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Statements

Subject Item
dbr:Molecular_Inversion_Probe
rdfs:label
Molecular Inversion Probe
rdfs:comment
Molecular Inversion Probe (MIP) belongs to the class of Capture by Circularization molecular techniques for performing genomic partitioning, a process through which one captures and enriches specific regions of the genome. Probes used in this technique are single stranded DNA molecules and, similar to other genomic partitioning techniques, contain sequences that are complementary to the target in the genome; these probes hybridize to and capture the genomic target. MIP stands unique from other genomic partitioning strategies in that MIP probes share the common design of two genomic target complementary segments separated by a linker region. With this design, when the probe hybridizes to the target, it undergoes an inversion in configuration (as suggested by the name of the technique) and c
foaf:depiction
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dbc:Genomics_techniques
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26061258
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1123483124
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dbr:Exonuclease dbr:Pharmacogenomics n7:GenomicPartitioning_timothy.png dbr:Single-nucleotide_polymorphism dbr:Heterozygotic dbr:Locus_(genetics) dbr:ABI_Solid_Sequencing n7:MIP_probe_details_timothy_final.png n7:MIP_technique_development_timothy_final.png n7:MIP_technique_timothy.png dbr:Allele dbr:Nucleic_acid_hybridization dbr:Precision_and_recall dbr:Restriction_site dbr:SNP_array dbr:Biomarker dbr:Nucleotide dbr:DNA dbr:Molecular_biology dbr:Zygosity dbr:International_HapMap_Project dbr:Genotyping dbr:SNP_genotyping dbr:Glioma dbr:Complementarity_(molecular_biology) dbr:Deletion_(genetics) dbr:Restriction_enzyme dbr:Metastasis dbr:Exon dbr:Genome dbr:HapMap dbr:GC_content dbr:Linkage_disequilibrium dbr:Base_pair dbr:Genome-wide_association_study dbr:Sensitivity_and_specificity dbr:Rolling_circle_replication dbr:Ligase dbr:Copy_number_variation dbr:Oligonucleotide dbr:Biotinylation dbr:DNA_sequencing dbr:Covalent_bond dbr:DNA_microarray dbr:Caspase dbr:Fixation_(histology) dbr:DNA_polymerase dbr:Accuracy_and_precision dbr:Leukemia dbr:Quantitative_trait_locus dbr:Endometrium dbr:Karyotype dbr:454_Life_Sciences dbr:Cystic_fibrosis dbr:Fluorescence_in_situ_hybridization dbc:Genomics_techniques dbr:Illumina_(company) dbr:Polymerase_chain_reaction dbr:Receptor_(biochemistry) dbr:Exon_trapping dbr:Array_comparative_genomic_hybridization dbr:Mutation dbr:Exome dbr:Restriction_enzymes dbr:Multiplex_(assay) dbr:Primer_(molecular_biology) dbr:In_situ_hybridization
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n13:MIP_probe_details_timothy_final.png?width=300
dbp:bot
InternetArchiveBot
dbp:date
February 2018
dbp:fixAttempted
yes
dbo:abstract
Molecular Inversion Probe (MIP) belongs to the class of Capture by Circularization molecular techniques for performing genomic partitioning, a process through which one captures and enriches specific regions of the genome. Probes used in this technique are single stranded DNA molecules and, similar to other genomic partitioning techniques, contain sequences that are complementary to the target in the genome; these probes hybridize to and capture the genomic target. MIP stands unique from other genomic partitioning strategies in that MIP probes share the common design of two genomic target complementary segments separated by a linker region. With this design, when the probe hybridizes to the target, it undergoes an inversion in configuration (as suggested by the name of the technique) and circularizes. Specifically, the two target complementary regions at the 5’ and 3’ ends of the probe become adjacent to one another while the internal linker region forms a free hanging loop. The technology has been used extensively in the HapMap project for large-scale SNP genotyping as well as for studying gene copy alterationsand characteristics of specific genomic loci to identify biomarkers for different diseases such as cancer. Key strengths of the MIP technology include its high specificity to the target and its scalability for high-throughput, multiplexed analyses where tens of thousands of genomic loci are assayed simultaneously.
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