"BRCA2"@es . "BRCA2"@en . "RAD51 es un gen eucariota que codifica una prote\u00EDna que pertenece a la familia de la prote\u00EDna RAD51, que ayuda a la reparaci\u00F3n de roturas de doble hebra en el ADN. Los miembros de la familia de RAD51 son hom\u00F3logos de la prote\u00EDna bacteriana RecA y de la Rad51 de la levadura Saccharomyces cerevisiae. La prote\u00EDna est\u00E1 muy conservada en la mayor\u00EDa de los eucariotas, desde las levaduras a los humanos."@es . . . . . . . . . . . . . "BRCA2 and BRCA2 (/\u02CCbr\u00E6k\u0259\u02C8tu\u02D0/) are a human gene and its protein product, respectively. The official symbol (BRCA2, italic for the gene, nonitalic for the protein) and the official name (originally breast cancer 2; currently BRCA2, DNA repair associated) are maintained by the HUGO Gene Nomenclature Committee. One alternative symbol, FANCD1, recognizes its association with the FANC protein complex. Orthologs, styled Brca2 and Brca2, are common in other vertebrate species. BRCA2 is a human tumor suppressor gene (specifically, a caretaker gene), found in all humans; its protein, also called by the synonym breast cancer type 2 susceptibility protein, is responsible for repairing DNA. BRCA2 and BRCA1 are normally expressed in the cells of breast and other tissue, where they help repair damaged DNA or destroy cells if DNA cannot be repaired. They are involved in the repair of chromosomal damage with an important role in the error-free repair of DNA double strand breaks. If BRCA1 or BRCA2 itself is damaged by a BRCA mutation, damaged DNA is not repaired properly, and this increases the risk for breast cancer. BRCA1 and BRCA2 have been described as \"breast cancer susceptibility genes\" and \"breast cancer susceptibility proteins\". The predominant allele has a normal tumor suppressive function whereas high penetrance mutations in these genes cause a loss of tumor suppressive function, which correlates with an increased risk of breast cancer. The BRCA2 gene is located on the long (q) arm of chromosome 13 at position 12.3 (13q12.3). The human reference BRCA2 gene contains 27 exons, and the cDNA has 10,254 base pairs coding for a protein of 3418 amino acids."@en . . . . . . . . . "BRCA2 (dall'inglese BReast CAncer gene 2) \u00E8 un gene che codifica per la proteina di suscettibilit\u00E0 al cancro della mammella tipo 2 (in inglese Breast Cancer Type 2 susceptibility protein). BRCA2 appartiene alla famiglia dei geni oncosoppressori e il suo prodotto genico \u00E8 coinvolto nella riparazione dei tratti cromosomici danneggiati, con un ruolo importante nella riparazione degli errori e delle rotture nel doppio filamento di DNA. Il gene BRCA2 \u00E8 situato sul braccio lungo (q) del cromosoma 13, nella posizione 12.3 (13q12.3), dalla coppia di basi 31,787,616 alla coppia 31,871,804."