"Naramycin A, hizarocin, actidione, actispray, kaken, U-4527"@en . . . "Cykloheksymid (\u0142ac. Cicloheximidum) \u2013 organiczny zwi\u0105zek chemiczny, antybiotyk o dzia\u0142aniu produkowany przez promieniowce Streptomyces griseus, inhibitor biosyntezy bia\u0142ek u organizm\u00F3w eukariotycznych. Jest u\u017Cywany w przemy\u015Ble winiarskim, s\u0142u\u017Cy zapobieganiu wt\u00F3rnej fermentacji, a tak\u017Ce stabilizacji win."@pl . "changed"@en . "La cicloesimide \u00E8 un composto chimico che inibisce la sintesi proteica in cellule eucariote bloccando l'attacco e l'uscita del tRNA dal ribosoma. Induce apoptosi in vari tipi cellulari. \u00C8 prodotta dal batterio Streptomyces griseus."@it . . "460110426"^^ . "8462"^^ . . . . "Cycloheximid ist ein Antibiotikum im weitesten Sinne, das von Streptomyceten (Streptomyces griseus) produziert wird. Es wirkt als Translationshemmer bei Eukaryoten und f\u00FChrt durch Unterbinden der Proteinbiosynthese an den Ribosomen zur Wachstumshemmung und zum Absterben eukaryontischer Zellen. Es handelt sich um einen klassischen Translationshemmer. Die mitochondriale und plastid\u00E4re Proteinsynthese eukaryotischer Zellen wird durch sehr hohe Konzentrationen von Cycloheximid ebenfalls gest\u00F6rt, weshalb dieses Antibiotikum auch zur Selektion von transgenen Pflanzen (Eukaryot) benutzt werden kann. Cycloheximid findet kaum noch Verwendung als Antibiotikum, da es im Menschen bei hoher Dosierung die mitochondriale Proteintranslation hemmt."@de . . . . . . "Cykloheximid (systematick\u00FD n\u00E1zev 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyklohexyl]-2-hydroxyethyl}piperidin-2,6-dion) je organick\u00E1 slou\u010Denina p\u0159irozen\u011B produkovan\u00E1 bakteri\u00ED . P\u016Fsob\u00ED jako inhibitor synt\u00E9zy b\u00EDlkovin u eukaryotick\u00FDch organism\u016F \u2013 interferuje s krokem (pohybem dvou molekul tRNA a mRNA ve vztahu k ribozom\u016Fm) t\u00E9to synt\u00E9zy a tak blokuje . \u0160iroce se pou\u017E\u00EDv\u00E1 ve v\u00FDzkumu pro inhibici proteosynt\u00E9zy u bun\u011Bk studovan\u00FDch in vitro (tj. mimo organismy). Je levn\u00FD a funguje rychle. Jeho \u00FA\u010Dinky lze rychle odstranit jednodu\u0161e jeho odstran\u011Bn\u00EDm z kultiva\u010Dn\u00EDho m\u00E9dia. Vzhledem k v\u00FDznamn\u00FDm vedlej\u0161\u00EDm toxick\u00FDm \u00FA\u010Dink\u016Fm, v\u010Detn\u011B po\u0161kozen\u00ED DNA, teratogeneze a dal\u0161\u00EDch reproduk\u010Dn\u00EDch \u00FA\u010Dink\u016F (nap\u0159. a toxicit\u011B pro spermie)), se cykloheximid obecn\u011B pou\u017E\u00EDv\u00E1 jen ve v\u00FDzkumn\u00FDch aplikac\u00EDch in vitro a nen\u00ED vhodn\u00FD jako l\u00E9\u010Divo pro \u010Dlov\u011Bka. By\u0165 se pou\u017E\u00EDval v zem\u011Bd\u011Blstv\u00ED jako fungicid, od takov\u00E9ho pou\u017Eit\u00ED se upou\u0161t\u00ED s lep\u0161\u00EDm pozn\u00E1n\u00EDm jeho zdravotn\u00EDch rizik. Cykloheximid je degradov\u00E1n z\u00E1sadami (pH>7), dekontaminaci pracovn\u00EDch ploch a n\u00E1dob lze prov\u00E1d\u011Bt myt\u00EDm ne\u0161kodn\u00FDmi z\u00E1sadit\u00FDmi roztoky, nap\u0159. m\u00FDdlem. Proto\u017Ee se inhibi\u010Dn\u00ED \u00FA\u010Dinky cykloheximidu projevuj\u00ED jen u eukaryot, lze ho pou\u017E\u00EDt pro rozli\u0161ov\u00E1n\u00ED gen\u016F v organel\u00E1ch a v j\u00E1d\u0159e. U gen\u016F v eukaryotick\u00E9m j\u00E1d\u0159e za p\u0159\u00EDtomnosti cykloheximidu nefunguje exprese, kde\u017Eto organelov\u00E9 geny z\u016Fst\u00E1vaj\u00ED cykloheximidem nedot\u010Deny a jejich exprese funguje."