. . . . . . . "1883421"^^ . . . . . . . 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"\u0410\u0434\u0435\u043D\u043E\u0430\u0441\u0441\u043E\u0446\u0438\u0438\u0440\u043E\u0432\u0430\u043D\u043D\u044B\u0439 \u0432\u0438\u0440\u0443\u0441 (\u0430\u043D\u0433\u043B. 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"\u0627\u0644\u0641\u064A\u0631\u0648\u0633\u0627\u062A \u0627\u0644\u0645\u0631\u062A\u0628\u0637\u0629 \u0628\u0627\u0644\u063A\u062F\u064A\u0629 (\u0627\u0644\u0627\u0633\u0645 \u0627\u0644\u0639\u0644\u0645\u064A: Adeno-associated virus) \u0627\u062E\u062A\u0635\u0627\u0631\u064B\u0627 AAV\u060C \u0647\u064A \u0641\u064A\u0631\u0648\u0633\u0627\u062A \u0635\u063A\u064A\u0631\u0629 \u062A\u0635\u064A\u0628 \u0627\u0644\u0628\u0634\u0631 \u0648\u0628\u0639\u0636 \u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0631\u0626\u064A\u0633\u064A\u0627\u062A \u0627\u0644\u0623\u062E\u0631\u0649. \u062A\u0646\u062A\u0645\u064A \u0647\u0630\u0647 \u0627\u0644\u0641\u064A\u0631\u0648\u0633\u0627\u062A \u0625\u0644\u0649 \u062C\u0646\u0633 \u062F\u064A\u0628\u064A\u0646\u062F\u0648\u0628\u0627\u0631\u0641\u0648\u0641\u064A\u0631\u0648\u0633\u060C \u0648\u0627\u0644\u0630\u064A \u064A\u0646\u062A\u0645\u064A \u0628\u062F\u0648\u0631\u0647 \u0625\u0644\u0649 \u0639\u0627\u0626\u0644\u0629 \u0627\u0644\u0641\u064A\u0631\u0648\u0633\u0627\u062A \u0627\u0644\u0635\u063A\u064A\u0631\u0629. \u0648\u0647\u064A \u0641\u064A\u0631\u0648\u0633\u0627\u062A \u0635\u063A\u064A\u0631\u0629 (\u0628\u0639\u0631\u0636 20 \u0646\u0627\u0646\u0648\u0645\u062A\u0631) \u0645\u0639\u064A\u0628\u0629 \u0627\u0644\u0646\u0633\u062E \u0648\u063A\u064A\u0631 \u0645\u063A\u0644\u0641\u0629 \u0648\u062A\u0645\u062A\u0644\u0643 \u062C\u064A\u0646\u0648\u0645 \u062F\u064A \u0625\u0646 \u0625\u064A\u0647 \u0623\u062D\u0627\u062F\u064A \u0627\u0644\u0633\u0644\u0633\u0644\u0629 (\u0625\u0633 \u0625\u0633 \u062F\u064A \u0625\u0646 \u0625\u064A\u0647) \u0628\u0637\u0648\u0644 4.8 \u0643\u064A\u0644\u0648 \u0642\u0627\u0639\u062F\u0629 (kb)."@ar . . . . . "I virus adeno-associati (AAV) sono un piccolo gruppo di virus a singola elica di DNA (appartenenti alla famiglia dei parvovirus), cos\u00EC chiamati perch\u00E9 isolati per la prima volta con gli adenovirus; sono difettivi e perci\u00F2 non riescono ad effettuare un'infezione produttiva (cio\u00E8 con replicazione del DNA virale, assemblaggio dei nuovi virus e infezione di altre cellule) senza la collaborazione di virus helper co-infettanti, ad esempio i suddetti adenovirus. Gli AAV normalmente non si integrano nel genoma della cellula ospite, tuttavia, in assenza del virus helper, il virus adenoassociato instaura uno stato di latenza integrandosi, grazie all'azione della proteina ricombinasi Rep, nel genoma dell'ospite in 19q13.3 in maniera sito specifica. In caso di co-infezione della cellula ospite da parte di un virus helper o di stress cellulare, come in seguito all'esposizione di agenti fisici (come raggi X o UV, shock termico) o chimici (idrossiurea, cisplatino, mitomicina C inibitori di proteasi e topoisomerasi), si osserva l'attivazione del processo replicativo virale con lisi cellulare e rilascio di particelle infettive."