"Anemia drepanoc\u00EDtica, drepanocitose ou anemia falciforme (do latim falci-, foice e -forme, formato de) \u00E9 uma doen\u00E7a hematol\u00F3gica heredit\u00E1ria monog\u00E9nica, caracterizada pela produ\u00E7\u00E3o anormal de hemoglobinas, entre as quais a mais comum \u00E9 a forma HbS (de Sickle, foice), que sob determinadas condi\u00E7\u00F5es de desoxigena\u00E7\u00E3o, polimeriza, deformando as hem\u00E1cias, que assumem uma forma semelhante a foices, causando defici\u00EAncia no transporte de oxig\u00E9nio e g\u00E1s carb\u00F3nico e outras complica\u00E7\u00F5es, nos indiv\u00EDduos acometidos pela doen\u00E7a. Por esse motivo, a anemia drepanoc\u00EDtica \u00E9 tamb\u00E9m conhecida por anemia falciforme. Do ponto de vista patogen\u00E9tico, est\u00E1 classificada entre as anemias por \"defeito da s\u00EDntese de hemoglobina\", a prote\u00EDna que transporta oxig\u00E9nio presente nos gl\u00F3bulos vermelhos, embora a anemia seja "@pt . . . "282.6" . . . . "La dr\u00E9panocytose, \u00E9galement appel\u00E9e an\u00E9mie falciforme, h\u00E9moglobinose S, et autrefois sickl\u00E9mie, est une maladie g\u00E9n\u00E9tique r\u00E9sultant d'une mutation sur un des g\u00E8nes codant l'h\u00E9moglobine. Cette affection peut notamment occasionner un retard du d\u00E9veloppement de l'enfant, des crises vasoocclusives, une pr\u00E9disposition aux infections bact\u00E9riennes et une an\u00E9mie h\u00E9molytique. Elle a \u00E9t\u00E9 d\u00E9crite pour la premi\u00E8re fois dans la litt\u00E9rature m\u00E9dicale en 1910 par le m\u00E9decin am\u00E9ricain James Herrick et sa transmission h\u00E9r\u00E9ditaire a \u00E9t\u00E9 \u00E9tablie en 1949 par James Neel. C'est la maladie g\u00E9n\u00E9tique la plus fr\u00E9quente dans le monde, avec environ 310 000 naissances concern\u00E9es chaque ann\u00E9e. Approximativement 80 % des cas de dr\u00E9panocytose se concentreraient en Afrique subsaharienne. La maladie est \u00E9galement assez fr\u00E9quente dans certaines r\u00E9gions de l'Inde, de la p\u00E9ninsule arabique et parmi les populations d'origine africaine dispers\u00E9es de par le monde. Elle a entra\u00EEn\u00E9 la mort de 114 000 personnes en 2015. La dr\u00E9panocytose est due \u00E0 la substitution d'un seul r\u00E9sidu d'acide amin\u00E9 sur la cha\u00EEne \u03B2 de l'h\u00E9moglobine, prot\u00E9ine des globules rouges assurant le transport de l'oxyg\u00E8ne dans le sang. Cette mutation g\u00E9n\u00E9tique \u2014 remplacement du glutamate en position 6 par une valine, donnant de l'h\u00E9moglobine S \u2014 favorise, dans certaines conditions, l'apparition de globules rouges rigides de forme allong\u00E9e, dites en faucille ou en feuille d'acanthe, susceptibles d'induire trois grandes cat\u00E9gories de manifestations cliniques qui peuvent \u00EAtre tr\u00E8s variables selon les cas : an\u00E9mie h\u00E9molytique chronique avec \u00E9pisodes d'aggravation aigu\u00EB, pr\u00E9disposition aux infections bact\u00E9riennes, et manifestations vasoocclusives. Les complications aigu\u00EBs peuvent notamment rev\u00EAtir la forme de crises d'an\u00E9mie aigu\u00EBs, de s\u00E9questrations spl\u00E9niques, d'infections, d'accidents vasculaires c\u00E9r\u00E9braux (AVC), de syndromes thoraciques aigus ou encore de crises vasoocclusives. Les sympt\u00F4mes apparaissent g\u00E9n\u00E9ralement d\u00E8s l'\u00E2ge de 5 \u00E0 6 mois et peuvent \u00E9voluer vers des douleurs chroniques. L'esp\u00E9rance de vie moyenne des patients dans les pays d\u00E9velopp\u00E9s varie entre 40 et 60 ans. La dr\u00E9panocytose se manifeste chez les personnes porteuses de deux all\u00E8les anormaux du g\u00E8ne HBB, h\u00E9rit\u00E9s des deux parents. Ce g\u00E8ne est situ\u00E9 sur le chromosome 11. Les personnes n'ayant qu'un seul all\u00E8le anormal du g\u00E8ne sont porteuses du trait dr\u00E9panocytaire et n'expriment pas la maladie. En 2015, on estimait \u00E0 environ 4,4 millions le nombre total de personnes atteintes de la dr\u00E9panocytose. Le diagnostic est pos\u00E9 \u00E0 l'aide d'un test sanguin. Le d\u00E9pistage est recommand\u00E9 \u00AB \u00E0 l\u2019ensemble des nouveau-n\u00E9s \u00BB en France comme cela se pratique dans certains pays dont le Royaume-Uni. Une crise aigu\u00EB peut \u00EAtre d\u00E9clench\u00E9e par un changement de temp\u00E9rature, par un stress, par la d\u00E9shydratation, ainsi que par une altitude \u00E9lev\u00E9e. La prise en charge de la dr\u00E9panocytose consiste notamment \u00E0 pr\u00E9venir les infections \u00E0 l'aide de vaccins et d'antibiotiques, \u00E0 assurer une bonne hydratation de l'organisme, \u00E0 traiter les douleurs induites par les crises, voire en une suppl\u00E9mentation en vitamine B9 (acide folique). On peut \u00E9galement \u00EAtre amen\u00E9 \u00E0 proc\u00E9der \u00E0 une transfusion sanguine ou \u00E0 l'administration d'hydroxyur\u00E9e (hydroxycarbamide). Une greffe de moelle osseuse peut permettre la gu\u00E9rison dans un petit nombre de cas."@fr . . "Niedokrwisto\u015B\u0107 sierpowatokrwinkowa"@pl . . . . . . . . . . "Sickle cell disease"@en . . "Srpkovit\u00E1 chudokrevnost nebo an\u00E9mie (tak\u00E9 falciformn\u00ED an\u00E9mie nebo drepanocyt\u00F3za) je autozom\u00E1ln\u011B recesivn\u00ED d\u011Bdi\u010Dn\u00E9 onemocn\u011Bn\u00ED, kter\u00E9 se projevuje zm\u011Bnou tvaru \u010Derven\u00FDch krvinek z tzv. prom\u00E1\u010Dknut\u00FDch pi\u0161kot\u016F na prota\u017Een\u00E9 srpky. Tato zm\u011Bna tvaru je zp\u016Fsoben\u00E1 mutac\u00ED genu pro hemoglobin, p\u0159i n\u00ED\u017E je na 6. pozici v \u03B2-\u0159et\u011Bzci valin m\u00EDsto glutamov\u00E9 kyseliny (vznik\u00E1 hemoglobin ozna\u010Dovan\u00FD jako \u201EHbS\u201C). Valin je hydrofobn\u00ED aminokyselina, zat\u00EDmco glutamov\u00E1 kyselina je . Takto vznikl\u00E1 molekula HbS vykazuje odli\u0161n\u00E9 vlastnosti a ve sv\u00E9 deoxygenovan\u00E9 podob\u011B (tzn. kdy\u017E nen\u00ED nav\u00E1z\u00E1n kysl\u00EDk) se molekuly hemoglobinu shlukuj\u00ED a deformuj\u00ED krvinku. To sni\u017Euje flexibilitu bu\u0148ky a m\u00E1 za n\u00E1sledek mnoho r\u016Fzn\u00FDch komplikac\u00ED. Pr\u016Fm\u011Brn\u00E1 d\u00E9lka \u017Eivota lid\u00ED posti\u017Een\u00FDch touto nemoc\u00ED je 42 let u mu\u017E\u016F a 48 let u \u017Een."@cs . . "603903"^^ . . . . . ""@en . . ""@en . . . . . . . "Anemia sel sabit"@in . . . . . . . . . . . . . . . "L'anemia drepanocitica (dal greco \u03B4\u03C1\u03AD\u03C0\u03B1\u03BD\u03BF\u03BD, \u00ABfalce\u00BB), o anemia falciforme, \u00E8 una malattia del sangue su base genetica/ereditaria, in cui i globuli rossi circolanti, in condizioni di bassa tensione di ossigeno o di circolazione lungo i capillari, assumono una forma irregolarmente cilindrica, spesso ricurva, che, allo striscio di sangue periferico, assomiglia a una mezzaluna o una falce."@it . . . . . . . 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"12069" . . . . . . . . "" . . . . "L'an\u00E8mia de c\u00E8l\u00B7lules falciformes, o an\u00E8mia drepanoc\u00EDtica, \u00E9s una hemoglobinopatia (una malaltia gen\u00E8tica que afecta l'hemoglobina). \u00C9s causada per l'hemoglobina S, la qual es crea al canviar una glutamina per una valina en les cadenes polip\u00E8ptiques beta; aix\u00F2 provoca que en una situaci\u00F3 de baixa tensi\u00F3 d'oxigen, l'hemoglobina es deforma i l'eritr\u00F2cit adquireix una aparen\u00E7a d'una fal\u00E7. Aquesta nova forma provoca dificultats pel que fa a la circulaci\u00F3 dels gl\u00F2buls vermells, s'obstrueixen els vasos sanguinis i causen s\u00EDmptomes com, per exemple, dolor en les extremitats. Els gl\u00F2buls vermells tamb\u00E9 tenen una vida m\u00E9s curta i, a la vegada, aix\u00F2 provoca una an\u00E8mia, ja que no poden ser reempla\u00E7ats a temps."@ca . . . . 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\u03C0\u03C1\u03BF\u03BA\u03BB\u03B7\u03B8\u03B5\u03AF \u03B1\u03C0\u03CC \u03B1\u03BB\u03BB\u03B1\u03B3\u03AD\u03C2 \u03B8\u03B5\u03C1\u03BC\u03BF\u03BA\u03C1\u03B1\u03C3\u03AF\u03B1\u03C2, \u03AC\u03B3\u03C7\u03BF\u03C2, \u03B1\u03C6\u03C5\u03B4\u03AC\u03C4\u03C9\u03C3\u03B7 \u03BA\u03B1\u03B9 \u03BC\u03B5\u03B3\u03AC\u03BB\u03BF \u03C5\u03C8\u03CC\u03BC\u03B5\u03C4\u03C1\u03BF. \u0386\u03C4\u03BF\u03BC\u03B1 \u03BC\u03B5 \u03AD\u03BD\u03B1 \u03BC\u03CC\u03BD\u03BF \u03B1\u03BD\u03CE\u03BC\u03B1\u03BB\u03BF \u03B1\u03BD\u03C4\u03AF\u03B3\u03C1\u03B1\u03C6\u03BF \u03B4\u03B5\u03BD \u03AD\u03C7\u03BF\u03C5\u03BD \u03C3\u03C5\u03BD\u03AE\u03B8\u03C9\u03C2 \u03C3\u03C5\u03BC\u03C0\u03C4\u03CE\u03BC\u03B1\u03C4\u03B1 \u03BA\u03B1\u03B9 \u03BB\u03AD\u03B3\u03B5\u03C4\u03B1\u03B9 \u03CC\u03C4\u03B9 \u03AD\u03C7\u03BF\u03C5\u03BD \u03B4\u03C1\u03B5\u03C0\u03B1\u03BD\u03BF\u03BA\u03C5\u03C4\u03C4\u03B1\u03C1\u03B9\u03BA\u03CC \u03C7\u03B1\u03C1\u03B1\u03BA\u03C4\u03B7\u03C1\u03B9\u03C3\u03C4\u03B9\u03BA\u03CC (sickle cell trait). \u03A4\u03AD\u03C4\u03BF\u03B9\u03B1 \u03AC\u03C4\u03BF\u03BC\u03B1 \u03B1\u03BD\u03B1\u03C6\u03AD\u03C1\u03BF\u03BD\u03C4\u03B1\u03B9 \u03B5\u03C0\u03AF\u03C3\u03B7\u03C2 \u03C9\u03C2 \u03B3\u03B5\u03BD\u03B5\u03C4\u03B9\u03BA\u03BF\u03AF \u03C6\u03BF\u03C1\u03B5\u03AF\u03C2 (Genetic carriers)]. \u0397 \u03B4\u03B9\u03AC\u03B3\u03BD\u03C9\u03C3\u03B7 \u03B3\u03AF\u03BD\u03B5\u03C4\u03B1\u03B9 \u03BC\u03B5 \u03B5\u03BE\u03B5\u03C4\u03AC\u03C3\u03B5\u03B9\u03C2 \u03B1\u03AF\u03BC\u03B1\u03C4\u03BF\u03C2 \u03BA\u03B1\u03B9 \u03BA\u03AC\u03C0\u03BF\u03B9\u03B5\u03C2 \u03C7\u03CE\u03C1\u03B5\u03C2 \u03B5\u03BB\u03AD\u03B3\u03C7\u03BF\u03C5\u03BD \u03CC\u03BB\u03B1 \u03C4\u03B1 \u03BC\u03C9\u03C1\u03AC \u03BA\u03B1\u03C4\u03AC \u03C4\u03B7 \u03B3\u03AD\u03BD\u03BD\u03B7\u03C3\u03B7 \u03B3\u03B9\u03B1 \u03C4\u03B7\u03BD \u03B1\u03C3\u03B8\u03AD\u03BD\u03B5\u03B9\u03B1. \u0397 \u03B4\u03B9\u03AC\u03B3\u03BD\u03C9\u03C3\u03B7 \u03B5\u03AF\u03BD\u03B1\u03B9 \u03B5\u03C0\u03AF\u03C3\u03B7\u03C2 \u03B5\u03C6\u03B9\u03BA\u03C4\u03AE \u03BA\u03B1\u03C4\u03AC \u03C4\u03B7\u03BD \u03B5\u03B3\u03BA\u03C5\u03BC\u03BF\u03C3\u03CD\u03BD\u03B7. \u0397 \u03C6\u03C1\u03BF\u03BD\u03C4\u03AF\u03B4\u03B1 \u03B3\u03B9\u03B1 \u03AC\u03C4\u03BF\u03BC\u03B1 \u03BC\u03B5 \u03B4\u03C1\u03B5\u03C0\u03B1\u03BD\u03BF\u03BA\u03C5\u03C4\u03C4\u03B1\u03C1\u03B9\u03BA\u03AE \u03BD\u03CC\u03C3\u03BF \u03BC\u03C0\u03BF\u03C1\u03B5\u03AF \u03BD\u03B1 \u03C0\u03B5\u03C1\u03B9\u03BB\u03B1\u03BC\u03B2\u03AC\u03BD\u03B5\u03B9 \u03C0\u03C1\u03CC\u03BB\u03B7\u03C8\u03B7 \u03C4\u03B7\u03C2 \u03BB\u03BF\u03AF\u03BC\u03C9\u03BE\u03B7\u03C2 \u03BC\u03B5 \u03B5\u03BC\u03B2\u03BF\u03BB\u03B9\u03B1\u03C3\u03BC\u03CC \u03BA\u03B1\u03B9 \u03B1\u03BD\u03C4\u03B9\u03B2\u03B9\u03BF\u03C4\u03B9\u03BA\u03AC, \u03C5\u03C8\u03B7\u03BB\u03AE \u03BB\u03AE\u03C8\u03B7 \u03C5\u03B3\u03C1\u03CE\u03BD, \u03C0\u03C1\u03BF\u03C3\u03B8\u03AE\u03BA\u03B7 \u03C6\u03C5\u03BB\u03BB\u03B9\u03BA\u03BF\u03CD \u03BF\u03BE\u03AD\u03BF\u03C2 \u03BA\u03B1\u03B9 \u03C0\u03B1\u03C5\u03C3\u03AF\u03C0\u03BF\u03BD\u03B1 (pain medication). \u0386\u03BB\u03BB\u03B1 \u03BC\u03AD\u03C4\u03C1\u03B1 \u03BC\u03C0\u03BF\u03C1\u03BF\u03CD\u03BD \u03BD\u03B1 \u03C0\u03B5\u03C1\u03B9\u03BB\u03B1\u03BC\u03B2\u03AC\u03BD\u03BF\u03C5\u03BD \u03BC\u03B5\u03C4\u03AC\u03B3\u03B3\u03B9\u03C3\u03B7 \u03B1\u03AF\u03BC\u03B1\u03C4\u03BF\u03C2 \u03BA\u03B1\u03B9 \u03C4\u03BF \u03C6\u03AC\u03C1\u03BC\u03B1\u03BA\u03BF \u03C5\u03B4\u03C1\u03BF\u03BE\u03C5\u03BA\u03B1\u03C1\u03B2\u03B1\u03BC\u03AF\u03B4\u03B9\u03BF (\u03C5\u03B4\u03C1\u03BF\u03BE\u03C5\u03BF\u03C5\u03C1\u03AF\u03B1). \u039C\u03B9\u03BA\u03C1\u03CC \u03C0\u03BF\u03C3\u03BF\u03C3\u03C4\u03CC \u03B1\u03C4\u03CC\u03BC\u03C9\u03BD \u03BC\u03C0\u03BF\u03C1\u03B5\u03AF \u03BD\u03B1 \u03B8\u03B5\u03C1\u03B1\u03C0\u03B5\u03C5\u03C4\u03B5\u03AF \u03BC\u03B5 \u03BC\u03B5\u03C4\u03B1\u03BC\u03CC\u03C3\u03C7\u03B5\u03C5\u03C3\u03B7 \u03BA\u03C5\u03C4\u03C4\u03AC\u03C1\u03C9\u03BD \u03BC\u03C5\u03B5\u03BB\u03BF\u03CD \u03C4\u03C9\u03BD \u03BF\u03C3\u03C4\u03CE\u03BD. \u0388\u03C9\u03C2 \u03C4\u03BF 2015, \u03C0\u03B5\u03C1\u03AF\u03C0\u03BF\u03C5 4,4 \u03B5\u03BA\u03B1\u03C4\u03BF\u03BC\u03BC\u03CD\u03C1\u03B9\u03B1 \u03C0\u03AC\u03C3\u03C7\u03BF\u03C5\u03BD \u03B1\u03C0\u03CC \u03B4\u03C1\u03B5\u03C0\u03B1\u03BD\u03BF\u03BA\u03C5\u03C4\u03C4\u03B1\u03C1\u03B9\u03BA\u03AE \u03B1\u03BD\u03B1\u03B9\u03BC\u03AF\u03B1, \u03B5\u03BD\u03CE 43 \u03B5\u03C0\u03B9\u03C0\u03BB\u03AD\u03BF\u03BD \u03B5\u03BA\u03B1\u03C4\u03BF\u03BC\u03BC\u03CD\u03C1\u03B9\u03B1 \u03B5\u03AF\u03BD\u03B1\u03B9 \u03C6\u03BF\u03C1\u03B5\u03AF\u03C2 \u03B4\u03C1\u03B5\u03C0\u03B1\u03BD\u03BF\u03BA\u03C5\u03C4\u03C4\u03AC\u03C1\u03C9\u03C3\u03B7\u03C2. \u03A0\u03B5\u03C1\u03AF\u03C0\u03BF\u03C5 \u03C4\u03BF 80% \u03C4\u03C9\u03BD \u03C0\u03B5\u03C1\u03B9\u03C0\u03C4\u03CE\u03C3\u03B5\u03C9\u03BD \u03C4\u03B7\u03C2 \u03B4\u03C1\u03B5\u03C0\u03B1\u03BD\u03BF\u03BA\u03C5\u03C4\u03C4\u03B1\u03C1\u03B9\u03BA\u03AE\u03C2 \u03BD\u03CC\u03C3\u03BF\u03C5 \u03C0\u03B9\u03C3\u03C4\u03B5\u03CD\u03B5\u03C4\u03B1\u03B9 \u03CC\u03C4\u03B9 \u03C3\u03C5\u03BC\u03B2\u03B1\u03AF\u03BD\u03BF\u03C5\u03BD \u03C3\u03C4\u03B7\u03BD \u03A5\u03C0\u03BF\u03C3\u03B1\u03C7\u03AC\u03C1\u03B9\u03B1 \u0391\u03C6\u03C1\u03B9\u03BA\u03AE. \u0395\u03BC\u03C6\u03B1\u03BD\u03AF\u03B6\u03B5\u03C4\u03B1\u03B9 \u03B5\u03C0\u03AF\u03C3\u03B7\u03C2 \u03C3\u03C7\u03B5\u03C4\u03B9\u03BA\u03AC \u03C3\u03C5\u03C7\u03BD\u03AC \u03C3\u03B5 \u03C4\u03BC\u03AE\u03BC\u03B1\u03C4\u03B1 \u03C4\u03B7\u03C2 \u0399\u03BD\u03B4\u03AF\u03B1\u03C2, \u03C4\u03B7\u03C2 \u0391\u03C1\u03B1\u03B2\u03AF\u03B1\u03C2 \u03BA\u03B1\u03B9 \u03BC\u03B5\u03C4\u03B1\u03BE\u03CD \u03B1\u03C4\u03CC\u03BC\u03C9\u03BD \u03B1\u03C6\u03C1\u03B9\u03BA\u03B1\u03BD\u03B9\u03BA\u03AE\u03C2 \u03C0\u03C1\u03BF\u03AD\u03BB\u03B5\u03C5\u03C3\u03B7\u03C2 \u03C0\u03BF\u03C5 \u03B6\u03BF\u03C5\u03BD \u03C3\u03B5 \u03AC\u03BB\u03BB\u03B1 \u03BC\u03AD\u03C1\u03B7 \u03C4\u03BF\u03C5 \u03BA\u03CC\u03C3\u03BC\u03BF\u03C5. \u03A4\u03BF 2015, \u03C3\u03C5\u03BD\u03AD\u03B2\u03B7\u03C3\u03B1\u03BD 114.800 \u03B8\u03AC\u03BD\u03B1\u03C4\u03BF\u03B9 \u03C0\u03B5\u03C1\u03AF\u03C0\u03BF\u03C5. \u0397 \u03C0\u03AC\u03B8\u03B7\u03C3\u03B7 \u03C0\u03C1\u03C9\u03C4\u03BF\u03C0\u03B5\u03C1\u03B9\u03B3\u03C1\u03AC\u03C6\u03C4\u03B7\u03BA\u03B5 \u03C3\u03C4\u03B7\u03BD \u03B9\u03B1\u03C4\u03C1\u03B9\u03BA\u03AE \u03B2\u03B9\u03B2\u03BB\u03B9\u03BF\u03B3\u03C1\u03B1\u03C6\u03AF\u03B1 \u03B1\u03C0\u03CC \u03C4\u03BF\u03BD \u0391\u03BC\u03B5\u03C1\u03B9\u03BA\u03B1\u03BD\u03CC \u03B3\u03B9\u03B1\u03C4\u03C1\u03CC James B. Herrick \u03C4\u03BF 1910. \u03A4\u03BF 1949, \u03C0\u03C1\u03BF\u03C3\u03B4\u03B9\u03BF\u03C1\u03AF\u03C3\u03C4\u03B7\u03BA\u03B5 \u03B7 \u03B3\u03B5\u03BD\u03B5\u03C4\u03B9\u03BA\u03AE \u03BC\u03B5\u03C4\u03AC\u03B4\u03BF\u03C3\u03B7 \u03B1\u03C0\u03CC \u03C4\u03BF\u03C5\u03C2 E. A. Beet \u03BA\u03B1\u03B9 J. V. Neel. \u03A4\u03BF 1954, \u03C0\u03B5\u03C1\u03B9\u03B3\u03C1\u03AC\u03C6\u03B7\u03BA\u03B5 \u03B7 \u03C0\u03C1\u03BF\u03C3\u03C4\u03B1\u03C4\u03B5\u03C5\u03C4\u03B9\u03BA\u03AE \u03B5\u03C0\u03AF\u03C0\u03C4\u03C9\u03C3\u03B7 \u03C9\u03C2 \u03C0\u03C1\u03BF\u03C2 \u03C4\u03B7\u03BD \u03B5\u03BB\u03BF\u03BD\u03BF\u03C3\u03AF\u03B1 \u03C4\u03C9\u03BD \u03C6\u03BF\u03C1\u03AD\u03C9\u03BD \u03C4\u03B7\u03C2 \u03B4\u03C1\u03B5\u03C0\u03B1\u03BD\u03BF\u03BA\u03C5\u03C4\u03C4\u03B1\u03C1\u03B9\u03BA\u03AE\u03C2 \u03BD\u03CC\u03C3\u03BF\u03C5."@el . "Sikkelcelanemie en sikkelcelziekte zijn hemoglobinopathie\u00EBn, ziekten van het bloed waarbij in de rode bloedcellen het zuurstoftransporteiwit hemoglobine (Hb) veranderd is. Het zijn recessief erfelijke aandoeningen: men erft het van beide ouders. Als iemand het gen van \u00E9\u00E9n ouder heeft gekregen (heterozygoot is), is diegene drager van het gen, maar heeft zelf meestal weinig klachten of symptomen. Als iemand het gen van beide ouders heeft gekregen (homozygoot is) dan heeft men doorgaans wel symptomen van sikkelcelziekte."@nl . . "Figure shows normal red blood cells flowing freely through a blood vessel. The inset shows a cross-section of a normal red blood cell with normal haemoglobin. Figure shows abnormal, sickled red blood cells sticking at the branching point in a blood vessel. The inset image shows a cross-section of a sickle cell with long polymerized sickle haemoglobin strands stretching and distorting the cell shape to look like a crescent moon."@en . . . . . . . . "Anemia drepanoc\u00EDtica, drepanocitose ou anemia falciforme (do latim falci-, foice e -forme, formato de) \u00E9 uma doen\u00E7a hematol\u00F3gica heredit\u00E1ria monog\u00E9nica, caracterizada pela produ\u00E7\u00E3o anormal de hemoglobinas, entre as quais a mais comum \u00E9 a forma HbS (de Sickle, foice), que sob determinadas condi\u00E7\u00F5es de desoxigena\u00E7\u00E3o, polimeriza, deformando as hem\u00E1cias, que assumem uma forma semelhante a foices, causando defici\u00EAncia no transporte de oxig\u00E9nio e g\u00E1s carb\u00F3nico e outras complica\u00E7\u00F5es, nos indiv\u00EDduos acometidos pela doen\u00E7a. Por esse motivo, a anemia drepanoc\u00EDtica \u00E9 tamb\u00E9m conhecida por anemia falciforme. Do ponto de vista patogen\u00E9tico, est\u00E1 classificada entre as anemias por \"defeito da s\u00EDntese de hemoglobina\", a prote\u00EDna que transporta oxig\u00E9nio presente nos gl\u00F3bulos vermelhos, embora a anemia seja em parte determinada pela hem\u00F3lise espl\u00E9nica. Os sintomas geralmente come\u00E7am a aparecer entre os 5 e 6 meses de idade. Podem desenvolver-se v\u00E1rios problemas de sa\u00FAde, tais como crises de dor, anemia, infec\u00E7\u00F5es bacterianas e acidentes vasculares cerebrais. Podem desenvolver-se dores cr\u00F3nicas \u00E0 medida que a pessoa envelhece. A esperan\u00E7a m\u00E9dia de vida nos pa\u00EDses desenvolvidos varia entre os 40 e 60 anos. A anemia falciforme ocorre quando a pessoa herda duas c\u00F3pias anormais do gene de hemoglobina, um de cada progenitor. Existem v\u00E1rios subtipos, dependendo da muta\u00E7\u00E3o exacta em cada gene de hemoglobina. Um ataque pode configurar-se por mudan\u00E7as de temperaturas, stress ou desidrata\u00E7\u00E3o em s\u00EDtios de elevada altitude. Uma pessoa com uma s\u00F3 c\u00F3pia an\u00F3mala normalmente n\u00E3o apresenta sintomas e diz-se que possui um tra\u00E7o drepanoc\u00EDtico ou falc\u00E9mico. Estas pessoas s\u00E3o tamb\u00E9m referidas como da doen\u00E7a. O diagn\u00F3stico \u00E9 feito por um exame de sangue e alguns pa\u00EDses examinam todos os beb\u00E9s quando nascem. O diagn\u00F3stico pode tamb\u00E9m ser feito durante a gravidez. O tratamento da pessoa com anemia falciforme pode incluir a preven\u00E7\u00E3o a infec\u00E7\u00F5es atrav\u00E9s da vacina\u00E7\u00E3o e uso de antibi\u00F3ticos, uma elevada ingest\u00E3o de l\u00EDquidos, a suplementa\u00E7\u00E3o de \u00E1cido f\u00F3lico e f\u00E1rmacos analg\u00E9sicos. Outras medidas podem incluir a transfus\u00E3o de sangue e a prescri\u00E7\u00E3o de (hidroxiureia). Um reduzido percentual de pessoas pode ser curado mediante um transplante de c\u00E9lulas da medula \u00F3ssea. Em 2013, cerca de 3,2 milh\u00F5es de pessoas sofriam de anemia drepanoc\u00EDtica, enquanto mais de 43 milh\u00F5es apresentavam tra\u00E7o falciforme. Considera-se que cerca de 80% dos casos de anemia falciforme ocorram na \u00C1frica subsariana. \u00C9 relativamente comum em algumas partes da \u00CDndia, da pen\u00EDnsula ar\u00E1bica e entre pessoas de origem africana que vivem noutras parte do mundo. No mesmo ano, a anemia falciforme provocou 176.000 mortes, acima das 113.000 mortes registadas em 1990. A primeira descri\u00E7\u00E3o m\u00E9dica da doen\u00E7a foi realizada pelo m\u00E9dico norte-americano , em 1910. Em 1949, E. A. Beet e J. V. Neel determinaram a origem gen\u00E9tica. Em 1954 foi descrito o efeito protector contra a mal\u00E1ria do tra\u00E7o falciforme."@pt . "Attacks of pain, anemia, swelling in the hands and feet, bacterial infections, stroke"@en . . . . . . . . . . . "Sickle Cell Disease"@en . . . . 