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Statements

Subject Item
dbr:Nalbuphine
rdf:type
yago:Drug103247620 yago:Beverage107881800 yago:Agent114778436 yago:DrugOfAbuse103248958 n10:ChemicalObject umbel-rc:DrugProduct dbo:ChemicalSubstance owl:Thing yago:Abstraction100002137 yago:Relation100031921 yago:Part113809207 yago:OrganicCompound114727670 yago:Quintessence114847103 wikidata:Q8386 yago:WikicatDiols yago:PhysicalEntity100001930 yago:Alcohol107884567 yago:Alcohol114708720 yago:Phenol114989545 yago:Food100021265 yago:Substance100019613 yago:Substance100020090 yago:WikicatEthers yago:Diol114835980 yago:CausalAgent100007347 yago:WikicatPhenols yago:Matter100020827 yago:Compound114818238 yago:WikicatAlcohols yago:Element114840755 dbo:Drug yago:Chemical114806838 yago:Material114580897 yago:Fluid114939900 yago:Liquid114940386
rdfs:label
Nalbufina Nalbufin Налбуфин 纳布啡 Nalbuphine نالبوفين Nalbuphin Налбуфін Nalbuphine
rdfs:comment
La nalbuphine est un antalgique opiacé fort utilisé pour traiter les douleurs intenses ou rebelles aux autres antalgiques. Elle est susceptible d'entraîner une dépendance. Elle agit en bloquant les influx nerveux véhiculant la douleur. 纳布啡是一种阿片类受体的镇静剂型精神药物，其镇静效果类似吗啡，有呼吸抑制作用但不明显。同时其抑制有封顶效应，无心血管副反应，临床上一般用于手术后镇痛。 Nalbuphin ist ein Arzneistoff aus der Gruppe der Schmerzmittel vom Opioid-Typ. Er wirkt agonistisch an den κ-Opioidrezeptoren und partiell antagonistisch an den µ-Opioidrezeptoren. Die Vorteile des Partialantagonisten liegen darin, dass eine opioidbedingte Atemdepression, z. B. postoperativ nach dem Einsatz von Fentanyl während der Narkose, aufgehoben werden kann bei gleichzeitiger Fortführung der Schmerzbehandlung, da Nalbuphin selbst analgetisch wirkt. Die analgetische Potenz verglichen mit Morphin liegt bei 0,5–0,8. Es ist dem Pentazocin ähnlich, steigert jedoch den Blutdruck und die Herzfrequenz nicht.Bei opiatabhängigen Patienten kann der Einsatz von Nalbuphin allerdings sofort nach der Injektion ein Entzugssyndrom hervorrufen. نالبوفين Nalbuphine أو Nubain هو مسكن أفيوني نصف صنعي. يكون فعال في النساء أكثر من الرجال، بل حتى يمكن أن يزيد الألم لدى الرجال. يُستَعمَل للتنويم خلال العمليات الجراحية كما يستخدم لتخفيف شدَّة الآلام.. يوجد على شكل ملحين بارابين أو سلفيت. Nalbufina é um fármaco utilizado como analgésico opióide, utilizado no tratamento da dor. Nalbufina é um analgésico narcótico agonista-antagonista. Relacionado quimicamente com naloxona, tem potência analgésica semelhante a morfina. Atua principalmente nos receptores kappa como agonista total e agonista parcial dos receptores mu. Produz depressao respiratória, porém diferente da morfina e outros opióides há efeito teto. Quando administrada concomitantemente com analgésicos opióides ou agonistas pode reverter parcialmente ou bloquear a depressao respiratória narcótico-induzida. Nalbufin je opioidní analgetikum používané pro léčbu bolesti. Podává se injekčně do žíly, svalu nebo tuku. Mezi vedlejší účinky nalbufinu patří sedace, pocení, nevolnost, zvracení, závrať, sucho v ústech a bolest hlavy. Na rozdíl od většiny ostatních opioidů vyvolává Nalbufin jen slabou euforii a od určité dávky již dále nezesiluje útlum dýchacího centra. Je zde také téměř nulová incidence dysforie, disociativních stavů či halucinací, bere-li se lék v obvyklých terapeutických dávkách. Nalbufin je smíšený agonista-antagonista opioidových receptorů. Nalbuphine, sold under the brand names Nubain among others, is an opioid analgesic which is used in the treatment of pain. It is given by injection into a vein, muscle, or fat. Side effects of nalbuphine include sedation, sweatiness, clamminess, nausea, vomiting, dizziness, vertigo, dry mouth, and headache. Unlike other opioids, it has little to no capacity for euphoria or respiratory depression. It also has little to no incidence of dysphoria, dissociation, hallucinations, and related side effects at typical therapeutic doses. Nalbuphine is a mixed agonist/antagonist opioid modulator. Specifically, it acts as a moderate-efficacy partial agonist or antagonist of the μ-opioid receptor (MOR) and as a high-efficacy partial agonist of the κ-opioid receptor (KOR), whereas it has relatively low Налбуфин (Nalbuphine) — опиоидный анальгетик. Налбуфін (англ. Nalbuphine, лат. Nalbuphinum) — синтетичний лікарський засіб, що належить до групи опіоїдних анальгетиків і є похідним фенантрену. Налбуфін застосовується переважно парентерально, як внутрішньовенно, так і внутрішньом'язово і підшкірно, вкрай рідко препарат застосовується перорально. Налбуфін уперше запатентовано у 1963 році в США і схвалено для клінічного застосування в 1979 році.