@it . . . "Rad51\u662F\u771F\u6838\u751F\u7269\u9AD4\u5167\u7684\u4E00\u7A2E\u86CB\u767D\u8CEA\uFF0C\u4E0E\u539F\u6838\u751F\u7269\u7684\u540C\u6E90\uFF0C\u662F\u4E00\u79CD\u9AD8\u5EA6\u4FDD\u5B88\u7684\u86CB\u767D\uFF0C\u5F9E\u9175\u6BCD\u83CC\u5230\u4EBA\u985E\u4E4B\u9593\u7684\u8B8A\u7570\u4E0D\u5927\u3002\u4EBA\u985E\u7684Rad51\u542B\u6709339\u500B\u6C28\u57FA\u9178\uFF0C\u65BC\u540C\u6E90\u91CD\u7D44\u4E2D\u626E\u6F14\u4E3B\u8981\u89D2\u8272\uFF0C\u53C3\u8207\u641C\u5C0B\u540C\u6E90\u90E8\u4F4D\u8207DNA\u7684\u914D\u5C0D\u904E\u7A0B\u3002 \u4EBA\u985E\u7684Rad51\u7684\u57FA\u56E0\u4F4D\u65BC\u7B2C15\u865F\u67D3\u8272\u9AD4\u3002\u5305\u62EC\u6B64\u57FA\u56E0\u5728\u5167\uFF0C\u54FA\u4E73\u985E\u5171\u6709\u4E03\u7A2E\u985E\u4F3CrecA\u7684\u57FA\u56E0\uFF0C\u5305\u62ECRad51\u3001Rad51L1/B\u3001Rad51L2/C\u3001Rad51L3/D\u3001XRCC2\u3001XRCC3\u4EE5\u53CADMC1\u3002"@zh . "RAD51 \u2013 gen b\u0119d\u0105cy homologiem prokariotycznego genu RecA. Podobne strukturalnie bia\u0142ka zosta\u0142y zgrupowane w rodzinie bia\u0142ek RAD51, zaanga\u017Cowanych w mechanizm naprawy DNA przez rekombinacj\u0119 homologiczn\u0105. U ludzi gen RAD51 znajduje si\u0119 na chromosomie 15 i koduje bia\u0142ko d\u0142ugo\u015Bci 339 reszt aminokwas\u00F3w."@pl . . . . . "Le g\u00E8ne BRCA2 (abr\u00E9viation de Breast Cancer 2, \u00AB cancer du sein 2 \u00BB) est un g\u00E8ne humain qui appartient \u00E0 une classe de g\u00E8nes suppresseurs de tumeur. Il est situ\u00E9 sur le chromosome 13 humain, et est impliqu\u00E9 dans environ 45 % des cancers familiaux et 10 \u00E0 20 % des cancers du sein et de l'ovaire."@fr . . . . . . . . . "RAD51 \u0647\u0648 \u062C\u064A\u0646 \u0644\u062F\u0649 \u062D\u0642\u064A\u0642\u064A\u0627\u062A \u0627\u0644\u0646\u0648\u0649\u060C \u064A\u0646\u062A\u0645\u064A \u0627\u0644\u0625\u0646\u0632\u064A\u0645 \u0627\u0644\u0645\u0634\u0641\u064E\u0651\u0631 \u0628\u0648\u0627\u0633\u0637\u0629 \u0647\u0630\u0627 \u0627\u0644\u062C\u064A\u0646 \u0625\u0644\u0649 \u0639\u0627\u0626\u0644\u0629 \u0627\u0644\u0628\u0631\u0648\u062A\u064A\u0646\u0627\u062A RAD51 \u0627\u0644\u062A\u064A \u062A\u0633\u0627\u0647\u0645 \u0641\u064A \u062A\u0631\u0645\u064A\u0645 \u0634\u0631\u0648\u062E \u0627\u0644\u062F\u0646\u0627 \u0645\u0632\u062F\u0648\u062C \u0627\u0644\u0633\u0644\u0627\u0633\u0644. \u0623\u0639\u0636\u0627\u0621 \u0627\u0644\u0639\u0627\u0626\u0644\u0629 RAD51 \u062A\u0645\u0627\u062B\u0644 \u0627\u0644\u0628\u0631\u0648\u062A\u064A\u0646 RecA \u0627\u0644\u0628\u0643\u062A\u064A\u0631\u064A\u060C RadA \u0644\u0644\u0639\u062A\u0627\u0626\u0642 \u0648Rad51 \u0641\u064A \u0627\u0644\u062E\u0645\u064A\u0631\u0629. \u064A\u064F\u062D\u062A\u0641\u0638 \u0628\u0627\u0644\u0628\u0631\u0648\u062A\u064A\u0646 \u0628\u0634\u0643\u0644 \u0643\u0628\u064A\u0631 \u0644\u062F\u0649 \u062D\u0642\u064A\u0642\u064A\u0627\u062A \u0627\u0644\u0646\u0648\u0649\u060C \u0645\u0646 \u0627\u0644\u0639\u062A\u0627\u0626\u0642 \u0625\u0644\u0649 \u0627\u0644\u0628\u0634\u0631."@ar . "BRCA2 (dall'inglese BReast CAncer gene 2) \u00E8 un gene che codifica per la proteina di suscettibilit\u00E0 al cancro della mammella tipo 2 (in inglese Breast Cancer Type 2 susceptibility protein). BRCA2 appartiene alla famiglia dei geni oncosoppressori e il suo prodotto genico \u00E8 coinvolto nella riparazione dei tratti cromosomici danneggiati, con un ruolo importante nella riparazione degli errori e delle rotture nel doppio filamento di DNA. Il gene BRCA2 \u00E8 situato sul braccio lungo (q) del cromosoma 13, nella posizione 12.3 (13q12.3), dalla coppia di basi 31,787,616 alla coppia 31,871,804."@it . . . . . . . . . "crystal structure of a rad51-brca2 brc repeat complex"@en . "RAD51"@fr . . . "\u064A\u0645\u062B\u0644 BRCA2 \u062C\u064A\u0646\u064B\u0627 \u0628\u0634\u0631\u064A\u064B\u0627 \u0648\u0627\u0644\u0628\u0631\u0648\u062A\u064A\u0646 \u0627\u0644\u062E\u0627\u0635 \u0628\u0647\u060C \u0648\u064A\u064F\u0643\u062A\u0628 \u0647\u0630\u0627 \u0627\u0644\u0631\u0645\u0632 \u0645\u0627\u0626\u0644\u064B\u0627 \u0644\u064A\u0645\u062B\u0644 \u0627\u0644\u062C\u064A\u0646 \u0648\u063A\u064A\u0631 \u0645\u0627\u0626\u0644 \u0644\u064A\u0645\u062B\u0644 \u0627\u0644\u0628\u0631\u0648\u062A\u064A\u0646 \u0646\u0641\u0633\u0647\u061B \u062D\u064A\u062B \u062A\u0645 \u0627\u0644\u0627\u062A\u0641\u0627\u0642 \u0639\u0644\u0649 \u0647\u0630\u0627 \u0627\u0644\u0627\u0633\u0645 \u0631\u0633\u0645\u064A\u064B\u0627 \u0645\u0646 \u0642\u0628\u0644 \u0645\u0646\u0638\u0645\u0629 \u0627\u0644\u062C\u064A\u0646\u0648\u0645 \u0627\u0644\u0628\u0634\u0631\u064A\u060C \u0648\u064A\u0648\u062C\u062F \u0631\u0645\u0632 \u0622\u062E\u0631 \u0648\u0647\u0648 FANCD1 \u0648\u0627\u0644\u0630\u064A \u064A\u0645\u062B\u0644 \u0627\u0631\u062A\u0628\u0627\u0637 \u0627\u0644\u062C\u064A\u0646 \u0628\u0628\u0631\u0648\u062A\u064A\u0646\u0627\u062A FANC\u060C \u0648\u064A\u0639\u0631\u0641 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062B\u062F\u064A2 \u0639\u0644\u0649 \u0627\u0646\u0647 \u062C\u064A\u0646 \u0627\u0644\u0648\u0631\u0645 \u0627\u0644\u0642\u0627\u0645\u0639. \u064A\u064F\u0639\u062F \u0628\u0631\u0648\u062A\u064A\u0646 \u0627\u0644\u062C\u064A\u0646 \u0627\u0644\u0646\u0627\u0638\u0631 -\u0627\u0644\u0645\u0648\u062C\u0648\u062F \u0641\u064A \u062C\u0645\u064A\u0639 \u0627\u0644\u0628\u0634\u0631-\u0645\u0633\u0626\u0648\u0644\u064B\u0627 \u0639\u0646 \u0627\u0635\u0644\u0627\u062D \u0627\u0644\u062D\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u0649 DNA. \u0625\u0646 \u062C\u064A\u0646 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062B\u062F\u064A \u064A\u0642\u0639 \u0639\u0644\u0649 \u0627\u0644\u0630\u0631\u0627\u0639 \u0627\u0644\u0623\u0643\u062B\u0631 \u0637\u0648\u0644\u064B\u0627 \u0645\u0646 \u0627\u0644\u0643\u0631\u0648\u0645\u0648\u0633\u0648\u0645 13 \u0641\u064A \u0627\u0644\u0645\u0648\u0636\u0639 12.3 .\u0627\u0644\u0645\u0631\u062C\u0639 \u0627\u0644\u0628\u0634\u0631\u064A \u0644\u062C\u064A\u0646 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062B\u062F\u064A \u064A\u062D\u0648\u064A 27 \u0625\u0643\u0633\u0648\u0646\u060C \u0648\u0634\u0631\u064A\u0637 DNA \u0627\u0644\u0645\u062A\u0645\u0645 \u064A\u062D\u0648\u064A 10.254 \u0632\u0648\u062C \u0645\u0646 \u0627\u0644\u0642\u0648\u0627\u0639\u062F \u0648\u0627\u0644\u062A\u064A \u062A\u064F\u062A\u064E\u0631\u062C\u064E\u0645 \u0625\u0644\u0649 \u0628\u0631\u0648\u062A\u064A\u0646\u064D \u0645\u0646 3418 \u062D\u0645\u0636\u064B\u0627 \u0623\u0645\u064A\u0646\u064A\u064B\u0627."@ar . . "RAD51"@pl . . . . . . . "RAD51 \u0647\u0648 \u062C\u064A\u0646 \u0644\u062F\u0649 \u062D\u0642\u064A\u0642\u064A\u0627\u062A \u0627\u0644\u0646\u0648\u0649\u060C \u064A\u0646\u062A\u0645\u064A \u0627\u0644\u0625\u0646\u0632\u064A\u0645 \u0627\u0644\u0645\u0634\u0641\u064E\u0651\u0631 \u0628\u0648\u0627\u0633\u0637\u0629 \u0647\u0630\u0627 \u0627\u0644\u062C\u064A\u0646 \u0625\u0644\u0649 \u0639\u0627\u0626\u0644\u0629 \u0627\u0644\u0628\u0631\u0648\u062A\u064A\u0646\u0627\u062A RAD51 \u0627\u0644\u062A\u064A \u062A\u0633\u0627\u0647\u0645 \u0641\u064A \u062A\u0631\u0645\u064A\u0645 \u0634\u0631\u0648\u062E \u0627\u0644\u062F\u0646\u0627 \u0645\u0632\u062F\u0648\u062C \u0627\u0644\u0633\u0644\u0627\u0633\u0644. \u0623\u0639\u0636\u0627\u0621 \u0627\u0644\u0639\u0627\u0626\u0644\u0629 RAD51 \u062A\u0645\u0627\u062B\u0644 \u0627\u0644\u0628\u0631\u0648\u062A\u064A\u0646 RecA \u0627\u0644\u0628\u0643\u062A\u064A\u0631\u064A\u060C RadA \u0644\u0644\u0639\u062A\u0627\u0626\u0642 \u0648Rad51 \u0641\u064A \u0627\u0644\u062E\u0645\u064A\u0631\u0629. \u064A\u064F\u062D\u062A\u0641\u0638 \u0628\u0627\u0644\u0628\u0631\u0648\u062A\u064A\u0646 \u0628\u0634\u0643\u0644 \u0643\u0628\u064A\u0631 \u0644\u062F\u0649 \u062D\u0642\u064A\u0642\u064A\u0627\u062A \u0627\u0644\u0646\u0648\u0649\u060C \u0645\u0646 \u0627\u0644\u0639\u062A\u0627\u0626\u0642 \u0625\u0644\u0649 \u0627\u0644\u0628\u0634\u0631."