@it . . . . . . "72066"^^ . . . . . . . . . . . . . . . . . . . . . . . . . . . "\u817A\u76F8\u5173\u75C5\u6BD2\uFF08Adeno-associated viruses\uFF0C\u5E38\u7F29\u5199\u4E3AAAV\uFF09\uFF0C\u662F\u4E00\u79CD\u96B6\u5C5E\u7EC6\u5C0F\u75C5\u6BD2\u79D1\u4F9D\u8D56\u6027\u7EC6\u5C0F\u75C5\u6BD2\u5C5E\u3001\u80FD\u591F\u611F\u67D3\u4EBA\u7C7B\u4EE5\u53CA\u5176\u4ED6\u90E8\u5206\u7075\u957F\u7C7B\u52A8\u7269\u7684\u75C5\u6BD2\u3002\u817A\u76F8\u5173\u75C5\u6BD2\u76F4\u5F84\u7EA620\u7EB3\u7C73\u3001\u65E0\u88AB\u819C\uFF0C\uFF0C\u5168\u57FA\u56E0\u7EC4\u957F\u7EA64.8\u5343\u78B1\u57FA\u5BF9\uFF08kb\uFF09\u3002 \u5C1A\u65E0\u5DF2\u77E5\u7684\u75BE\u75C5\u4E0E\u817A\u76F8\u5173\u75C5\u6BD2\u6709\u5173\u3002\u817A\u76F8\u5173\u75C5\u6BD2\u4E00\u822C\u53EA\u80FD\u5F15\u53D1\u8F7B\u5EA6\u7684\u514D\u75AB\u53CD\u5E94\u3002\u52A0\u4E4B\u817A\u76F8\u5173\u75C5\u6BD2\u987B\u5728\u5176\u4ED6\u75C5\u6BD2\u540C\u65F6\u611F\u67D3\u5BBF\u4E3B\u7684\u524D\u63D0\u4E0B\u624D\u80FD\u590D\u5236\uFF0C\u4F7F\u7814\u7A76\u8005\u8BA4\u4E3A\u817A\u76F8\u5173\u75C5\u6BD2\u9002\u5408\u7528\u4E8E\u6539\u9020\u7528\u4F5C\u4EBA\u57FA\u56E0\u6CBB\u7597\u7684\u8F7D\u4F53\uFF0C\u4EE5\u53CA\u4F53\u5916\u7684\u6784\u5EFA\u3002\u7531\u817A\u75C5\u6BD2\u6539\u9020\u800C\u6210\u7684\u57FA\u56E0\u6CBB\u7597\u8F7D\u4F53\u80FD\u591F\u540C\u65F6\u611F\u67D3\u5206\u88C2\u4E2D\u548C\u5206\u88C2\u4E0D\u6D3B\u8DC3\u7684\u7EC6\u80DE\uFF0C\u5E76\u5C06\u8F7D\u4F53DNA\u4EE5\u4E00\u79CD\u4E0D\u6574\u5408\u5165\u67D3\u8272\u4F53\u7684\u65B9\u5F0F\u5BFC\u5165\u5230\u7EC6\u80DE\u4E2D\uFF08\u4E0D\u8FC7\u5728\u81EA\u7136\u6761\u4EF6\u4E0B\uFF0C\u4E5F\u6709\u817A\u76F8\u5173\u75C5\u6BD2\u643A\u5E26\u7684DNA\u5728\u611F\u67D3\u540E\u63D2\u5165\u67D3\u8272\u4F53\u7684\u62A5\u5BFC\uFF09\u3002\u76EE\u524D\uFF0C\u4E00\u90E8\u5206\u4F7F\u7528\u817A\u76F8\u5173\u75C5\u6BD2\u7684\u57FA\u56E0\u6CBB\u7597\u4E34\u5E8A\u8BD5\u9A8C\u5DF2\u53D6\u5F97\u6B63\u9762\u7684\u7ED3\u679C\u3002"@zh . "\u30A2\u30C7\u30CE\u968F\u4F34\u30A6\u30A4\u30EB\u30B9(\u82F1: Adeno-associated virus:AAV)\u3068\u306F\u30D2\u30C8\u3084\u970A\u9577\u76EE\u306E\u52D5\u7269\u306B\u611F\u67D3\u3059\u308B\u5C0F\u578B(20nm\u7A0B\u5EA6)\u306E\u3001\u30D1\u30EB\u30DC\u30A6\u30A4\u30EB\u30B9\u79D1\u306B\u5206\u985E\u3055\u308C\u308B\u30D8\u30EB\u30D1\u30FC\u4F9D\u5B58\u578B\u306E\u30A8\u30F3\u30D9\u30ED\u30FC\u30D7\u3092\u6301\u305F\u306A\u3044\u30A6\u30A4\u30EB\u30B9\u3067\u3042\u308B\u3002\u975E\u5E38\u306B\u5F31\u3044\u514D\u75AB\u53CD\u5FDC\u3057\u304B\u5F15\u304D\u8D77\u3053\u3055\u305A\u3001\u75C5\u539F\u6027\u306F\u73FE\u5728\u306E\u6240\u78BA\u8A8D\u3055\u308C\u3066\u3044\u306A\u3044\u3002\u5206\u88C2\u671F\u306B\u3042\u308B\u7D30\u80DE\u306B\u3082\u305D\u3046\u3067\u306A\u3044\u7D30\u80DE\u306B\u3082\u30B2\u30CE\u30E0\u3092\u9001\u308A\u8FBC\u3080\u3053\u3068\u304C\u3067\u304D\u3001\u5BBF\u4E3B\u7D30\u80DE\u306B\u30B2\u30CE\u30E0\u3092\u9001\u308A\u8FBC\u307E\u305A\u3068\u3082\u67D3\u8272\u4F53\u5916\u3067\u751F\u5B58\u3059\u308B\u3053\u3068\u304C\u3067\u304D\u308B \u3002\u305D\u306E\u3088\u3046\u306A\u7279\u8272\u304C\u3042\u308B\u305F\u3081\u306B\u30D9\u30AF\u30BF\u30FC\u30A6\u30A4\u30EB\u30B9\u3092\u7528\u3044\u305F\u907A\u4F1D\u5B50\u6CBB\u7642\u3084\u30D2\u30C8\u306E\u75BE\u60A3\u30E2\u30C7\u30EB\u7D30\u80DE\u306E\u4F5C\u6210\u306A\u3069\u306B\u7528\u3044\u3089\u308C\u308B\u30021\u578B\u304B\u30895\u578B\u307E\u3067\u3042\u308B\u3002"@ja . . . . . . . . . . . . "Adeno-associated virus serotype 2 structure from 1LP3. One fivefold axis shown center."