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dbr:Nalorphine
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dcterms:subject
dbc:4,5-Epoxymorphinans dbc:Kappa-opioid_receptor_agonists dbc:Tertiary_alcohols dbc:Mu-opioid_receptor_agonists dbc:Semisynthetic_opioids dbc:Cyclobutyl_compounds dbc:Analgesics dbc:Ethers dbc:Phenols
dbo:wikiPageID
2395985
dbo:wikiPageRevisionID
1112575781
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n38:
owl:sameAs
n7:DB00844 yago-res:Nalbuphine wikidata:Q10335410 dbpedia-tr:Nalbufin dbpedia-de:Nalbuphin dbpedia-ru:Налбуфин freebase:m.0793_1 n21:4419 dbpedia-sh:Nalbufin dbpedia-uk:Налбуфін dbpedia-fr:Nalbuphine dbpedia-sr:Nalbufin dbpedia-zh:纳布啡 n29:7aEQ dbpedia-cy:Nalbwffin wikidata:Q277979 dbpedia-pt:Nalbufina dbpedia-fi:Nalbufiini dbpedia-ro:Nalbufină dbpedia-cs:Nalbufin dbpedia-ar:نالبوفين
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dbt:Drugs.com dbt:Opioid_receptor_modulators dbt:Fdacite dbt:Abbrlink dbt:Short_description dbt:Ebicite dbt:Drugbox dbt:Abbr dbt:Drugbankcite dbt:Analgesics dbt:Cascite dbt:Chemspidercite dbt:Distinguish dbt:Reflist dbt:Clarify dbt:Stdinchicite dbt:More_footnotes_needed
dbo:thumbnail
n20:Nalbuphine.svg?width=300
dbp:atcSuffix
AF02
dbp:onset
900.0 1800.0 3600.0 -180.0
dbp:alt
Skeletal formula Ball-and-stick model of nalbuphine
dbp:atcPrefix
N02
dbp:bioavailability
• : 81% , 83% • Oral: 11% , >44% • : 76% , 79%
dbp:c
21
dbp:casNumber
20594
dbp:chebi
7454
dbp:chembl
895
dbp:chemspiderid
4470813
dbp:drugbank
DB00844
dbp:eliminationHalfLife
18000.0
dbp:excretion
21600.0
dbp:h
27
dbp:image
Nalbuphine molecule ball.png
dbp:iupacName
-3
dbp:legalStatus
Federally Uncontrolled , except in KY, C-IV
dbp:legalUs
Rx only Schedule IV in some states
dbp:medlineplus
a682668
dbp:metabolism
Liver
dbp:n
1
dbp:o
4
dbp:pregnancyCategory
B
dbp:pubchem
5311304
dbp:routesOfAdministration
dbr:Subcutaneous_injection dbr:Intravenous dbr:Intramuscular
dbp:smiles
O[C@@H]4[C@@H]5Oc1c2cC[C@H]3NCC6CCC6
dbp:stdinchi
1
dbp:stdinchikey
NETZHAKZCGBWSS-CEDHKZHLSA-N
dbp:synonyms
EN-2234A; N-Cyclobutylmethyl-14-hydroxydihydronormorphine; 17-Cyclobutylmethyl-4,5α-epoxymorphinan-3,6α,14-triol; N-Cyclobutylmethyl-4,5α-epoxy-3,6α,14-morphinantriol
dbp:tradename
Nubain, Nalpain, Nalbuphin, others
dbp:unii
L2T84IQI2K
dbp:verifiedfields
verified
dbp:verifiedrevid
459830736
dbp:watchedfields
verified
dbp:width
225 250
dbo:abstract
Nalbuphin ist ein Arzneistoff aus der Gruppe der Schmerzmittel vom Opioid-Typ. Er wirkt agonistisch an den κ-Opioidrezeptoren und partiell antagonistisch an den µ-Opioidrezeptoren. Die Vorteile des Partialantagonisten liegen darin, dass eine opioidbedingte Atemdepression, z. B. postoperativ nach dem Einsatz von Fentanyl während der Narkose, aufgehoben werden kann bei gleichzeitiger Fortführung der Schmerzbehandlung, da Nalbuphin selbst analgetisch wirkt. Die analgetische Potenz verglichen mit Morphin liegt bei 0,5–0,8. Es ist dem Pentazocin ähnlich, steigert jedoch den Blutdruck und die Herzfrequenz nicht.Bei opiatabhängigen Patienten kann der Einsatz von Nalbuphin allerdings sofort nach der Injektion ein Entzugssyndrom hervorrufen. Nalbuphin wird als Hydrochlorid in Injektionslösungen eingesetzt. Die Wirkung tritt rasch nach zwei bis drei Minuten ein. Die Halbwertszeit beträgt circa drei Stunden, die Wirkdauer bis zu sechs Stunden. Die gleichzeitige Gabe zu einer Behandlung mit μ-agonistischen Opioiden wie etwa Morphin oder Fentanyl ist kontraindiziert. 纳布啡是一种阿片类受体的镇静剂型精神药物，其镇静效果类似吗啡，有呼吸抑制作用但不明显。同时其抑制有封顶效应，无心血管副反应，临床上一般用于手术后镇痛。 