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\u043F\u043E\u044F\u0441\u043D\u044E\u0454 \u0432\u0438\u0441\u043E\u043A\u0443 \u0447\u0430\u0441\u0442\u043E\u0442\u0443 \u0446\u044C\u043E\u0433\u043E \u0448\u043A\u0456\u0434\u043B\u0438\u0432\u043E\u0433\u043E \u0430\u043B\u0435\u043B\u044F \u0432 \u0430\u0444\u0440\u0438\u043A\u0430\u043D\u0441\u044C\u043A\u0438\u0445 \u043F\u043E\u043F\u0443\u043B\u044F\u0446\u0456\u044F\u0445. \u041B\u044E\u0434\u0438 \u0437 \u0441\u0435\u0440\u043F\u043E\u043F\u043E\u0434\u0456\u0431\u043D\u043E\u043A\u043B\u0456\u0442\u0438\u043D\u043D\u043E\u044E \u0430\u043D\u0435\u043C\u0456\u0454\u044E \u0442\u0430 \u0434\u0435\u044F\u043A\u0438\u043C\u0438 \u0456\u043D\u0448\u0438\u043C\u0438 \u0445\u0432\u043E\u0440\u043E\u0431\u0430\u043C\u0438 \u043A\u0440\u043E\u0432\u0456 (\u0442\u0430\u043B\u0430\u0441\u0435\u043C\u0456\u0454\u044E, \u0434\u0435\u0444\u0456\u0446\u0438\u0442\u043E\u043C \u0433\u043B\u044E\u043A\u043E\u0437\u043E-6-\u0444\u043E\u0441\u0444\u0430\u0442-\u0434\u0435\u0433\u0456\u0434\u0440\u043E\u0433\u0435\u043D\u0430\u0437\u0438 (\u04136\u0424\u0414) \u0442\u0430 \u0456\u043D\u0442\u0435\u0440\u043B\u0435\u0439\u043A\u0456\u043D\u0443-4, \u043E\u0432\u0430\u043B\u043E\u0446\u0438\u0442\u043E\u0437\u043E\u043C \u0442\u043E\u0449\u043E), \u0449\u043E \u0437\u0431\u0435\u0440\u0435\u0433\u043B\u0438 \u0430\u043D\u043E\u043C\u0430\u043B\u044C\u043D\u0456 \u0433\u0435\u043C\u043E\u0433\u043B\u043E\u0431\u0456\u043D\u0438 \u0432 \u0435\u0440\u0438\u0442\u0440\u043E\u0446\u0438\u0442\u0430\u0445, \u043E\u0442\u0440\u0438\u043C\u0430\u043B\u0438 \u0441\u0435\u043B\u0435\u043A\u0442\u0438\u0432\u043D\u0443 \u043F\u0435\u0440\u0435\u0432\u0430\u0433\u0443 \u043F\u0440\u043E\u0442\u0438 \u043C\u0430\u043B\u044F\u0440\u0456\u0439\u043D\u043E\u0457 \u0456\u043D\u0444\u0435\u043A\u0446\u0456\u0457 (\u0441\u0442\u0430\u0431\u0456\u043B\u0456\u0437\u0443\u044E\u0447\u0438\u0439 \u0432\u0456\u0434\u0431\u0456\u0440), \u0442\u043E\u043C\u0443 \u0449\u043E \u0437\u0431\u0443\u0434\u043D\u0438\u043A \u043C\u0430\u043B\u044F\u0440\u0456\u0457 \u2014 \u043F\u043B\u0430\u0437\u043C\u043E\u0434\u0456\u0439, \u044F\u043A\u0438\u0439 \u043F\u0456\u0434 \u0447\u0430\u0441 \u043F\u0435\u0440\u0435\u0431\u0443\u0432\u0430\u043D\u043D\u044F \u0432 \u0435\u0440\u0438\u0442\u0440\u043E\u0446\u0438\u0442\u0430\u0445 \u0445\u0430\u0440\u0447\u0443\u0454\u0442\u044C\u0441\u044F \u0432\u0438\u043A\u043B\u044E\u0447\u043D\u043E \u043D\u043E\u0440\u043C\u0430\u043B\u044C\u043D\u0438\u043C \u0433\u0435\u043C\u043E\u0433\u043B\u043E\u0431\u0456\u043D\u043E\u043C, \u0430\u043D\u043E\u043C\u0430\u043B\u044C\u043D\u0438\u043C\u0438 \u0436\u0438\u0432\u0438\u0442\u0438\u0441\u044F \u043D\u0435 \u043C\u043E\u0436\u0435, \u0442\u043E\u043C\u0443 \u0439 \u043D\u0435 \u0440\u043E\u0441\u0442\u0435, \u0430, \u0432\u0456\u0434\u043F\u043E\u0432\u0456\u0434\u043D\u043E, \u0442\u044F\u0436\u043A\u043E\u0433\u043E \u0440\u043E\u0437\u0432\u0438\u0442\u043A\u0443 \u043C\u0430\u043B\u044F\u0440\u0456\u044F \u043D\u0435 \u043D\u0430\u0431\u0443\u0432\u0430\u0454 \u0430\u0431\u043E, \u043D\u0430\u0432\u0456\u0442\u044C, \u043D\u0435 \u0440\u043E\u0437\u0432\u0438\u0432\u0430\u0454\u0442\u044C\u0441\u044F. \u0417\u0430 \u0443\u043C\u043E\u0432\u0438 \u043F\u0435\u0440\u0435\u0434\u0430\u0447\u0456 \u0441\u0435\u0440\u043F\u043E\u043F\u043E\u0434\u0456\u0431\u043D\u043E\u043A\u043B\u0456\u0442\u0438\u043D\u043D\u043E\u0457 \u0430\u043D\u0435\u043C\u0456\u0457 \u043F\u043E\u0442\u043E\u043C\u0441\u0442\u0432\u0443, \u0446\u0435 \u0441\u0442\u0432\u043E\u0440\u0438\u043B\u043E \u0431\u0456\u043B\u044C\u0448\u0456 \u043C\u043E\u0436\u043B\u0438\u0432\u043E\u0441\u0442\u0456 \u0434\u043B\u044F \u0432\u0438\u0436\u0438\u0432\u0430\u043D\u043D\u044F \u0432 \u043C\u0456\u0441\u0446\u044F\u0445 \u0433\u0435\u043E\u0433\u0440\u0430\u0444\u0456\u0447\u043D\u043E\u0433\u043E \u043F\u043E\u0448\u0438\u0440\u0435\u043D\u043D\u044F \u043C\u0430\u043B\u044F\u0440\u0456\u0457, \u043F\u0440\u0438\u0440\u043E\u0434\u043D\u0443 \u0440\u0435\u0437\u0438\u0441\u0442\u0435\u043D\u0442\u043D\u0456\u0441\u0442\u044C \u0434\u043E \u043D\u0435\u0457, \u043F\u0440\u0430\u0432\u0434\u0430, \u0446\u0456\u043D\u043E\u044E \u0440\u043E\u0437\u0432\u0438\u0442\u043A\u0443 \u043A\u0430\u043F\u0456\u043B\u044F\u0440\u043E\u043F\u0430\u0442\u0456\u0439 \u0456 \u0441\u0445\u0438\u043B\u044C\u043D\u043E\u0441\u0442\u0456 \u0434\u043E \u0442\u0440\u043E\u043C\u0431\u043E\u0443\u0442\u0432\u043E\u0440\u0435\u043D\u043D\u044F."@uk . . "\u942E\u5200\u578B\u7D05\u8840\u7403\u75BE\u75C5"@zh . "L'anemia drepanocitica (dal greco \u03B4\u03C1\u03AD\u03C0\u03B1\u03BD\u03BF\u03BD, \u00ABfalce\u00BB), o anemia falciforme, \u00E8 una malattia del sangue su base genetica/ereditaria, in cui i globuli rossi circolanti, in condizioni di bassa tensione di ossigeno o di circolazione lungo i capillari, assumono una forma irregolarmente cilindrica, spesso ricurva, che, allo striscio di sangue periferico, assomiglia a una mezzaluna o una falce. Questa patologia \u00E8 dovuta alla presenza di un gene sito a livello del cromosoma 11 che si manifesta in forma recessiva su entrambi gli alleli. L'anemia falciforme \u00E8 dunque una malattia autosomica recessiva ed \u00E8 caratterizzata dalla produzione di emoglobine patologiche, tra cui la pi\u00F9 comune \u00E8 la forma HbS (dall'inglese sickle, falce) che, per le sue caratteristiche chimiche, tende a precipitare e a conferire all'eritrocita la tipica forma a falce; per questo motivo l'anemia drepanocitica \u00E8 anche detta anemia falciforme. Da un punto di vista patogenetico, \u00E8 classificata fra le anemie da aumentata distruzione dei globuli rossi. I sintomi legati alla condizione di solito iniziano a manifestarsi tra i 5 e i 6 mesi di et\u00E0. Pu\u00F2 svilupparsi un certo numero di problemi di salute, come ad esempio attacchi di dolore, anemia, infezioni batteriche e ictus. L'anemia drepanocitica \u00E8 una anemia iperrigenerativa, caratterizzata da un elevato numero di reticolociti nel sangue periferico. Un dolore a lungo termine pu\u00F2 svilupparsi con l'invecchiamento del paziente. La speranza di vita media nel mondo sviluppato \u00E8 tra i 50 e i 70 anni. L'anemia falciforme si verifica quando una persona eredita due copie anormali del gene dell'emoglobina, uno da ciascun genitore. Esistono diversi sottotipi, a seconda dell'esatta mutazione in ogni gene dell'emoglobina. Un individuo con una sola copia anomala non presenta di solito i sintomi e si dice che ha un \"tratto falciforme\" o \"portatore\". La diagnosi avviene tramite un esame del sangue e in alcuni Paesi \u00E8 usuale testare tutti i bambini al momento della nascita. \u00C8 possibile formulare una diagnosi anche durante la gravidanza. Il trattamento delle persone con anemia falciforme pu\u00F2 includere la prevenzione delle infezioni tramite la vaccinazione e l'uso di antibiotici, una elevata assunzione di liquidi, la supplementazione di acido folico e farmaci antidolorifici. Altre misure possono includere una trasfusione di sangue e la prescrizione di N-idrossiurea. Una ristretta percentuale di persone pu\u00F2 essere curata ad et\u00E0 infantile grazie al trapianto di cellule del midollo osseo. Nel 2013, circa 3,2 milioni di persone soffriva di anemia drepanocitica, mentre ulteriori 43 milioni presentavano il tratto falciforme. Si ritiene che circa l'80% dei casi di anemia falciforme si verifichi nell'Africa sub-sahariana. Si riscontra relativamente frequentemente in alcune parti dell'India, della penisola arabica e tra le persone di origine africana che vivono in altre parti del mondo. Sempre nel 2013 \u00E8 stata la causa di 176.000 decessi, in aumento rispetto ai 113.000 registrati nel 1990. La prima descrizione medica della condizione fu pubblicata dal medico statunitense nel 1910. Nel 1949 E. A. Beet e J. V. Neel hanno determinato l'origine genetica. Nel 1954 \u00E8 stato descritto l'effetto protettivo contro la malaria del tratto falciforme."@it . . . . "An\u00E8mia de c\u00E8l\u00B7lules falciformes"@ca . . "4400000"^^ . . . . . . . . . . . . . . . . . . . "\u938C\u72B6\u8D64\u8840\u7403\u75C7\uFF08\u304B\u307E\u3058\u3087\u3046\u305B\u3063\u3051\u3063\u304D\u3085\u3046\u3057\u3087\u3046\uFF09\u306F\u907A\u4F1D\u6027\u306E\u8CA7\u8840\u75C5\u3067\u3001\u8D64\u8840\u7403\u306E\u5F62\u72B6\u304C\u938C\u72B6\u306B\u306A\u308A\u9178\u7D20\u904B\u642C\u6A5F\u80FD\u304C\u4F4E\u4E0B\u3057\u3066\u8D77\u3053\u308B\u8CA7\u8840\u75C7\u3002\u938C\u72B6\u8D64\u8840\u7403\u8CA7\u8840\u75C7\u3068\u3082\u3044\u3046\u3002ICD-10\u5206\u985E\u3067\u306FD57\u3002\u307B\u3068\u3093\u3069\u304C\u9ED2\u4EBA\u306B\u767A\u75C7\u3057\u4E3B\u306B\u30A2\u30D5\u30EA\u30AB\u3001\u5730\u4E2D\u6D77\u6CBF\u5CB8\u3001\u4E2D\u8FD1\u6771\u3001\u30A4\u30F3\u30C9\u5317\u90E8\u3067\u898B\u3089\u308C\u308B\u3002 \u5E38\u67D3\u8272\u4F53\u4E0D\u5B8C\u5168\u512A\u6027\u907A\u4F1D\u3092\u3059\u308B\u3002\u73FE\u5728\uFF0C\u907A\u4F1D\u5B50\u578B\u304C\u30DB\u30E2\u63A5\u5408\u578B\u60A3\u8005\u306E\u4E88\u5F8C\u306F\u6539\u5584\u3057\u3066\u304A\u308A\u3001\u5E73\u5747\u751F\u5B58\u671F\u9593\u304C60\u6B73\u524D\u5F8C\u3068\u306A\u3063\u3066\u3044\u308B\u3002\u3057\u304B\u3057\u305D\u306E\u7D50\u679C\u3001\u6162\u6027\u7684\u306A\u591A\u81D3\u5668\u969C\u5BB3\u3092\u6709\u3059\u308B\u60A3\u8005\u306E\u5272\u5408\u306F\u5897\u52A0\u3057\u3066\u3044\u308B\u3002\u4E00\u822C\u7684\u306A\u6B7B\u56E0\u306F\uFF0C\u6025\u6027\u80F8\u90E8\u75C7\u5019\u7FA4\uFF0C\u4F75\u767A\u611F\u67D3\u75C7\uFF0C\u80BA\u585E\u6813\u75C7\uFF0C\u91CD\u8981\u81D3\u5668\u306E\u6897\u585E\uFF0C\u304A\u3088\u3073\u6162\u6027\u814E\u81D3\u75C5\u3067\u3042\u308B\u3002\u907A\u4F1D\u5B50\u578B\u304C\u30D8\u30C6\u30ED\u63A5\u5408\u578B\u306E\u5834\u5408\u3001\u4F4E\u9178\u7D20\u72B6\u614B\u3067\u306E\u307F\u767A\u75C7\u3059\u308B\u306E\u3067\u901A\u5E38\u306E\u65E5\u5E38\u751F\u6D3B\u306F\u55B6\u3081\u308B\u3002"@ja . . . . "\u0394\u03C1\u03B5\u03C0\u03B1\u03BD\u03BF\u03BA\u03C5\u03C4\u03C4\u03B1\u03C1\u03B9\u03BA\u03AE \u03BD\u03CC\u03C3\u03BF\u03C2"@el . . "603903"^^ . . . . "2126"^^ . . . . . "Sickle cell disease"@en . . . . . . . . . "D57." . . "Sickle+Cell+anemia"@en . . . . . . . . . . "" . "Anemia faltziforme edo drepanozitosia eritrozitoen itxura deformatzen duen gaixotasun hematologikoa da, oinarri genetikoa duena. Anemia mota honetan hemoglobinaren egitura molekularra ezohikoa da, \u03B2 kate polipeptidikoetan aminoazido bat aldatuta dagoelako (glutamina egon beharrean balina baitago)."@eu . . . . . . . "Srpkovit\u00E1 an\u00E9mie"@cs . "La serpo\u0109ela anemio estas genetika malsano, kiam korpo de malsanulo formas nekutiman hemoglobinon kaj tiel serpoformajn eritrocitojn, kiujn la le\u016Dkocitoj kaptas kaj solvas (hemolizo)."