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Statements

Subject Item
dbr:Leukotriene_C4
rdf:type
yago:OrganicCompound114727670 yago:Chemical114806838 yago:Amide114724264 wikidata:Q11173 owl:Thing yago:Formula106816935 yago:WikicatAmides yago:Compound114818238 yago:Relation100031921 yago:Substance100019613 yago:Part113809207 yago:Statement106722453 yago:Material114580897 yago:Message106598915 yago:PhysicalEntity100001930 n22:ChemicalObject yago:Abstraction100002137 dbo:ChemicalSubstance yago:WikicatMolecularFormulas dbo:ChemicalCompound yago:Communication100033020 umbel-rc:ChemicalSubstanceType yago:MolecularFormula106817173 yago:Matter100020827
rdfs:label
Leucotriène C4 白三烯C4 Leucotrieno C4 Leukotriene C4
rdfs:comment
Le leucotriène C4 (LTC4) est un composé biochimique de la famille des leucotriènes. Il dérive du leucotriène A4 par condensation avec une molécule de glutathion sous l'action d'une glutathion S-transférase. C'est, avec le leucotriène D4, un intermédiaire à faible durée de vie dans la production de leucotriène E4. 白三烯C4 (英語：Leukotriene C4)是一种白三烯，是白三烯A4在谷胱甘肽S-转移酶或白三烯C4合酶的作用下与谷胱甘肽分子缩合而成。 Leukotriene C4 (LTC4) is a leukotriene. LTC4 has been extensively studied in the context of allergy and asthma. In cells of myeloid origin such as mast cells, its biosynthesis is orchestrated by translocation to the nuclear envelope along with co-localization of cytosolic phospholipase A2 (cPLA2), Arachidonate 5-lipoxygenase (5-LO), 5-lipoxygenase-activating protein (FLAP) and LTC4 synthase (LTC4S), which couples glutathione to an LTA4 intermediate. The MRP1 transporter then secretes cytosolic LTC4 and cell surface proteases further metabolize it by sequential cleavage of the γ-glutamyl and glycine residues off its glutathione segment, generating the more stable products LTD4 and LTE4. All three leukotrienes then bind at different affinities to two G-protein coupled receptors: CYSLTR1 and Leucotrieno C4 (LTC4) é um tipo de leucotrieno.
foaf:depiction
n6:Eicosanoid_synthesis.png n6:Leukotriene_C4.svg
dcterms:subject
dbc:Eicosanoids
dbo:wikiPageID
10993389
dbo:wikiPageRevisionID
1048626626
dbo:wikiPageWikiLink
dbr:PLA2G4A dbr:Asthma dbc:Eicosanoids dbr:Glycine dbr:Nuclear_envelope dbr:Myeloid dbr:Haematopoietic dbr:Leukotriene_C4_synthase n16:Eicosanoid_synthesis.png dbr:Vasoconstriction dbr:Intracrine dbr:Leukotriene dbr:G-protein_coupled_receptors dbr:CYSLTR1 dbr:NOX4 dbr:CYSLTR2 dbr:Allergy dbr:MGST2 dbr:5-lipoxygenase-activating_protein dbr:Chemotherapy dbr:Bronchoconstriction dbr:Glutamyl dbr:Endoplasmic_reticulum dbr:Mast_cells dbr:5-lipoxygenase dbr:ABCC1 dbr:Glutathione dbr:Leukotriene_D4 dbr:Leukotriene_E4 dbr:Leukotriene_A4
owl:sameAs
dbpedia-zh:白三烯C4 n13:2XUCV dbpedia-pt:Leucotrieno_C4 wikidata:Q2704310 dbpedia-fr:Leucotriène_C4 freebase:m.02qxjld dbpedia-sh:Leukotrien_C4 yago-res:Leukotriene_C4 dbpedia-sr:Leukotrien_C4 dbpedia-fa:لوکوترین_سی۴ n29:لوکوترین_سی۴
dbp:wikiPageUsesTemplate
dbt:Cascite dbt:Chemspidercite dbt:Fdacite dbt:Stdinchicite dbt:Leukotrienergics dbt:Reflist dbt:Leukotrienes dbt:Ebicite dbt:Keggcite dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox dbt:Chembox_Properties
dbo:thumbnail
n6:Leukotriene_C4.svg?width=300
dbp:imagefile
Leukotriene C4.svg
dbp:pin
-6
dbp:verifiedfields
changed
dbp:verifiedrevid
396932578
dbp:watchedfields
changed
dbo:abstract
Leukotriene C4 (LTC4) is a leukotriene. LTC4 has been extensively studied in the context of allergy and asthma. In cells of myeloid origin such as mast cells, its biosynthesis is orchestrated by translocation to the nuclear envelope along with co-localization of cytosolic phospholipase A2 (cPLA2), Arachidonate 5-lipoxygenase (5-LO), 5-lipoxygenase-activating protein (FLAP) and LTC4 synthase (LTC4S), which couples glutathione to an LTA4 intermediate. The MRP1 transporter then secretes cytosolic LTC4 and cell surface proteases further metabolize it by sequential cleavage of the γ-glutamyl and glycine residues off its glutathione segment, generating the more stable products LTD4 and LTE4. All three leukotrienes then bind at different affinities to two G-protein coupled receptors: CYSLTR1 and CYSLTR2, triggering pulmonary vasoconstriction and bronchoconstriction. In cells of non-haematopoietic lineage, endoplasmic reticulum (ER) stress and chemotherapy induce LTC4 biosynthesis by transcriptionally upregulating and activating the enzyme microsomal glutathione-S-transferase 2 (MGST2). ER stress and chemotherapy also trigger nuclear translocation of the two LTC4 receptors. Acting in an intracrine manner, LTC4 then elicits nuclear translocation of NADPH oxidase 4 (NOX4), ROS accumulation and oxidative DNA damage. Besides being a potent lipid mediator in asthma and inflammation, LTC4 was reported to be involved in several other diseases, such as allergic airway diseases, dermatological diseases, cardiovascular diseases, liver injury, atherosclerosis and colon cancer. 白三烯C4 (英語：Leukotriene C4)是一种白三烯，是白三烯A4在谷胱甘肽S-转移酶或白三烯C4合酶的作用下与谷胱甘肽分子缩合而成。 Le leucotriène C4 (LTC4) est un composé biochimique de la famille des leucotriènes. Il dérive du leucotriène A4 par condensation avec une molécule de glutathion sous l'action d'une glutathion S-transférase. C'est, avec le leucotriène D4, un intermédiaire à faible durée de vie dans la production de leucotriène E4. Leucotrieno C4 (LTC4) é um tipo de leucotrieno.
gold:hypernym
dbr:Leukotriene
prov:wasDerivedFrom
wikipedia-en:Leukotriene_C4?oldid=1048626626&ns=0
dbo:wikiPageLength
7178
dbo:iupacName
(5S,6R,7E,9E,11Z,14Z)-6-({(2R)-2-[(4S)-4-Amino-4-carboxybutanamido]-3-[(carboxymethyl)amino]-3-oxopropyl}sulfanyl)-5-hydroxyicosa-7,9,11,14-tetraenoic acid
foaf:isPrimaryTopicOf
wikipedia-en:Leukotriene_C4