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Statements

Subject Item
dbr:Preiser_disease
rdf:type
yago:Attribute100024264 owl:Thing yago:Disorder114052403 yago:Condition113920835 yago:Abstraction100002137 yago:PhysicalCondition114034177 yago:State100024720 yago:WikicatSkeletalDisorders dbo:Disease wikidata:Q12136
rdfs:label
Preiser disease
rdfs:comment
Preiser disease, or (idiopathic) avascular necrosis of the scaphoid, is a rare condition where ischemia and necrosis of the scaphoid bone occurs without previous fracture. It is thought to be caused by repetitive microtrauma or side effects of drugs (e.g., steroids or chemotherapy) in conjunction with existing defective vascular supply to the proximal pole of the scaphoid. MRI coupled with CT and X-ray are the methods of choice for diagnosis.
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n12:Scaphoid_bone_(left_hand)_01_palmar_view.png
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dbc:Skeletal_disorders
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dbr:Avascular_necrosis dbr:Scaphoid dbr:Idiopathic dbr:Four_corner_fusion dbc:Skeletal_disorders
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dbp:caption
Scaphoid bone
dbo:abstract
Preiser disease, or (idiopathic) avascular necrosis of the scaphoid, is a rare condition where ischemia and necrosis of the scaphoid bone occurs without previous fracture. It is thought to be caused by repetitive microtrauma or side effects of drugs (e.g., steroids or chemotherapy) in conjunction with existing defective vascular supply to the proximal pole of the scaphoid. MRI coupled with CT and X-ray are the methods of choice for diagnosis. Preiser's disease is initially treated by immobilising the wrist with a cast. However, in most cases the avascular scaphoid will start to collapse leading to degeneration within the wrist joints. This often requires surgical intervention to prevent the progression of arthris. Two commonly performed procedures are:1. Proximal row carpectomy (PRC), which involves removing the first row of the carpal bones, i.e. the scaphoid, lunate and triquetrum. The wrist is immobilised in a cast for six weeks after the surgery and then physiotherapy is started.2. Scaphoid excision and 4-corner fusion, which is a procedure consisting of the removal of the scaphoid and fixation of the remaining wrist bones with a plate (called a "spider plate") or wires in order to provide stability. The plate usually is left inside the patient's wrist, while the wires (usually K-wires) have to be removed in a second surgery. This procedure of partial wrist fusion allows for limited wrist movement, whereas total wrist fusion immobilizes the wrist permanently. Following surgery it can take several months for affected patients to regain strength.Unfortunately both of these operations are salvage procedures and movements in the wrist will be significantly reduced.
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