. . . . "Urine"@en . . . . . . "Zopiclon is een slaapmiddel dat in 1987 werd ge\u00EFntroduceerd. Het middel is ook bekend onder de merknaam Imovane en wordt door op de markt gebracht. Diverse andere fabrikanten produceren een generieke (merkloze) versie. Hoewel Z-slaapmiddelen, zoals zolpidem en zopiclon de meest voorgeschreven slaapmiddelen ter wereld zijn, werken deze middelen volgens recent onderzoek waarschijnlijk nauwelijks beter dan een placebo. De effectiviteit van deze groep slaapmiddelen zou overschat zijn geweest en de bijwerkingen onderschat door publicatiebias."@nl . "DB01198"@en . . "3"^^ . . . . . . "GBBSUAFBMRNDJC-UHFFFAOYSA-N"@en . . "135400" . . "La zopiclona es un f\u00E1rmaco an\u00E1logo de las benzodiazepinas, tambi\u00E9n conocidos como F\u00E1rmacos Z, siendo \u00E9sta una ciclopirrolona, e imitando en parte la estructura del anillo pirid\u00EDnico. Se une al complejo GABA - Cl por un sitio distinto que las benzodiazepinas Al igual que otros an\u00E1logos de benzodiazepinas, se metabolizan fundamentalmente en el h\u00EDgado, lo que desaconseja su utilizaci\u00F3n a enfermos hep\u00E1ticos y se usa fundamentalmente como hipn\u00F3tico de elecci\u00F3n ya que conserva las fases REM del sue\u00F1o."@es . . "5735"^^ . . "D01372" . "\u0632\u0648\u0628\u064A\u0643\u0644\u0648\u0646 (\u0627\u0644\u0623\u0633\u0645\u0627\u0621 \u0627\u0644\u062A\u062C\u0627\u0631\u064A\u0629 \u0632\u064A\u0645\u0648\u0641\u0627\u0646 \u0648\u0625\u064A\u0645\u0648\u0641\u0627\u0646) \u0647\u0648 \u0623\u062D\u062F \u0627\u0644\u0644\u0627\u0628\u0646\u0632\u0648\u062F\u064A\u0627\u0632\u064A\u0628\u064A\u0646\u0627\u062A \u0627\u0644\u0645\u0646\u0648\u0645\u0629 \u0627\u0644\u0645\u0633\u062A\u062E\u062F\u0645\u0629 \u0641\u064A \u0639\u0644\u0627\u062C \u0627\u0644\u0623\u0631\u0642. \u0648\u0647\u0648 \u0623\u062D\u062F \u060C \u0627\u0644\u062A\u064A \u062A\u0632\u064A\u062F \u0645\u0646 \u0627\u0644\u0627\u0646\u062A\u0642\u0627\u0644 \u0627\u0644\u0637\u0628\u064A\u0639\u064A \u0644\u0644\u0646\u0627\u0642\u0644 \u0627\u0644\u0639\u0635\u0628\u064A \u062D\u0645\u0636 \u0627\u0644\u063A\u0627\u0645\u0627-\u0623\u0645\u064A\u0646\u0648\u0628\u064A\u0648\u062A\u064A\u0631\u064A\u0643 \u0641\u064A \u0627\u0644\u062C\u0647\u0627\u0632 \u0627\u0644\u0639\u0635\u0628\u064A \u0627\u0644\u0645\u0631\u0643\u0632\u064A\u060C \u0643\u0645\u0627 \u062A\u0641\u0639\u0644 \u0627\u0644\u0628\u0646\u0632\u0648\u062F\u064A\u0627\u0632\u064A\u0628\u064A\u0646\u0627\u062A\u060C \u0648\u0644\u0643\u0646 \u0628\u0637\u0631\u064A\u0642\u0629 \u0645\u062E\u062A\u0644\u0641\u0629."@ar . . . "Imovane, Zimovane, Dopareel, others"@en . . . . "Zopiklon (s\u00E4ljs \u00E4ven under varunamnen Zopiclon, Zopiclone, Imovane och Zimovane) \u00E4r en l\u00E4kemedelssubstans som framf\u00F6rallt anv\u00E4nds f\u00F6r behandling av tillf\u00E4lliga s\u00F6mnbesv\u00E4r. Zopiklon \u00E4r ett s\u00F6mnmedel vilket i likhet med bensodiazepiner p\u00E5verkar ett system i hj\u00E4rnan som kallas f\u00F6r GABA-receptorsystemet. GABA \u00E4r ett \u00E4mne som finns naturligt i kroppen och som har en lugnande, \u00E5ngestd\u00E4mpande och s\u00F6mngivande verkan. Zopiklon f\u00F6rst\u00E4rker GABA:s s\u00F6mngivande effekt. Det g\u00F6r att man l\u00E4ttare kan somna in, att man vaknar f\u00E4rre g\u00E5nger p\u00E5 natten och att man kan sova l\u00E4ngre p\u00E5 morgonen."