@eo . . . "La anemia de c\u00E9lulas falciformes,\u200B llamada tambi\u00E9n drepanocitosis o anemia drepanoc\u00EDtica, es una alteraci\u00F3n de la sangre que hace que los gl\u00F3bulos rojos se deformen hasta adquirir apariencia de hoz (de ah\u00ED el nombre de \u00ABeritrocitos falciformes\u00BB o \u00ABdrepanocitos\u00BB). Esta deformidad estructural entorpece la circulaci\u00F3n sangu\u00EDnea y causa en el enfermo obstrucciones vasculares, microinfartos en m\u00FAltiples \u00F3rganos y hem\u00F3lisis. Se trata de una anemia cr\u00F3nica y grave que se diagnostica mediante el estudio de la hemoglobina, la mol\u00E9cula que transporta el ox\u00EDgeno en la sangre.\u200B La enfermedad tiene su origen en la sustituci\u00F3n, consecuencia de una mutaci\u00F3n gen\u00E9tica, de un amino\u00E1cido polar (el \u00E1cido glut\u00E1mico) por otro no polar (la valina) en la sexta posici\u00F3n de la cadena de globina \u03B2, uno de los componentes de la hemoglobina adulta (HbA1)\u200B de tal manera que disminuye la uni\u00F3n de ox\u00EDgeno y el eritrocito se atrofia."@es . . . . "Anemia sel sabit adalah kondisi serius di mana sel-sel darah merah menjadi berbentuk bulan sabit, seperti huruf C. Sel darah merah normal berbentuk donat tanpa lubang (lingkaran, pipih di bagian tengahnya), sehingga memungkinkan mereka melewati pembuluh darah dengan mudah dan memasok oksigen bagi seluruh bagian tubuh. Sulit bagi sel darah merah berbentuk bulan sabit untuk melewati pembuluh darah terutama di bagian pembuluh darah yang jadi menyempit dengan sendirinya, karena sel darah merah ini akan tersangkut dan akan menimbulkan rasa sakit, infeksi serius, dan kerusakan organ pada tubuh."@in . "\u062F\u0627\u0621 \u0627\u0644\u062E\u0644\u0627\u064A\u0627 \u0627\u0644\u0645\u0646\u062C\u0644\u064A\u0629"@ar . . . . . . "114800"^^ . . . "Sikkelcelanemie en sikkelcelziekte zijn hemoglobinopathie\u00EBn, ziekten van het bloed waarbij in de rode bloedcellen het zuurstoftransporteiwit hemoglobine (Hb) veranderd is. Het zijn recessief erfelijke aandoeningen: men erft het van beide ouders. Als iemand het gen van \u00E9\u00E9n ouder heeft gekregen (heterozygoot is), is diegene drager van het gen, maar heeft zelf meestal weinig klachten of symptomen. Als iemand het gen van beide ouders heeft gekregen (homozygoot is) dan heeft men doorgaans wel symptomen van sikkelcelziekte. De meerderheid van deze populatie wordt door genetische selectie in balans gehouden, voornamelijk veroorzaakt door malaria en andere ziektes die normale rode bloedcellen aantasten en vernietigen, waardoor sikkelcelziekte als overlevingsaanpassing kan worden gezien."@nl . . "\uB0AB \uBAA8\uC591 \uC801\uD608\uAD6C \uBE48\uD608\uC99D(\uC601\uC5B4: sickle-cell anemia) \uB610\uB294 \uACB8\uC0C1 \uC801\uD608\uAD6C \uBE48\uD608\uC99D, \uACB8\uD615 \uC801\uD608\uAD6C \uBE48\uD608\uC99D\uC740 \uC720\uC804\uC790 \uC774\uC0C1\uC5D0 \uB530\uB978 \uD5E4\uBAA8\uAE00\uB85C\uBE48 \uB2E8\uBC31\uC9C8\uC758 \uC544\uBBF8\uB178\uC0B0 \uC11C\uC5F4 \uC911 \uD558\uB098\uAC00 \uC815\uC0C1\uC758 \uAC83\uACFC \uB2E4\uB974\uAC8C \uBCC0\uC774\uD558\uC5EC \uC801\uD608\uAD6C\uAC00 \uB0AB\uBAA8\uC591\uC73C\uB85C \uBCC0\uD558\uC5EC \uC744 \uC720\uBC1C\uD558\uB294 \uC720\uC804\uBCD1\uC774\uB2E4. \uC544\uD504\uB9AC\uCE74\uC758 \uD751\uC778\uC758 \uC77C\uBD80\uC5D0\uC11C \uD754\uD788 \uB098\uD0C0\uB09C\uB2E4. \uB9D0\uB77C\uB9AC\uC544\uC5D0 \uC800\uD56D\uC131\uC774 \uC788\uC5B4 \uC774 \uC774\uC0C1 \uC720\uC804\uC790\uB97C \uAC00\uC9C4 \uC0AC\uB78C\uC740 \uB9D0\uB77C\uB9AC\uC544\uC5D0\uB294 \uC798 \uAC78\uB9AC\uC9C0 \uC54A\uC9C0\uB9CC \uC801\uD608\uAD6C\uAC00 \uC27D\uAC8C \uD30C\uAD34\uB418\uC5B4 \uC2EC\uAC01\uD55C \uBE48\uD608\uC744 \uC720\uBC1C\uD558\uB294 \uC9C8\uBCD1\uC774\uB2E4. \uB0AB \uBAA8\uC591 \uC801\uD608\uAD6C \uBE48\uD608, \uD5E4\uB9AD \uBE48\uD608(Herrick's anemia)\uB4F1\uC73C\uB85C\uB3C4 \uBD88\uB9B0\uB2E4. \uC801\uD608\uAD6C \uC18D\uC758 \uD5E4\uBAA8\uAE00\uB85C\uBE48 \uB2E8\uBC31\uC9C8\uC744 \uAD6C\uC131\uD558\uB294 \uC544\uBBF8\uB178\uC0B0\uC758 \uAD6C\uC131 \uC911 \uD558\uB098\uAC00 \uBE44\uC815\uC0C1\uC801\uC73C\uB85C \uBC14\uB00C\uC5B4 \uC77C\uC5B4\uB098\uB294 \uC544\uD504\uB9AC\uCE74 \uC77C\uBD80 \uC9C0\uC5ED\uC758 \uC720\uC804\uBCD1\uC774\uB2E4. (\uB178\uC608\uC0AC\uB0E5\uC73C\uB85C \uC778\uD574 \uD604\uC7AC \uBBF8\uAD6D \uC544\uD504\uB85C-\uC544\uBA54\uB9AC\uCE78\uC758 \uC77C\uBD80\uB3C4 \uC774 \uBCD1\uC744 \uAC00\uC9C0\uACE0 \uC788\uB2E4.) \uD658\uC790\uB294 \uC0AC\uB78C\uC758 11\uBC88 \uC5FC\uC0C9\uCCB4 \uC0C1\uC5D0 \uC874\uC7AC\uD558\uB294 \uD5E4\uBAA8\uAE00\uB85C\uBE48 \uBCA0\uD0C0 \uC720\uC804\uC790\uC758 \uC5FC\uAE30\uC11C\uC5F4 \uD558\uB098\uAC00 \uBC14\uB00C\uC5B4 \uC788\uB2E4(GAG \u2192 GTG). \uB530\uB77C\uC11C \uC544\uBBF8\uB178\uC0B0 \uC11C\uC5F4 \uC911 6\uBC88\uC9F8 \uAE00\uB8E8\uD0D0\uC0B0\uC774 \uBC1C\uB9B0\uC73C\uB85C \uBC14\uB00C\uAC8C \uB418\uBA70, \uC774\uB7EC\uD55C \uB3CC\uC5F0\uBCC0\uC774 \uD5E4\uBAA8\uAE00\uB85C\uBE48\uC740 \uC0B0\uC18C\uC640 \uACB0\uD569\uD558\uC9C0 \uC54A\uC740 \uC0C1\uD0DC\uC5D0\uC11C \uC11C\uB85C \uB2EC\uB77C\uBD99\uC5B4 \uAE34 \uBC14\uB298\uBAA8\uC591\uC758 \uAD6C\uC870\uB97C \uD615\uC131\uD560 \uC218 \uC788\uAC8C \uB418\uBBC0\uB85C \uC801\uD608\uAD6C\uC758 \uBAA8\uC591\uC774 \uAE38\uAC8C \uCC0C\uADF8\uB7EC\uC9C4 \uB0AB \uBAA8\uC591\uC73C\uB85C \uBC14\uB00C\uAC8C \uB41C\uB2E4. \uB530\uB77C\uC11C \uC5FC\uC0C9\uCCB4 \uD55C \uC30D \uBAA8\uB450\uC5D0 \uC774\uC0C1 \uC720\uC804\uC778\uC790\uB97C \uAC00\uC9C0\uACE0 \uC788\uB294 \uD658\uC790(\uD638\uBAA8\uD615)\uB294 \uB300\uB2E8\uD788 \uC27D\uAC8C \uC801\uD608\uAD6C\uAC00 \uD30C\uAD34\uB418\uBBC0\uB85C \uC2EC\uAC01\uD55C \uBE48\uD608 \uC99D\uC0C1\uACFC \uB9D0\uCD08 \uBAA8\uC138\uD608\uAD00\uC758 \uAD34\uC0AC\uB97C \uC77C\uC73C\uD0A4\uAC8C \uB41C\uB2E4. \uADF8\uB7EC\uB098 \uC774 \uC720\uC804\uC801 \uC774\uC0C1\uC740 \uB9D0\uB77C\uB9AC\uC544 \uC6D0\uCDA9\uC5D0 \uB300\uD574 \uAC15\uD55C \uC800\uD56D\uB825\uC744 \uBCF4\uC774\uAC8C \uB418\uB294\uB370, \uB0AB \uBAA8\uC591 \uC801\uD608\uAD6C\uC758 \uB9C9\uC740 \uBB3C\uC9C8\uC758 \uD22C\uACFC\uC131\uC774 \uBE44\uC815\uC0C1\uC801\uC774\uC5B4\uC11C \uC801\uD608\uAD6C \uB0B4\uC5D0 \uB18D\uCD95\uB41C \uCE7C\uB968 \uC774\uC628(K+)\uC774 \uC138\uD3EC \uBC16\uC73C\uB85C \uBE60\uC838 \uB098\uAC00\uBBC0\uB85C \uC774 \uB300\uC0AC \uC7A5\uC560\uB97C \uBC1B\uAE30 \uB54C\uBB38\uC774\uB2E4. \uADF8\uB9AC\uACE0 \uC774 \uB300\uB9BD \uC720\uC804\uC790\uB97C \uC5F4\uC131 \uB3D9\uD615\uC811\uD569(\uD638\uBAA8)\uC774 \uC544\uB2CC \uC774\uD615\uC811\uD569(\uD5E4\uD14C\uB85C)\uC73C\uB85C \uAC00\uC9C0\uACE0 \uC788\uC744 \uACBD\uC6B0, \uBE48\uD608 \uC99D\uC0C1\uC774 \uC0DD\uC874\uC5D0 \uC704\uD611\uC801\uC77C \uC815\uB3C4\uB85C \uC2EC\uD558\uAC8C \uB098\uD0C0\uB098\uC9C0 \uC54A\uB294\uB2E4. \uB530\uB77C\uC11C \uB9D0\uB77C\uB9AC\uC544\uAC00 \uC720\uD589\uD558\uB294 \uC544\uD504\uB9AC\uCE74 \uB4F1\uC758 \uC9C0\uC5ED\uC5D0\uC11C\uB294 \uC774 \uC720\uC804\uC9C8\uD658\uC744 \uC774\uD615\uC811\uD569\uC73C\uB85C \uAC00\uC9C0\uACE0 \uC788\uB294 \uACBD\uC6B0 \uC0DD\uC874\uC5D0 \uC720\uB9AC\uD558\uAC8C \uB41C\uB2E4."@ko . . . . . . . . . . . . . . . "\u0421\u0435\u0440\u043F\u043E\u043F\u043E\u0434\u0456\u0431\u043D\u043E\u043A\u043B\u0456\u0442\u0438\u043D\u043D\u0430 \u0430\u043D\u0435\u043C\u0456\u044F \u0430\u0431\u043E \u0434\u0440\u0435\u043F\u0430\u043D\u043E\u0446\u0438\u0442\u043E\u0437[\u0434\u0436\u0435\u0440\u0435\u043B\u043E?] \u2014 \u0441\u043F\u0430\u0434\u043A\u043E\u0432\u0430 \u0433\u0435\u043C\u043E\u0433\u043B\u043E\u0431\u0456\u043D\u043E\u043F\u0430\u0442\u0456\u044F, \u043F\u0440\u0438 \u044F\u043A\u0456\u0439 \u043C\u0430\u0454 \u043C\u0456\u0441\u0446\u0435 \u043F\u043E\u0440\u0443\u0448\u0435\u043D\u043D\u044F \u0443\u0442\u0432\u043E\u0440\u0435\u043D\u043D\u044F \u0431\u0456\u043B\u043A\u0430 \u0433\u0435\u043C\u043E\u0433\u043B\u043E\u0431\u0456\u043D\u0443 \u0456 \u0432\u0456\u043D \u043D\u0430\u0431\u0443\u0432\u0430\u0454 \u043F\u0430\u0442\u043E\u043B\u043E\u0433\u0456\u0447\u043D\u043E\u0457 \u0444\u043E\u0440\u043C\u0438 \u2014 \u0433\u0435\u043C\u043E\u0433\u043B\u043E\u0431\u0456\u043D S. \u0415\u0440\u0438\u0442\u0440\u043E\u0446\u0438\u0442\u0438, \u044F\u043A\u0456 \u043C\u0456\u0441\u0442\u044F\u0442\u044C \u0433\u0435\u043C\u043E\u0433\u043B\u043E\u0431\u0456\u043D S, \u043F\u0456\u0434 \u043C\u0456\u043A\u0440\u043E\u0441\u043A\u043E\u043F\u043E\u043C \u043C\u0430\u044E\u0442\u044C \u0445\u0430\u0440\u0430\u043A\u0442\u0435\u0440\u043D\u0443 \u0441\u0435\u0440\u043F\u043E\u043F\u043E\u0434\u0456\u0431\u043D\u0443 \u0444\u043E\u0440\u043C\u0443 (\u0444\u043E\u0440\u043C\u0443 \u0441\u0435\u0440\u043F\u0430), \u0437\u0430 \u0449\u043E \u0446\u044F \u0433\u0435\u043C\u043E\u0433\u043B\u043E\u0431\u0456\u043D\u043E\u043F\u0430\u0442\u0456\u044F \u0456 \u043E\u0442\u0440\u0438\u043C\u0430\u043B\u0430 \u0441\u0432\u043E\u044E \u043D\u0430\u0437\u0432\u0443."@uk . . . . "Anaemacht chorr\u00E1ncheallach"@ga . . "Anemia faltziforme"@eu . . "Sickle cell disease"@en . . "M\u00EDnorm\u00E1ltacht cheimiceach i haemagl\u00F3ibin na fola (an l\u00ED a iompra\u00EDonn an oscaigin sna cealla dearga fola), a fhaightear le hoidhreacht is a chiapann daoine \u00F3n Afraic fho-Shah\u00E1rach. G\u00E9in mh\u00EDnorm\u00E1lta is bun l\u00E9i. M\u00E1 fhaightear an gh\u00E9in seo \u00F3 thuismitheoir amh\u00E1in n\u00ED bh\u00EDonn m\u00F3r\u00E1n siompt\u00F3m ann (an tr\u00E9ith chorr\u00E1ncheallach), ach is f\u00E9idir an gh\u00E9in a thabhairt ar aghaidh don ch\u00E9ad ghl\u00FAin eile. Fulaing\u00EDonn daoine a fhaigheann g\u00E9inte m\u00EDnorm\u00E1lta \u00F3n d\u00E1 thuismitheoir an galar ina ioml\u00E1ine. B\u00EDonn haemagl\u00F3ibin S sna cealla dearga fola in ionad gn\u00E1th-haemagl\u00F3ibin A. Mar thoradh air seo \u00E9ir\u00EDonn na cealla seo corr\u00E1nach in ionad a ngn\u00E1thchrutha chiorclaigh dh\u00E9chuasaigh, b\u00EDonn siad sobhriste, agus n\u00ED mhaireann r\u00F3fhada san imshruth\u00FA. B\u00EDonn anaemacht ainsealach ag an duine sin, agus go minic baineann ionfhabhtuithe d\u00F3 mar gheall ar fhuilead\u00E1in bheaga a bheith calctha ag na cealla dearga briste, ag cur bac ar shol\u00E1thar ocsaigine do na f\u00EDoch\u00E1in."