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Statements

Subject Item
dbr:Nidoviral_papain-like_protease
rdf:type
dbo:Protein wikidata:Q8054 dbo:Biomolecule wikidata:Q206229 owl:Thing
rdfs:label
Nidoviral papain-like protease
rdfs:comment
The nidoviral papain-like protease (PLPro or PLP) is a papain-like protease protein domain encoded in the genomes of nidoviruses. It is expressed as part of a large polyprotein from the ORF1a gene and has cysteine protease enzymatic activity responsible for proteolytic cleavage of some of the N-terminal viral nonstructural proteins within the polyprotein. A second protease also encoded by ORF1a, called the 3C-like protease or main protease, is responsible for the majority of further cleavages. Coronaviruses have one or two papain-like protease domains; in SARS-CoV and SARS-CoV-2, one PLPro domain is located in (nsp3). Arteriviruses have two to three PLP domains. In addition to their protease activity, PLP domains function as deubiquitinating enzymes (DUBs) that can cleave the isopeptide b
dbp:name
Coronavirus papain-like peptidase
foaf:depiction
n11:6wzu_sarscov2_plpro.png
dcterms:subject
dbc:Viral_proteins dbc:Proteases
dbo:wikiPageID
69492836
dbo:wikiPageRevisionID
1066204194
dbo:wikiPageWikiLink
dbr:Deubiquitinase dbr:Catalytic_mechanism dbr:Essential_gene dbc:Viral_proteins dbr:ORF1ab dbr:N-terminal dbr:Ubiquitin dbr:SARS-CoV dbr:MERS-CoV dbc:Proteases dbr:SARS-CoV-2 dbr:Enzyme dbr:ISG15 dbr:Post-translational_modification dbr:Replicase-transcriptase_complex dbr:Ubiquitin-like_protein dbr:Isopeptide_bond dbr:Coronavirus dbr:Antiviral_drug dbr:Innate_immune_system dbr:Pathogen dbr:Drug_target dbr:Cysteine_protease dbr:In_vitro dbr:Viral_replication dbr:Protein_domain dbr:Viral_nonstructural_protein dbr:Proteolysis dbr:ORF1a dbr:Polyprotein dbr:Deubiquitinating_enzyme dbr:3C-like_protease dbr:Arterivirus dbr:Sequence_similarity dbr:Ubiquitin-like_domain dbr:Gene dbr:Domains_of_life dbr:MEROPS dbr:Human_genome dbr:Coronavirus_nonstructural_protein_3 dbr:Papain dbr:Papain-like_protease dbr:Zinc dbr:Genome dbr:USP18 dbr:Protease dbr:Nidovirus
owl:sameAs
n13:GJUzY wikidata:Q110618157
dbp:wikiPageUsesTemplate
dbt:PDB dbt:Reflist dbt:Infobox_protein_family
dbo:thumbnail
n11:6wzu_sarscov2_plpro.png?width=300
dbp:caption
X-ray crystallography structure of the papain-like protease domain from SARS-CoV-2 non-structural protein 3. The catalytic residues are highlighted with cysteine in green and histidine in blue. The blue sphere is a bound zinc ion. From .
dbp:interpro
IPR013016
dbp:pfam
PF08715
dbp:symbol
CoV_peptidase
dbo:abstract
The nidoviral papain-like protease (PLPro or PLP) is a papain-like protease protein domain encoded in the genomes of nidoviruses. It is expressed as part of a large polyprotein from the ORF1a gene and has cysteine protease enzymatic activity responsible for proteolytic cleavage of some of the N-terminal viral nonstructural proteins within the polyprotein. A second protease also encoded by ORF1a, called the 3C-like protease or main protease, is responsible for the majority of further cleavages. Coronaviruses have one or two papain-like protease domains; in SARS-CoV and SARS-CoV-2, one PLPro domain is located in (nsp3). Arteriviruses have two to three PLP domains. In addition to their protease activity, PLP domains function as deubiquitinating enzymes (DUBs) that can cleave the isopeptide bond found in ubiquitin chains. They are also "deISGylating" enzymes that remove the ubiquitin-like domain interferon-stimulated gene 15 (ISG15) from cellular proteins. These activities are likely responsible for antagonizing the activity of the host innate immune system. Because they are essential for viral replication, papain-like protease domains are considered drug targets for the development of antiviral drugs against human pathogens such as MERS-CoV, SARS-CoV, and SARS-CoV-2.
prov:wasDerivedFrom
wikipedia-en:Nidoviral_papain-like_protease?oldid=1066204194&ns=0
dbo:wikiPageLength
12195
dbo:symbol
CoV_peptidase
foaf:isPrimaryTopicOf
wikipedia-en:Nidoviral_papain-like_protease