@en . . "Adeno-associated virus"@en . . . "Un virus ad\u00E9no-associ\u00E9 (ou AAV, pour adeno associated virus en anglais) est un petit virus \u00E0 ADN, non pathog\u00E8ne, existant \u00E0 la fois chez l'homme et les primates. Les virus ad\u00E9no-associ\u00E9s, tr\u00E8s attractifs comme vecteur de transfert de g\u00E8nes, ont d\u00E9montr\u00E9 au travers de nombreuses \u00E9tudes pr\u00E9-cliniques de th\u00E9rapie g\u00E9nique leur fort potentiel th\u00E9rapeutique, confort\u00E9 par des essais cliniques de phase I \u00E0 III. Ce virus a la propri\u00E9t\u00E9 de traverser la barri\u00E8re h\u00E9mato-enc\u00E9phalique. Il se loge ensuite chez l'adulte dans les astrocytes ou dans les neurones chez le nouveau n\u00E9. Il est utile en laboratoire coupl\u00E9 \u00E0 un g\u00E8ne rapporteur (GFP). Il est prometteur en recherche car il pourrait apporter via la circulation sanguine des prot\u00E9ines dans le cerveau et donc changer l'activit\u00E9 des cellules nerveuses. Cela pourrait mener \u00E0 un traitement dans les maladies neurod\u00E9g\u00E9n\u00E9ratives en th\u00E9rapie g\u00E9nique."@fr . . "Virus adenoasociado"@es . . . . . "\u817A\u76F8\u5173\u75C5\u6BD2"@zh . . . . "Los virus adenoasociados (AAV, por sus siglas en ingl\u00E9s) constituyen un grupo de virus sat\u00E9lite de la familia Parvoviridae y del g\u00E9nero Dependovirus.\u200B El AAV es un virus muy simple y no aut\u00F3nomo, que contiene ADN lineal de cadena sencilla. El virus requiere la coinfecci\u00F3n con adenovirus u otros para replicarse. El AAV est\u00E1 extendido en la poblaci\u00F3n humana pero no est\u00E1 asociado con ninguna enfermedad conocida. La organizaci\u00F3n del genoma es extremadamente simple, comprendiendo s\u00F3lo dos genes: \n* rep, que codifica una familia de prote\u00EDnas superpuestas involucradas en la replicaci\u00F3n e integraci\u00F3n. \n* cap, que codifica una familia de tres prote\u00EDnas estructurales v\u00EDricas. La longitud m\u00EDnima aceptada para codificar en los genes \"rep\" y \"cap\" es de 1 kb y la m\u00E1xima del genoma nativo es de 4.7 kb ya que este tama\u00F1o es el ideal para mantener una funci\u00F3n \u00F3ptima de empaquetamiento. Los extremos del genoma comprenden repeticiones terminales (TR) de cerca de 145 nucle\u00F3tidos. Los AAV de tipo salvaje pueden integrar su ADN en el cromosoma del hospedador en ausencia del virus ayudante. Esta integraci\u00F3n puede ocurrir con m\u00E1s frecuencia en regiones del cromosoma 19 y est\u00E1 involucrada la prote\u00EDna rep. Los vectores de AAV contienen s\u00F3lo las secuencias v\u00EDricas TR que bordean la unidad de transcripci\u00F3n de inter\u00E9s. El \u00FAnico problema parece ser que la longitud del vector ADN no puede exceder mucho de la longitud del genoma viral con 4680 nucle\u00F3tidos. Generalmente, el desarrollo de vectores AAV es voluminoso y lleva consigo la introducci\u00F3n en la c\u00E9lula hospedadora, no solo del propio vector, sino tambi\u00E9n de un pl\u00E1smido que codifica rep y cap para proveer de las funciones de virus ayudante. La ventaja potencial del vector AAV es que parece capaz de una expresi\u00F3n a largo plazo en c\u00E9lulas que no se dividen. Los vectores son estructuralmente simples, y pueden de todas formas provocar menos respuesta de la c\u00E9lula hospedadora que del adenovirus."@es . . . "\u0627\u0644\u0641\u064A\u0631\u0648\u0633\u0627\u062A \u0627\u0644\u0645\u0631\u062A\u0628\u0637\u0629 \u0628\u0627\u0644\u063A\u062F\u064A\u0629"@ar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "I virus adeno-associati (AAV) sono un piccolo gruppo di virus a singola elica di DNA (appartenenti alla famiglia dei parvovirus), cos\u00EC chiamati perch\u00E9 isolati per la prima volta con gli adenovirus; sono difettivi e perci\u00F2 non riescono ad effettuare un'infezione produttiva (cio\u00E8 con replicazione del DNA virale, assemblaggio dei nuovi virus e infezione di altre cellule) senza la collaborazione di virus helper co-infettanti, ad esempio i suddetti adenovirus."