@ga . . "Sicklecellanemi"@sv . . . . . . . . . . . . "Sicklecellanemi \u00E4r en genetisk sjukdom d\u00E4r de r\u00F6da blodkropparna (erytrocyterna) ser ut som sk\u00E4ror (eng. sickle) ist\u00E4llet f\u00F6r att ha normal rund form. Sjukdomen beror p\u00E5 en mutation som fr\u00E4mst drabbar personer med afrikanskt ursprung, och (om \u00E4n s\u00E4llsynt) befolkning vid Medelhavet. Den heterozygota formen ger en viss motst\u00E5ndskraft mot malaria, och d\u00E4rf\u00F6r har den muterade genen levt kvar bland befolkningen. Sjukdomen \u00E4r recessiv, det vill s\u00E4ga anlagen m\u00E5ste ned\u00E4rvas fr\u00E5n b\u00E5da f\u00F6r\u00E4ldrarna f\u00F6r att sjukdomen skall bryta ut. Den typiska formen hos erytrocyten g\u00F6r att den blir extra k\u00E4nslig f\u00F6r att f\u00F6rst\u00F6ras i mj\u00E4lten. D\u00E5 patienten kommer att lida brist p\u00E5 erytrocyter uppst\u00E5r blodbrist (anemi). Sjukdomen leder till allvarliga komplikationer i flera olika organ och organsystem. Formen p\u00E5 cellen g\u00F6r \u00E4ven att risken f\u00F6r venocklusion (sicklecellkris) \u00F6kar p\u00E5 grund av att cellerna \"fastnar\" i k\u00E4rlv\u00E4ggen och byggs upp ungef\u00E4r som en trombos, vilket kan ge sm\u00E4rtor i det p\u00E5verkade omr\u00E5det."@sv . "L'an\u00E8mia de c\u00E8l\u00B7lules falciformes, o an\u00E8mia drepanoc\u00EDtica, \u00E9s una hemoglobinopatia (una malaltia gen\u00E8tica que afecta l'hemoglobina). \u00C9s causada per l'hemoglobina S, la qual es crea al canviar una glutamina per una valina en les cadenes polip\u00E8ptiques beta; aix\u00F2 provoca que en una situaci\u00F3 de baixa tensi\u00F3 d'oxigen, l'hemoglobina es deforma i l'eritr\u00F2cit adquireix una aparen\u00E7a d'una fal\u00E7. Aquesta nova forma provoca dificultats pel que fa a la circulaci\u00F3 dels gl\u00F2buls vermells, s'obstrueixen els vasos sanguinis i causen s\u00EDmptomes com, per exemple, dolor en les extremitats. Els gl\u00F2buls vermells tamb\u00E9 tenen una vida m\u00E9s curta i, a la vegada, aix\u00F2 provoca una an\u00E8mia, ja que no poden ser reempla\u00E7ats a temps."@ca . . "\u942E\u5200\u578B\u7D05\u8840\u7403\u75BE\u75C5\uFF08\u82F1\u8A9E\uFF1ASickle-cell disease, SCD\uFF09\u662F\u4E00\u7D44\u901A\u5E38\u7531\u96D9\u89AA\u907A\u50B3\u800C\u4F86\u7684\u8840\u6DB2\u75BE\u75C5\u3002\u5176\u4E2D\u6700\u5E38\u898B\u7684\u4E00\u7A2E\u985E\u578B\uFF0C\u53EB\u505A\u942E\u72C0\u7D05\u8840\u7403\u8CA7\u8840\u75C7\uFF08Sickle-cell anemia, SCA\uFF09\u3002\u8A72\u75BE\u75C5\u6703\u5F15\u8D77\u7D05\u8840\u7403\u4E2D\u7684\u8F09\u6C27\u8840\u7D05\u86CB\u767D\u7570\u5E38\u3002\u5728\u67D0\u7279\u5B9A\u7684\u60C5\u6CC1\u4E0B\uFF08\u901A\u5E38\u662F\u7F3A\u6C27\u72C0\u6CC1\uFF09\uFF0C\u7D05\u8840\u7403\u6703\u8B8A\u6210\u5805\u786C\u7684\u942E\u5200\u578B \u3002\u942E\u5200\u72C0\u7D05\u8840\u7403\u75BE\u75C5\u7684\u554F\u984C\u901A\u5E38\u6703\u5728\u4E94\u5230\u516D\u500B\u6708\u9F61\u6642\u767C\u4F5C\u3002\u60A3\u8005\u53EF\u80FD\u6703\u51FA\u73FE\u591A\u9805\u5065\u5EB7\u554F\u984C\uFF0C\u4F8B\u5982\u7A81\u767C\u7684\u75BC\u75DB\uFF08\u942E\u5200\u578B\u8CA7\u8840\u5371\u6A5F\uFF0Csickle-cell crisis\uFF09\u3001\u8CA7\u8840\u3001\u7D30\u83CC\u611F\u67D3\u8207\u4E2D\u98A8\u3002\u7576\u60A3\u8005\u5E74\u7D00\u7A0D\u9577\u4E4B\u5F8C\u53EF\u80FD\u6703\u51FA\u73FE\u6162\u6027\u75BC\u75DB\u3002\u5728\u5DF2\u958B\u767C\u570B\u5BB6\u4E2D\u7684\u60A3\u8005\u5E73\u5747\u58FD\u547D\u70BA40\u523060\u6B72\u3002 \u942E\u5200\u578B\u7D05\u8840\u7403\u75BE\u75C5\u901A\u5E38\u767C\u75C5\u65BC\u64C1\u6709\u5169\u500B\u4E0D\u6B63\u5E38\u8840\u7D05\u7D20\u57FA\u56E0\u7684\u4EBA\uFF0C\u5F9E\u7236\u6BCD\u96D9\u65B9\u5404\u907A\u50B3\u904E\u4F86\u4E00\u500B\u4E0D\u6B63\u5E38\u7684\u57FA\u56E0\u3002\u7A81\u8B8A\u7684\u8840\u7D05\u7D20\u57FA\u56E0\u5B58\u5728\u8A31\u591A\u4E9E\u578B\uFF0C\u5176\u5206\u985E\u53D6\u6C7A\u65BC\u5176\u57FA\u56E0\u7684\u3002\u7576\u6EAB\u5EA6\u6539\u8B8A\uFF0C\u627F\u53D7\u58D3\u529B\uFF0C\u812B\u6C34\u6216\u662F\u8655\u65BC\u9AD8\u6D77\u62D4\u6642\u6703\u51FA\u73FE\u8EAB\u9AD4\u4E0D\u9069\u7684\u7DCA\u6025\u75C7\u72C0\u3002\u5982\u679C\u53EA\u6709\u4E00\u500B\u4E0D\u6B63\u5E38\u57FA\u56E0\u7684\u4EBA\u901A\u5E38\u4E0D\u6703\u6709\u3002\u9019\u985E\u578B\u7684\u4EBA\u901A\u5E38\u88AB\u8996\u70BA \u3002\u6AA2\u9A57\u662F\u5426\u6709\u942E\u5200\u578B\u7D05\u8840\u7403\u75BE\u75C5\u901A\u5E38\u662F\u85C9\u7531\u8840\u6DB2\u6AA2\u67E5\u5F97\u77E5\uFF0C\u6709\u4E9B\u570B\u5BB6\u5728\u65B0\u751F\u5152\u51FA\u751F\u4E4B\u5F8C\u4FBF\u6703\u9032\u884C\u6AA2\u9A57 \uFF0C\u5728\u61F7\u5B55\u6642\u4E5F\u6709\u6A5F\u6703\u53EF\u4EE5\u9A57\u51FA\u80CE\u5152\u662F\u5426\u6709\u942E\u5200\u578B\u7D05\u8840\u7403\u75BE\u75C5\u3002 \u7167\u8B77\u942E\u5200\u578B\u7D05\u8840\u7403\u75BE\u75C5\u60A3\u8005\u7684\u65B9\u5F0F\u5305\u542B\u75AB\u82D7\u548C\u6297\u751F\u7D20\u4E4B\u4F7F\u7528\u3001\u591A\u559D\u6C34\u3001\u88DC\u5145\u8449\u9178\u4EE5\u53CA\u6B62\u75DB\u5291\u3002\u5176\u4ED6\u65B9\u6CD5\u5305\u62EC\u8F38\u8840\u548C\u3002\u4E00\u5C0F\u90E8\u5206\u7684\u4EBA\u53EF\u4EE5\u5229\u7528\u4F86\u9032\u884C\u6CBB\u7642\u3002 2013\u5E74\u4E4B\u524D\uFF0C\u5168\u7403\u7D04\u6709320\u842C\u4EBA\u60A3\u6709\u942E\u578B\u7D05\u8840\u7403\u75BE\u75C5\uFF1B\u53E6\u5916\u7D04\u67094300\u842C\u4EBA\u5177\u6709\u942E\u578B\u7D05\u8840\u7403\u75BE\u75C5\u8868\u5FB5\u3002\u64DA\u4FE1\u5927\u7D0480%\u7684\u942E\u578B\u7D05\u8840\u7403\u75BE\u75C5\u75C5\u4F8B\u51FA\u73FE\u5728\u6492\u54C8\u62C9\u6C99\u6F20\u4EE5\u5357\u7684\u975E\u6D32\u3002\u6B64\u5916\uFF0C\u5370\u5EA6\u90E8\u5206\u5340\u57DF\u3001\u963F\u62C9\u4F2F\u534A\u5CF6\u4EE5\u53CA\u4E16\u754C\u5404\u5730\u7684\u4E5F\u662F\u7D93\u5E38\u6709\u75C5\u4F8B\u51FA\u73FE\u7684\u5730\u65B9\u3002\u57281990\u5E74\uFF0C\u6B64\u75BE\u75C5\u9020\u621011\u842C3\u5343\u4EBA\u6B7B\u4EA1\uFF0C\u5230\u4E862013\uFF0C\u6B64\u75BE\u75C5\u5DF2\u7D93\u9020\u621017\u842C6\u5343\u7684\u4EBA\u53E3\u6B7B\u4EA1 \u3002\u6B64\u75BE\u75C5\u6700\u521D\u662F\u8A18\u8F09\u57281910\u5E74\u7F8E\u570B\u91AB\u5E2B\u8A79\u59C6\u65AF\u00B7\u8D6B\u91CC\u514B\u6240\u5BEB\u7684\u91AB\u5B78\u6587\u737B \u30021949\u5E74\uFF0C\u6B64\u75C5\u7684\u907A\u50B3\u73FE\u8C61\u88ABE. A. Beet\u548CJ. V. Neel\u6240\u78BA\u8A8D \u3002\u57281954\u5E74\uFF0C\u942E\u578B\u7D05\u8840\u7403\u75BE\u75C5\u8868\u5FB5\u6709\u80FD\u529B\u5C0D\u7627\u75BE\u7522\u751F\u62B5\u6297\u6027\u7684\u6548\u679C\u5DF2\u6709\u76F8\u95DC\u8A18\u8F09\u8AD6\u8FF0\u3002"@zh . . . . . "Anemia sel sabit adalah kondisi serius di mana sel-sel darah merah menjadi berbentuk bulan sabit, seperti huruf C. Sel darah merah normal berbentuk donat tanpa lubang (lingkaran, pipih di bagian tengahnya), sehingga memungkinkan mereka melewati pembuluh darah dengan mudah dan memasok oksigen bagi seluruh bagian tubuh. Sulit bagi sel darah merah berbentuk bulan sabit untuk melewati pembuluh darah terutama di bagian pembuluh darah yang jadi menyempit dengan sendirinya, karena sel darah merah ini akan tersangkut dan akan menimbulkan rasa sakit, infeksi serius, dan kerusakan organ pada tubuh."@in . . . "Serpo\u0109ela anemio"@eo . . . . . . . . . . . "med"@en . . . "1123609168"^^ . . . . "M\u00EDnorm\u00E1ltacht cheimiceach i haemagl\u00F3ibin na fola (an l\u00ED a iompra\u00EDonn an oscaigin sna cealla dearga fola), a fhaightear le hoidhreacht is a chiapann daoine \u00F3n Afraic fho-Shah\u00E1rach. G\u00E9in mh\u00EDnorm\u00E1lta is bun l\u00E9i. M\u00E1 fhaightear an gh\u00E9in seo \u00F3 thuismitheoir amh\u00E1in n\u00ED bh\u00EDonn m\u00F3r\u00E1n siompt\u00F3m ann (an tr\u00E9ith chorr\u00E1ncheallach), ach is f\u00E9idir an gh\u00E9in a thabhairt ar aghaidh don ch\u00E9ad ghl\u00FAin eile. Fulaing\u00EDonn daoine a fhaigheann g\u00E9inte m\u00EDnorm\u00E1lta \u00F3n d\u00E1 thuismitheoir an galar ina ioml\u00E1ine. B\u00EDonn haemagl\u00F3ibin S sna cealla dearga fola in ionad gn\u00E1th-haemagl\u00F3ibin A. Mar thoradh air seo \u00E9ir\u00EDonn na cealla seo corr\u00E1nach in ionad a ngn\u00E1thchrutha chiorclaigh dh\u00E9chuasaigh, b\u00EDonn siad sobhriste, agus n\u00ED mhaireann r\u00F3fhada san imshruth\u00FA. B\u00EDonn anaemacht ainsealach ag an duine sin, agus go minic baineann ionfhabhtuit"@ga . "Anemia de c\u00E9lulas falciformes"@es . . . "Sicklecellanemi \u00E4r en genetisk sjukdom d\u00E4r de r\u00F6da blodkropparna (erytrocyterna) ser ut som sk\u00E4ror (eng. sickle) ist\u00E4llet f\u00F6r att ha normal rund form. Sjukdomen beror p\u00E5 en mutation som fr\u00E4mst drabbar personer med afrikanskt ursprung, och (om \u00E4n s\u00E4llsynt) befolkning vid Medelhavet. Den heterozygota formen ger en viss motst\u00E5ndskraft mot malaria, och d\u00E4rf\u00F6r har den muterade genen levt kvar bland befolkningen. Sjukdomen \u00E4r recessiv, det vill s\u00E4ga anlagen m\u00E5ste ned\u00E4rvas fr\u00E5n b\u00E5da f\u00F6r\u00E4ldrarna f\u00F6r att sjukdomen skall bryta ut."