Nalbufina é um fármaco utilizado como analgésico opióide, utilizado no tratamento da dor. Nalbufina é um analgésico narcótico agonista-antagonista. Relacionado quimicamente com naloxona, tem potência analgésica semelhante a morfina. Atua principalmente nos receptores kappa como agonista total e agonista parcial dos receptores mu. Produz depressao respiratória, porém diferente da morfina e outros opióides há efeito teto. Quando administrada concomitantemente com analgésicos opióides ou agonistas pode reverter parcialmente ou bloquear a depressao respiratória narcótico-induzida. utilizada em casos de intoxicação por hipnoanalgésicos. Налбуфин (Nalbuphine) — опиоидный анальгетик. La nalbuphine est un antalgique opiacé fort utilisé pour traiter les douleurs intenses ou rebelles aux autres antalgiques. Elle est susceptible d'entraîner une dépendance. Elle agit en bloquant les influx nerveux véhiculant la douleur. Nalbufin je opioidní analgetikum používané pro léčbu bolesti. Podává se injekčně do žíly, svalu nebo tuku. Mezi vedlejší účinky nalbufinu patří sedace, pocení, nevolnost, zvracení, závrať, sucho v ústech a bolest hlavy. Na rozdíl od většiny ostatních opioidů vyvolává Nalbufin jen slabou euforii a od určité dávky již dále nezesiluje útlum dýchacího centra. Je zde také téměř nulová incidence dysforie, disociativních stavů či halucinací, bere-li se lék v obvyklých terapeutických dávkách. Nalbufin je smíšený agonista-antagonista opioidových receptorů. Nalbufin byl objeven roku 1965 a v roce 1979 byl ve Spojených státech amerických schválen Úřadem pro kontrolu potravin a léčiv. Налбуфін (англ. Nalbuphine, лат. Nalbuphinum) — синтетичний лікарський засіб, що належить до групи опіоїдних анальгетиків і є похідним фенантрену. Налбуфін застосовується переважно парентерально, як внутрішньовенно, так і внутрішньом'язово і підшкірно, вкрай рідко препарат застосовується перорально. Налбуфін уперше запатентовано у 1963 році в США і схвалено для клінічного застосування в 1979 році. Nalbuphine, sold under the brand names Nubain among others, is an opioid analgesic which is used in the treatment of pain. It is given by injection into a vein, muscle, or fat. Side effects of nalbuphine include sedation, sweatiness, clamminess, nausea, vomiting, dizziness, vertigo, dry mouth, and headache. Unlike other opioids, it has little to no capacity for euphoria or respiratory depression. It also has little to no incidence of dysphoria, dissociation, hallucinations, and related side effects at typical therapeutic doses. Nalbuphine is a mixed agonist/antagonist opioid modulator. Specifically, it acts as a moderate-efficacy partial agonist or antagonist of the μ-opioid receptor (MOR) and as a high-efficacy partial agonist of the κ-opioid receptor (KOR), whereas it has relatively low affinity for the δ-opioid receptor (DOR) and sigma receptors. Nalbuphine was patented in 1963 and was introduced for medical use in the United States in 1979. It is marketed in many countries throughout the world. نالبوفين Nalbuphine أو Nubain هو مسكن أفيوني نصف صنعي. يكون فعال في النساء أكثر من الرجال، بل حتى يمكن أن يزيد الألم لدى الرجال. يُستَعمَل للتنويم خلال العمليات الجراحية كما يستخدم لتخفيف شدَّة الآلام.. يوجد على شكل ملحين بارابين أو سلفيت.
dbp:durationOfAction
-21600.0
dbp:iupharLigand
1663
dbp:legalAu
S4
dbp:legalCa
Schedule IV
dbp:metabolites
Glucuronide conjugates , others
dbp:proteinBound
50.0
gold:hypernym
dbr:Opioid
prov:wasDerivedFrom
wikipedia-en:Nalbuphine?oldid=1112575781&ns=0
dbo:wikiPageLength
25615
dbo:alternativeName
Nubain, Nalpain, Nalbuphin, others
dbo:casNumber
20594-83-6
dbo:chEBI
7454
dbo:chEMBL
895
dbo:drugbank
DB00844
dbo:fdaUniiCode
L2T84IQI2K
dbo:medlinePlus
a682668
dbo:pubchem
5311304
foaf:isPrimaryTopicOf
wikipedia-en:Nalbuphine