@sv . . . "Zopiclon"@de . . . . "N05"@en . . "Imovane, Zimovane, Dopareel, others"@en . . "O=CN4CCNCC4"@en . . "ZPC"@en . "17"^^ . . . . . . . . "5533"^^ . . "Zopiclona (DCI; nomes comerciais: Somnosan, Imovane, entre outros) \u00E9 um medicamento hipn\u00F3tico utilizado para induzir e manter o sono. Pertence \u00E0 classe dos n\u00E3o benzodiazep\u00EDnicos, similar aos benzodiazep\u00EDnicos, por\u00E9m com menor potencial de causar depend\u00EAncia."@pt . . . . . . "32315" . "\u0417\u043E\u043F\u0456\u043A\u043B\u043E\u043D"@uk . . . . . . . "Lo zopiclone \u00E8 un farmaco sedativo ad azione ipnotica con attivit\u00E0 ansiolitica, anticonvulsivante e miorilassante. Possiede un profilo farmacologico simile a quello delle benzodiazepine, ma una struttura chimica diversa (lo zopiclone appartiene alla classe dei ).Lo zopiclone agisce in maniera selettiva a livello dei siti di legame delle benzodiazepine presenti sul recettore di tipo A dell'acido \u03B3-amminobutirrico (GABA), principale neurotrasmettitore con funzione inibitoria; tale interazione determina l'apertura dei canali del cloro e un potenziamento della trasmissione GABAergica a livello centrale."@it . . "6"^^ . . . . "Rx-only"@en . . . . . . . . . . "\u0632\u0648\u0628\u064A\u0643\u0644\u0648\u0646"@ar . . . "Zopiclon is een slaapmiddel dat in 1987 werd ge\u00EFntroduceerd. Het middel is ook bekend onder de merknaam Imovane en wordt door op de markt gebracht. Diverse andere fabrikanten produceren een generieke (merkloze) versie. Hoewel Z-slaapmiddelen, zoals zolpidem en zopiclon de meest voorgeschreven slaapmiddelen ter wereld zijn, werken deze middelen volgens recent onderzoek waarschijnlijk nauwelijks beter dan een placebo. De effectiviteit van deze groep slaapmiddelen zou overschat zijn geweest en de bijwerkingen onderschat door publicatiebias."@nl . . . . "Schedule IV"@en . "03A5ORL08Q" . . . "\u0417\u043E\u043F\u0438\u043A\u043B\u043E\u043D (Zopiclone) \u2014 \u043D\u0435\u0431\u0435\u043D\u0437\u043E\u0434\u0438\u0430\u0437\u0435\u043F\u0438\u043D\u043E\u0432\u043E\u0435 \u043B\u0435\u043A\u0430\u0440\u0441\u0442\u0432\u0435\u043D\u043D\u043E\u0435 \u0441\u0440\u0435\u0434\u0441\u0442\u0432\u043E, \u043F\u0440\u0438\u043C\u0435\u043D\u044F\u0435\u043C\u043E\u0435 \u0434\u043B\u044F \u043B\u0435\u0447\u0435\u043D\u0438\u044F \u0431\u0435\u0441\u0441\u043E\u043D\u043D\u0438\u0446\u044B, \u043E\u0442\u043D\u043E\u0441\u0438\u0442\u0441\u044F \u043A \u043A\u043B\u0430\u0441\u0441\u0443 \u0446\u0438\u043A\u043B\u043E\u043F\u0438\u0440\u0440\u043E\u043B\u043E\u043D\u043E\u0432. \u041D\u0435\u0441\u043C\u043E\u0442\u0440\u044F \u043D\u0430 \u043C\u043E\u043B\u0435\u043A\u0443\u043B\u044F\u0440\u043D\u043E\u0435 \u043E\u0442\u043B\u0438\u0447\u0438\u0435 \u043E\u0442 \u0431\u0435\u043D\u0437\u043E\u0434\u0438\u0430\u0437\u0435\u043F\u0438\u043D\u043E\u0432, \u043E\u0431\u043B\u0430\u0434\u0430\u0435\u0442 \u0441\u0445\u043E\u0436\u0438\u043C \u0444\u0430\u0440\u043C\u0430\u043A\u043E\u043B\u043E\u0433\u0438\u0447\u0435\u0441\u043A\u0438\u043C \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435\u043C."