@ar . . "Rad51 \u306F\u3001\u5358\u7D30\u80DE\u771F\u6838\u751F\u7269\u304B\u3089\u30D2\u30C8\u307E\u3067\u306E\u77E5\u3089\u308C\u3066\u3044\u308B\u9650\u308A\u3059\u3079\u3066\u306E\u771F\u6838\u751F\u7269\u306B\u5B58\u5728\u3059\u308B\u3001\u907A\u4F1D\u5B50\u3042\u308B\u3044\u306F\u305D\u308C\u306B\u30B3\u30FC\u30C9\u3055\u308C\u308B\u30BF\u30F3\u30D1\u30AF\u8CEA\u3067\u3042\u308B\u3002DNA\u4E8C\u91CD\u9396\u5207\u65AD\u306E\u4FEE\u5FA9\u306B\u95A2\u4E0E\u3059\u308B\u3002\u539F\u6838\u751F\u7269\u306ERecA\u30BF\u30F3\u30D1\u30AF\u8CEA\u3068\u914D\u5217\u306E\u76F8\u540C\u6027\u3092\u6709\u3059\u308B\u3002"@ja . . . . . . "BRCA2 \u2013 ludzki gen zlokalizowany na chromosomie 13. Germinalne mutacje genu prowadz\u0105, podobnie jak mutacje w BRCA1, do zwi\u0119kszonego ryzyka raka sutka i jajnika. Bia\u0142ko kodowane przez BRCA2 jest zaanga\u017Cowane w napraw\u0119 DNA (napraw\u0119 przez rekombinacj\u0119 uszkodze\u0144 obu nici DNA)."@pl . "IPR002093"@en . . "BRCA2 \u2013 ludzki gen zlokalizowany na chromosomie 13. Germinalne mutacje genu prowadz\u0105, podobnie jak mutacje w BRCA1, do zwi\u0119kszonego ryzyka raka sutka i jajnika. Bia\u0142ko kodowane przez BRCA2 jest zaanga\u017Cowane w napraw\u0119 DNA (napraw\u0119 przez rekombinacj\u0119 uszkodze\u0144 obu nici DNA)."@pl . . . . . . . . . . "RAD51 (\u0430\u043D\u0433\u043B. RAD51 recombinase) \u2013 \u0431\u0456\u043B\u043E\u043A, \u044F\u043A\u0438\u0439 \u043A\u043E\u0434\u0443\u0454\u0442\u044C\u0441\u044F \u043E\u0434\u043D\u043E\u0439\u043C\u0435\u043D\u043D\u0438\u043C \u0433\u0435\u043D\u043E\u043C, \u0440\u043E\u0437\u0442\u0430\u0448\u043E\u0432\u0430\u043D\u0438\u043C \u0443 \u043B\u044E\u0434\u0435\u0439 \u043D\u0430 \u043A\u043E\u0440\u043E\u0442\u043A\u043E\u043C\u0443 \u043F\u043B\u0435\u0447\u0456 15-\u0457 \u0445\u0440\u043E\u043C\u043E\u0441\u043E\u043C\u0438. \u0414\u043E\u0432\u0436\u0438\u043D\u0430 \u043F\u043E\u043B\u0456\u043F\u0435\u043F\u0442\u0438\u0434\u043D\u043E\u0433\u043E \u043B\u0430\u043D\u0446\u044E\u0433\u0430 \u0431\u0456\u043B\u043A\u0430 \u0441\u0442\u0430\u043D\u043E\u0432\u0438\u0442\u044C 339 \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442, \u0430 \u043C\u043E\u043B\u0435\u043A\u0443\u043B\u044F\u0440\u043D\u0430 \u043C\u0430\u0441\u0430 \u2014 36 