@cs . "Cycloheximid ist ein Antibiotikum im weitesten Sinne, das von Streptomyceten (Streptomyces griseus) produziert wird. Es wirkt als Translationshemmer bei Eukaryoten und f\u00FChrt durch Unterbinden der Proteinbiosynthese an den Ribosomen zur Wachstumshemmung und zum Absterben eukaryontischer Zellen. Es handelt sich um einen klassischen Translationshemmer. Die mitochondriale und plastid\u00E4re Proteinsynthese eukaryotischer Zellen wird durch sehr hohe Konzentrationen von Cycloheximid ebenfalls gest\u00F6rt, weshalb dieses Antibiotikum auch zur Selektion von transgenen Pflanzen (Eukaryot) benutzt werden kann. Cycloheximid findet kaum noch Verwendung als Antibiotikum, da es im Menschen bei hoher Dosierung die mitochondriale Proteintranslation hemmt."@de . . . . . . . "Le cycloheximide est un antifongique qui bloque la biosynth\u00E8se des prot\u00E9ines chez les cellules eucaryotes. C'est un inhibiteur \u00E0 la fois de la phase d'initiation et d'\u00E9longation dans la synth\u00E8se prot\u00E9ique. Vu son haut niveau de toxicit\u00E9 chez l'humain, il n'est pas utilis\u00E9 comme antifongique. On l'utilise surtout en biologie cellulaire pour savoir ce qui permet l'entr\u00E9e dans la phase M ( : mitose) du cycle cellulaire. On l'utilise aussi en microbiologie comme inhibiteur de croissance des myc\u00E8tes (antifongique) dans la conception de milieux de cultures s\u00E9lectifs tels que le milieu Glyc\u00E9rol et extrait de levure additionn\u00E9 de cycloheximide pour isoler les actinomyc\u00E8tes. Le cycloheximide est un compos\u00E9 amer comme la quinine et le benzoate de d\u00E9natonium."@fr . "Cicloesimide"@it . . "Naramycin A, hizarocin, actidione, actispray, kaken, U-4527"@en . . . "Cycloheximide (doorgaans afgekort tot CHX) is een organische verbinding met als brutoformule C15H23NO4. De stof komt voor als kleurloze kristallen."@nl . . "Cycloheximide"@en . . . . . . . . . "Cykloheximid \u00E4r en naturligt f\u00F6rekommande fungicid och inhibitor f\u00F6r biosyntesen i eukaryota organismer. \u00C4mnet produceras av bland andra bakterierna och Lactobacillus sanfranciscensis. Cykloheximid st\u00F6r translokeringssteget vid proteinsyntesen (r\u00F6relse av tv\u00E5 tRNA-molekyler och mRNA i f\u00F6rh\u00E5llande till ribosomen) och blockerar p\u00E5 detta s\u00E4tt translationen. Cykloheximid anv\u00E4nds ofta i biomedicinsk forskning f\u00F6r att h\u00E4mma proteinsyntesen i eukaryota celler som studerats in vitro (dvs. utanf\u00F6r organismer). Det \u00E4r billigt och fungerar snabbt. Dess effekter v\u00E4nds snabbt genom att helt enkelt ta bort det fr\u00E5n odlingsmediet. P\u00E5 grund av betydande toxiska biverkningar, s\u00E5som DNA-skador, teratogener och andra reproduktionseffekter (till exempel fosterskador och toxicitet f\u00F6r spermier), anv\u00E4nds cykloheximid i allm\u00E4nhet endast i in vitro-forskningsapplikationer och \u00E4r inte l\u00E4mplig f\u00F6r humant bruk som en terapeutisk f\u00F6rening. \u00C4ven om det har anv\u00E4nts som en fungicid i jordbruksapplikationer, minskar denna anv\u00E4ndning nu efterhand som h\u00E4lsoriskerna har blivit b\u00E4ttre f\u00F6rst\u00E5dda. Cykloheximid klassificeras som ett extremt farligt \u00E4mne i USA enligt definitionen i avsnitt 302 i U.S. Emergency Planning and Community Right-to-Know Act (42 U.S.C. 11002) och \u00E4r f\u00F6rem\u00E5l f\u00F6r strikta rapporteringskrav av anl\u00E4ggningar som producerar, lagrar eller anv\u00E4nder det i icke f\u00F6rsumbara m\u00E4ngder."