@ru . . . . . "Lo zopiclone \u00E8 un farmaco sedativo ad azione ipnotica con attivit\u00E0 ansiolitica, anticonvulsivante e miorilassante. Possiede un profilo farmacologico simile a quello delle benzodiazepine, ma una struttura chimica diversa (lo zopiclone appartiene alla classe dei ).Lo zopiclone agisce in maniera selettiva a livello dei siti di legame delle benzodiazepine presenti sul recettore di tipo A dell'acido \u03B3-amminobutirrico (GABA), principale neurotrasmettitore con funzione inibitoria; tale interazione determina l'apertura dei canali del cloro e un potenziamento della trasmissione GABAergica a livello centrale."@it . "\u30BE\u30D4\u30AF\u30ED\u30F3\uFF08\u82F1\u8A9E: Zopiclone\uFF09\u306F\u3001\u306E\u7761\u7720\u969C\u5BB3\u6539\u5584\u5264\u3067\u3042\u308A\u3001\u975E\u30D9\u30F3\u30BE\u30B8\u30A2\u30BC\u30D4\u30F3\u7CFB\u306E\u8D85\u77ED\u6642\u9593\u4F5C\u7528\u578B\u7761\u7720\u85AC\u3068\u3057\u3066\u77E5\u3089\u308C\u3066\u3044\u308B\u3002GABA\u53D7\u5BB9\u4F53\u3078\u5F71\u97FF\u3059\u308B\u3053\u3068\u3067GABA\u7CFB\u306E\u6291\u5236\u6A5F\u69CB\u3092\u5897\u5F37\u3059\u308B\u70B9\u3067\u306F\u30D9\u30F3\u30BE\u30B8\u30A2\u30BC\u30D4\u30F3\u7CFB\u306E\u85AC\u7269\u3068\u4F3C\u3066\u3044\u308B\u3002\u7761\u7720\u3078\u306E\u5F71\u97FF\u3067\u306F\u6539\u826F\u3055\u308C\u3066\u3044\u308B\u3002\u65E5\u672C\u3067\u306F1989\u5E74\u304B\u3089\u30A2\u30E2\u30D0\u30F3\u304C\u8CA9\u58F2\u3055\u308C\u3001\u5F8C\u767A\u533B\u85AC\u54C1\u3082\u5B58\u5728\u3059\u308B\u3002\u3046\u3061\u85AC\u52B9\u3092\u6709\u3059\u308B\u93E1\u50CF\u7570\u6027\u4F53\u3092\u5206\u5225\u3057\u305F\u85AC\u5264\u304C\u30A8\u30B9\u30BE\u30D4\u30AF\u30ED\u30F3\uFF08\u30EB\u30CD\u30B9\u30BF\uFF09\u3067\u3042\u308B\u3002 \u9023\u7528\u306B\u3088\u308A\u4F9D\u5B58\u75C7\u3001\u6025\u6FC0\u306A\u91CF\u306E\u6E1B\u5C11\u306B\u3088\u308A\u96E2\u8131\u75C7\u72B6\u3092\u751F\u3058\u308B\u3053\u3068\u304C\u3042\u308B\u3002\u85AC\u6A5F\u6CD5\u306E\u7FD2\u6163\u6027\u533B\u85AC\u54C1\u3001\u9EBB\u85AC\u53CA\u3073\u5411\u7CBE\u795E\u85AC\u53D6\u7DE0\u6CD5\u306E\u7B2C\u4E09\u7A2E\u5411\u7CBE\u795E\u85AC\u306B\u6307\u5B9A\u3055\u308C\u3066\u3044\u308B\u3002"@ja . "230"^^ . "La zopiclone est un hypnotique de la famille chimique des cyclopyrrolones, apparent\u00E9 aux benzodiaz\u00E9pines. Elle est commercialis\u00E9e notamment sous le nom d'Imovane. La zopiclone poss\u00E8de des propri\u00E9t\u00E9s hypnotiques, s\u00E9datives, anxiolytiques, myorelaxantes et amn\u00E9siantes. Il est fabriqu\u00E9 par le laboratoire Sanofi depuis 1984."@fr . "18000.0"^^ . . . . "\u0417\u043E\u043F\u0438\u043A\u043B\u043E\u043D (Zopiclone) \u2014 \u043D\u0435\u0431\u0435\u043D\u0437\u043E\u0434\u0438\u0430\u0437\u0435\u043F\u0438\u043D\u043E\u0432\u043E\u0435 \u043B\u0435\u043A\u0430\u0440\u0441\u0442\u0432\u0435\u043D\u043D\u043E\u0435 \u0441\u0440\u0435\u0434\u0441\u0442\u0432\u043E, \u043F\u0440\u0438\u043C\u0435\u043D\u044F\u0435\u043C\u043E\u0435 \u0434\u043B\u044F \u043B\u0435\u0447\u0435\u043D\u0438\u044F \u0431\u0435\u0441\u0441\u043E\u043D\u043D\u0438\u0446\u044B, \u043E\u0442\u043D\u043E\u0441\u0438\u0442\u0441\u044F \u043A \u043A\u043B\u0430\u0441\u0441\u0443 \u0446\u0438\u043A\u043B\u043E\u043F\u0438\u0440\u0440\u043E\u043B\u043E\u043D\u043E\u0432. \u041D\u0435\u0441\u043C\u043E\u0442\u0440\u044F \u043D\u0430 \u043C\u043E\u043B\u0435\u043A\u0443\u043B\u044F\u0440\u043D\u043E\u0435 \u043E\u0442\u043B\u0438\u0447\u0438\u0435 \u043E\u0442 \u0431\u0435\u043D\u0437\u043E\u0434\u0438\u0430\u0437\u0435\u043F\u0438\u043D\u043E\u0432, \u043E\u0431\u043B\u0430\u0434\u0430\u0435\u0442 \u0441\u0445\u043E\u0436\u0438\u043C \u0444\u0430\u0440\u043C\u0430\u043A\u043E\u043B\u043E\u0433\u0438\u0447\u0435\u0441\u043A\u0438\u043C \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435\u043C."@ru . "3"^^ . . . . . . . . . . . "POM"@en . "Hepatic through CYP3A4 and CYP2E1"@en . . "Oral tablets, 3.75 mg or 7.5mg , 5 mg, 7.5 mg, or 10 mg"@en . "Zopiclone, sold under the brand name Imovane among others, is a nonbenzodiazepine used to treat difficulty sleeping. Zopiclone is molecularly distinct from benzodiazepine drugs and is classed as a cyclopyrrolone. However, zopiclone increases the normal transmission of the neurotransmitter gamma-aminobutyric acid (GABA) in the central nervous system, via modulating GABAA receptors similarly to the way benzodiazepine drugs do."@en . "\u0417\u043E\u043F\u0438\u043A\u043B\u043E\u043D"@ru . "Zopiclone"@en . . . "Zopiclon ist ein Arzneistoff aus der Wirkstoffgruppe der Cyclopyrrolone. Zopiclon wirkt in geringen Dosen schlafansto\u00DFend \u2013 in hohen Dosen schlaferzwingend. Auch wirkt es anxiolytisch, antikonvulsiv und muskelrelaxierend. In Deutschland wurde der Wirkstoff als Ximovan im M\u00E4rz 1990 zugelassen, die Markteinf\u00FChrung erfolgte im April 1991 durch Rh\u00F4ne-Poulenc."@de . "-6"^^ . . . . "Zopiklon"@sv . . . . . "75.0"^^ . . . . . . . . . . . "200"^^ . . . . . . "458773669"^^ . . . . . . . . . . . . "\u0632\u0648\u0628\u064A\u0643\u0644\u0648\u0646 (\u0627\u0644\u0623\u0633\u0645\u0627\u0621 \u0627\u0644\u062A\u062C\u0627\u0631\u064A\u0629 \u0632\u064A\u0645\u0648\u0641\u0627\u0646 \u0648\u0625\u064A\u0645\u0648\u0641\u0627\u0646) \u0647\u0648 \u0623\u062D\u062F \u0627\u0644\u0644\u0627\u0628\u0646\u0632\u0648\u062F\u064A\u0627\u0632\u064A\u0628\u064A\u0646\u0627\u062A \u0627\u0644\u0645\u0646\u0648\u0645\u0629 \u0627\u0644\u0645\u0633\u062A\u062E\u062F\u0645\u0629 \u0641\u064A \u0639\u0644\u0627\u062C \u0627\u0644\u0623\u0631\u0642. \u0648\u0647\u0648 \u0623\u062D\u062F \u060C \u0627\u0644\u062A\u064A \u062A\u0632\u064A\u062F \u0645\u0646 \u0627\u0644\u0627\u0646\u062A\u0642\u0627\u0644 \u0627\u0644\u0637\u0628\u064A\u0639\u064A \u0644\u0644\u0646\u0627\u0642\u0644 \u0627\u0644\u0639\u0635\u0628\u064A \u062D\u0645\u0636 \u0627\u0644\u063A\u0627\u0645\u0627-\u0623\u0645\u064A\u0646\u0648\u0628\u064A\u0648\u062A\u064A\u0631\u064A\u0643 \u0641\u064A 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"changed"@en . . . . . "-32400.0"^^ . . . . "C"@en . "Zopiclone"@fr . . "La zopiclone est un hypnotique de la famille chimique des cyclopyrrolones, apparent\u00E9 aux benzodiaz\u00E9pines. Elle est commercialis\u00E9e notamment sous le nom d'Imovane. La zopiclone poss\u00E8de des propri\u00E9t\u00E9s hypnotiques, s\u00E9datives, anxiolytiques, myorelaxantes et amn\u00E9siantes. Elle fait partie des hypnotiques les plus couramment utilis\u00E9s, avec le zolpidem et le