966. \u041F\u043E\u0441\u043B\u0456\u0434\u043E\u0432\u043D\u0456\u0441\u0442\u044C \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442 A: \u0410\u043B\u0430\u043D\u0456\u043DC: \u0426\u0438\u0441\u0442\u0435\u0457\u043DD: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430E: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430F: \u0424\u0435\u043D\u0456\u043B\u0430\u043B\u0430\u043D\u0456\u043DG: \u0413\u043B\u0456\u0446\u0438\u043DH: \u0413\u0456\u0441\u0442\u0438\u0434\u0438\u043DI: \u0406\u0437\u043E\u043B\u0435\u0439\u0446\u0438\u043DK: \u041B\u0456\u0437\u0438\u043DL: \u041B\u0435\u0439\u0446\u0438\u043DM: \u041C\u0435\u0442\u0456\u043E\u043D\u0456\u043DN: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043DP: \u041F\u0440\u043E\u043B\u0456\u043DQ: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043DR: \u0410\u0440\u0433\u0456\u043D\u0456\u043DS: \u0421\u0435\u0440\u0438\u043DT: \u0422\u0440\u0435\u043E\u043D\u0456\u043DV: \u0412\u0430\u043B\u0456\u043D Y: \u0422\u0438\u0440\u043E\u0437\u0438\u043D \u041A\u043E\u0434\u043E\u0432\u0430\u043D\u0438\u0439 \u0433\u0435\u043D\u043E\u043C \u0431\u0456\u043B\u043E\u043A \u0437\u0430 \u0444\u0443\u043D\u043A\u0446\u0456\u0454\u044E \u043D\u0430\u043B\u0435\u0436\u0438\u0442\u044C \u0434\u043E \u0444\u043E\u0441\u0444\u043E\u043F\u0440\u043E\u0442\u0435\u0457\u043D\u0456\u0432. \u0417\u0430\u0434\u0456\u044F\u043D\u0438\u0439 \u0443 \u0442\u0430\u043A\u0438\u0445 \u0431\u0456\u043E\u043B\u043E\u0433\u0456\u0447\u043D\u0438\u0445 \u043F\u0440\u043E\u0446\u0435\u0441\u0430\u0445, \u044F\u043A \u043F\u043E\u0448\u043A\u043E\u0434\u0436\u0435\u043D\u043D\u044F \u0414\u041D\u041A, \u0440\u0435\u043F\u0430\u0440\u0430\u0446\u0456\u044F \u0414\u041D\u041A, \u0440\u0435\u043A\u043E\u043C\u0431\u0456\u043D\u0430\u0446\u0456\u044F \u0414\u041D\u041A, \u0430\u0446\u0435\u0442\u0438\u043B\u044E\u0432\u0430\u043D\u043D\u044F, \u0430\u043B\u044C\u0442\u0435\u0440\u043D\u0430\u0442\u0438\u0432\u043D\u0438\u0439 \u0441\u043F\u043B\u0430\u0439\u0441\u0438\u043D\u0433. \u0411\u0456\u043B\u043E\u043A \u043C\u0430\u0454 \u0441\u0430\u0439\u0442 \u0434\u043B\u044F \u0437\u0432'\u044F\u0437\u0443\u0432\u0430\u043D\u043D\u044F \u0437 \u0410\u0422\u0424, \u043D\u0443\u043A\u043B\u0435\u043E\u0442\u0438\u0434\u0430\u043C\u0438, \u0414\u041D\u041A. \u041B\u043E\u043A\u0430\u043B\u0456\u0437\u043E\u0432\u0430\u043D\u0438\u0439 \u0443 \u0446\u0438\u0442\u043E\u043F\u043B\u0430\u0437\u043C\u0456, \u0446\u0438\u0442\u043E\u0441\u043A\u0435\u043B\u0435\u0442\u0456, \u044F\u0434\u0440\u0456, \u043C\u0456\u0442\u043E\u0445\u043E\u043D\u0434\u0440\u0456\u0457."