@sv . "\u653E\u7EBF\u83CC\u916E"@zh . . "\u653E\u7EBF\u83CC\u916E\u662F\u4E00\u79CD\u5177\u82E6\u5473\u7684\u7269\u8CEA\uFF0C\u5728\u771F\u6838\u751F\u7269\u4E2D\u5BF9\u86CB\u767D\u8CEA\u751F\u7269\u5408\u6210\u8FC7\u7A0B\u6709\u6291\u5236\u6548\u5E94\u7684\u5316\u5408\u7269\uFF0C\u5B83\u662F\uFF08Streptomyces griseus\uFF09\u7684\u4E00\u79CD\u4EA7\u7269\u3002\u5B83\u901A\u8FC7\u5E72\u6270\u86CB\u767D\u8D28\u5408\u6210\u8FC7\u7A0B\u4E2D\u7684\u6613\u4F4D\u6B65\u9AA4\u800C\u963B\u788D\u8F49\u8BD1\u8FC7\u7A0B\u3002\u5728\u751F\u7269\u836F\u5B66\u7814\u7A76\u4E2D\u653E\u7EBF\u83CC\u916E\u5E38\u88AB\u7528\u6765\u6291\u5236\u751F\u7269\u4F53\u5916\u771F\u6838\u7EC6\u80DE\u7684\u86CB\u767D\u8D28\u5408\u6210\u3002\u8FD9\u4E2A\u65B9\u6CD5\u975E\u5E38\u6709\u6548\u3001\u5FEB\u901F\u548C\u5EC9\u4EF7\u3002\u800C\u4E14\u901A\u8FC7\u5C06\u653E\u7EBF\u83CC\u916E\u4ECE\u8BD5\u7BA1\u4E2D\u53BB\u9664\u6389\u53EF\u4EE5\u5F88\u5FEB\u5730\u53D6\u6D88\u5B83\u7684\u4F5C\u7528\u3002 \u7531\u4E8E\u653E\u7EBF\u83CC\u916E\u62E5\u6709\u975E\u5E38\u5F3A\u70C8\u7684\u6BD2\u6027\uFF0C\u5305\u62EC\u635F\u5BB3DNA\u3001\u5BFC\u81F4\u7578\u5F62\u80CE\u513F\u548C\u5176\u5B83\u5BF9\u7E41\u6B96\u8FC7\u7A0B\u7684\u6548\u5E94\uFF08\u5305\u62EC\u51FA\u751F\u969C\u788D\u548C\u5BF9\u7CBE\u5B50\u7684\u6BD2\u6027\uFF09\uFF0C\u5B83\u4E00\u822C\u53EA\u88AB\u7528\u5728\u4F53\u5916\u7684\u7814\u7A76\u5E94\u7528\u4E2D\uFF0C\u5B83\u4E0D\u9002\u5B9C\u5728\u4EBA\u4F53\u5185\u4F5C\u4E3A\u6297\u83CC\u7D20\u4F7F\u7528\u3002\u8FC7\u53BB\u5728\u519C\u4E1A\u4E2D\u5B83\u88AB\u7528\u6765\u4F5C\u4E3A\u6740\u771F\u83CC\u5242\uFF0C\u4F46\u662F\u7531\u4E8E\u5BF9\u5B83\u7684\u5371\u9669\u6027\u7684\u8BA4\u8BC6\u4E0D\u65AD\u63D0\u9AD8\u8FD9\u4E2A\u7528\u6CD5\u5DF2\u7ECF\u5F88\u5C11\u4E86\u3002 \u78B1\u53EF\u4EE5\u7834\u574F\u653E\u7EBF\u83CC\u916E\uFF0C\u56E0\u6B64\u5047\u5982\u5DE5\u4F5C\u53F0\u9762\u6216\u8005\u5BB9\u5668\u88AB\u653E\u7EBF\u83CC\u916E\u6C61\u67D3\u540E\uFF0C\u53EA\u8981\u4F7F\u7528\u65E0\u5BB3\u7684\u78B1\u6EB6\u6DB2\uFF08\u6BD4\u5982\u80A5\u7682\uFF09\u6E05\u6D17\u5C31\u53EF\u4EE5\u4E86\u3002"@zh . . . "4"^^ . . . . . "4-{(2R)-2-[(1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione"@en . . "Cicloheximida"@pt . "175"^^ . . "Cycloheximide"@nl . "Cycloheximide is a naturally occurring fungicide produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effects by interfering with the translocation step in protein synthesis (movement of two tRNA molecules and mRNA in relation to the ribosome), thus blocking eukaryotic translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells studied in vitro (i.e. outside of organisms). It is inexpensive and works rapidly. Its effects are rapidly reversed by simply removing it from the culture medium. Due to significant toxic side effects, including DNA damage, teratogenesis, and other reproductive effects (including birth defects and toxicity to sperm), cycloheximide is generally used only in in vitro research applications, and is not suitable for human use as a therapeutic compound. Although it has been used as a fungicide in agricultural applications, this application is now decreasing as the health risks have become better understood. Because cycloheximide rapidly breaks down in a basic environment, decontamination of work surfaces and containers can be achieved by washing with a non-harmful alkali solution such as soapy water or aqueous sodium bicarbonate. It is classified as an extremely hazardous substance in the United States as defined in Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act (42 U.S.C. 11002), and is subject to strict reporting requirements by facilities which produce, store, or use it in significant quantities."