"457140717"^^ . . "100.0"^^ . . . "Argatroban is an anticoagulant that is a small molecule direct thrombin inhibitor. In 2000, argatroban was licensed by the Food and Drug Administration (FDA) for prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia (HIT). In 2002, it was approved for use during percutaneous coronary interventions in patients who have HIT or are at risk for developing it. In 2012, it was approved by the MHRA in the UK for anticoagulation in patients with heparin-induced thrombocytopenia Type II (HIT) who require parenteral antithrombotic therapy. Argatroban is given intravenously and drug plasma concentrations reach steady state in 1\u20133 hours. Argatroban is metabolized in the liver and has a half-life of about 50 minutes. It is monitored by PTT. Because of its hepatic metabolism, it may be used in patients with renal dysfunction. (This is in contrast to lepirudin, a direct thrombin inhibitor that is primarily renally cleared)."@en . . . . . . . "DB00278" . "\u0627\u0631\u062C\u0627\u062A\u0631\u0648\u0628\u0627\u0646(\u0628\u0627\u0644\u0625\u0646\u062C\u0644\u064A\u0632\u064A\u0629: Argatroban)\u200F \u0647\u0648 \u0645\u0631\u0643\u0628 \u0643\u064A\u0645\u064A\u0627\u0626\u064A \u064A\u0633\u062A\u062E\u062F\u0645 \u0643\u062F\u0648\u0627\u0621 \u0645\u0636\u0627\u062F \u0644\u0644\u062A\u062C\u0644\u0637 \u0627\u0644\u062F\u0645\u0648\u064A \u064A\u0639\u062A\u0628\u0631 \u0645\u0646 \u0645\u062B\u0628\u0637\u0627\u062A \u0627\u0644\u062B\u0631\u0648\u0645\u0628\u064A\u0646 \u062A\u0645 \u0627\u0644\u062A\u0631\u062E\u064A\u0635 \u0639\u0644\u064A\u0647 \u0645\u0646 \u0642\u0628\u0644 \u0625\u062F\u0627\u0631\u0629 \u0627\u0644\u063A\u0630\u0627\u0621 \u0648\u0627\u0644\u062F\u0648\u0627\u0621 \u0627\u0644\u0623\u0645\u0631\u064A\u0643\u064A\u0629 \u0641\u064A \u0639\u0627\u0645 2002\u060C \u064A\u0633\u062A\u062E\u062F\u0645 \u0644\u0639\u0644\u0627\u062C \u0627\u0644\u062C\u0644\u0637\u0627\u062A \u0627\u0644\u062F\u0645\u0648\u064A\u0629 \u0627\u0644\u0636\u0627\u0631\u0629\u060C \u0648\u064A\u0633\u062A\u062E\u062F\u0645 \u0644\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064A\u0646 \u064A\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0646\u0642\u0635 \u0627\u0644\u0635\u0641\u062D\u064A\u0627\u062A \u0627\u0644\u062F\u0645\u0648\u064A\u0629 \u0627\u0644\u0646\u0627\u062A\u062C\u0629 \u0639\u0646 \u0627\u0633\u062A\u062E\u062F\u0627\u0645 \u062F\u0648\u0627\u0621 \u0627\u0644\u0647\u064A\u0628\u0627\u0631\u064A\u0646\u060C \u0648\u064A\u0633\u062A\u062E\u062F\u0645 \u0641\u064A \u0628\u0639\u0636 \u0627\u0644\u0639\u0644\u0645\u064A\u0627\u062A \u0627\u0644\u062C\u0631\u0627\u062D\u064A\u0629 \u0644\u0644\u0642\u0644\u0628. \u0625\u062E\u0644\u0627\u0621 \u0645\u0633\u0624\u0648\u0644\u064A\u0629 \u0637\u0628\u064A\u0629 \n* \u0628\u0648\u0627\u0628\u0629 \u0637\u0628 \n* \u0628\u0648\u0627\u0628\u0629 \u0635\u064A\u062F\u0644\u0629 \n* \u0628\u0648\u0627\u0628\u0629 \u0627\u0644\u0643\u064A\u0645\u064A\u0627\u0621"@ar . . "OCY3U280Y3" . . . . . . . "B01"@en . "74863"^^ . . . "Argatroban"@it . . "\u30A2\u30EB\u30AC\u30C8\u30ED\u30D0\u30F3\uFF08Argatroban\uFF09\u306F\u5C0F\u5206\u5B50\u306E\u306B\u5C5E\u3059\u308B\u6297\u51DD\u56FA\u85AC\u3067\u3042\u308B\u3002\u5546\u54C1\u540D\u30CE\u30D0\u30B9\u30BF\u30F3\u3001\u30B9\u30ED\u30F3\u30CE\u30F3\u3002"@ja . "2669812"^^ . "1166"^^ . "\u30A2\u30EB\u30AC\u30C8\u30ED\u30D0\u30F3\uFF08Argatroban\uFF09\u306F\u5C0F\u5206\u5B50\u306E\u306B\u5C5E\u3059\u308B\u6297\u51DD\u56FA\u85AC\u3067\u3042\u308B\u3002\u5546\u54C1\u540D\u30CE\u30D0\u30B9\u30BF\u30F3\u3001\u30B9\u30ED\u30F3\u30CE\u30F3\u3002"@ja . "Argatroban"@fr . . "6"^^ . "36"^^ . . "Argatroban ist ein Arzneistoff zur Hemmung der Blutgerinnung. Der synthetische direkte Inhibitor des Thrombins ist in Deutschland und \u00D6sterreich seit 2005 und seit 2016 in der Schweiz unter dem Namen Argatra zur Antikoagulation bei Erwachsenen mit einer heparininduzierten Thrombozytopenie vom Typ II (HIT II) zugelassen, wenn diese einer parenteralen antithrombotischen Therapie bed\u00FCrfen. Chemisch geh\u00F6rt Argatroban zu den nicht-peptidischen Thrombin-Inhibitoren. Arzneilich kommen sowohl das Monohydrat als auch die wasserfreie Form zum Einsatz."@de . "440542" . "23"^^ . . . "1166" . "changed"@en . . "KXNPVXPOPUZYGB-IOVMHBDKSA-N"@en . . . . . . "[[-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]"@en . . . . "389444"^^ . . "OCY3U280Y3"@en . . "4931.0"^^ . "100.0"^^ . . . . . "1"^^ . . . . . . . "1028316469"^^ . . . . "Argatroban \u00E8 un farmaco anticoagulante appartenente alla nuova categoria degli inibitori diretti della trombina (Direct thrombin inhibitors - DTI). Argatroban \u00E8 stato autorizzato dalla Food and Drug Administration (FDA) per la profilassi o il trattamento di trombosi nei pazienti con trombocitopenia indotta da eparina (HIT). Nel 2002, \u00E8 stato approvato per l'uso percutaneo durante interventi coronarici in pazienti a rischio di trombosi. Nel 2012, \u00E8 stato approvato dalla del Regno Unito per la terapia anticoagulante nei pazienti con trombocitopenia indotta da eparina di tipo II (HIT) che richiedono una terapia antitrombotica parenterale."@it . "Argatroban ist ein Arzneistoff zur Hemmung der Blutgerinnung. Der synthetische direkte Inhibitor des Thrombins ist in Deutschland und \u00D6sterreich seit 2005 und seit 2016 in der Schweiz unter dem Namen Argatra zur Antikoagulation bei Erwachsenen mit einer heparininduzierten Thrombozytopenie vom Typ II (HIT II) zugelassen, wenn diese einer parenteralen antithrombotischen Therapie bed\u00FCrfen. Chemisch geh\u00F6rt Argatroban zu den nicht-peptidischen Thrombin-Inhibitoren. Arzneilich kommen sowohl das Monohydrat als auch die wasserfreie Form zum Einsatz."@de . . "Argatroban"@en . "Argatroban"@en . . "Argatroban \u00E8 un farmaco anticoagulante appartenente alla nuova categoria degli inibitori diretti della trombina (Direct thrombin inhibitors - DTI). Argatroban \u00E8 stato autorizzato dalla Food and Drug Administration (FDA) per la profilassi o il trattamento di trombosi nei pazienti con trombocitopenia indotta da eparina (HIT). Nel 2002, \u00E8 stato approvato per l'uso percutaneo durante interventi coronarici in pazienti a rischio di trombosi. Nel 2012, \u00E8 stato approvato dalla del Regno Unito per la terapia anticoagulante nei pazienti con trombocitopenia indotta da eparina di tipo II (HIT) che richiedono una terapia antitrombotica parenterale."@it . "3060.0"^^ . . "Argatroban"@de . "L'Argatroban est un m\u00E9dicament anticoagulant utilis\u00E9 en cas de thrombop\u00E9nie induite par l'h\u00E9parine ou HIT, de l'anglais : Heparine induced thrombocytopenia, une pathologie provoquant saignement et thrombose et contre-indiquant le traitement par tout autre h\u00E9parine qu'elle soit de haut ou de bas poids mol\u00E9culaire."@fr . "-1"^^ . "Argatrobana \u00E9 um anticoagulante que age como inibidor direto da trombina (IDT)."