@sv . . . . "Anemia drepanocitica"@it . . . . "\u062F\u0627\u0621 \u0627\u0644\u062E\u0644\u0627\u064A\u0627 \u0627\u0644\u0645\u0646\u062C\u0644\u064A\u0629 \u0623\u0648 \u062F\u0627\u0621 \u0627\u0644\u0643\u0631\u064A\u0627\u062A \u0627\u0644\u0645\u0646\u062C\u0644\u064A\u0629 \u0647\u0648 \u0645\u062C\u0645\u0648\u0639\u0629 \u0645\u0646 \u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062A \u0627\u0644\u062F\u0645 \u0627\u0644\u0645\u0648\u0631\u0648\u062B\u0629 \u0639\u0627\u062F\u0629 \u0645\u0646 \u0648\u0627\u0644\u062F\u064A \u0627\u0644\u0634\u062E\u0635. \u064A\u0639\u0631\u0641 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u0623\u0643\u062B\u0631 \u0634\u064A\u0648\u0639\u064B\u0627 \u0628\u0627\u0633\u0645 \u0641\u0642\u0631 \u0627\u0644\u062F\u0645 \u0627\u0644\u0645\u0646\u062C\u0644\u064A. \u0625\u0646\u0647 \u064A\u0624\u062F\u064A \u0625\u0644\u0649 \u062E\u0644\u0644 \u0641\u064A \u0627\u0644\u0647\u064A\u0645\u0648\u062C\u0644\u0648\u0628\u064A\u0646 \u0627\u0644\u0628\u0631\u0648\u062A\u064A\u0646\u064A \u0627\u0644\u062D\u0627\u0645\u0644 \u0644\u0644\u0623\u0643\u0633\u062C\u064A\u0646 \u0627\u0644\u0645\u0648\u062C\u0648\u062F \u0641\u064A \u062E\u0644\u0627\u064A\u0627 \u0627\u0644\u062F\u0645 \u0627\u0644\u062D\u0645\u0631\u0627\u0621. \u0647\u0630\u0627 \u064A\u0624\u062F\u064A \u0625\u0644\u0649 \u0634\u0643\u0644 \u0635\u0644\u0628 \u064A\u0634\u0628\u0647 \u0627\u0644\u0645\u0646\u062C\u0644 \u0641\u064A \u0638\u0644 \u0638\u0631\u0648\u0641 \u0645\u0639\u064A\u0646\u0629. \u062A\u0628\u062F\u0623 \u0645\u0634\u0627\u0643\u0644 \u0645\u0631\u0636 \u0627\u0644\u062E\u0644\u0627\u064A\u0627 \u0627\u0644\u0645\u0646\u062C\u0644\u064A\u0629 \u0639\u0627\u062F\u0629 \u062D\u0648\u0627\u0644\u064A 5 \u0625\u0644\u0649 6 \u0623\u0634\u0647\u0631 \u0645\u0646 \u0627\u0644\u0639\u0645\u0631. \u0642\u062F \u062A\u062A\u0637\u0648\u0631 \u0639\u062F\u062F \u0645\u0646 \u0627\u0644\u0645\u0634\u0627\u0643\u0644 \u0627\u0644\u0635\u062D\u064A\u0629\u060C \u0645\u062B\u0644 \u0646\u0648\u0628\u0627\u062A \u0627\u0644\u0623\u0644\u0645 (\u0627\u0644\u0645\u0639\u0631\u0648\u0641\u0629 \u0628\u0627\u0633\u0645 \u0623\u0632\u0645\u0629 \u0627\u0644\u062E\u0644\u0627\u064A\u0627 \u0627\u0644\u0645\u0646\u062C\u0644\u064A\u0629)\u060C \u0641\u0642\u0631 \u0627\u0644\u062F\u0645\u060C \u062A\u0648\u0631\u0645 \u0627\u0644\u064A\u062F\u064A\u0646 \u0648\u0627\u0644\u0642\u062F\u0645\u064A\u0646\u060C \u0627\u0644\u0627\u0644\u062A\u0647\u0627\u0628\u0627\u062A \u0627\u0644\u0628\u0643\u062A\u064A\u0631\u064A\u0629 \u0648\u0627\u0644\u0633\u0643\u062A\u0629 \u0627\u0644\u062F\u0645\u0627\u063A\u064A\u0629. \u0642\u062F \u064A\u062A\u0637\u0648\u0631 \u0627\u0644\u0623\u0644\u0645 \u0637\u0648\u064A\u0644 \u0627\u0644\u0645\u062F\u0649 \u0645\u0639 \u062A\u0642\u062F\u0645 \u0627\u0644\u0646\u0627\u0633 \u0641\u064A \u0627\u0644\u0633\u0646. \u064A\u062A\u0631\u0627\u0648\u062D \u0645\u062A\u0648\u0633\u0637 \u0627\u0644\u0639\u0645\u0631 \u0627\u0644\u0645\u062A\u0648\u0642\u0639 \u0641\u064A \u0627\u0644\u0639\u0627\u0644\u0645 \u0627\u0644\u0645\u062A\u0642\u062F\u0645 \u0628\u064A\u0646 40 \u064860 \u0639\u0627\u0645\u064B\u0627."@ar . "Sickle cell disorder"@en . . . "" . . . "Die Sichelzellkrankheit (auch Sichelzell(en)an\u00E4mie) oder Drepanozytose ist eine erbliche Erkrankung der roten Blutk\u00F6rperchen (Erythrozyten). Sie geh\u00F6rt zur Gruppe der H\u00E4moglobinopathien (St\u00F6rungen des H\u00E4moglobins) und f\u00FChrt zu einer korpuskul\u00E4ren h\u00E4molytischen An\u00E4mie. Bei den Betroffenen liegt eine Mutation der \u03B2-Kette des H\u00E4moglobins vor. Es k\u00F6nnen entweder alle \u03B2-Ketten betroffen sein (schwere, homozygote Form) oder nur ein Teil (mildere, heterozygote Form). Die Krankheit tritt vor allem bei Personen aus Subsahara-Afrika und deren Nachfahren, aber auch in Teilen des Mittelmeerraums und des Nahen Ostens bis Indien auf und wurde durch Migration global verbreitet. Sie ist nach wie vor in den Entwicklungsl\u00E4ndern mit einer hohen Mortalit\u00E4t verbunden. Die Krankheit wurde 1910 von und bei einem Patienten aus der Karibik beschrieben und die Bezeichnung Sichelzellenan\u00E4mie wurde zuerst von Vernon Mason 1922 benutzt."@de . . . "2126"@en . "12069"^^ . ""@en . . . . . . . . . . . . . . "Chronic pain, stroke, aseptic bone necrosis, gallstones, leg ulcers, priapism, pulmonary hypertension, vision problems, kidney problems"@en . . . "" . . . . "Srpkovit\u00E1 chudokrevnost nebo an\u00E9mie (tak\u00E9 falciformn\u00ED an\u00E9mie nebo drepanocyt\u00F3za) je autozom\u00E1ln\u011B recesivn\u00ED d\u011Bdi\u010Dn\u00E9 onemocn\u011Bn\u00ED, kter\u00E9 se projevuje zm\u011Bnou tvaru \u010Derven\u00FDch krvinek z tzv. prom\u00E1\u010Dknut\u00FDch pi\u0161kot\u016F na prota\u017Een\u00E9 srpky. Tato zm\u011Bna tvaru je zp\u016Fsoben\u00E1 mutac\u00ED genu pro hemoglobin, p\u0159i n\u00ED\u017E je na 6. pozici v \u03B2-\u0159et\u011Bzci valin m\u00EDsto glutamov\u00E9 kyseliny (vznik\u00E1 hemoglobin ozna\u010Dovan\u00FD jako \u201EHbS\u201C). Valin je hydrofobn\u00ED aminokyselina, zat\u00EDmco glutamov\u00E1 kyselina je . Takto vznikl\u00E1 molekula HbS vykazuje odli\u0161n\u00E9 vlastnosti a ve sv\u00E9 deoxygenovan\u00E9 podob\u011B (tzn. kdy\u017E nen\u00ED nav\u00E1z\u00E1n kysl\u00EDk) se molekuly hemoglobinu shlukuj\u00ED a deformuj\u00ED krvinku. To sni\u017Euje flexibilitu bu\u0148ky a m\u00E1 za n\u00E1sledek mnoho r\u016Fzn\u00FDch komplikac\u00ED. Pr\u016Fm\u011Brn\u00E1 d\u00E9lka \u017Eivota lid\u00ED posti\u017Een\u00FDch touto nemoc\u00ED je 42 let u mu\u017E\u016F a 48 let u \u017Een. Tato nemoc se objevuje u\u017E v d\u011Btstv\u00ED v\u011Bt\u0161inou u lid\u00ED (nebo jejich potomk\u016F) z tropick\u00FDch a subtropick\u00FDch p\u00E1sem \u2013 tedy z region\u016F, ve kter\u00FDch je b\u011B\u017En\u00E1 mal\u00E1rie. Obyvatel\u00E9, kte\u0159\u00ED maj\u00ED jeden gen ze dvou poznamenan\u00FD srpkovitou an\u00E9mi\u00ED, jsou toti\u017E proti mal\u00E1rii imunn\u00ED (heterozygotn\u00ED v\u00FDhoda). Roz\u0161\u00ED\u0159en\u00ED t\u00E9to nemoci br\u00E1n\u00ED z\u0159ejm\u011B zm\u011Bna tvaru \u010Derven\u00FDch krvinek, ale byla ji\u017E navr\u017Eena i jin\u00E1 vysv\u011Btlen\u00ED.[zdroj?]"@cs . . . . . . . . ""@en . . . . . . . . "21010263"^^ . . . . . "Sickle Cell Disease"@en . "232"^^ . . "Sickle cell disease (SCD) is a group of blood disorders typically inherited from a person's parents. The most common type is known as sickle cell anaemia. It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. This leads to a rigid, sickle-like shape under certain circumstances. Problems in sickle cell disease typically begin around 5 to 6 months of age. A number of health problems may develop, such as attacks of pain (known as a sickle cell crisis), anemia, swelling in the hands and feet, bacterial infections and stroke. Long-term pain may develop as people get older. The average life expectancy in the developed world is 40 to 60 years."@en . . . . . . . "NBK1377"@en . . . . "Anemia faltziforme edo drepanozitosia eritrozitoen itxura deformatzen duen gaixotasun hematologikoa da, oinarri genetikoa duena. Anemia mota honetan hemoglobinaren egitura molekularra ezohikoa da, \u03B2 kate polipeptidikoetan aminoazido bat aldatuta dagoelako (glutamina egon beharrean balina baitago). Hemoglobinaren aldaketa molekular horrek eritrozitoen desitxuratzea dakar: globulu gorriak ez dira biribilak, luzeak baizik, eta igitaiaren itxura hartu ohi dute (hortik gaitzaren izena). Hemoglobina eta eritrozito ezohiko horiek gaitzaren arazoak eragiten dituzte: odolean oxigenoaren garraoia okertzen da, odol-zirkulazioa ere bai (odol-hodiak buxatu egiten dira), anemia azaltzen da (eritrozito faltziformeek bizitza laburragoa dutelako), etab."@eu . . "Niedokrwisto\u015B\u0107 sierpowata, anemia sierpowata (\u0142ac. anaemia drepanocytica, ang. sickle cell anemia) \u2013 rodzaj wrodzonej niedokrwisto\u015Bci spowodowanej nieprawid\u0142ow\u0105 budow\u0105 hemoglobiny. Mutacja punktowa w genie \u0142a\u0144cucha \u03B2 (HBB) hemoglobiny powoduje zmian\u0119 pojedynczego aminokwasu w sekwencji bia\u0142ka (z kwasu glutaminowego na walin\u0119, w pozycji 6 od ko\u0144ca NH2). Hemoglobin\u0119 z tak zmienion\u0105, nieprawid\u0142ow\u0105 struktur\u0105 I-rz\u0119dow\u0105 okre\u015Bla si\u0119 jako hemoglobin\u0119 S (HbS) w przeciwie\u0144stwie do normalnej, wyst\u0119puj\u0105cej u doros\u0142ych hemoglobiny A (HbA). Hemoglobina S charakteryzuje si\u0119 zmienionymi w por\u00F3wnaniu z hemoglobin\u0105 A w\u0142asno\u015Bciami fizykochemicznymi."@pl . . "\u0394\u03C1\u03B5\u03C0\u03B1\u03BD\u03BF\u03BA\u03C5\u03C4\u03C4\u03B1\u03C1\u03B9\u03BA\u03AE \u03BD\u03CC\u03C3\u03BF\u03C2 \u03AE \u03B4\u03C1\u03B5\u03C0\u03B1\u03BD\u03BF\u03BA\u03C5\u03C4\u03C4\u03AC\u03C1\u03C9\u03C3\u03B7 \u03B5\u03AF\u03BD\u03B1\u03B9 \u03BC\u03B9\u03B1 \u03BF\u03BC\u03AC\u03B4\u03B1 \u03B1\u03C3\u03B8\u03B5\u03BD\u03B5\u03B9\u03CE\u03BD \u03C4\u03BF\u03C5 \u03B1\u03AF\u03BC\u03B1\u03C4\u03BF\u03C2 \u03C0\u03BF\u03C5 \u03C3\u03C5\u03BD\u03AE\u03B8\u03C9\u03C2 \u03BA\u03BB\u03B7\u03C1\u03BF\u03BD\u03BF\u03BC\u03B5\u03AF\u03C4\u03B1\u03B9 \u03B1\u03C0\u03CC \u03C4\u03BF\u03C5\u03C2 \u03B3\u03BF\u03BD\u03B5\u03AF\u03C2 \u03B5\u03BD\u03CC\u03C2 \u03B1\u03C4\u03CC\u03BC\u03BF\u03C5. \u039F \u03C0\u03B9\u03BF \u03C3\u03C5\u03BD\u03B7\u03B8\u03B9\u03C3\u03BC\u03AD\u03BD\u03BF\u03C2 \u03C4\u03CD\u03C0\u03BF\u03C2 \u03B5\u03AF\u03BD\u03B1\u03B9 \u03B3\u03BD\u03C9\u03C3\u03C4\u03CC\u03C2 \u03C9\u03C2 \u03B4\u03C1\u03B5\u03C0\u03B1\u03BD\u03BF\u03BA\u03C5\u03C4\u03C4\u03B1\u03C1\u03B9\u03BA\u03AE \u03B1\u03BD\u03B1\u03B9\u03BC\u03AF\u03B1. \u0388\u03C7\u03B5\u03B9 \u03C9\u03C2 \u03B1\u03C0\u03BF\u03C4\u03AD\u03BB\u03B5\u03C3\u03BC\u03B1 \u03BC\u03B9\u03B1 \u03B1\u03BD\u03C9\u03BC\u03B1\u03BB\u03AF\u03B1 \u03C3\u03C4\u03B7\u03BD \u03C0\u03C1\u03C9\u03C4\u03B5\u0390\u03BD\u03B7 \u03C0\u03BF\u03C5 \u03BC\u03B5\u03C4\u03B1\u03C6\u03AD\u03C1\u03B5\u03B9 \u03C4\u03BF \u03BF\u03BE\u03C5\u03B3\u03CC\u03BD\u03BF \u03C4\u03B7\u03BD \u03B1\u03B9\u03BC\u03BF\u03C3\u03C6\u03B1\u03B9\u03C1\u03AF\u03BD\u03B7 \u03BA\u03B1\u03B9 \u03B2\u03C1\u03AF\u03C3\u03BA\u03B5\u03C4\u03B1\u03B9 \u03C3\u03C4\u03B1 \u03B5\u03C1\u03C5\u03B8\u03C1\u03BF\u03BA\u03CD\u03C4\u03C4\u03B1\u03C1\u03B1. \u0391\u03C5\u03C4\u03CC \u03BF\u03B4\u03B7\u03B3\u03B5\u03AF \u03C3\u03B5 \u03B4\u03CD\u03C3\u03BA\u03B1\u03BC\u03C0\u03C4\u03BF \u03B4\u03C1\u03B5\u03C0\u03B1\u03BD\u03BF\u03B5\u03B9\u03B4\u03AD\u03C2 \u03C3\u03C7\u03AE\u03BC\u03B1 \u03BA\u03AC\u03C4\u03C9 \u03B1\u03C0\u03CC \u03C3\u03C5\u03B3\u03BA\u03B5\u03BA\u03C1\u03B9\u03BC\u03AD\u03BD\u03B5\u03C2 \u03C3\u03C5\u03BD\u03B8\u03AE\u03BA\u03B5\u03C2. \u03A4\u03B1 \u03C0\u03C1\u03BF\u03B2\u03BB\u03AE\u03BC\u03B1\u03C4\u03B1 \u03C3\u03C4\u03B7 \u03B4\u03C1\u03B5\u03C0\u03B1\u03BD\u03BF\u03BA\u03C5\u03C4\u03C4\u03B1\u03C1\u03B9\u03BA\u03AE \u03BD\u03CC\u03C3\u03BF \u03BE\u03B5\u03BA\u03B9\u03BD\u03BF\u03CD\u03BD \u03C3\u03C5\u03BD\u03AE\u03B8\u03C9\u03C2 \u03BC\u03B5\u03C4\u03B1\u03BE\u03CD \u03C4\u03B7\u03C2 \u03B7\u03BB\u03B9\u03BA\u03AF\u03B1\u03C2 \u03C4\u03C9\u03BD 5 \u03BA\u03B1\u03B9 6 \u03BC\u03B7\u03BD\u03CE\u03BD. \u039C\u03C0\u03BF\u03C1\u03BF\u03CD\u03BD \u03BD\u03B1 \u03B1\u03BD\u03B1\u03C0\u03C4\u03C5\u03C7\u03B8\u03BF\u03CD\u03BD \u03C0\u03C1\u03BF\u03B2\u03BB\u03AE\u03BC\u03B1\u03C4\u03B1 \u03C5\u03B3\u03B5\u03AF\u03B1\u03C2, \u03CC\u03C0\u03C9\u03C2 \u03BA\u03C1\u03AF\u03C3\u03B5\u03B9\u03C2 \u03C0\u03CC\u03BD\u03BF\u03C5 (\"\u03B4\u03C1\u03B5\u03C0\u03B1\u03BD\u03BF\u03BA\u03C5\u03C4\u03C4\u03B1\u03C1\u03B9\u03BA\u03AE \u03BA\u03C1\u03AF\u03C3\u03B7 (sickle cell crisis\")), \u03B1\u03BD\u03B1\u03B9\u03BC\u03AF\u03B1, \u03B4\u03B1\u03BA\u03C4\u03C5\u03BB\u03AF\u03C4\u03B9\u03B4\u03B1 (\u03B4\u03B9\u03CC\u03B3\u03BA\u03C9\u03C3\u03B7 \u03C4\u03C9\u03BD \u03C7\u03B5\u03C1\u03B9\u03CE\u03BD \u03BA\u03B1\u03B9 \u03C4\u03C9\u03BD \u03C0\u03BF\u03B4\u03B9\u03CE\u03BD), \u03B2\u03B1\u03BA\u03C4\u03B7\u03C1\u03B9\u03B1\u03BA\u03AD\u03C2 \u03BB\u03BF\u03B9\u03BC\u03CE\u03BE\u03B5\u03B9\u03C2 \u03BA\u03B1\u03B9 \u03B5\u03B3\u03BA\u03B5\u03C6\u03B1\u03BB\u03B9\u03BA\u03CC \u03B5\u03C0\u03B5\u03B9\u03C3\u03CC\u03B4\u03B9\u03BF. \u039C\u03C0\u03BF\u03C1\u03B5\u03AF \u03BD\u03B1 \u03B1\u03BD\u03B1\u03C0\u03C4\u03C5\u03C7\u03B8\u03B5\u03AF \u03C7\u03C1\u03CC\u03BD\u03B9\u03BF\u03C2 \u03C0\u03CC\u03BD\u03BF\u03C2 \u03BA\u03B1\u03B8\u03CE\u03C2 \u03B3\u03B5\u03C1\u03BD\u03AC\u03BD \u03C4\u03B1 \u03AC\u03C4\u03BF\u03BC\u03B1. \u039F \u03BC\u03AD\u03C3\u03BF\u03C2 \u03CC\u03C1\u03BF\u03C2 \u03C0\u03C1\u03BF\u03C3\u03B4\u03CC\u03BA\u03B9\u03BC\u03BF\u03C5 \u03B6\u03C9\u03AE\u03C2"@el . "" . . "-1.893456E9"^^ . . . . "527"^^ . . . . . . . . . . "\u0421\u0435\u0440\u043F\u043E\u0432\u0438\u0434\u043D\u043E\u043A\u043B\u0435\u0442\u043E\u0447\u043D\u0430\u044F \u0430\u043D\u0435\u043C\u0438\u044F \u2014 \u043D\u0430\u0441\u043B\u0435\u0434\u0441\u0442\u0432\u0435\u043D\u043D\u0430\u044F \u0433\u0435\u043C\u043E\u0433\u043B\u043E\u0431\u0438\u043D\u043E\u043F\u0430\u0442\u0438\u044F, \u0441\u0432\u044F\u0437\u0430\u043D\u043D\u0430\u044F \u0441 \u0442\u0430\u043A\u0438\u043C \u043D\u0430\u0440\u0443\u0448\u0435\u043D\u0438\u0435\u043C \u0441\u0442\u0440\u043E\u0435\u043D\u0438\u044F \u0431\u0435\u043B\u043A\u0430 \u0433\u0435\u043C\u043E\u0433\u043B\u043E\u0431\u0438\u043D\u0430, \u043F\u0440\u0438 \u043A\u043E\u0442\u043E\u0440\u043E\u043C \u043E\u043D \u043F\u0440\u0438\u043E\u0431\u0440\u0435\u0442\u0430\u0435\u0442 \u043E\u0441\u043E\u0431\u043E\u0435 \u043A\u0440\u0438\u0441\u0442\u0430\u043B\u043B\u0438\u0447\u0435\u0441\u043A\u043E\u0435 \u0441\u0442\u0440\u043E\u0435\u043D\u0438\u0435. \u0424\u043E\u0440\u043C\u0430 \u0433\u0435\u043C\u043E\u0433\u043B\u043E\u0431\u0438\u043D\u0430 \u0431\u043E\u043B\u044C\u043D\u044B\u0445 \u2014 \u0442\u0430\u043A \u043D\u0430\u0437\u044B\u0432\u0430\u0435\u043C\u044B\u0439 \u0433\u0435\u043C\u043E\u0433\u043B\u043E\u0431\u0438\u043D S. \u042D\u0440\u0438\u0442\u0440\u043E\u0446\u0438\u0442\u044B, \u043D\u0435\u0441\u0443\u0449\u0438\u0435 \u0433\u0435\u043C\u043E\u0433\u043B\u043E\u0431\u0438\u043D S \u0432\u043C\u0435\u0441\u0442\u043E \u043D\u043E\u0440\u043C\u0430\u043B\u044C\u043D\u043E\u0433\u043E \u0433\u0435\u043C\u043E\u0433\u043B\u043E\u0431\u0438\u043D\u0430 \u0410, \u0438\u043C\u0435\u044E\u0442 \u0445\u0430\u0440\u0430\u043A\u0442\u0435\u0440\u043D\u0443\u044E \u0441\u0435\u0440\u043F\u043E\u043E\u0431\u0440\u0430\u0437\u043D\u0443\u044E \u0444\u043E\u0440\u043C\u0443 (\u0444\u043E\u0440\u043C\u0443 \u0441\u0435\u0440\u043F\u0430), \u0437\u0430 \u0447\u0442\u043E \u044D\u0442\u0430 \u0444\u043E\u0440\u043C\u0430 \u0433\u0435\u043C\u043E\u0433\u043B\u043E\u0431\u0438\u043D\u043E\u043F\u0430\u0442\u0438\u0438 \u0438 \u043F\u043E\u043B\u0443\u0447\u0438\u043B\u0430 \u043D\u0430\u0437\u0432\u0430\u043D\u0438\u0435 \u0441\u0435\u0440\u043F\u043E\u0432\u0438\u0434\u043D\u043E\u043A\u043B\u0435\u0442\u043E\u0447\u043D\u043E\u0439 \u0430\u043D\u0435\u043C\u0438\u0438."@ru . . . . "Die Sichelzellkrankheit (auch Sichelzell(en)an\u00E4mie) oder Drepanozytose ist eine erbliche Erkrankung der roten Blutk\u00F6rperchen (Erythrozyten). Sie geh\u00F6rt zur Gruppe der H\u00E4moglobinopathien (St\u00F6rungen des H\u00E4moglobins) und f\u00FChrt zu einer korpuskul\u00E4ren h\u00E4molytischen An\u00E4mie. Bei den Betroffenen liegt eine Mutation der \u03B2-Kette des H\u00E4moglobins vor. Es k\u00F6nnen entweder alle \u03B2-Ketten betroffen sein (schwere, homozygote Form) oder nur ein Teil (mildere, heterozygote Form)."@de . . . . . . . . . . . . . . . . . "Dr\u00E9panocytose"@fr . . "\u0421\u0435\u0440\u043F\u043E\u043F\u043E\u0434\u0456\u0431\u043D\u043E\u043A\u043B\u0456\u0442\u0438\u043D\u043D\u0430 \u0430\u043D\u0435\u043C\u0456\u044F"@uk . "med"@en . . . . . . . . . "Niedokrwisto\u015B\u0107 sierpowata, anemia sierpowata (\u0142ac. anaemia drepanocytica, ang. sickle cell anemia) \u2013 rodzaj wrodzonej niedokrwisto\u015Bci spowodowanej nieprawid\u0142ow\u0105 budow\u0105 hemoglobiny. Mutacja punktowa w genie \u0142a\u0144cucha \u03B2 (HBB) hemoglobiny powoduje zmian\u0119 pojedynczego aminokwasu w sekwencji bia\u0142ka (z kwasu glutaminowego na walin\u0119, w pozycji 6 od ko\u0144ca NH2). Hemoglobin\u0119 z tak zmienion\u0105, nieprawid\u0142ow\u0105 struktur\u0105 I-rz\u0119dow\u0105 okre\u015Bla si\u0119 jako hemoglobin\u0119 S (HbS) w przeciwie\u0144stwie do normalnej, wyst\u0119puj\u0105cej u doros\u0142ych hemoglobiny A (HbA). Hemoglobina S charakteryzuje si\u0119 zmienionymi w por\u00F3wnaniu z hemoglobin\u0105 A w\u0142asno\u015Bciami fizykochemicznymi. Chorob\u0119 dziedziczy si\u0119 w spos\u00F3b autosomalny (nie jest sprz\u0119\u017Cona z p\u0142ci\u0105) recesywny, z allelem kodominuj\u0105cym. Ten rodzaj dziedziczenia polega na tym, \u017Ce nosiciele tylko jednej kopii wadliwego genu (heterozygoty) w normalnych warunkach nie maj\u0105 objaw\u00F3w klinicznych, jednak ich erytrocyty zawieraj\u0105 oko\u0142o 40% HbS. Heterozygoty s\u0105 r\u00F3wnie\u017C w du\u017Cym stopniu odporne na malari\u0119. Zjawisko takie nazywa si\u0119 przewag\u0105 heterozygot lub naddominacj\u0105. Naddominacja powoduje, \u017Ce na terenach wyst\u0119powania malarii mutacja powoduj\u0105ca anemi\u0119 sierpowat\u0105 utrzymuje si\u0119 w populacji."@pl . . . "Sichelzellkrankheit"@de . . . . . . . . "Chronic pain,stroke,aseptic bone necrosis,gallstones,leg ulcers,priapism,pulmonary hypertension, vision problems,kidney problems" . . . . "232" . . . "\uACB8\uD615 \uC801\uD608\uAD6C \uBE48\uD608\uC99D"@ko . . . . "Sikkelcelanemie"@nl . . . . "La anemia de c\u00E9lulas falciformes,\u200B llamada tambi\u00E9n drepanocitosis o anemia drepanoc\u00EDtica, es una alteraci\u00F3n de la sangre que hace que los gl\u00F3bulos rojos se deformen hasta adquirir apariencia de hoz (de ah\u00ED el nombre de \u00ABeritrocitos falciformes\u00BB o \u00ABdrepanocitos\u00BB). Esta deformidad estructural entorpece la circulaci\u00F3n sangu\u00EDnea y causa en el enfermo obstrucciones vasculares, microinfartos en m\u00FAltiples \u00F3rganos y hem\u00F3lisis. Se trata de una anemia cr\u00F3nica y grave que se diagnostica mediante el estudio de la hemoglobina, la mol\u00E9cula que transporta el ox\u00EDgeno en la sangre.\u200B"@es . "NBK1377" . . "D57."@en . "La serpo\u0109ela anemio estas genetika malsano, kiam korpo de malsanulo formas nekutiman hemoglobinon kaj tiel serpoformajn eritrocitojn, kiujn la le\u016Dkocitoj kaptas kaj solvas (hemolizo)."@eo . . . . . . . . "\uB0AB \uBAA8\uC591 \uC801\uD608\uAD6C \uBE48\uD608\uC99D(\uC601\uC5B4: sickle-cell anemia) \uB610\uB294 \uACB8\uC0C1 \uC801\uD608\uAD6C \uBE48\uD608\uC99D, \uACB8\uD615 \uC801\uD608\uAD6C \uBE48\uD608\uC99D\uC740 \uC720\uC804\uC790 \uC774\uC0C1\uC5D0 \uB530\uB978 \uD5E4\uBAA8\uAE00\uB85C\uBE48 \uB2E8\uBC31\uC9C8\uC758 \uC544\uBBF8\uB178\uC0B0 \uC11C\uC5F4 \uC911 \uD558\uB098\uAC00 \uC815\uC0C1\uC758 \uAC83\uACFC \uB2E4\uB974\uAC8C \uBCC0\uC774\uD558\uC5EC \uC801\uD608\uAD6C\uAC00 \uB0AB\uBAA8\uC591\uC73C\uB85C \uBCC0\uD558\uC5EC \uC744 \uC720\uBC1C\uD558\uB294 \uC720\uC804\uBCD1\uC774\uB2E4. \uC544\uD504\uB9AC\uCE74\uC758 \uD751\uC778\uC758 \uC77C\uBD80\uC5D0\uC11C \uD754\uD788 \uB098\uD0C0\uB09C\uB2E4. \uB9D0\uB77C\uB9AC\uC544\uC5D0 \uC800\uD56D\uC131\uC774 \uC788\uC5B4 \uC774 \uC774\uC0C1 \uC720\uC804\uC790\uB97C \uAC00\uC9C4 \uC0AC\uB78C\uC740 \uB9D0\uB77C\uB9AC\uC544\uC5D0\uB294 \uC798 \uAC78\uB9AC\uC9C0 \uC54A\uC9C0\uB9CC \uC801\uD608\uAD6C\uAC00 \uC27D\uAC8C \uD30C\uAD34\uB418\uC5B4 \uC2EC\uAC01\uD55C \uBE48\uD608\uC744 \uC720\uBC1C\uD558\uB294 \uC9C8\uBCD1\uC774\uB2E4. \uB0AB \uBAA8\uC591 \uC801\uD608\uAD6C \uBE48\uD608, \uD5E4\uB9AD \uBE48\uD608(Herrick's anemia)\uB4F1\uC73C\uB85C\uB3C4 \uBD88\uB9B0\uB2E4. \uADF8\uB7EC\uB098 \uC774 \uC720\uC804\uC801 \uC774\uC0C1\uC740 \uB9D0\uB77C\uB9AC\uC544 \uC6D0\uCDA9\uC5D0 \uB300\uD574 \uAC15\uD55C \uC800\uD56D\uB825\uC744 \uBCF4\uC774\uAC8C \uB418\uB294\uB370, \uB0AB \uBAA8\uC591 \uC801\uD608\uAD6C\uC758 \uB9C9\uC740 \uBB3C\uC9C8\uC758 \uD22C\uACFC\uC131\uC774 \uBE44\uC815\uC0C1\uC801\uC774\uC5B4\uC11C \uC801\uD608\uAD6C \uB0B4\uC5D0 \uB18D\uCD95\uB41C \uCE7C\uB968 \uC774\uC628(K+)\uC774 \uC138\uD3EC \uBC16\uC73C\uB85C \uBE60\uC838 \uB098\uAC00\uBBC0\uB85C \uC774 \uB300\uC0AC \uC7A5\uC560\uB97C \uBC1B\uAE30 \uB54C\uBB38\uC774\uB2E4. \uADF8\uB9AC\uACE0 \uC774 \uB300\uB9BD \uC720\uC804\uC790\uB97C \uC5F4\uC131 \uB3D9\uD615\uC811\uD569(\uD638\uBAA8)\uC774 \uC544\uB2CC \uC774\uD615\uC811\uD569(\uD5E4\uD14C\uB85C)\uC73C\uB85C \uAC00\uC9C0\uACE0 \uC788\uC744 \uACBD\uC6B0, \uBE48\uD608 \uC99D\uC0C1\uC774 \uC0DD\uC874\uC5D0 \uC704\uD611\uC801\uC77C \uC815\uB3C4\uB85C \uC2EC\uD558\uAC8C \uB098\uD0C0\uB098\uC9C0 \uC54A\uB294\uB2E4. \uB530\uB77C\uC11C \uB9D0\uB77C\uB9AC\uC544\uAC00 \uC720\uD589\uD558\uB294 \uC544\uD504\uB9AC\uCE74 \uB4F1\uC758 \uC9C0\uC5ED\uC5D0\uC11C\uB294 \uC774 \uC720\uC804\uC9C8\uD658\uC744 \uC774\uD615\uC811\uD569\uC73C\uB85C \uAC00\uC9C0\uACE0 \uC788\uB294 \uACBD\uC6B0 \uC0DD\uC874\uC5D0 \uC720\uB9AC\uD558\uAC8C \uB41C\uB2E4."