@it . . . . . . . . . . . . "Los virus adenoasociados (AAV, por sus siglas en ingl\u00E9s) constituyen un grupo de virus sat\u00E9lite de la familia Parvoviridae y del g\u00E9nero Dependovirus.\u200B El AAV es un virus muy simple y no aut\u00F3nomo, que contiene ADN lineal de cadena sencilla. El virus requiere la coinfecci\u00F3n con adenovirus u otros para replicarse. El AAV est\u00E1 extendido en la poblaci\u00F3n humana pero no est\u00E1 asociado con ninguna enfermedad conocida. La organizaci\u00F3n del genoma es extremadamente simple, comprendiendo s\u00F3lo dos genes:"@es . . . . . . . . . . . . "Adeno-associated virus serotype 2 structure from 1LP3. One fivefold axis shown center."@en . . . . . "Adeno-assoziierte Viren"@de . "*Adeno-associated dependoparvovirus A\n*Adeno-associated dependoparvovirus B"@en . . . "\u0410\u0434\u0435\u043D\u043E\u0430\u0441\u0441\u043E\u0446\u0438\u0438\u0440\u043E\u0432\u0430\u043D\u043D\u044B\u0439 \u0432\u0438\u0440\u0443\u0441"@ru . "Adeno-assoziierte Viren (AAV), offiziell Adeno-assoziierte Dependoparvoviren, geh\u00F6ren zu den Dependoviren, das hei\u00DFt, sie sind abh\u00E4ngig (lat. dependere) von einem Helfervirus, das dieselbe Zelle bef\u00E4llt. Die AAV sind von einem Adenovirus abh\u00E4ngig (daher \"adeno\"-assoziierte Viren). Das Helfervirus liefert Proteine, die vom AAV f\u00FCr die Replikation in der Zelle ben\u00F6tigt werden. Diese Proteine sind die Adenoviralen Proteine E1A, E2A, E4 und VA-RNA. Als Helfervirus k\u00F6nnen aber auch das Herpes-simplex-Virus 1 oder das Humane Cytomegalievirus dienen. Ohne die Anwesenheit eines Helfervirus kann sich das virale Erbgut beim Menschen auf Chromosom 19 integrieren, liegt jedoch meist als Episom neben dem Humanen Genom vor. Sobald Adenoviren anwesend sind, geht die Zelle in den lytischen Zyklus \u00FCber, das hei\u00DFt die Partikel vermehren sich und die Zelle platzt dann auf, so dass sich AAV weiterverbreiten kann. AAV werden als viraler Vektor in der Gentherapie verwendet, da sie nicht mit Krankheiten assoziiert sind und sich das virale Erbgut nur selten unspezifisch in das Genom der Wirtszelle integriert. So wird das onkogene Potential dieser Gentherapien reduziert. Zudem sind die Partikel sehr stabil und es lassen sich auch Ruhegewebe (z. B. Neuronen) damit infizieren. Gravierender Nachteil von AAV ist ihr kleines Genom, welches von zwei ITRs (inverted terminal repeats) flankiert wird. Zwischen den ITRs befinden sich nur 4,7kb. Damit sind f\u00FCr eine rekombinante Variante nur <2,5kb verf\u00FCgbar. Mit Stand November 2018 unterscheidet das International Committee on Taxonomy of Viruses zwei Spezies, die zuvor nur als unterschiedliche Serotypen gef\u00FChrt wurden: AAV-A und AAV-B."@de . "Virus ad\u00E9no-associ\u00E9"@fr . "\u0410\u0434\u0435\u043D\u043E\u0430\u0441\u043E\u0446\u0456\u0439\u043E\u0432\u0430\u043D\u0438\u0439 \u0432\u0456\u0440\u0443\u0441 (\u0430\u043D\u0433\u043B. Adeno-associated dependoparvovirus A, AAV) \u2014 \u043C\u0430\u043B\u0438\u0439 \u0432\u0456\u0440\u0443\u0441, \u0449\u043E \u0456\u043D\u0444\u0456\u043A\u0443\u0454 \u043A\u043B\u0456\u0442\u0438\u043D\u0438 \u043B\u044E\u0434\u0438\u043D\u0438 \u0456 \u0434\u0435\u044F\u043A\u0438\u0445 \u0456\u043D\u0448\u0438\u0445 \u043F\u0440\u0438\u043C\u0430\u0442\u0456\u0432. \u0410\u0434\u0435\u043D\u043E\u0430\u0441\u043E\u0446\u0456\u0439\u043E\u0432\u0430\u043D\u0438\u0439 \u0432\u0456\u0440\u0443\u0441, \u043C\u0430\u0431\u0443\u0442\u044C, \u043D\u0435 \u0432\u0438\u043A\u043B\u0438\u043A\u0430\u0454 \u0437\u0430\u0445\u0432\u043E\u0440\u044E\u0432\u0430\u043D\u043D\u044F \u0443 \u043B\u044E\u0434\u0438\u043D\u0438 \u0456, \u0432\u0456\u0434\u043F\u043E\u0432\u0456\u0434\u043D\u043E, \u0432\u0438\u043A\u043B\u0438\u043A\u0430\u0454 \u0441\u043B\u0430\u0431\u043A\u0443 \u0456\u043C\u0443\u043D\u043D\u0443 \u0432\u0456\u0434\u043F\u043E\u0432\u0456\u0434\u044C. \u0410\u0434\u0435\u043D\u043E\u0430\u0441\u043E\u0446\u0456\u0439\u043E\u0432\u0430\u043D\u0438\u0439 \u0432\u0456\u0440\u0443\u0441 \u043C\u043E\u0436\u0435 \u0456\u043D\u0444\u0456\u043A\u0443\u0432\u0430\u0442\u0438 \u043A\u043B\u0456\u0442\u0438\u043D\u0438 \u0449\u043E \u0434\u0456\u043B\u044F\u0442\u044C\u0441\u044F \u0456 \u043D\u0435 \u0434\u0456\u043B\u044F\u0442\u044C\u0441\u044F, \u0456 \u043C\u043E\u0436\u0435 \u0432\u0431\u0443\u0434\u043E\u0432\u0443\u0432\u0430\u0442\u0438 \u0441\u0432\u0456\u0439 \u0433\u0435\u043D\u043E\u043C \u0432 \u0433\u0435\u043D\u043E\u043C \u0433\u043E\u0441\u043F\u043E\u0434\u0430\u0440\u044F. \u0426\u0456 \u043E\u0441\u043E\u0431\u043B\u0438\u0432\u043E\u0441\u0442\u0456 \u0440\u043E\u0431\u043B\u044F\u0442\u044C AAV \u043E\u0441\u043E\u0431\u043B\u0438\u0432\u043E \u043F\u0440\u0438\u0432\u0430\u0431\u043B\u0438\u0432\u0438\u043C \u043A\u0430\u043D\u0434\u0438\u0434\u0430\u0442\u043E\u043C \u0434\u043B\u044F \u0441\u0442\u0432\u043E\u0440\u0435\u043D\u043D\u044F \u0432\u0456\u0440\u0443\u0441\u043D\u0438\u0445 \u0432\u0435\u043A\u0442\u043E\u0440\u0456\u0432 \u0434\u043B\u044F \u0433\u0435\u043D\u043E\u0442\u0435\u0440\u0430\u043F\u0456\u0457. \u0410\u0434\u0435\u043D\u043E\u0430\u0441\u043E\u0446\u0456\u0439\u043E\u0432\u0430\u043D\u0438\u0439 \u0432\u0456\u0440\u0443\u0441 \u043D\u0430\u043B\u0435\u0436\u0438\u0442\u044C \u0434\u043E \u0440\u043E\u0434\u0443 Dependoparvovirus \u0440\u043E\u0434\u0438\u043D\u0438 \u043F\u0430\u0440\u0432\u043E\u0432\u0438\u0440\u0443\u0441\u043E\u0432. \u0412\u0456\u0440\u0443\u0441 \u043C\u0430\u0454 \u043D\u0435\u0432\u0435\u043B\u0438\u043A\u0456 \u0440\u043E\u0437\u043C\u0456\u0440\u0438 (20 \u043D\u043C), \u043D\u0435 \u043C\u0430\u0454 \u043B\u0456\u043F\u0456\u0434\u043D\u043E\u0457 \u043E\u0431\u043E\u043B\u043E\u043D\u043A\u0438 \u0456 \u043D\u0435 \u043A\u043E\u0434\u0443\u0454 \u0432\u043B\u0430\u0441\u043D\u0438\u0445 \u0444\u0435\u0440\u043C\u0435\u043D\u0442\u0456\u0432 \u0440\u0435\u043F\u043B\u0456\u043A\u0430\u0446\u0456\u0457."@uk . "\u0410\u0434\u0435\u043D\u043E\u0430\u0441\u043E\u0446\u0456\u0439\u043E\u0432\u0430\u043D\u0438\u0439 \u0432\u0456\u0440\u0443\u0441"@uk . . . . . . . "\u30A2\u30C7\u30CE\u968F\u4F34\u30A6\u30A4\u30EB\u30B9"@ja . . . . . "Virus adeno-associati"@it . . . . "Adeno-associated viruses (AAV) are small viruses that infect humans and some other primate species. They belong to the genus Dependoparvovirus, which in turn belongs to the family Parvoviridae. They are small (approximately 26 nm in diameter) replication-defective, nonenveloped viruses and have linear single-stranded DNA (ssDNA) genome of approximately 4.8 kilobases (kb)."