@en . "1100397383"^^ . . . . . "\u30B7\u30AF\u30ED\u30D8\u30AD\u30B7\u30DF\u30C9\u306F\u7D30\u83CC\u306E1\u7A2E\u306B\u3088\u3063\u3066\u4F5C\u3089\u308C\u308B\u771F\u6838\u751F\u7269\u306E\u30BF\u30F3\u30D1\u30AF\u8CEA\u5408\u6210\u306E\u963B\u5BB3\u5264\u3067\u3042\u308B\u3002\u30B7\u30AF\u30ED\u30D8\u30AD\u30B7\u30DF\u30C9\u306F\u30BF\u30F3\u30D1\u30AF\u8CEA\u5408\u6210\u306E\u8EE2\u4F4D\u904E\u7A0B\uFF08\u30EA\u30DC\u30BD\u30FC\u30E0\u306B\u7D50\u5408\u3059\u308B2\u3064\u306EtRNA\u5206\u5B50\u3068mRNA\u306E\u79FB\u52D5\uFF09\u306B\u5E72\u6E09\u3059\u308B\u3053\u3068\u3067\u305D\u306E\u52B9\u679C\u3092\u793A\u3057\u3001\u7FFB\u8A33\u3092\u963B\u5BB3\u3059\u308B\u3002\u30B7\u30AF\u30ED\u30D8\u30AD\u30B7\u30DF\u30C9\u306F\u3001in vitro\uFF08\u3059\u306A\u308F\u3061\u751F\u4F53\u5916\uFF09\u3067\u7814\u7A76\u3055\u308C\u308B\u771F\u6838\u751F\u7269\u7D30\u80DE\u306B\u304A\u3051\u308B\u30BF\u30F3\u30D1\u30AF\u8CEA\u5408\u6210\u3092\u963B\u5BB3\u3059\u308B\u7528\u9014\u3067\u751F\u5316\u5B66\u7814\u7A76\u306B\u5E83\u304F\u7528\u3044\u3089\u308C\u3066\u3044\u308B\u3002\u30B7\u30AF\u30ED\u30D8\u30AD\u30B7\u30DF\u30C9\u306F\u9AD8\u4FA1\u3067\u306F\u306A\u304F\u3001\u8FC5\u901F\u306B\u4F5C\u7528\u3057\u3001\u5358\u7D14\u306B\u57F9\u5730\u304B\u3089\u9664\u304F\u3053\u3068\u3067\u305D\u306E\u52B9\u679C\u3092\u5931\u304F\u3059\u3053\u3068\u304C\u3067\u304D\u308B\u3002 DNA\u640D\u50B7\u3001\u50AC\u5947\u6027\u3001\u304A\u3088\u3073\u4ED6\u306E\u751F\u6B96\u3078\u306E\u5F71\u97FF\uFF08\u5148\u5929\u6027\u7570\u5E38\u3068\u7CBE\u5B50\u3078\u306E\u6BD2\u6027\uFF09\u3092\u542B\u3080\u6BD2\u6027\u306E\u5F37\u3044\u526F\u4F5C\u7528\u306E\u305F\u3081\u3001\u30B7\u30AF\u30ED\u30D8\u30AD\u30B7\u30DF\u30C9\u306F\u4E00\u822C\u7684\u306B\u306Fin vitro\u306E\u7814\u7A76\u306B\u306E\u307F\u4F7F\u7528\u3055\u308C\u3001\u30D2\u30C8\u306E\u6CBB\u7642\u85AC\u3068\u3057\u3066\u306F\u9069\u5207\u3067\u306A\u3044\u3002\u8FB2\u696D\u306B\u304A\u3044\u3066\u306F\u6297\u771F\u83CC\u5264\u3068\u3057\u3066\u4F7F\u7528\u3055\u308C\u3066\u304D\u3066\u3044\u308B\u304C\u3001\u3053\u306E\u7A2E\u306E\u5229\u7528\u306F\u3001\u5065\u5EB7\u3078\u306E\u30EA\u30B9\u30AF\u306B\u5BFE\u3059\u308B\u7406\u89E3\u304C\u9032\u3080\u306B\u3064\u308C\u3066\u6E1B\u5C11\u3057\u3064\u3064\u3042\u308B\u3002\u6BD2\u7269\u53CA\u3073\u5287\u7269\u53D6\u7DE0\u6CD5\u306B\u3088\u308A\u5287\u7269\u306B\u6307\u5B9A\u3055\u308C\u3066\u3044\u308B\u3002 \u30B7\u30AF\u30ED\u30D8\u30AD\u30B7\u30DF\u30C9\u306F\u30A2\u30EB\u30AB\u30EA\uFF08pH > 7\uFF09\u3067\u5206\u89E3\u3059\u308B\u3002\u4F7F\u7528\u3057\u305F\u5834\u6240\u306E\u8868\u9762\u3084\u5BB9\u5668\u304B\u3089\u30B7\u30AF\u30ED\u30D8\u30AD\u30B7\u30DF\u30C9\u3092\u9664\u304F\u306B\u306F\u3001\u77F3\u9E78\u306E\u3088\u3046\u306A\u6BD2\u6027\u306E\u306A\u3044\u30A2\u30EB\u30AB\u30EA\u6EB6\u6DB2\u3067\u51E6\u7406\u3059\u308C\u3070\u3088\u3044\u3002 \u30B7\u30AF\u30ED\u30D8\u30AD\u30B7\u30DF\u30C9\u306F\u771F\u6838\u751F\u7269\u3067\u306E\u307F\u30BF\u30F3\u30D1\u30AF\u8CEA\u5408\u6210\u3092\u52B9\u679C\u7684\u306B\u963B\u5BB3\u3059\u308B\u306E\u3067\u3001\u30DF\u30C8\u30B3\u30F3\u30C9\u30EA\u30A2\u3067\u7FFB\u8A33\u3055\u308C\u308B\u30BF\u30F3\u30D1\u30AF\u8CEA\u3068\u7D30\u80DE\u8CEA\u3067\u7FFB\u8A33\u3055\u308C\u308B\u30BF\u30F3\u30D1\u30AF\u8CEA\u3092\u533A\u5225\u3059\u308B\u305F\u3081\u306B\u7528\u3044\u3089\u308C\u308B\u3053\u3068\u304C\u3042\u308B\u3002\u6838\u304B\u3089\u8F38\u9001\u3055\u308C\u3001\u7D30\u80DE\u8CEA\u307E\u305F\u306F\u5C0F\u80DE\u4F53\u3067\u7FFB\u8A33\u3055\u308C\u308B\u3079\u304DmRNA\u306F\u3001\u30B7\u30AF\u30ED\u30D8\u30AD\u30B7\u30DF\u30C9\u306E\u5B58\u5728\u4E0B\u3067\u306F\u7FFB\u8A33\u3055\u308C\u306A\u3044\u3002\u53CD\u5BFE\u306B\u3001\u30DF\u30C8\u30B3\u30F3\u30C9\u30EA\u30A2\u306E\u30EA\u30DC\u30BD\u30FC\u30E0\u3092\u4F7F\u3063\u305F\u7FFB\u8A33\u306F\u30B7\u30AF\u30ED\u30D8\u30AD\u30B7\u30DF\u30C9\u306E\u5F71\u97FF\u3092\u53D7\u3051\u305A\u3001\u30DF\u30C8\u30B3\u30F3\u30C9\u30EA\u30A2\u306E\u907A\u4F1D\u5B50\u306F\u767A\u73FE\u3057\u7D9A\u3051\u308B\u3002"@ja . . . . "A cicloheximida \u00E9 um inibidor da s\u00EDntese de prote\u00EDnas, em eucariotos produzida pela bact\u00E9ria Streptomyces griseus. A cicloheximida exerce o seu efeito interferindo na etapa de transloca\u00E7\u00E3o durante a s\u00EDntese proteica (movimento de dois tRNA e mol\u00E9culas de mRNA em rela\u00E7\u00E3o ao ribossomo), bloqueando a tradu\u00E7\u00E3o. A cicloheximida \u00E9 amplamente utilizado na pesquisa cl\u00EDnica para inibir a s\u00EDntese de prote\u00EDnas nas c\u00E9lulas eucari\u00F3ticas estudadas in vitro (isto \u00E9, fora dos organismos). \u00C9 barata e funciona rapidamente. Seus efeitos s\u00E3o rapidamente revertidas por simplesmente remov\u00EA-la do meio de cultura."@pt . . "Cycloheximide is a naturally occurring fungicide produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effects by interfering with the translocation step in protein synthesis (movement of two tRNA molecules and mRNA in relation to the ribosome), thus blocking eukaryotic translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells studied in vitro (i.e. outside of organisms). It is inexpensive and works rapidly. Its effects are rapidly reversed by simply removing it from the culture medium."@en . "Cycloheximid"@de . . . "Cykloheximid (systematick\u00FD n\u00E1zev 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyklohexyl]-2-hydroxyethyl}piperidin-2,6-dion) je organick\u00E1 slou\u010Denina p\u0159irozen\u011B produkovan\u00E1 bakteri\u00ED . P\u016Fsob\u00ED jako inhibitor synt\u00E9zy b\u00EDlkovin u eukaryotick\u00FDch organism\u016F \u2013 interferuje s krokem (pohybem dvou molekul tRNA a mRNA ve vztahu k ribozom\u016Fm) t\u00E9to synt\u00E9zy a tak blokuje . \u0160iroce se pou\u017E\u00EDv\u00E1 ve v\u00FDzkumu pro inhibici proteosynt\u00E9zy u bun\u011Bk studovan\u00FDch in vitro (tj. mimo organismy). Je levn\u00FD a funguje rychle. Jeho \u00FA\u010Dinky lze rychle odstranit jednodu\u0161e jeho odstran\u011Bn\u00EDm z kultiva\u010Dn\u00EDho m\u00E9dia."@cs . "Cykloheksymid (\u0142ac. Cicloheximidum) \u2013 organiczny zwi\u0105zek chemiczny, antybiotyk o dzia\u0142aniu produkowany przez promieniowce Streptomyces griseus, inhibitor biosyntezy bia\u0142ek u organizm\u00F3w eukariotycznych. Jest u\u017Cywany w przemy\u015Ble winiarskim, s\u0142u\u017Cy zapobieganiu wt\u00F3rnej fermentacji, a tak\u017Ce stabilizacji win."