zaleplon, tous les trois souvent qualifi\u00E9s de Z-Drugs. Leur usage a supplant\u00E9 celui des benzodiaz\u00E9pines en raison d'une \u00E9limination plus rapide ce qui \u00E9vite les effets r\u00E9siduels le lendemain matin. Il n'est donc pas n\u00E9cessairement efficace pour \u00E9viter les r\u00E9veils nocturnes le temps d'une nuit enti\u00E8re. Le traitement avec la zopiclone \u00E9tait originellement recommand\u00E9 pour une utilisation \u00E0 court terme, c\u2019est-\u00E0-dire pour deux semaines. En France, sa dur\u00E9e de prescription est officiellement limit\u00E9e \u00E0 4 semaines, de mani\u00E8re \u00E0 limiter les risques de d\u00E9pendance. Cependant, son utilisation \u00E0 long-terme demeure pertinente et pr\u00E9sente un profil d'effets secondaires limit\u00E9 compar\u00E9 aux hypnotiques \u00E0 dur\u00E9e d'\u00E9limination plus longue (cf. estazolam ou nitrazepam). Il est fabriqu\u00E9 par le laboratoire Sanofi depuis 1984."@fr . "Zopiklon (zopiclone, ATC N05 CF01) \u2013 organiczny zwi\u0105zek chemiczny, pochodna , stosowany jako lek nasenny."@pl . . . "7430"^^ . . . . . . "Zopiclon ist ein Arzneistoff aus der Wirkstoffgruppe der Cyclopyrrolone. Zopiclon wirkt in geringen Dosen schlafansto\u00DFend \u2013 in hohen Dosen schlaferzwingend. Auch wirkt es anxiolytisch, antikonvulsiv und muskelrelaxierend. In Deutschland wurde der Wirkstoff als Ximovan im M\u00E4rz 1990 zugelassen, die Markteinf\u00FChrung erfolgte im April 1991 durch Rh\u00F4ne-Poulenc."@de . . . "\u4F50\u5339\u514B\u9686"@zh . "D01372"@en . . . . . . . "Zopiklon (zopiclone, ATC N05 CF01) \u2013 organiczny zwi\u0105zek chemiczny, pochodna , stosowany jako lek nasenny."@pl . "Zopiclona"@pt . . "Zopiclona"@es . . . . . . "43200-80-2" . . "43200"^^ . . . . . "17"^^ . . . . "Zopiklon (s\u00E4ljs \u00E4ven under varunamnen Zopiclon, Zopiclone, Imovane och Zimovane) \u00E4r en l\u00E4kemedelssubstans som framf\u00F6rallt anv\u00E4nds f\u00F6r behandling av tillf\u00E4lliga s\u00F6mnbesv\u00E4r. Zopiklon \u00E4r ett s\u00F6mnmedel vilket i likhet med bensodiazepiner p\u00E5verkar ett system i hj\u00E4rnan som kallas f\u00F6r GABA-receptorsystemet. GABA \u00E4r ett \u00E4mne som finns naturligt i kroppen och som har en lugnande, \u00E5ngestd\u00E4mpande och s\u00F6mngivande verkan. Zopiklon f\u00F6rst\u00E4rker GABA:s s\u00F6mngivande effekt. Det g\u00F6r att man l\u00E4ttare kan somna in, att man vaknar f\u00E4rre g\u00E5nger p\u00E5 natten och att man kan sova l\u00E4ngre p\u00E5 morgonen. Risk f\u00F6r tillv\u00E4njning f\u00F6religger. Substansen \u00E4r narkotikaklassad i Sverige, ing\u00E5ende i f\u00F6rteckning V, vilket inneb\u00E4r att den inte omfattas av internationella narkotikakonventioner, men dock i stor utstr\u00E4ckning inom psykiatrin. Kemiskt namn: (RS)-4-Metyl-1-piperazinkarboxylsyre[6,7-dihydro-6-(5-klor-2-pyridyl)-7-oxo-5H-pyrrolo[3,4-b]pyrazin-5-yl]ester Biverkningar: d\u00E5sighet, muntorrhet, f\u00F6r\u00E4ndrat smaksinne (vanliga), huvudv\u00E4rk, oro och \u00E5ngest (mindre vanliga). En vanlig biverkan f\u00F6r personer som varit vakna under p\u00E5verkan av Zopiklon \u00E4r minnesluckor. Hallucinationer vid s\u00E5dana tillf\u00E4llen kan ocks\u00E5 f\u00F6rekomma. L\u00E4kemedlet kan i s\u00E4llsynta fall leda till beteendest\u00F6rningar, till exempel aggressivitet."