure bearing an alkene directly attached to two alkynyl appendages—kedarcidin was likely evolved to kill bacteria that compete with the producing organism. Because it achieves this by causing DNA damage, however, kedarcidin is capable of harming tumor cells, as well. Kedarcidin is thus the subject of scientific research, both for its structural complexity as well as its anticancer properties.
foaf:name
Kedarcidin chromophore
dbp:name
Kedarcidin chromophore
foaf:depiction
n14:Transannular_cyclization.png n14:Epoxide_stereochemistry_kedarcidin.png n14:Azatyrosine_biosynthesis.png n14:2-naphthonate_biosynthesis.png n14:Ring_strain_MM2.png n14:Retrosynthetic_approach_kedarcidin.png n14:DNA_damage_mechanism.png n14:Kedarcidin_core_Bergman_equilibrium.png n14:Kedarcidin_structure_series_of_revisions.png n14:Kedarcidin_borohydride_reduction.png n14:Martin_sulfurane_mechanism.png n14:Kedarcidin_chromophore_2007_revised_1.png n14:Kedarcidin_3D_structure.png n14:Kedarcidin_biosynthesis.png
dcterms:subject
dbc:Epoxides dbc:Cancer_research dbc:Nine-membered_rings dbc:Lactones dbc:Experimental_drugs dbc:Antineoplastic_drugs dbc:Isopropyl_compounds dbc:Naphthalenes dbc:Enediynes
dbo:wikiPageID
40430775
dbo:wikiPageRevisionID
1081059967
dbo:wikiPageWikiLink
dbr:Glaser_coupling dbc:Epoxides dbr:Netropsin dbr:NMR dbr:Propargyl dbr:Martin_sulfurane dbc:Cancer_research dbr:Deoxyribose dbr:IC50 n8:Retrosynthetic_approach_kedarcidin.png n8:Ring_strain_MM2.png dbr:Bridge_(chemical) dbr:Intercalation_(chemistry) dbr:Retrosynthetic_analysis dbr:Alpha-amino_acid dbr:Beta_amino_acid dbr:Antibody-drug_conjugate n8:Martin_sulfurane_mechanism.png dbr:Chelation dbr:Sonogashira_coupling dbr:Benzyne n8:MNBA-lactonization-Kedarcidin.tif dbr:Noncovalent_bonding dbr:4-dimethylaminopyridine dbr:C-1027 dbr:Flavin_adenine_dinucleotide dbr:Calicheamicin dbr:Aglycone dbr:Chromoprotein dbr:Chromophore n8:Epoxide_stereochemistry_kedarcidin.png dbr:Scripps_Research_Institute dbr:Neocarzinostatin dbr:Maduropeptin dbr:Bristol-Myers_Squibb dbc:Nine-membered_rings dbr:Actinomycetota dbc:Lactones dbr:Antineoplastic_drug dbr:Shiina_macrolactonization dbc:Experimental_drugs dbr:Nucleophile dbr:Methyltransferase dbr:Benzoate dbr:Radical_SAM dbr:Carrier_protein dbr:Protecting_group dbr:Anticarcinogen dbr:University_of_Wisconsin-Madison dbr:Alkene n8:Transannular_cyclization.png dbr:Thiolate dbr:2-Mercaptoethanol dbc:Antineoplastic_drugs dbr:Biosynthesis dbr:Enediyne dbr:In_vivo dbr:Organolithium_reagent dbr:Naphthoic_acid dbr:Vinyllithium dbr:DNA dbc:Isopropyl_compounds dbr:Inotuzumab_ozogamicin dbc:Enediynes dbr:Dehydration_reaction dbr:Mutase dbr:Alkyne dbr:Regioselectivity dbr:Baldwin's_rules dbr:Chemical_synthesis n8:Azatyrosine_biosynthesis.png dbc:Naphthalenes dbr:Esperamicin dbr:Triethylamine dbr:Bergman_cyclization n8:Kedarcidin_biosynthesis.png n8:Kedarcidin_borohydride_reduction.png dbr:Nuclear_Overhauser_effect n8:Kedarcidin_core_Bergman_equilibrium.png n8:Kedarcidin_structure_series_of_revisions.png dbr:Dynemicin_A dbr:Sodium_borohydride dbr:Organic_synthesis dbr:Force_field_(chemistry) dbr:Tohoku_University n8:2-naphthonate_biosynthesis.png dbr:Sporolides dbr:Harvard_University dbr:Tetrahydrofuran dbr:Apolipoprotein dbr:2-Methyl-6-nitrobenzoic_anhydride n8:DNA_damage_mechanism.png dbr:Tyrosine dbr:HCT116_cells dbr:Mass_spectrometry