@pt . "Argatrobana \u00E9 um anticoagulante que age como inibidor direto da trombina (IDT)."@pt . "sulfonylamino]pentanoyl]-4-methyl-piperidine-2-"@en . . . "L'Argatroban est un m\u00E9dicament anticoagulant utilis\u00E9 en cas de thrombop\u00E9nie induite par l'h\u00E9parine ou HIT, de l'anglais : Heparine induced thrombocytopenia, une pathologie provoquant saignement et thrombose et contre-indiquant le traitement par tout autre h\u00E9parine qu'elle soit de haut ou de bas poids mol\u00E9culaire."@fr . . "AE03"@en . . "carboxylic acid"@en . . "6726"^^ . . "Rx-only"@en . "C04931" . . "O=C[C@@H]3NCC[C@@H]C3"@en . "hepatic"@en . . "DB00278"@en . . . . . . . "54.0"^^ . "Argatroban is an anticoagulant that is a small molecule direct thrombin inhibitor. In 2000, argatroban was licensed by the Food and Drug Administration (FDA) for prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia (HIT). In 2002, it was approved for use during percutaneous coronary interventions in patients who have HIT or are at risk for developing it. In 2012, it was approved by the MHRA in the UK for anticoagulation in patients with heparin-induced thrombocytopenia Type II (HIT) who require parenteral antithrombotic therapy."@en . . . . "1"^^ . . . . . "Argatrobana"@pt . . . . "74863-84-6" . "\u0627\u0631\u062C\u0627\u062A\u0631\u0648\u0628\u0627\u0646(\u0628\u0627\u0644\u0625\u0646\u062C\u0644\u064A\u0632\u064A\u0629: Argatroban)\u200F \u0647\u0648 \u0645\u0631\u0643\u0628 \u0643\u064A\u0645\u064A\u0627\u0626\u064A \u064A\u0633\u062A\u062E\u062F\u0645 \u0643\u062F\u0648\u0627\u0621 \u0645\u0636\u0627\u062F \u0644\u0644\u062A\u062C\u0644\u0637 \u0627\u0644\u062F\u0645\u0648\u064A \u064A\u0639\u062A\u0628\u0631 \u0645\u0646 \u0645\u062B\u0628\u0637\u0627\u062A \u0627\u0644\u062B\u0631\u0648\u0645\u0628\u064A\u0646 \u062A\u0645 \u0627\u0644\u062A\u0631\u062E\u064A\u0635 \u0639\u0644\u064A\u0647 \u0645\u0646 \u0642\u0628\u0644 \u0625\u062F\u0627\u0631\u0629 \u0627\u0644\u063A\u0630\u0627\u0621 \u0648\u0627\u0644\u062F\u0648\u0627\u0621 \u0627\u0644\u0623\u0645\u0631\u064A\u0643\u064A\u0629 \u0641\u064A \u0639\u0627\u0645 2002\u060C \u064A\u0633\u062A\u062E\u062F\u0645 \u0644\u0639\u0644\u0627\u062C \u0627\u0644\u062C\u0644\u0637\u0627\u062A \u0627\u0644\u062F\u0645\u0648\u064A\u0629 \u0627\u0644\u0636\u0627\u0631\u0629\u060C \u0648\u064A\u0633\u062A\u062E\u062F\u0645 \u0644\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064A\u0646 \u064A\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0646\u0642\u0635 \u0627\u0644\u0635\u0641\u062D\u064A\u0627\u062A \u0627\u0644\u062F\u0645\u0648\u064A\u0629 \u0627\u0644\u0646\u0627\u062A\u062C\u0629 \u0639\u0646 \u0627\u0633\u062A\u062E\u062F\u0627\u0645 \u062F\u0648\u0627\u0621 \u0627\u0644\u0647\u064A\u0628\u0627\u0631\u064A\u0646\u060C \u0648\u064A\u0633\u062A\u062E\u062F\u0645 \u0641\u064A \u0628\u0639\u0636 \u0627\u0644\u0639\u0644\u0645\u064A\u0627\u062A \u0627\u0644\u062C\u0631\u0627\u062D\u064A\u0629 \u0644\u0644\u0642\u0644\u0628. \u0625\u062E\u0644\u0627\u0621 \u0645\u0633\u0624\u0648\u0644\u064A\u0629 \u0637\u0628\u064A\u0629 \n* \u0628\u0648\u0627\u0628\u0629 \u0637\u0628 \n* \u0628\u0648\u0627\u0628\u0629 \u0635\u064A\u062F\u0644\u0629 \n* \u0628\u0648\u0627\u0628\u0629 \u0627\u0644\u0643\u064A\u0645\u064A\u0627\u0621"@ar . "\u0627\u0631\u062C\u0627\u062A\u0631\u0648\u0628\u0627\u0646"@ar . . . . . . . "\u30A2\u30EB\u30AC\u30C8\u30ED\u30D0\u30F3"@ja . . . "5"^^ . "440542"^^ .