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Statements

Subject Item
dbr:Serazapine
rdf:type
wikidata:Q8386 dbo:Drug n16:ChemicalObject dbo:ChemicalSubstance owl:Thing
rdfs:label
Serazapine
rdfs:comment
Serazapine (developmental code name CGS-15040A) is a serotonin 5-HT2 receptor antagonist that was investigated as a potential treatment for generalized anxiety disorder in the 1990s. In humans, serazapine was well tolerated at doses of 10 to 40 mg and was found to be superior to placebo for reducing anxiety symptoms as indicated by HAM-A scores. However, clinical development was discontinued.
foaf:depiction
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dcterms:subject
dbc:Heterocyclic_compounds_with_5_rings dbc:Nitrogen_heterocycles dbc:5-HT2_antagonists dbc:Anxiolytics dbc:Abandoned_drugs
dbo:wikiPageID
67339218
dbo:wikiPageRevisionID
1040199660
dbo:wikiPageWikiLink
dbr:5-HT2_receptor dbr:Receptor_antagonist dbr:Serotonin dbc:Heterocyclic_compounds_with_5_rings dbc:5-HT2_antagonists dbc:Nitrogen_heterocycles dbr:Generalized_anxiety_disorder dbr:Oral_administration dbc:Anxiolytics dbr:Hamilton_Anxiety_Rating_Scale dbc:Abandoned_drugs
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dbo:thumbnail
n10:Serazapine_Structure.svg?width=300
dbp:atcPrefix
None
dbp:c
22
dbp:casNumber
115313
dbp:chembl
2110702
dbp:chemspiderid
54685
dbp:h
23
dbp:iupacName
120.0
dbp:n
3
dbp:o
2
dbp:pubchem
60677
dbp:routesOfAdministration
dbr:Oral_administration
dbp:smiles
O=CC1=C2NCC4=CC=CC=C4N5C2CNCC5
dbp:stdinchi
1
dbp:stdinchikey
WPGUWABWNUSPMW-UHFFFAOYSA-N
dbp:synonyms
CGS-15040A
dbp:unii
8
dbp:width
200
dbo:abstract
Serazapine (developmental code name CGS-15040A) is a serotonin 5-HT2 receptor antagonist that was investigated as a potential treatment for generalized anxiety disorder in the 1990s. In humans, serazapine was well tolerated at doses of 10 to 40 mg and was found to be superior to placebo for reducing anxiety symptoms as indicated by HAM-A scores. However, clinical development was discontinued.
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2804
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115313-22-9
dbo:chEMBL
2110702
dbo:fdaUniiCode
8A8FOB4J3U
dbo:pubchem
60677
foaf:isPrimaryTopicOf
wikipedia-en:Serazapine