dbo:wikiPageExternalLink
n22:1399845
owl:sameAs
wikidata:Q15426249 yago-res:Kedarcidin n16:YbCL dbpedia-sh:Kedarcidin dbpedia-sr:Kedarcidin freebase:m.0wzpkyg dbpedia-uk:Кедарцидін
dbp:wikiPageUsesTemplate
dbt:Reflist dbt:Enediynes dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox dbt:Chembox_Properties dbt:Cascite
dbo:thumbnail
n14:Kedarcidin_chromophore_2007_revised_1.png?width=300
dbp:imagefile
Kedarcidin 3D structure.png Kedarcidin chromophore 2007 revised 1.png
dbp:imagesize
250
dbp:iupacname
N-[-6-chloro-24-[-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-14-[-5--4-hydroxy-6-methyloxan-2-yl]oxy-11-oxo-4,12,20-trioxa-7-azapentacyclo[13.6.2.25,8.13,21.019,21]hexacosa-1,5,7,15,25-pentaen-17,22-diyn-9-yl]-3-hydroxy-7,8-dimethoxy-6-propan-2-yloxynaphthalene-2-carboxamide
dbo:abstract
Kedarcidin is a chromoprotein antitumor antibiotic first isolated from an Actinomycete in 1992, comprising an ansa-bridged enediyne chromophore (shown) as well as an apoprotein that serves to stabilize the toxin in the Actinomycete. Like other members of the enediyne class of drugs—so named for the nine-or-ten-membered core structure bearing an alkene directly attached to two alkynyl appendages—kedarcidin was likely evolved to kill bacteria that compete with the producing organism. Because it achieves this by causing DNA damage, however, kedarcidin is capable of harming tumor cells, as well. Kedarcidin is thus the subject of scientific research, both for its structural complexity as well as its anticancer properties. Кедарцидін — хромопротеїн протипухлинний препарат вперше виділений з актиноміцетів у 1992 році. Кедарцидін, ймовірно, виробляється мікроорганізмами для вбивства конкурентних бактерій. Оскільки це досягається шляхом пошкодження ДНК кедарцидін здатний також завдавати шкоди пухлинним клітинам. Кедарцидін є предметом наукових досліджень, як з точки зору його структурної складності, так і його протипухлинних властивостей.
gold:hypernym
dbr:Chromoprotein
prov:wasDerivedFrom
wikipedia-en:Kedarcidin?oldid=1081059967&ns=0
dbo:wikiPageLength
25036
dbo:iupacName
N-[(3S,9R,14S,15E,19S,21R,24R)-6-chloro-24-[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-14-[(2S,4S,5S,6S)-5-(dimethylamino)-4-hydroxy-6-methyloxan-2-yl]oxy-11-oxo-4,12,20-trioxa-7-azapentacyclo[13.6.2.25,8.13,21.019,21]hexacosa-1,5,7,15,25-pentaen-17,22-diyn-9-yl]-3-hydroxy-7,8-dimethoxy-6-propan-2-yloxynaphthalene-2-carboxamide
foaf:isPrimaryTopicOf
wikipedia-en:Kedarcidin