@pl . "Cycloheximide.svg"@en . . . . . . . . . "Cycloheximide (doorgaans afgekort tot CHX) is een organische verbinding met als brutoformule C15H23NO4. De stof komt voor als kleurloze kristallen."@nl . . . . . . . . . "Cycloheximide"@en . . . . "Cykloheksymid"@pl . . "La cicloheximida es un inhibidor de la s\u00EDntesis proteica en organismos eucariotas, y es producida por la bacteria Streptomyces griseus. Act\u00FAa interfiriendo la actividad peptidil transferasa del ribosoma 60S, bloqueando la elongaci\u00F3n traduccional. Tiene un uso extendido en la investigaci\u00F3n biom\u00E9dica para inhibir la s\u00EDntesis de prote\u00EDnas en c\u00E9lulas eucariotas in vitro. Su costo es bajo y act\u00FAa r\u00E1pidamente, siendo sus efectos revertidos al quitarla del medio de cultivo. Dado los importantes efectos t\u00F3xicos, incluyendo da\u00F1o al ADN, teratog\u00E9nesis, y otros efectos en la reproducci\u00F3n, tales como enfermedades cong\u00E9nitas y toxicidad para los espermatozoides, la cicloheximida es generalmente usada solamente en investigaciones in vitro, y no es apta para su uso en humanos como antibi\u00F3tico. Ha sido usada en la agricultura como un fungicida, aunque su uso est\u00E1 mermando debido a que presenta altos riesgos para la salud. La cicloheximida es degradada por \u00E1lcali (pH > 7). La descontaminaci\u00F3n de superficies de trabajo y contenedores se puede realizar lavando con una soluci\u00F3n alcalina no da\u00F1ina como el jab\u00F3n."@es . . . . . . . "changed"@en . . . "Cycloheximide"@en . "\u30B7\u30AF\u30ED\u30D8\u30AD\u30B7\u30DF\u30C9"@ja . . . . "2109062"^^ . . . . . "Cykloheximid \u00E4r en naturligt f\u00F6rekommande fungicid och inhibitor f\u00F6r biosyntesen i eukaryota organismer. \u00C4mnet produceras av bland andra bakterierna och Lactobacillus sanfranciscensis. Cykloheximid st\u00F6r translokeringssteget vid proteinsyntesen (r\u00F6relse av tv\u00E5 tRNA-molekyler och mRNA i f\u00F6rh\u00E5llande till ribosomen) och blockerar p\u00E5 detta s\u00E4tt translationen. Cykloheximid anv\u00E4nds ofta i biomedicinsk forskning f\u00F6r att h\u00E4mma proteinsyntesen i eukaryota celler som studerats in vitro (dvs. utanf\u00F6r organismer). Det \u00E4r billigt och fungerar snabbt. Dess effekter v\u00E4nds snabbt genom att helt enkelt ta bort det fr\u00E5n odlingsmediet."@sv . . . "\u653E\u7EBF\u83CC\u916E\u662F\u4E00\u79CD\u5177\u82E6\u5473\u7684\u7269\u8CEA\uFF0C\u5728\u771F\u6838\u751F\u7269\u4E2D\u5BF9\u86CB\u767D\u8CEA\u751F\u7269\u5408\u6210\u8FC7\u7A0B\u6709\u6291\u5236\u6548\u5E94\u7684\u5316\u5408\u7269\uFF0C\u5B83\u662F\uFF08Streptomyces griseus\uFF09\u7684\u4E00\u79CD\u4EA7\u7269\u3002\u5B83\u901A\u8FC7\u5E72\u6270\u86CB\u767D\u8D28\u5408\u6210\u8FC7\u7A0B\u4E2D\u7684\u6613\u4F4D\u6B65\u9AA4\u800C\u963B\u788D\u8F49\u8BD1\u8FC7\u7A0B\u3002\u5728\u751F\u7269\u836F\u5B66\u7814\u7A76\u4E2D\u653E\u7EBF\u83CC\u916E\u5E38\u88AB\u7528\u6765\u6291\u5236\u751F\u7269\u4F53\u5916\u771F\u6838\u7EC6\u80DE\u7684\u86CB\u767D\u8D28\u5408\u6210\u3002\u8FD9\u4E2A\u65B9\u6CD5\u975E\u5E38\u6709\u6548\u3001\u5FEB\u901F\u548C\u5EC9\u4EF7\u3002\u800C\u4E14\u901A\u8FC7\u5C06\u653E\u7EBF\u83CC\u916E\u4ECE\u8BD5\u7BA1\u4E2D\u53BB\u9664\u6389\u53EF\u4EE5\u5F88\u5FEB\u5730\u53D6\u6D88\u5B83\u7684\u4F5C\u7528\u3002 \u7531\u4E8E\u653E\u7EBF\u83CC\u916E\u62E5\u6709\u975E\u5E38\u5F3A\u70C8\u7684\u6BD2\u6027\uFF0C\u5305\u62EC\u635F\u5BB3DNA\u3001\u5BFC\u81F4\u7578\u5F62\u80CE\u513F\u548C\u5176\u5B83\u5BF9\u7E41\u6B96\u8FC7\u7A0B\u7684\u6548\u5E94\uFF08\u5305\u62EC\u51FA\u751F\u969C\u788D\u548C\u5BF9\u7CBE\u5B50\u7684\u6BD2\u6027\uFF09\uFF0C\u5B83\u4E00\u822C\u53EA\u88AB\u7528\u5728\u4F53\u5916\u7684\u7814\u7A76\u5E94\u7528\u4E2D\uFF0C\u5B83\u4E0D\u9002\u5B9C\u5728\u4EBA\u4F53\u5185\u4F5C\u4E3A\u6297\u83CC\u7D20\u4F7F\u7528\u3002\u8FC7\u53BB\u5728\u519C\u4E1A\u4E2D\u5B83\u88AB\u7528\u6765\u4F5C\u4E3A\u6740\u771F\u83CC\u5242\uFF0C\u4F46\u662F\u7531\u4E8E\u5BF9\u5B83\u7684\u5371\u9669\u6027\u7684\u8BA4\u8BC6\u4E0D\u65AD\u63D0\u9AD8\u8FD9\u4E2A\u7528\u6CD5\u5DF2\u7ECF\u5F88\u5C11\u4E86\u3002 \u78B1\u53EF\u4EE5\u7834\u574F\u653E\u7EBF\u83CC\u916E\uFF0C\u56E0\u6B64\u5047\u5982\u5DE5\u4F5C\u53F0\u9762\u6216\u8005\u5BB9\u5668\u88AB\u653E\u7EBF\u83CC\u916E\u6C61\u67D3\u540E\uFF0C\u53EA\u8981\u4F7F\u7528\u65E0\u5BB3\u7684\u78B1\u6EB6\u6DB2\uFF08\u6BD4\u5982\u80A5\u7682\uFF09\u6E05\u6D17\u5C31\u53EF\u4EE5\u4E86\u3002"@zh . . . . . . . "La cicloheximida es un inhibidor de la s\u00EDntesis proteica en organismos eucariotas, y es producida por la bacteria Streptomyces griseus. Act\u00FAa interfiriendo la actividad peptidil transferasa del ribosoma 60S, bloqueando la elongaci\u00F3n traduccional. Tiene un uso extendido en la investigaci\u00F3n biom\u00E9dica para inhibir la s\u00EDntesis de prote\u00EDnas en c\u00E9lulas eucariotas in vitro. Su costo es bajo y act\u00FAa r\u00E1pidamente, siendo sus efectos revertidos al quitarla del medio de cultivo."@es . "Cykloheximid"@cs . . "\u30B7\u30AF\u30ED\u30D8\u30AD\u30B7\u30DF\u30C9\u306F\u7D30\u83CC\u306E1\u7A2E\u306B\u3088\u3063\u3066\u4F5C\u3089\u308C\u308B\u771F\u6838\u751F\u7269\u306E\u30BF\u30F3\u30D1\u30AF\u8CEA\u5408\u6210\u306E\u963B\u5BB3\u5264\u3067\u3042\u308B\u3002\u30B7\u30AF\u30ED\u30D8\u30AD\u30B7\u30DF\u30C9\u306F\u30BF\u30F3\u30D1\u30AF\u8CEA\u5408\u6210\u306E\u8EE2\u4F4D\u904E\u7A0B\uFF08\u30EA\u30DC\u30BD\u30FC\u30E0\u306B\u7D50\u5408\u3059\u308B2\u3064\u306EtRNA\u5206\u5B50\u3068mRNA\u306E\u79FB\u52D5\uFF09\u306B\u5E72\u6E09\u3059\u308B\u3053\u3068\u3067\u305D\u306E\u52B9\u679C\u3092\u793A\u3057\u3001\u7FFB\u8A33\u3092\u963B\u5BB3\u3059\u308B\u3002\u30B7\u30AF\u30ED\u30D8\u30AD\u30B7\u30DF\u30C9\u306F\u3001in vitro\uFF08\u3059\u306A\u308F\u3061\u751F\u4F53\u5916\uFF09\u3067\u7814\u7A76\u3055\u308C\u308B\u771F\u6838\u751F\u7269\u7D30\u80DE\u306B\u304A\u3051\u308B\u30BF\u30F3\u30D1\u30AF\u8CEA\u5408\u6210\u3092\u963B\u5BB3\u3059\u308B\u7528\u9014\u3067\u751F\u5316\u5B66\u7814\u7A76\u306B\u5E83\u304F\u7528\u3044\u3089\u308C\u3066\u3044\u308B\u3002\u30B7\u30AF\u30ED\u30D8\u30AD\u30B7\u30DF\u30C9\u306F\u9AD8\u4FA1\u3067\u306F\u306A\u304F\u3001\u8FC5\u901F\u306B\u4F5C\u7528\u3057\u3001\u5358\u7D14\u306B\u57F9\u5730\u304B\u3089\u9664\u304F\u3053\u3068\u3067\u305D\u306E\u52B9\u679C\u3092\u5931\u304F\u3059\u3053\u3068\u304C\u3067\u304D\u308B\u3002 DNA\u640D\u50B7\u3001\u50AC\u5947\u6027\u3001\u304A\u3088\u3073\u4ED6\u306E\u751F\u6B96\u3078\u306E\u5F71\u97FF\uFF08\u5148\u5929\u6027\u7570\u5E38\u3068\u7CBE\u5B50\u3078\u306E\u6BD2\u6027\uFF09\u3092\u542B\u3080\u6BD2\u6027\u306E\u5F37\u3044\u526F\u4F5C\u7528\u306E\u305F\u3081\u3001\u30B7\u30AF\u30ED\u30D8\u30AD\u30B7\u30DF\u30C9\u306F\u4E00\u822C\u7684\u306B\u306Fin