@sv . . . . . "1102307"^^ . . . . . "DB01198" . . "\u30BE\u30D4\u30AF\u30ED\u30F3"@ja . . . . "1"^^ . . "2006-04-04"^^ . "1124081549"^^ . "Zopiclone-from-xtal-Mercury-3D-bs.png"@en . "C"@en . . "135400"^^ . . . . . "Zopiklon"@pl . "La zopiclona es un f\u00E1rmaco an\u00E1logo de las benzodiazepinas, tambi\u00E9n conocidos como F\u00E1rmacos Z, siendo \u00E9sta una ciclopirrolona, e imitando en parte la estructura del anillo pirid\u00EDnico. Se une al complejo GABA - Cl por un sitio distinto que las benzodiazepinas Al igual que otros an\u00E1logos de benzodiazepinas, se metabolizan fundamentalmente en el h\u00EDgado, lo que desaconseja su utilizaci\u00F3n a enfermos hep\u00E1ticos y se usa fundamentalmente como hipn\u00F3tico de elecci\u00F3n ya que conserva las fases REM del sue\u00F1o. Este an\u00E1logo conserva muchos de los efectos adversos de las benzodiazepinas, siendo los m\u00E1s remarcables, la amnesia anterograda, la tolerancia y la resaca generada tras su utilizaci\u00F3n Sin embargo no presenta efecto rebote tras la supresi\u00F3n del tratamiento.Dentro de sus contraindicaciones est\u00E1n Hipersensibilidad al principio activo, en insuficiencia respiratoria no grave. No es recomendable en ni\u00F1os menores de 15 a\u00F1os."@es . "1"^^ . . . . . "\u4F50\u5339\u514B\u9686\uFF08\u82F1\u8A9E\uFF1AZopiclone\uFF09\uFF0C\u53C8\u8B6F\u5511\u5421\u916E\uFF0C\u66B1\u7A31\u5B89\u7720\u85E5\uFF08\u82F1\u8A9E\uFF1AImovane\uFF09\uFF0C\u9999\u6E2F\u6FEB\u7528\u8005\u4FD7\u7A31\u5176\u767D\u74DC\u5B50\u3001\u53F0\u7063\u7A31\u6A02\u6BD4\u514B\u53C8\u7A31\u5B9C\u7720\u5B89\uFF1B\u662F\u4E00\u79CD\u6CBB\u7597\u5931\u7720\u836F\u7269\u3002 \u4F50\u5339\u514B\u9686\u96D6\u7136\u5728BZ1\u53D7\u9AD4\u4E0A\u7522\u751F\u4F5C\u7528\uFF0C\u5B83\u537B\u4E0D\u5C6C\u65BC\u82EF\u4E8C\u6C2E\u44EC\u985E\u85E5\u7269\uFF0C\u800C\u662F\u4E00\u7A2E\u884D\u751F\u7269\u3002"@zh . . . . . . . "Class C"@en . . . . . . "\u0417\u043E\u043F\u0456\u043A\u043B\u043E\u043D (\u0430\u043D\u0433\u043B. Zopiclone, \u043B\u0430\u0442. Zopiclonum) \u2014 \u0441\u0438\u043D\u0442\u0435\u0442\u0438\u0447\u043D\u0438\u0439 \u043B\u0456\u043A\u0430\u0440\u0441\u044C\u043A\u0438\u0439 \u0437\u0430\u0441\u0456\u0431, \u0449\u043E \u043D\u0430\u043B\u0435\u0436\u0438\u0442\u044C \u0434\u043E \u0433\u0440\u0443\u043F\u0438 \u0441\u043D\u043E\u0434\u0456\u0439\u043D\u0438\u0445 \u0456 \u0441\u0435\u0434\u0430\u0442\u0438\u0432\u043D\u0438\u0445 \u0437\u0430\u0441\u043E\u0431\u0456\u0432, \u0442\u0430 \u0454 \u043F\u043E\u0445\u0456\u0434\u043D\u0438\u043C , \u0441\u043F\u043E\u0440\u0456\u0434\u043D\u0435\u043D\u0438\u0439 \u0456\u0437 \u043F\u043E\u0445\u0456\u0434\u043D\u0438\u043C\u0438 \u0431\u0435\u043D\u0437\u043E\u0434\u0456\u0430\u0437\u0435\u043F\u0456\u043D\u0443. \u0417\u043E\u043F\u0456\u043A\u043B\u043E\u043D \u0437\u0430\u0441\u0442\u043E\u0441\u043E\u0432\u0443\u0454\u0442\u044C\u0441\u044F \u043F\u0435\u0440\u043E\u0440\u0430\u043B\u044C\u043D\u043E. \u0417\u043E\u043F\u0456\u043A\u043B\u043E\u043D \u0441\u0438\u043D\u0442\u0435\u0437\u043E\u0432\u0430\u043D\u0438\u0439 \u0443 1986 \u0440\u043E\u0446\u0456 \u0432 \u043B\u0430\u0431\u043E\u0440\u0430\u0442\u043E\u0440\u0456\u0457 \u043A\u043E\u043C\u043F\u0430\u043D\u0456\u0457 \u00ABRh\u00F4ne-Poulenc\u00BB, \u044F\u043A\u0430 \u043D\u0430\u0442\u0435\u043F\u0435\u0440 \u0454 \u0447\u0430\u0441\u0442\u0438\u043D\u043E\u044E \u043A\u043E\u043C\u043F\u0430\u043D\u0456\u0457 \u00ABSanofi\u00BB."