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Statements

Subject Item
dbr:RNA_silencing_suppressor_p19
rdf:type
dbo:Biomolecule wikidata:Q8054 wikidata:Q206229 dbo:Protein owl:Thing
rdfs:label
RNA silencing suppressor p19
rdfs:comment
RNA silencing suppressor p19 (also known as Tombusvirus P19 core protein and 19 kDa symptom severity modulator) is a protein expressed from the ORF4 gene in the genome of tombusviruses. These viruses are positive-sense single-stranded RNA viruses that infect plant cells, in which RNA silencing forms a widespread and robust antiviral defense system. The p19 protein serves as a counter-defense strategy, specifically binding the 19- to 21-nucleotide double-stranded RNAs that function as small interfering RNA (siRNA) in the RNA silencing system. By sequestering siRNA, p19 suppresses RNA silencing and promotes viral proliferation. The p19 protein is considered a significant virulence factor and a component of an evolutionary arms race between plants and their pathogens.
dbp:name
RNA silencing suppressor p19
foaf:depiction
n11:1R9F_tombusvirus_p19.png n11:1R9F_tombusvirus_p19_dimer.png
dcterms:subject
dbc:Viral_nonstructural_proteins
dbo:wikiPageID
52500756
dbo:wikiPageRevisionID
1032089947
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dbo:thumbnail
n11:1R9F_tombusvirus_p19_dimer.png?width=300
dbp:caption
The protein dimer formed by two p19 molecules. Each monomer is colored from N-terminus to C-terminus to illustrate the end-to-end orientation of the dimer. The dotted gray line in the center highlights the dimer interface. From .
dbp:interpro
IPR004905
dbp:pfam
PF03220
dbp:symbol
Tombus_p19
dbo:abstract
RNA silencing suppressor p19 (also known as Tombusvirus P19 core protein and 19 kDa symptom severity modulator) is a protein expressed from the ORF4 gene in the genome of tombusviruses. These viruses are positive-sense single-stranded RNA viruses that infect plant cells, in which RNA silencing forms a widespread and robust antiviral defense system. The p19 protein serves as a counter-defense strategy, specifically binding the 19- to 21-nucleotide double-stranded RNAs that function as small interfering RNA (siRNA) in the RNA silencing system. By sequestering siRNA, p19 suppresses RNA silencing and promotes viral proliferation. The p19 protein is considered a significant virulence factor and a component of an evolutionary arms race between plants and their pathogens.
prov:wasDerivedFrom
wikipedia-en:RNA_silencing_suppressor_p19?oldid=1032089947&ns=0
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11022
dbo:symbol
Tombus_p19
foaf:isPrimaryTopicOf
wikipedia-en:RNA_silencing_suppressor_p19