vitro\u306E\u7814\u7A76\u306B\u306E\u307F\u4F7F\u7528\u3055\u308C\u3001\u30D2\u30C8\u306E\u6CBB\u7642\u85AC\u3068\u3057\u3066\u306F\u9069\u5207\u3067\u306A\u3044\u3002\u8FB2\u696D\u306B\u304A\u3044\u3066\u306F\u6297\u771F\u83CC\u5264\u3068\u3057\u3066\u4F7F\u7528\u3055\u308C\u3066\u304D\u3066\u3044\u308B\u304C\u3001\u3053\u306E\u7A2E\u306E\u5229\u7528\u306F\u3001\u5065\u5EB7\u3078\u306E\u30EA\u30B9\u30AF\u306B\u5BFE\u3059\u308B\u7406\u89E3\u304C\u9032\u3080\u306B\u3064\u308C\u3066\u6E1B\u5C11\u3057\u3064\u3064\u3042\u308B\u3002\u6BD2\u7269\u53CA\u3073\u5287\u7269\u53D6\u7DE0\u6CD5\u306B\u3088\u308A\u5287\u7269\u306B\u6307\u5B9A\u3055\u308C\u3066\u3044\u308B\u3002 \u30B7\u30AF\u30ED\u30D8\u30AD\u30B7\u30DF\u30C9\u306F\u30A2\u30EB\u30AB\u30EA\uFF08pH > 7\uFF09\u3067\u5206\u89E3\u3059\u308B\u3002\u4F7F\u7528\u3057\u305F\u5834\u6240\u306E\u8868\u9762\u3084\u5BB9\u5668\u304B\u3089\u30B7\u30AF\u30ED\u30D8\u30AD\u30B7\u30DF\u30C9\u3092\u9664\u304F\u306B\u306F\u3001\u77F3\u9E78\u306E\u3088\u3046\u306A\u6BD2\u6027\u306E\u306A\u3044\u30A2\u30EB\u30AB\u30EA\u6EB6\u6DB2\u3067\u51E6\u7406\u3059\u308C\u3070\u3088\u3044\u3002"@ja . "Le cycloheximide est un antifongique qui bloque la biosynth\u00E8se des prot\u00E9ines chez les cellules eucaryotes. C'est un inhibiteur \u00E0 la fois de la phase d'initiation et d'\u00E9longation dans la synth\u00E8se prot\u00E9ique. Vu son haut niveau de toxicit\u00E9 chez l'humain, il n'est pas utilis\u00E9 comme antifongique. Le cycloheximide est un compos\u00E9 amer comme la quinine et le benzoate de d\u00E9natonium."@fr . . "Cykloheximid"@sv . . "La cicloesimide \u00E8 un composto chimico che inibisce la sintesi proteica in cellule eucariote bloccando l'attacco e l'uscita del tRNA dal ribosoma. Induce apoptosi in vari tipi cellulari. \u00C8 prodotta dal batterio Streptomyces griseus."@it . . . . . . . . . . . . . . . . . "Cicloheximida"@es . . . . . "Cycloheximide"@fr . . . . . . . . "A cicloheximida \u00E9 um inibidor da s\u00EDntese de prote\u00EDnas, em eucariotos produzida pela bact\u00E9ria Streptomyces griseus. A cicloheximida exerce o seu efeito interferindo na etapa de transloca\u00E7\u00E3o durante a s\u00EDntese proteica (movimento de dois tRNA e mol\u00E9culas de mRNA em rela\u00E7\u00E3o ao ribossomo), bloqueando a tradu\u00E7\u00E3o. A cicloheximida \u00E9 amplamente utilizado na pesquisa cl\u00EDnica para inibir a s\u00EDntese de prote\u00EDnas nas c\u00E9lulas eucari\u00F3ticas estudadas in vitro (isto \u00E9, fora dos organismos). \u00C9 barata e funciona rapidamente. Seus efeitos s\u00E3o rapidamente revertidas por simplesmente remov\u00EA-la do meio de cultura. Devido a significativos efeitos colaterais t\u00F3xicos, incluindo danos ao DNA, teratogenesis, e outros reprodutiva efeitos (incluindo defeitos de nascimento e toxicidade para o esperma), a cicloheximida geralmente \u00E9 usado apenas em in vitro aplica\u00E7\u00F5es de pesquisa, e n\u00E3o \u00E9 adequado para uso humano de forma terap\u00EAutica. A cicloheximida \u00E9 degradada em condi\u00E7\u00F5es alcalinas (pH > 7), por isso a descontamina\u00E7\u00E3o das superf\u00EDcies de trabalho e os recipientes podem ser alcan\u00E7ados por meio de lavagem com uma solu\u00E7\u00E3o de sab\u00E3o de pH b\u00E1sico. Ele \u00E9 classificada como extremamente perigosa nos Estados Unidos, conforme definido na Se\u00E7\u00E3o 302 dos EUA, o Planeamento de Emerg\u00EAncia e de Direito Comunit\u00E1rio-to-Know Act (42 U. S. C. 11002), e est\u00E1 sujeita a rigorosas exig\u00EAncias de relat\u00F3rios pelos estabelecimentos que produzem, armazenam, ou us\u00E1-lo em quantidades significativas."@pt . . . . "Cycloheximide"@en . .