@uk . . "5735" . "52891"^^ . "Zopiclon"@nl . . . . . "Zopiclone, sold under the brand name Imovane among others, is a nonbenzodiazepine used to treat difficulty sleeping. Zopiclone is molecularly distinct from benzodiazepine drugs and is classed as a cyclopyrrolone. However, zopiclone increases the normal transmission of the neurotransmitter gamma-aminobutyric acid (GABA) in the central nervous system, via modulating GABAA receptors similarly to the way benzodiazepine drugs do. Zopiclone is a sedative. It works by causing a depression or tranquilization of the central nervous system. After prolonged use, the body can become accustomed to the effects of zopiclone. When the dose is then reduced or the drug is abruptly stopped, withdrawal symptoms may result. These can include a range of symptoms similar to those of benzodiazepine withdrawal. Although withdrawal symptoms from therapeutic doses of zopiclone and its isomers (i.e., eszopiclone) do not typically present with convulsions and are therefore not considered life-threatening, patients may experience such significant agitation or anxiety that they seek emergency medical attention. In the United States, zopiclone is not commercially available, although its active stereoisomer, eszopiclone is. Zopiclone is a controlled substance in the United States, Japan, Brazil, and some European countries, and may be illegal to possess without a prescription. However, it is readily available in other countries and is not a controlled substance. Zopiclone is known colloquially as a \"Z-drug\". Other Z-drugs include zaleplon and zolpidem and were initially thought to be less addictive than benzodiazepines. However, this appraisal has shifted somewhat in the last few years as cases of addiction and habituation have been presented. Zopiclone is recommended to be taken on a short-term basis, usually no more than a week or two. Daily or continuous use of the drug is not usually advised, and caution must be taken when the compound is used in conjunction with antidepressants, sedatives or other drugs affecting the central nervous system."@en . . "S4"@en . "CF01"@en . . . . "\u30BE\u30D4\u30AF\u30ED\u30F3\uFF08\u82F1\u8A9E: Zopiclone\uFF09\u306F\u3001\u306E\u7761\u7720\u969C\u5BB3\u6539\u5584\u5264\u3067\u3042\u308A\u3001\u975E\u30D9\u30F3\u30BE\u30B8\u30A2\u30BC\u30D4\u30F3\u7CFB\u306E\u8D85\u77ED\u6642\u9593\u4F5C\u7528\u578B\u7761\u7720\u85AC\u3068\u3057\u3066\u77E5\u3089\u308C\u3066\u3044\u308B\u3002GABA\u53D7\u5BB9\u4F53\u3078\u5F71\u97FF\u3059\u308B\u3053\u3068\u3067GABA\u7CFB\u306E\u6291\u5236\u6A5F\u69CB\u3092\u5897\u5F37\u3059\u308B\u70B9\u3067\u306F\u30D9\u30F3\u30BE\u30B8\u30A2\u30BC\u30D4\u30F3\u7CFB\u306E\u85AC\u7269\u3068\u4F3C\u3066\u3044\u308B\u3002\u7761\u7720\u3078\u306E\u5F71\u97FF\u3067\u306F\u6539\u826F\u3055\u308C\u3066\u3044\u308B\u3002\u65E5\u672C\u3067\u306F1989\u5E74\u304B\u3089\u30A2\u30E2\u30D0\u30F3\u304C\u8CA9\u58F2\u3055\u308C\u3001\u5F8C\u767A\u533B\u85AC\u54C1\u3082\u5B58\u5728\u3059\u308B\u3002\u3046\u3061\u85AC\u52B9\u3092\u6709\u3059\u308B\u93E1\u50CF\u7570\u6027\u4F53\u3092\u5206\u5225\u3057\u305F\u85AC\u5264\u304C\u30A8\u30B9\u30BE\u30D4\u30AF\u30ED\u30F3\uFF08\u30EB\u30CD\u30B9\u30BF\uFF09\u3067\u3042\u308B\u3002 \u9023\u7528\u306B\u3088\u308A\u4F9D\u5B58\u75C7\u3001\u6025\u6FC0\u306A\u91CF\u306E\u6E1B\u5C11\u306B\u3088\u308A\u96E2\u8131\u75C7\u72B6\u3092\u751F\u3058\u308B\u3053\u3068\u304C\u3042\u308B\u3002\u85AC\u6A5F\u6CD5\u306E\u7FD2\u6163\u6027\u533B\u85AC\u54C1\u3001\u9EBB\u85AC\u53CA\u3073\u5411\u7CBE\u795E\u85AC\u53D6\u7DE0\u6CD5\u306E\u7B2C\u4E09\u7A2E\u5411\u7CBE\u795E\u85AC\u306B\u6307\u5B9A\u3055\u308C\u3066\u3044\u308B\u3002"@ja . "32315"^^ . . "\u4F50\u5339\u514B\u9686\uFF08\u82F1\u8A9E\uFF1AZopiclone\uFF09\uFF0C\u53C8\u8B6F\u5511\u5421\u916E\uFF0C\u66B1\u7A31\u5B89\u7720\u85E5\uFF08\u82F1\u8A9E\uFF1AImovane\uFF09\uFF0C\u9999\u6E2F\u6FEB\u7528\u8005\u4FD7\u7A31\u5176\u767D\u74DC\u5B50\u3001\u53F0\u7063\u7A31\u6A02\u6BD4\u514B\u53C8\u7A31\u5B9C\u7720\u5B89\uFF1B\u662F\u4E00\u79CD\u6CBB\u7597\u5931\u7720\u836F\u7269\u3002 \u4F50\u5339\u514B\u9686\u96D6\u7136\u5728BZ1\u53D7\u9AD4\u4E0A\u7522\u751F\u4F5C\u7528\uFF0C\u5B83\u537B\u4E0D\u5C6C\u65BC\u82EF\u4E8C\u6C2E\u44EC\u985E\u85E5\u7269\uFF0C\u800C\u662F\u4E00\u7A2E\u884D\u751F\u7269\u3002"@zh . "52"^^ . "Zopiclone"@it . . . . "75"^^ . "\u0417\u043E\u043F\u0456\u043A\u043B\u043E\u043D (\u0430\u043D\u0433\u043B. Zopiclone, \u043B\u0430\u0442. Zopiclonum) \u2014 \u0441\u0438\u043D\u0442\u0435\u0442\u0438\u0447\u043D\u0438\u0439 \u043B\u0456\u043A\u0430\u0440\u0441\u044C\u043A\u0438\u0439 \u0437\u0430\u0441\u0456\u0431, \u0449\u043E \u043D\u0430\u043B\u0435\u0436\u0438\u0442\u044C \u0434\u043E \u0433\u0440\u0443\u043F\u0438 \u0441\u043D\u043E\u0434\u0456\u0439\u043D\u0438\u0445 \u0456 \u0441\u0435\u0434\u0430\u0442\u0438\u0432\u043D\u0438\u0445 \u0437\u0430\u0441\u043E\u0431\u0456\u0432, \u0442\u0430 \u0454 \u043F\u043E\u0445\u0456\u0434\u043D\u0438\u043C , \u0441\u043F\u043E\u0440\u0456\u0434\u043D\u0435\u043D\u0438\u0439 \u0456\u0437 \u043F\u043E\u0445\u0456\u0434\u043D\u0438\u043C\u0438 \u0431\u0435\u043D\u0437\u043E\u0434\u0456\u0430\u0437\u0435\u043F\u0456\u043D\u0443. \u0417\u043E\u043F\u0456\u043A\u043B\u043E\u043D \u0437\u0430\u0441\u0442\u043E\u0441\u043E\u0432\u0443\u0454\u0442\u044C\u0441\u044F \u043F\u0435\u0440\u043E\u0440\u0430\u043B\u044C\u043D\u043E. \u0417\u043E\u043F\u0456\u043A\u043B\u043E\u043D \u0441\u0438\u043D\u0442\u0435\u0437\u043E\u0432\u0430\u043D\u0438\u0439 \u0443 1986 \u0440\u043E\u0446\u0456 \u0432 \u043B\u0430\u0431\u043E\u0440\u0430\u0442\u043E\u0440\u0456\u0457 \u043A\u043E\u043C\u043F\u0430\u043D\u0456\u0457 \u00ABRh\u00F4ne-Poulenc\u00BB, \u044F\u043A\u0430 \u043D\u0430\u0442\u0435\u043F\u0435\u0440 \u0454 \u0447\u0430\u0441\u0442\u0438\u043D\u043E\u044E \u043A\u043E\u043C\u043F\u0430\u043D\u0456\u0457 \u00ABSanofi\u00BB."@uk . "Zopiclona (DCI; nomes comerciais: Somnosan, Imovane, entre outros) \u00E9 um medicamento hipn\u00F3tico utilizado para induzir e manter o sono. Pertence \u00E0 classe dos n\u00E3o benzodiazep\u00EDnicos, similar aos benzodiazep\u00EDnicos, por\u00E9m com menor potencial de causar depend\u00EAncia."@pt . .