@en . . . . . . . . . . . . . . . "\u30A2\u30C7\u30CE\u968F\u4F34\u30A6\u30A4\u30EB\u30B9(\u82F1: Adeno-associated virus:AAV)\u3068\u306F\u30D2\u30C8\u3084\u970A\u9577\u76EE\u306E\u52D5\u7269\u306B\u611F\u67D3\u3059\u308B\u5C0F\u578B(20nm\u7A0B\u5EA6)\u306E\u3001\u30D1\u30EB\u30DC\u30A6\u30A4\u30EB\u30B9\u79D1\u306B\u5206\u985E\u3055\u308C\u308B\u30D8\u30EB\u30D1\u30FC\u4F9D\u5B58\u578B\u306E\u30A8\u30F3\u30D9\u30ED\u30FC\u30D7\u3092\u6301\u305F\u306A\u3044\u30A6\u30A4\u30EB\u30B9\u3067\u3042\u308B\u3002\u975E\u5E38\u306B\u5F31\u3044\u514D\u75AB\u53CD\u5FDC\u3057\u304B\u5F15\u304D\u8D77\u3053\u3055\u305A\u3001\u75C5\u539F\u6027\u306F\u73FE\u5728\u306E\u6240\u78BA\u8A8D\u3055\u308C\u3066\u3044\u306A\u3044\u3002\u5206\u88C2\u671F\u306B\u3042\u308B\u7D30\u80DE\u306B\u3082\u305D\u3046\u3067\u306A\u3044\u7D30\u80DE\u306B\u3082\u30B2\u30CE\u30E0\u3092\u9001\u308A\u8FBC\u3080\u3053\u3068\u304C\u3067\u304D\u3001\u5BBF\u4E3B\u7D30\u80DE\u306B\u30B2\u30CE\u30E0\u3092\u9001\u308A\u8FBC\u307E\u305A\u3068\u3082\u67D3\u8272\u4F53\u5916\u3067\u751F\u5B58\u3059\u308B\u3053\u3068\u304C\u3067\u304D\u308B \u3002\u305D\u306E\u3088\u3046\u306A\u7279\u8272\u304C\u3042\u308B\u305F\u3081\u306B\u30D9\u30AF\u30BF\u30FC\u30A6\u30A4\u30EB\u30B9\u3092\u7528\u3044\u305F\u907A\u4F1D\u5B50\u6CBB\u7642\u3084\u30D2\u30C8\u306E\u75BE\u60A3\u30E2\u30C7\u30EB\u7D30\u80DE\u306E\u4F5C\u6210\u306A\u3069\u306B\u7528\u3044\u3089\u308C\u308B\u30021\u578B\u304B\u30895\u578B\u307E\u3067\u3042\u308B\u3002"@ja . . . "Viruses included:"@en . . . . . "Un virus ad\u00E9no-associ\u00E9 (ou AAV, pour adeno associated virus en anglais) est un petit virus \u00E0 ADN, non pathog\u00E8ne, existant \u00E0 la fois chez l'homme et les primates. Les virus ad\u00E9no-associ\u00E9s, tr\u00E8s attractifs comme vecteur de transfert de g\u00E8nes, ont d\u00E9montr\u00E9 au travers de nombreuses \u00E9tudes pr\u00E9-cliniques de th\u00E9rapie g\u00E9nique leur fort potentiel th\u00E9rapeutique, confort\u00E9 par des essais cliniques de phase I \u00E0 III. Ce virus a la propri\u00E9t\u00E9 de traverser la barri\u00E8re h\u00E9mato-enc\u00E9phalique. Il se loge ensuite chez l'adulte dans les astrocytes ou dans les neurones chez le nouveau n\u00E9. Il est utile en laboratoire coupl\u00E9 \u00E0 un g\u00E8ne rapporteur (GFP). Il est prometteur en recherche car il pourrait apporter via la circulation sanguine des prot\u00E9ines dans le cerveau et donc changer l'activit\u00E9 des cellules nerveuses. C"@fr . . "\u0410\u0434\u0435\u043D\u043E\u0430\u0441\u0441\u043E\u0446\u0438\u0438\u0440\u043E\u0432\u0430\u043D\u043D\u044B\u0439 \u0432\u0438\u0440\u0443\u0441 (\u0430\u043D\u0433\u043B. Adeno-associated dependoparvovirus A, AAV) \u2014 \u043C\u0430\u043B\u044B\u0439 \u0432\u0438\u0440\u0443\u0441, \u0438\u043D\u0444\u0438\u0446\u0438\u0440\u0443\u044E\u0449\u0438\u0439 \u043A\u043B\u0435\u0442\u043A\u0438 \u0447\u0435\u043B\u043E\u0432\u0435\u043A\u0430 \u0438 \u043D\u0435\u043A\u043E\u0442\u043E\u0440\u044B\u0445 \u0434\u0440\u0443\u0433\u0438\u0445 \u043F\u0440\u0438\u043C\u0430\u0442\u043E\u0432. \u0410\u0434\u0435\u043D\u043E\u0430\u0441\u0441\u043E\u0446\u0438\u0438\u0440\u043E\u0432\u0430\u043D\u043D\u044B\u0439 \u0432\u0438\u0440\u0443\u0441, \u043F\u043E-\u0432\u0438\u0434\u0438\u043C\u043E\u043C\u0443, \u043D\u0435 \u0432\u044B\u0437\u044B\u0432\u0430\u0435\u0442 \u0437\u0430\u0431\u043E\u043B\u0435\u0432\u0430\u043D\u0438\u044F \u0443 \u0447\u0435\u043B\u043E\u0432\u0435\u043A\u0430 \u0438, \u0441\u043E\u043E\u0442\u0432\u0435\u0442\u0441\u0442\u0432\u0435\u043D\u043D\u043E, \u0432\u044B\u0437\u044B\u0432\u0430\u0435\u0442 \u0441\u043B\u0430\u0431\u044B\u0439 \u0438\u043C\u043C\u0443\u043D\u043D\u044B\u0439 \u043E\u0442\u0432\u0435\u0442. \u0410\u0434\u0435\u043D\u043E\u0430\u0441\u0441\u043E\u0446\u0438\u0438\u0440\u043E\u0432\u0430\u043D\u043D\u044B\u0439 \u0432\u0438\u0440\u0443\u0441 \u043C\u043E\u0436\u0435\u0442 \u0438\u043D\u0444\u0438\u0446\u0438\u0440\u043E\u0432\u0430\u0442\u044C \u0434\u0435\u043B\u044F\u0449\u0438\u0435\u0441\u044F \u0438 \u043D\u0435\u0434\u0435\u043B\u044F\u0449\u0438\u0435\u0441\u044F \u043A\u043B\u0435\u0442\u043A\u0438 \u0438 \u043C\u043E\u0436\u0435\u0442 \u0432\u0441\u0442\u0440\u0430\u0438\u0432\u0430\u0442\u044C \u0441\u0432\u043E\u0439 \u0433\u0435\u043D\u043E\u043C \u0432 \u0433\u0435\u043D\u043E\u043C \u0445\u043E\u0437\u044F\u0438\u043D\u0430. \u042D\u0442\u0438 \u043E\u0441\u043E\u0431\u0435\u043D\u043D\u043E\u0441\u0442\u0438 \u0434\u0435\u043B\u0430\u044E\u0442 AAV \u043E\u0441\u043E\u0431\u0435\u043D\u043D\u043E \u043F\u0440\u0438\u0432\u043B\u0435\u043A\u0430\u0442\u0435\u043B\u044C\u043D\u044B\u043C \u043A\u0430\u043D\u0434\u0438\u0434\u0430\u0442\u043E\u043C \u0434\u043B\u044F \u0441\u043E\u0437\u0434\u0430\u043D\u0438\u044F \u0432\u0438\u0440\u0443\u0441\u043D\u044B\u0445 \u0432\u0435\u043A\u0442\u043E\u0440\u043E\u0432 \u0434\u043B\u044F \u0433\u0435\u043D\u043D\u043E\u0439 \u0442\u0435\u0440\u0430\u043F\u0438\u0438."@ru . . . . "Adeno-associated viruses (AAV) are small viruses that infect humans and some other primate species. They belong to the genus Dependoparvovirus, which in turn belongs to the family Parvoviridae. They are small (approximately 26 nm in diameter) replication-defective, nonenveloped viruses and have linear single-stranded DNA (ssDNA) genome of approximately 4.8 kilobases (kb). AAV are not currently known to cause disease. The viruses cause a very mild immune response. Several additional features make AAV an attractive candidate for creating viral vectors for gene therapy, and for the creation of isogenic human disease models. Gene therapy vectors using AAV can infect both dividing and quiescent cells and persist in an extrachromosomal state without integrating into the genome of the host cell. In the native virus, however, integration of virally carried genes into the host genome does occur. Integration can be important for certain applications, but can also have unwanted consequences. Recent human clinical trials using AAV for gene therapy in the retina have shown promise."@en . . "Adeno-assoziierte Viren (AAV), offiziell Adeno-assoziierte Dependoparvoviren, geh\u00F6ren zu den Dependoviren, das hei\u00DFt, sie sind abh\u00E4ngig (lat. dependere) von einem Helfervirus, das dieselbe Zelle bef\u00E4llt. Die AAV sind von einem Adenovirus abh\u00E4ngig (daher \"adeno\"-assoziierte Viren). Das Helfervirus liefert Proteine, die vom AAV f\u00FCr die Replikation in der Zelle ben\u00F6tigt werden. Diese Proteine sind die Adenoviralen Proteine E1A, E2A, E4 und VA-RNA. Als Helfervirus k\u00F6nnen aber auch das Herpes-simplex-Virus 1 oder das Humane Cytomegalievirus dienen."@de . . . . "\u0410\u0434\u0435\u043D\u043E\u0430\u0441\u043E\u0446\u0456\u0439\u043E\u0432\u0430\u043D\u0438\u0439 \u0432\u0456\u0440\u0443\u0441 (\u0430\u043D\u0433\u043B. Adeno-associated dependoparvovirus A, AAV) \u2014 \u043C\u0430\u043B\u0438\u0439 \u0432\u0456\u0440\u0443\u0441, \u0449\u043E \u0456\u043D\u0444\u0456\u043A\u0443\u0454 \u043A\u043B\u0456\u0442\u0438\u043D\u0438 \u043B\u044E\u0434\u0438\u043D\u0438 \u0456 \u0434\u0435\u044F\u043A\u0438\u0445 \u0456\u043D\u0448\u0438\u0445 \u043F\u0440\u0438\u043C\u0430\u0442\u0456\u0432. \u0410\u0434\u0435\u043D\u043E\u0430\u0441\u043E\u0446\u0456\u0439\u043E\u0432\u0430\u043D\u0438\u0439 \u0432\u0456\u0440\u0443\u0441, \u043C\u0430\u0431\u0443\u0442\u044C, \u043D\u0435 \u0432\u0438\u043A\u043B\u0438\u043A\u0430\u0454 \u0437\u0430\u0445\u0432\u043E\u0440\u044E\u0432\u0430\u043D\u043D\u044F \u0443 \u043B\u044E\u0434\u0438\u043D\u0438 \u0456, \u0432\u0456\u0434\u043F\u043E\u0432\u0456\u0434\u043D\u043E, \u0432\u0438\u043A\u043B\u0438\u043A\u0430\u0454 \u0441\u043B\u0430\u0431\u043A\u0443 \u0456\u043C\u0443\u043D\u043D\u0443 \u0432\u0456\u0434\u043F\u043E\u0432\u0456\u0434\u044C. \u0410\u0434\u0435\u043D\u043E\u0430\u0441\u043E\u0446\u0456\u0439\u043E\u0432\u0430\u043D\u0438\u0439 \u0432\u0456\u0440\u0443\u0441 \u043C\u043E\u0436\u0435 \u0456\u043D\u0444\u0456\u043A\u0443\u0432\u0430\u0442\u0438 \u043A\u043B\u0456\u0442\u0438\u043D\u0438 \u0449\u043E \u0434\u0456\u043B\u044F\u0442\u044C\u0441\u044F \u0456 \u043D\u0435 \u0434\u0456\u043B\u044F\u0442\u044C\u0441\u044F, \u0456 \u043C\u043E\u0436\u0435 \u0432\u0431\u0443\u0434\u043E\u0432\u0443\u0432\u0430\u0442\u0438 \u0441\u0432\u0456\u0439 \u0433\u0435\u043D\u043E\u043C \u0432 \u0433\u0435\u043D\u043E\u043C \u0433\u043E\u0441\u043F\u043E\u0434\u0430\u0440\u044F. \u0426\u0456 \u043E\u0441\u043E\u0431\u043B\u0438\u0432\u043E\u0441\u0442\u0456 \u0440\u043E\u0431\u043B\u044F\u0442\u044C AAV \u043E\u0441\u043E\u0431\u043B\u0438\u0432\u043E \u043F\u0440\u0438\u0432\u0430\u0431\u043B\u0438\u0432\u0438\u043C \u043A\u0430\u043D\u0434\u0438\u0434\u0430\u0442\u043E\u043C \u0434\u043B\u044F \u0441\u0442\u0432\u043E\u0440\u0435\u043D\u043D\u044F \u0432\u0456\u0440\u0443\u0441\u043D\u0438\u0445 \u0432\u0435\u043A\u0442\u043E\u0440\u0456\u0432 \u0434\u043B\u044F \u0433\u0435\u043D\u043E\u0442\u0435\u0440\u0430\u043F\u0456\u0457."@uk . . . . . "\u817A\u76F8\u5173\u75C5\u6BD2\uFF08Adeno-associated viruses\uFF0C\u5E38\u7F29\u5199\u4E3AAAV\uFF09\uFF0C\u662F\u4E00\u79CD\u96B6\u5C5E\u7EC6\u5C0F\u75C5\u6BD2\u79D1\u4F9D\u8D56\u6027\u7EC6\u5C0F\u75C5\u6BD2\u5C5E\u3001\u80FD\u591F\u611F\u67D3\u4EBA\u7C7B\u4EE5\u53CA\u5176\u4ED6\u90E8\u5206\u7075\u957F\u7C7B\u52A8\u7269\u7684\u75C5\u6BD2\u3002\u817A\u76F8\u5173\u75C5\u6BD2\u76F4\u5F84\u7EA620\u7EB3\u7C73\u3001\u65E0\u88AB\u819C\uFF0C\uFF0C\u5168\u57FA\u56E0\u7EC4\u957F\u7EA64.8\u5343\u78B1\u57FA\u5BF9\uFF08kb\uFF09\u3002 \u5C1A\u65E0\u5DF2\u77E5\u7684\u75BE\u75C5\u4E0E\u817A\u76F8\u5173\u75C5\u6BD2\u6709\u5173\u3002\u817A\u76F8\u5173\u75C5\u6BD2\u4E00\u822C\u53EA\u80FD\u5F15\u53D1\u8F7B\u5EA6\u7684\u514D\u75AB\u53CD\u5E94\u3002\u52A0\u4E4B\u817A\u76F8\u5173\u75C5\u6BD2\u987B\u5728\u5176\u4ED6\u75C5\u6BD2\u540C\u65F6\u611F\u67D3\u5BBF\u4E3B\u7684\u524D\u63D0\u4E0B\u624D\u80FD\u590D\u5236\uFF0C\u4F7F\u7814\u7A76\u8005\u8BA4\u4E3A\u817A\u76F8\u5173\u75C5\u6BD2\u9002\u5408\u7528\u4E8E\u6539\u9020\u7528\u4F5C\u4EBA\u57FA\u56E0\u6CBB\u7597\u7684\u8F7D\u4F53\uFF0C\u4EE5\u53CA\u4F53\u5916\u7684\u6784\u5EFA\u3002\u7531\u817A\u75C5\u6BD2\u6539\u9020\u800C\u6210\u7684\u57FA\u56E0\u6CBB\u7597\u8F7D\u4F53\u80FD\u591F\u540C\u65F6\u611F\u67D3\u5206\u88C2\u4E2D\u548C\u5206\u88C2\u4E0D\u6D3B\u8DC3\u7684\u7EC6\u80DE\uFF0C\u5E76\u5C06\u8F7D\u4F53DNA\u4EE5\u4E00\u79CD\u4E0D\u6574\u5408\u5165\u67D3\u8272\u4F53\u7684\u65B9\u5F0F\u5BFC\u5165\u5230\u7EC6\u80DE\u4E2D\uFF08\u4E0D\u8FC7\u5728\u81EA\u7136\u6761\u4EF6\u4E0B\uFF0C\u4E5F\u6709\u817A\u76F8\u5173\u75C5\u6BD2\u643A\u5E26\u7684DNA\u5728\u611F\u67D3\u540E\u63D2\u5165\u67D3\u8272\u4F53\u7684\u62A5\u5BFC\uFF09\u3002\u76EE\u524D\uFF0C\u4E00\u90E8\u5206\u4F7F\u7528\u817A\u76F8\u5173\u75C5\u6BD2\u7684\u57FA\u56E0\u6CBB\u7597\u4E34\u5E8A\u8BD5\u9A8C\u5DF2\u53D6\u5F97\u6B63\u9762\u7684\u7ED3\u679C\u3002"@zh . . . . . . . . . . "Dependoparvovirus"@en . . . . "1118803619"^^ . . "virus"@en .