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Statements

Subject Item
dbr:Platinum-based_antineoplastic
rdf:type
yago:CausalAgent100007347 yago:PhysicalEntity100001930 yago:Agent109190918 yago:WikicatPlatinum-basedAntineoplasticAgents
rdfs:label
Препараты платины Sel de platine Platinum-based antineoplastic
rdfs:comment
Platinum-based antineoplastic drugs (informally called platins) are chemotherapeutic agents used to treat cancer. They are coordination complexes of platinum. These drugs are used to treat almost half of people receiving chemotherapy for cancer. In this form of chemotherapy, commonly used drugs include cisplatin, oxaliplatin, and carboplatin, but several have been proposed or are under development. Addition of platinum-based chemotherapy drugs to chemoradiation in women with early cervical cancer seems to improve survival and reduce risk of recurrence. Препара́ты пла́тины — цитостатические противоопухолевые химиотерапевтические лекарственные препараты алкилирующего типа, содержащие в составе молекул двухвалентную платину (II) и неформально называемые просто «платиной». Все эти препараты являются координационными комплексами двухвалентной платины. Les sels de platine sont une classe de médicaments de chimiothérapie. Cette classe regroupe trois molécules couramment utilisées : le cisplatine, l'oxaliplatine, et le carboplatine. Ce sont des agents alkylants de l'ADN, qui inhibent la réplication cellulaire et induisent la mort cellulaire préférentielle des cellules cancéreuses.
foaf:depiction
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dcterms:subject
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dbr:Cervical_cancer dbr:Satraplatin dbr:Spectator_ligands dbr:Platinum dbr:Carboplatin dbc:Chemotherapy dbr:Nedaplatin dbr:Cisplatin dbr:Oxaliplatin dbr:Polyneuropathy dbr:Peripheral_neuropathy dbr:Medulloblastoma dbr:Triplatin_tetranitrate dbr:Pharmaceutical_drug dbr:Alkylating_antineoplastic_agent dbr:Alkyl dbr:Crosslinking_of_DNA dbr:Nanotechnology dbr:Picoplatin dbc:Platinum-based_antineoplastic_agents dbr:Phenanthriplatin dbr:Lipoplatin dbc:Medicinal_inorganic_chemistry dbr:Coordination_complex dbr:Neurotoxicity dbr:Guanine dbr:DNA_synthesis dbr:Testicular_cancer dbr:Cancer dbc:Platinum_compounds dbr:DNA_repair dbr:Chemotherapy
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dbt:Short_description dbt:Intracellular_chemotherapeutic_agents dbt:Reflist
dbo:thumbnail
n8:Cisplatin-stereo.svg?width=300
dbo:abstract
Les sels de platine sont une classe de médicaments de chimiothérapie. Cette classe regroupe trois molécules couramment utilisées : le cisplatine, l'oxaliplatine, et le carboplatine. Ce sont des agents alkylants de l'ADN, qui inhibent la réplication cellulaire et induisent la mort cellulaire préférentielle des cellules cancéreuses. Препара́ты пла́тины — цитостатические противоопухолевые химиотерапевтические лекарственные препараты алкилирующего типа, содержащие в составе молекул двухвалентную платину (II) и неформально называемые просто «платиной». Все эти препараты являются координационными комплексами двухвалентной платины. Platinum-based antineoplastic drugs (informally called platins) are chemotherapeutic agents used to treat cancer. They are coordination complexes of platinum. These drugs are used to treat almost half of people receiving chemotherapy for cancer. In this form of chemotherapy, commonly used drugs include cisplatin, oxaliplatin, and carboplatin, but several have been proposed or are under development. Addition of platinum-based chemotherapy drugs to chemoradiation in women with early cervical cancer seems to improve survival and reduce risk of recurrence. In total, these drugs can cause a combination of more than 40 specific side effects which include neurotoxicity, which is manifested by peripheral neuropathies including polyneuropathy.
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