@ko . . . "\u938C\u72B6\u8D64\u8840\u7403\u75C7\uFF08\u304B\u307E\u3058\u3087\u3046\u305B\u3063\u3051\u3063\u304D\u3085\u3046\u3057\u3087\u3046\uFF09\u306F\u907A\u4F1D\u6027\u306E\u8CA7\u8840\u75C5\u3067\u3001\u8D64\u8840\u7403\u306E\u5F62\u72B6\u304C\u938C\u72B6\u306B\u306A\u308A\u9178\u7D20\u904B\u642C\u6A5F\u80FD\u304C\u4F4E\u4E0B\u3057\u3066\u8D77\u3053\u308B\u8CA7\u8840\u75C7\u3002\u938C\u72B6\u8D64\u8840\u7403\u8CA7\u8840\u75C7\u3068\u3082\u3044\u3046\u3002ICD-10\u5206\u985E\u3067\u306FD57\u3002\u307B\u3068\u3093\u3069\u304C\u9ED2\u4EBA\u306B\u767A\u75C7\u3057\u4E3B\u306B\u30A2\u30D5\u30EA\u30AB\u3001\u5730\u4E2D\u6D77\u6CBF\u5CB8\u3001\u4E2D\u8FD1\u6771\u3001\u30A4\u30F3\u30C9\u5317\u90E8\u3067\u898B\u3089\u308C\u308B\u3002 \u5E38\u67D3\u8272\u4F53\u4E0D\u5B8C\u5168\u512A\u6027\u907A\u4F1D\u3092\u3059\u308B\u3002\u73FE\u5728\uFF0C\u907A\u4F1D\u5B50\u578B\u304C\u30DB\u30E2\u63A5\u5408\u578B\u60A3\u8005\u306E\u4E88\u5F8C\u306F\u6539\u5584\u3057\u3066\u304A\u308A\u3001\u5E73\u5747\u751F\u5B58\u671F\u9593\u304C60\u6B73\u524D\u5F8C\u3068\u306A\u3063\u3066\u3044\u308B\u3002\u3057\u304B\u3057\u305D\u306E\u7D50\u679C\u3001\u6162\u6027\u7684\u306A\u591A\u81D3\u5668\u969C\u5BB3\u3092\u6709\u3059\u308B\u60A3\u8005\u306E\u5272\u5408\u306F\u5897\u52A0\u3057\u3066\u3044\u308B\u3002\u4E00\u822C\u7684\u306A\u6B7B\u56E0\u306F\uFF0C\u6025\u6027\u80F8\u90E8\u75C7\u5019\u7FA4\uFF0C\u4F75\u767A\u611F\u67D3\u75C7\uFF0C\u80BA\u585E\u6813\u75C7\uFF0C\u91CD\u8981\u81D3\u5668\u306E\u6897\u585E\uFF0C\u304A\u3088\u3073\u6162\u6027\u814E\u81D3\u75C5\u3067\u3042\u308B\u3002\u907A\u4F1D\u5B50\u578B\u304C\u30D8\u30C6\u30ED\u63A5\u5408\u578B\u306E\u5834\u5408\u3001\u4F4E\u9178\u7D20\u72B6\u614B\u3067\u306E\u307F\u767A\u75C7\u3059\u308B\u306E\u3067\u901A\u5E38\u306E\u65E5\u5E38\u751F\u6D3B\u306F\u55B6\u3081\u308B\u3002"@ja . . . "Vaccination, antibiotics, high fluid intake, folic acid supplementation, pain medication, blood transfusions"@en . . . . . . "\u0421\u0435\u0440\u043F\u043E\u0432\u0438\u0434\u043D\u043E\u043A\u043B\u0435\u0442\u043E\u0447\u043D\u0430\u044F \u0430\u043D\u0435\u043C\u0438\u044F \u2014 \u043D\u0430\u0441\u043B\u0435\u0434\u0441\u0442\u0432\u0435\u043D\u043D\u0430\u044F \u0433\u0435\u043C\u043E\u0433\u043B\u043E\u0431\u0438\u043D\u043E\u043F\u0430\u0442\u0438\u044F, \u0441\u0432\u044F\u0437\u0430\u043D\u043D\u0430\u044F \u0441 \u0442\u0430\u043A\u0438\u043C \u043D\u0430\u0440\u0443\u0448\u0435\u043D\u0438\u0435\u043C \u0441\u0442\u0440\u043E\u0435\u043D\u0438\u044F \u0431\u0435\u043B\u043A\u0430 \u0433\u0435\u043C\u043E\u0433\u043B\u043E\u0431\u0438\u043D\u0430, \u043F\u0440\u0438 \u043A\u043E\u0442\u043E\u0440\u043E\u043C \u043E\u043D \u043F\u0440\u0438\u043E\u0431\u0440\u0435\u0442\u0430\u0435\u0442 \u043E\u0441\u043E\u0431\u043E\u0435 \u043A\u0440\u0438\u0441\u0442\u0430\u043B\u043B\u0438\u0447\u0435\u0441\u043A\u043E\u0435 \u0441\u0442\u0440\u043E\u0435\u043D\u0438\u0435. \u0424\u043E\u0440\u043C\u0430 \u0433\u0435\u043C\u043E\u0433\u043B\u043E\u0431\u0438\u043D\u0430 \u0431\u043E\u043B\u044C\u043D\u044B\u0445 \u2014 \u0442\u0430\u043A \u043D\u0430\u0437\u044B\u0432\u0430\u0435\u043C\u044B\u0439 \u0433\u0435\u043C\u043E\u0433\u043B\u043E\u0431\u0438\u043D S. \u042D\u0440\u0438\u0442\u0440\u043E\u0446\u0438\u0442\u044B, \u043D\u0435\u0441\u0443\u0449\u0438\u0435 \u0433\u0435\u043C\u043E\u0433\u043B\u043E\u0431\u0438\u043D S \u0432\u043C\u0435\u0441\u0442\u043E \u043D\u043E\u0440\u043C\u0430\u043B\u044C\u043D\u043E\u0433\u043E \u0433\u0435\u043C\u043E\u0433\u043B\u043E\u0431\u0438\u043D\u0430 \u0410, \u0438\u043C\u0435\u044E\u0442 \u0445\u0430\u0440\u0430\u043A\u0442\u0435\u0440\u043D\u0443\u044E \u0441\u0435\u0440\u043F\u043E\u043E\u0431\u0440\u0430\u0437\u043D\u0443\u044E \u0444\u043E\u0440\u043C\u0443 (\u0444\u043E\u0440\u043C\u0443 \u0441\u0435\u0440\u043F\u0430), \u0437\u0430 \u0447\u0442\u043E \u044D\u0442\u0430 \u0444\u043E\u0440\u043C\u0430 \u0433\u0435\u043C\u043E\u0433\u043B\u043E\u0431\u0438\u043D\u043E\u043F\u0430\u0442\u0438\u0438 \u0438 \u043F\u043E\u043B\u0443\u0447\u0438\u043B\u0430 \u043D\u0430\u0437\u0432\u0430\u043D\u0438\u0435 \u0441\u0435\u0440\u043F\u043E\u0432\u0438\u0434\u043D\u043E\u043A\u043B\u0435\u0442\u043E\u0447\u043D\u043E\u0439 \u0430\u043D\u0435\u043C\u0438\u0438."@ru . . "Anemia falciforme"@pt . . . . . . . . . "Sickle cell disease (SCD) is a group of blood disorders typically inherited from a person's parents. The most common type is known as sickle cell anaemia. It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. This leads to a rigid, sickle-like shape under certain circumstances. Problems in sickle cell disease typically begin around 5 to 6 months of age. A number of health problems may develop, such as attacks of pain (known as a sickle cell crisis), anemia, swelling in the hands and feet, bacterial infections and stroke. Long-term pain may develop as people get older. The average life expectancy in the developed world is 40 to 60 years. Sickle cell disease occurs when a person inherits two abnormal copies of the \u03B2-globin gene (HBB) that makes haemoglobin, one from each parent. This gene occurs in chromosome 11. Several subtypes exist, depending on the exact mutation in each haemoglobin gene. An attack can be set off by temperature changes, stress, dehydration, and high altitude. A person with a single abnormal copy does not usually have symptoms and is said to have sickle cell trait. Such people are also referred to as carriers. Diagnosis is by a blood test, and some countries test all babies at birth for the disease. Diagnosis is also possible during pregnancy. The care of people with sickle cell disease may include infection prevention with vaccination and antibiotics, high fluid intake, folic acid supplementation, and pain medication. Other measures may include blood transfusion and the medication hydroxycarbamide (hydroxyurea). A small percentage of people can be cured by a transplant of bone marrow cells. As of 2015, about 4.4 million people have sickle cell disease, while an additional 43 million have sickle cell trait. About 80% of sickle cell disease cases are believed to occur in Sub-Saharan Africa. It also occurs to a lesser degree in parts of India, Southern Europe, West Asia, North Africa and among people of African origin (sub-Saharan) living in other parts of the world. In 2015, it resulted in about 114,800 deaths. The condition was first described in the medical literature by American physician James B. Herrick in 1910. In 1949, its genetic transmission was determined by E. A. Beet and J. V. Neel. In 1954, the protective effect against malaria of sickle cell trait was described."@en . . "\u938C\u72B6\u8D64\u8840\u7403\u75C7"@ja . . . . . . . . . "000527" . . "282.6"^^ . . . . . . "-1.57788E7"^^ . "\u0421\u0435\u0440\u043F\u043E\u0432\u0438\u0434\u043D\u043E\u043A\u043B\u0435\u0442\u043E\u0447\u043D\u0430\u044F \u0430\u043D\u0435\u043C\u0438\u044F"@ru . "Genetic"@en . "La dr\u00E9panocytose, \u00E9galement appel\u00E9e an\u00E9mie falciforme, h\u00E9moglobinose S, et autrefois sickl\u00E9mie, est une maladie g\u00E9n\u00E9tique r\u00E9sultant d'une mutation sur un des g\u00E8nes codant l'h\u00E9moglobine. Cette affection peut notamment occasionner un retard du d\u00E9veloppement de l'enfant, des crises vasoocclusives, une pr\u00E9disposition aux infections bact\u00E9riennes et une an\u00E9mie h\u00E9molytique. Elle a \u00E9t\u00E9 d\u00E9crite pour la premi\u00E8re fois dans la litt\u00E9rature m\u00E9dicale en 1910 par le m\u00E9decin am\u00E9ricain James Herrick et sa transmission h\u00E9r\u00E9ditaire a \u00E9t\u00E9 \u00E9tablie en 1949 par James Neel. C'est la maladie g\u00E9n\u00E9tique la plus fr\u00E9quente dans le monde, avec environ 310 000 naissances concern\u00E9es chaque ann\u00E9e. Approximativement 80 % des cas de dr\u00E9panocytose se concentreraient en Afrique subsaharienne. La maladie est \u00E9galement assez fr\u00E9"@fr . . . "\u942E\u5200\u578B\u7D05\u8840\u7403\u75BE\u75C5\uFF08\u82F1\u8A9E\uFF1ASickle-cell disease, SCD\uFF09\u662F\u4E00\u7D44\u901A\u5E38\u7531\u96D9\u89AA\u907A\u50B3\u800C\u4F86\u7684\u8840\u6DB2\u75BE\u75C5\u3002\u5176\u4E2D\u6700\u5E38\u898B\u7684\u4E00\u7A2E\u985E\u578B\uFF0C\u53EB\u505A\u942E\u72C0\u7D05\u8840\u7403\u8CA7\u8840\u75C7\uFF08Sickle-cell anemia, SCA\uFF09\u3002\u8A72\u75BE\u75C5\u6703\u5F15\u8D77\u7D05\u8840\u7403\u4E2D\u7684\u8F09\u6C27\u8840\u7D05\u86CB\u767D\u7570\u5E38\u3002\u5728\u67D0\u7279\u5B9A\u7684\u60C5\u6CC1\u4E0B\uFF08\u901A\u5E38\u662F\u7F3A\u6C27\u72C0\u6CC1\uFF09\uFF0C\u7D05\u8840\u7403\u6703\u8B8A\u6210\u5805\u786C\u7684\u942E\u5200\u578B \u3002\u942E\u5200\u72C0\u7D05\u8840\u7403\u75BE\u75C5\u7684\u554F\u984C\u901A\u5E38\u6703\u5728\u4E94\u5230\u516D\u500B\u6708\u9F61\u6642\u767C\u4F5C\u3002\u60A3\u8005\u53EF\u80FD\u6703\u51FA\u73FE\u591A\u9805\u5065\u5EB7\u554F\u984C\uFF0C\u4F8B\u5982\u7A81\u767C\u7684\u75BC\u75DB\uFF08\u942E\u5200\u578B\u8CA7\u8840\u5371\u6A5F\uFF0Csickle-cell crisis\uFF09\u3001\u8CA7\u8840\u3001\u7D30\u83CC\u611F\u67D3\u8207\u4E2D\u98A8\u3002\u7576\u60A3\u8005\u5E74\u7D00\u7A0D\u9577\u4E4B\u5F8C\u53EF\u80FD\u6703\u51FA\u73FE\u6162\u6027\u75BC\u75DB\u3002\u5728\u5DF2\u958B\u767C\u570B\u5BB6\u4E2D\u7684\u60A3\u8005\u5E73\u5747\u58FD\u547D\u70BA40\u523060\u6B72\u3002 \u942E\u5200\u578B\u7D05\u8840\u7403\u75BE\u75C5\u901A\u5E38\u767C\u75C5\u65BC\u64C1\u6709\u5169\u500B\u4E0D\u6B63\u5E38\u8840\u7D05\u7D20\u57FA\u56E0\u7684\u4EBA\uFF0C\u5F9E\u7236\u6BCD\u96D9\u65B9\u5404\u907A\u50B3\u904E\u4F86\u4E00\u500B\u4E0D\u6B63\u5E38\u7684\u57FA\u56E0\u3002\u7A81\u8B8A\u7684\u8840\u7D05\u7D20\u57FA\u56E0\u5B58\u5728\u8A31\u591A\u4E9E\u578B\uFF0C\u5176\u5206\u985E\u53D6\u6C7A\u65BC\u5176\u57FA\u56E0\u7684\u3002\u7576\u6EAB\u5EA6\u6539\u8B8A\uFF0C\u627F\u53D7\u58D3\u529B\uFF0C\u812B\u6C34\u6216\u662F\u8655\u65BC\u9AD8\u6D77\u62D4\u6642\u6703\u51FA\u73FE\u8EAB\u9AD4\u4E0D\u9069\u7684\u7DCA\u6025\u75C7\u72C0\u3002\u5982\u679C\u53EA\u6709\u4E00\u500B\u4E0D\u6B63\u5E38\u57FA\u56E0\u7684\u4EBA\u901A\u5E38\u4E0D\u6703\u6709\u3002\u9019\u985E\u578B\u7684\u4EBA\u901A\u5E38\u88AB\u8996\u70BA \u3002\u6AA2\u9A57\u662F\u5426\u6709\u942E\u5200\u578B\u7D05\u8840\u7403\u75BE\u75C5\u901A\u5E38\u662F\u85C9\u7531\u8840\u6DB2\u6AA2\u67E5\u5F97\u77E5\uFF0C\u6709\u4E9B\u570B\u5BB6\u5728\u65B0\u751F\u5152\u51FA\u751F\u4E4B\u5F8C\u4FBF\u6703\u9032\u884C\u6AA2\u9A57 \uFF0C\u5728\u61F7\u5B55\u6642\u4E5F\u6709\u6A5F\u6703\u53EF\u4EE5\u9A57\u51FA\u80CE\u5152\u662F\u5426\u6709\u942E\u5200\u578B\u7D05\u8840\u7403\u75BE\u75C5\u3002 \u7167\u8B77\u942E\u5200\u578B\u7D05\u8840\u7403\u75BE\u75C5\u60A3\u8005\u7684\u65B9\u5F0F\u5305\u542B\u75AB\u82D7\u548C\u6297\u751F\u7D20\u4E4B\u4F7F\u7528\u3001\u591A\u559D\u6C34\u3001\u88DC\u5145\u8449\u9178\u4EE5\u53CA\u6B62\u75DB\u5291\u3002\u5176\u4ED6\u65B9\u6CD5\u5305\u62EC\u8F38\u8840\u548C\u3002\u4E00\u5C0F\u90E8\u5206\u7684\u4EBA\u53EF\u4EE5\u5229\u7528\u4F86\u9032\u884C\u6CBB\u7642\u3002"@zh . . . . . "C15.378.071.141.150.150"@en . . "131451"^^ . .