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Statements

Subject Item
dbr:Leu-enkephalin
rdf:type
dbo:ChemicalCompound yago:Part113809207 yago:Amide114724264 yago:WikicatOpioidPeptides dbo:ChemicalSubstance owl:Thing yago:Matter100020827 n20:ChemicalObject yago:Abstraction100002137 yago:Chemical114806838 umbel-rc:ChemicalSubstanceType yago:Material114580897 yago:Compound114818238 wikidata:Q11173 yago:PhysicalEntity100001930 yago:WikicatPeptides yago:Substance100019613 yago:Peptide114743046 yago:Relation100031921 yago:OrganicCompound114727670
rdfs:label
Leu-enkephalin
rdfs:comment
Leu-enkephalin is an endogenous opioid peptide neurotransmitter with the amino acid sequence Tyr-Gly-Gly-Phe-Leu that is found naturally in the brains of many animals, including humans. It is one of the two forms of enkephalin; the other is met-enkephalin. The tyrosine residue at position 1 is thought to be analogous to the 3-hydroxyl group on morphine. Leu-enkephalin has agonistic actions at both the μ- and δ-opioid receptors, with significantly greater preference for the latter. It has little to no effect on the κ-opioid receptor.
foaf:depiction
n11:Leu-enkephalin_Structure.svg
dcterms:subject
dbc:Delta-opioid_receptor_agonists dbc:Opioid_peptides
dbo:wikiPageID
13495833
dbo:wikiPageRevisionID
1051001284
dbo:wikiPageWikiLink
dbr:Enkephalin dbr:Met-enkephalin dbr:Opioid_peptide dbc:Opioid_peptides dbr:Endogenous dbr:Agonist dbr:Mu-Opioid_receptor dbr:Amino_acid_sequence n21:nowiki%3E(2''R'')-2-amino-3-%3Cwbr%3E(4-hydroxyphenyl)propanoyl%5Damino%5Dacetyl%5D%3Cwbr%3Eamino%5Dacetyl%5Damino%5D-3-phenylpropanoyl%5D%3Cwbr%3Eamino%5D-4-methylpentanoic_acid dbc:Delta-opioid_receptor_agonists dbr:Neurotransmitter dbr:Morphine dbr:Delta-Opioid_receptor dbr:Kappa-Opioid_receptor dbr:Tyrosine
owl:sameAs
yago-res:Leu-enkephalin wikidata:Q6533903 dbpedia-sr:Leu-enkefalin dbpedia-sh:Leu-enkefalin n19:4pnqH n23:لئو-انکفالین freebase:m.03c76_c dbpedia-fa:لئو-انکفالین
dbp:wikiPageUsesTemplate
dbt:Reflist dbt:Neuropeptides dbt:Stdinchicite dbt:Chembox_Properties dbt:Fdacite dbt:Chembox_Hazards dbt:Short_description dbt:Chembox_Identifiers dbt:Chembox dbt:Chemspidercite dbt:Cascite dbt:Ebicite dbt:Biochemistry-stub dbt:Opioidergics
dbo:thumbnail
n11:Leu-enkephalin_Structure.svg?width=300
dbp:imagefile
Leu-enkephalin Structure.svg
dbp:imagesize
300
dbp:iupacname
-2
dbp:othernames
[Leu]enkephalin; [Leu5]enkephalin;
dbp:verifiedfields
changed
dbp:verifiedrevid
442009113
dbp:watchedfields
changed
dbo:abstract
Leu-enkephalin is an endogenous opioid peptide neurotransmitter with the amino acid sequence Tyr-Gly-Gly-Phe-Leu that is found naturally in the brains of many animals, including humans. It is one of the two forms of enkephalin; the other is met-enkephalin. The tyrosine residue at position 1 is thought to be analogous to the 3-hydroxyl group on morphine. Leu-enkephalin has agonistic actions at both the μ- and δ-opioid receptors, with significantly greater preference for the latter. It has little to no effect on the κ-opioid receptor.
gold:hypernym
dbr:Neurotransmitter
prov:wasDerivedFrom
wikipedia-en:Leu-enkephalin?oldid=1051001284&ns=0
dbo:wikiPageLength
5170
dbo:alternativeName
[Leu]enkephalin;[Leu5]enkephalin;
dbo:iupacName
(2R)-2-(2R)-2-[[2-[[2-[[(2R)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
foaf:isPrimaryTopicOf
wikipedia-en:Leu-enkephalin