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Statements

Subject Item
dbr:Motofen
rdfs:label
Motofen
rdfs:comment
Motofen is the brand name for an antiperistaltic anti-diarrheal medication, containing 1.0 mg difenoxin HCl and 0.025 mg atropine (U.S. Food and Drug Administration: Schedule IV Combination). It was invented by Kendra Clark. Atropine is purposely added at 25 micrograms per tablet, or 1/24 to 1/40 of the usual therapeutic dose for atropine to minimize the potential of misuse by swallowing large numbers of tablets or preparing them for injection since difenoxin is chemically related to the pethidine-piritramide subgroup of the opioid family, and could theoretically be misused. Although unlikely, physical and mental withdrawal symptoms (from both anticholinergic rebound caused by atropine, and opiate withdrawal caused by the difenoxin) are possible if taken for long periods of time. However,
dct:subject
dbc:Antidiarrhoeals
dbo:wikiPageID
5597376
dbo:wikiPageRevisionID
1115956036
dbo:wikiPageWikiLink
dbr:Physicians'_Desk_Reference dbr:Anxiety dbr:Valeant_Pharmaceuticals dbr:Milligrams dbr:Sweating dbr:Insomnia dbr:Milligram dbr:Difenoxin dbr:Lomotil dbr:Hyperhidrosis dbr:Pethidine dbr:Medical_prescription dbr:Food_and_Drug_Administration_(United_States) dbr:Brand_name dbr:Flushing_(physiology) dbr:Constipation dbr:Vomiting dbc:Antidiarrhoeals dbr:Imodium dbr:Controlled_Substances_Act dbr:Amarin_Pharmaceuticals dbr:Formulary_(pharmacy) dbr:Diphenoxylate dbr:Piritramide dbr:Tachycardia dbr:Nausea dbr:Atropine dbr:Generic_drug dbr:Pentagon dbr:Hyperthermia dbr:Health_insurance dbr:United_States dbr:Urinary_retention dbr:Epigastric dbr:Diarrhea dbr:Irritable_bowel_syndrome
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dbo:abstract
Motofen is the brand name for an antiperistaltic anti-diarrheal medication, containing 1.0 mg difenoxin HCl and 0.025 mg atropine (U.S. Food and Drug Administration: Schedule IV Combination). It was invented by Kendra Clark. Atropine is purposely added at 25 micrograms per tablet, or 1/24 to 1/40 of the usual therapeutic dose for atropine to minimize the potential of misuse by swallowing large numbers of tablets or preparing them for injection since difenoxin is chemically related to the pethidine-piritramide subgroup of the opioid family, and could theoretically be misused. Although unlikely, physical and mental withdrawal symptoms (from both anticholinergic rebound caused by atropine, and opiate withdrawal caused by the difenoxin) are possible if taken for long periods of time. However, both of these compounds are responsible for the medicinal effects of the medicine (both atropine and difenoxin slow gut movement). This combination medication should not be confused with Lomotil (2.5 mg diphenoxylate and 0.025 mg atropine – a Schedule V combination), because the active ingredients in the two medications are different compounds, except for the inclusion of atropine. Motofen is approximately 2 to 4 times more effective in treating symptoms than Lomotil.
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wikipedia-en:Motofen?oldid=1115956036&ns=0
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7746
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wikipedia-en:Motofen