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Statements

Subject Item
dbr:MDA-MB-468
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MDA-MB-468 MDA-MB-468
rdfs:comment
MDA-MB-468 is a cell line that was isolated from a 51-year-old female human in 1977, and is commonly used in breast cancer research. MDA-MB-468 cells were extracted from a pleural effusion of mammary gland and breast tissues, and have proven useful for the study of metastasis, migration, and breast cancer proliferation. MDA-MB-468 has been used to test chemical breast cancer treatments. MDA-MB-468（MD Anderson-Metastatic Breast-468）是一種轉移性乳腺癌細胞系，最初在1977年分離自一名51歲的患有轉移性腺癌的黑人女性患者的胸腔積液。儘管組織供體對於G6PD等位基因是雜合的，但是該細胞系始終顯示出G6PD A的表型。 MDA-MB-468細胞的模態染色體數為64，而不同細胞中的實際染色體數在60-67之間，染色體總數在次三倍體範圍內。正常染色體X、N2、N3、N7、N8、N10和N22參與該細胞系中，形成標誌染色體的過程而出現明顯不足的現象。MDA-MB-468細胞不表達，高度表達表皮生長因子受體（每個細胞表達約1.3×106EGFR），並且被表皮生長因子抑制生長及將DNA片段化成核小體低聚物，最終導致細胞出現凋亡形態。MDA-MB-468細胞通常應用於乳腺癌研究，目前已被證明可用於研究乳腺癌的增殖和轉移，同時也可以用於測試乳腺癌的化學治療方法。
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dbo:abstract
MDA-MB-468 is a cell line that was isolated from a 51-year-old female human in 1977, and is commonly used in breast cancer research. MDA-MB-468 cells were extracted from a pleural effusion of mammary gland and breast tissues, and have proven useful for the study of metastasis, migration, and breast cancer proliferation. The cell line was isolated in 1977 by Relda Cailleau, et al., from a pleural effusion of a 51-year-old Black female patient with metastatic adenocarcinoma of the breast. Although the tissue donor was heterozygous for G6PD alleles, the cell line consistently showed only the G6PD A phenotype. MDA-MB-468 cells have a modal chromosome number of 64, though the actual number can vary from 60 to 67 in different cells. MDA-MB-468 has been used to test chemical breast cancer treatments. MDA-MB-468（MD Anderson-Metastatic Breast-468）是一種轉移性乳腺癌細胞系，最初在1977年分離自一名51歲的患有轉移性腺癌的黑人女性患者的胸腔積液。儘管組織供體對於G6PD等位基因是雜合的，但是該細胞系始終顯示出G6PD A的表型。 MDA-MB-468細胞的模態染色體數為64，而不同細胞中的實際染色體數在60-67之間，染色體總數在次三倍體範圍內。正常染色體X、N2、N3、N7、N8、N10和N22參與該細胞系中，形成標誌染色體的過程而出現明顯不足的現象。MDA-MB-468細胞不表達，高度表達表皮生長因子受體（每個細胞表達約1.3×106EGFR），並且被表皮生長因子抑制生長及將DNA片段化成核小體低聚物，最終導致細胞出現凋亡形態。MDA-MB-468細胞通常應用於乳腺癌研究，目前已被證明可用於研究乳腺癌的增殖和轉移，同時也可以用於測試乳腺癌的化學治療方法。
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