@uk . . . . "\u4E73\u817A\u764C\u4E8C\u53F7\u57FA\u56E0\uFF08BRCA2\uFF09\u662F\u4E00\u79CD\u5BFC\u81F4\u4E73\u817A\u764C\u7684\u86CB\u767D\u8D28\u57FA\u56E0\uFF0C\u5728\u4EBA\u4F53\u4E2D\u8868\u8FBE\u4E3A\u7F16\u7801BRCA2\u7684\u57FA\u56E0\u5176\u4E0EBRCA1\u4E00\u8D77\u6784\u6210\u4E86\u4E73\u817A\u764C\u7684\u4E3B\u8981\u81F4\u75C5\u57FA\u56E0\u3002 BRCA1\u4E0EBRCA2\u662F\u4E24\u79CD\u4E0D\u76F8\u5173\u7684\u86CB\u767D\u8D28\uFF0C\u4F46\u901A\u5E38\u90FD\u5728\u4E73\u623F\u4E0E\u5176\u4ED6\u7EC6\u80DE\u7EC4\u7EC7\u4E2D\u51FA\u73B0\u3002\u5B83\u4EEC\u53EF\u5E2E\u52A9\u4FEE\u590DDNA\uFF0C\u4E5F\u53EF\u5728\u65E0\u6CD5\u4FEE\u590DDNA\u7684\u60C5\u51B5\u4E0B\u7834\u574F\u7EC6\u80DE\u3002\u5B83\u4EEC\u53C2\u4E0E\u67D3\u8272\u4F53\u635F\u4F24\u7684\u4FEE\u590D\uFF0C\u5728DNA\u53CC\u94FE\u65AD\u88C2\u7684\u65E0\u9519\u4FEE\u590D\u4E2D\u8D77\u7740\u91CD\u8981\u4F5C\u7528\u3002\u5982\u679CBRCA1\u6216BRCA2\u672C\u8EAB\u56E0\u800C\u53D7\u635F\uFF0C\u5219\u53D7\u635F\u7684DNA\u65E0\u6CD5\u6B63\u786E\u4FEE\u590D\uFF0C\u8FD9\u4F1A\u589E\u52A0\u60A3\u4E73\u817A\u764C\u7684\u98CE\u9669\u3002BRCA1\u548CBRCA2\u88AB\u63CF\u8FF0\u4E3A\u201C\u4E73\u817A\u764C\u6613\u611F\u57FA\u56E0\u201D\u548C\u201C\u4E73\u817A\u764C\u6613\u611F\u86CB\u767D\u201D\u3002\u4E3B\u8981\u7684\u7B49\u4F4D\u57FA\u56E0\u5177\u6709\u6B63\u5E38\u7684\u80BF\u7624\u6291\u5236\u529F\u80FD\uFF0C\u800C\u8FD9\u4E9B\u57FA\u56E0\u4E2D\u7684\u9AD8\u6E17\u900F\u6027\u7A81\u53D8\u4F1A\u5BFC\u81F4\u80BF\u7624\u6291\u5236\u529F\u80FD\u7684\u4E27\u5931\uFF0C\u8FD9\u4E0E\u60A3\u4E73\u817A\u764C\u7684\u98CE\u9669\u589E\u52A0\u76F8\u5173\u3002 BRCA2\u57FA\u56E0\u4F4D\u4E8E\u7B2C\u5341\u4E09\u53F7\u67D3\u8272\u4F53\u7684\u957Fq\u81C212.3\u4F4D\uFF0813q12.3\uFF09\u3002\u4EBA\u7C7B\u53C2\u8003 BRCA 2 \u57FA\u56E0\u5305\u542B 27 \u4E2A\u5916\u663E\u5B50\uFF0C\u8BE5 cDNA \u6709 10,254 \u4E2A\u78B1\u57FA\u5BF9\u7F16\u7801 3418 \u4E2A\u6C28\u57FA\u9178\u7684\u86CB\u767D\u8D28\u3002"@zh . "1248100"^^ . "BRCA2"@pt . . . . "RAD51 (\u0430\u043D\u0433\u043B. RAD51 recombinase) \u2013 \u0431\u0456\u043B\u043E\u043A, \u044F\u043A\u0438\u0439 \u043A\u043E\u0434\u0443\u0454\u0442\u044C\u0441\u044F \u043E\u0434\u043D\u043E\u0439\u043C\u0435\u043D\u043D\u0438\u043C \u0433\u0435\u043D\u043E\u043C, \u0440\u043E\u0437\u0442\u0430\u0448\u043E\u0432\u0430\u043D\u0438\u043C \u0443 \u043B\u044E\u0434\u0435\u0439 \u043D\u0430 \u043A\u043E\u0440\u043E\u0442\u043A\u043E\u043C\u0443 \u043F\u043B\u0435\u0447\u0456 15-\u0457 \u0445\u0440\u043E\u043C\u043E\u0441\u043E\u043C\u0438. \u0414\u043E\u0432\u0436\u0438\u043D\u0430 \u043F\u043E\u043B\u0456\u043F\u0435\u043F\u0442\u0438\u0434\u043D\u043E\u0433\u043E \u043B\u0430\u043D\u0446\u044E\u0433\u0430 \u0431\u0456\u043B\u043A\u0430 \u0441\u0442\u0430\u043D\u043E\u0432\u0438\u0442\u044C 339 \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442, \u0430 \u043C\u043E\u043B\u0435\u043A\u0443\u043B\u044F\u0440\u043D\u0430 \u043C\u0430\u0441\u0430 \u2014 36 966. \u041F\u043E\u0441\u043B\u0456\u0434\u043E\u0432\u043D\u0456\u0441\u0442\u044C \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442 A: \u0410\u043B\u0430\u043D\u0456\u043DC: \u0426\u0438\u0441\u0442\u0435\u0457\u043DD: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430E: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430F: \u0424\u0435\u043D\u0456\u043B\u0430\u043B\u0430\u043D\u0456\u043DG: \u0413\u043B\u0456\u0446\u0438\u043DH: \u0413\u0456\u0441\u0442\u0438\u0434\u0438\u043DI: \u0406\u0437\u043E\u043B\u0435\u0439\u0446\u0438\u043DK: \u041B\u0456\u0437\u0438\u043DL: \u041B\u0435\u0439\u0446\u0438\u043DM: \u041C\u0435\u0442\u0456\u043E\u043D\u0456\u043DN: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043DP: \u041F\u0440\u043E\u043B\u0456\u043DQ: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043DR: \u0410\u0440\u0433\u0456\u043D\u0456\u043DS: \u0421\u0435\u0440\u0438\u043DT: \u0422\u0440\u0435\u043E\u043D\u0456\u043DV: \u0412\u0430\u043B\u0456\u043D Y: \u0422\u0438\u0440\u043E\u0437\u0438\u043D"@uk . "RAD51 \u2013 gen b\u0119d\u0105cy homologiem prokariotycznego genu RecA. Podobne strukturalnie bia\u0142ka zosta\u0142y zgrupowane w rodzinie bia\u0142ek RAD51, zaanga\u017Cowanych w mechanizm naprawy DNA przez rekombinacj\u0119 homologiczn\u0105. U ludzi gen RAD51 znajduje si\u0119 na chromosomie 15 i koduje bia\u0142ko d\u0142ugo\u015Bci 339 reszt aminokwas\u00F3w."@pl . "BRCA2"@ar . . . . . . . . . "BRCA2 (em ingl\u00EAs, breast cancer 2) \u00E9 um gene supressor de tumor e, assim como BRCA1, a identifica\u00E7\u00E3o de muta\u00E7\u00F5es nesse gene \u00E9 relevante para o diagn\u00F3stico de predisposi\u00E7\u00E3o ao c\u00E2ncer de mama e ov\u00E1rio. Muta\u00E7\u00F5es nesse gene tamb\u00E9m conferem risco aumentado para o muitos outros tipos de c\u00E2ncer, incluindo c\u00E2ncer de mama em homens, c\u00E2ncer de p\u00E2ncreas e c\u00E2ncer de pr\u00F3stata. Os produtos g\u00EAnicos de BRCA1 e BRCA2 atuam em uma via comum importante para a integridade do genoma e manuten\u00E7\u00E3o da estabilidade cromoss\u00F4mica. O gene foi identificado em 1994 por pesquisadores do (Londres) sob a lideran\u00E7a do Professor , a partir de estudos em fam\u00EDlias acometidas pelo c\u00E2ncer de mama e que n\u00E3o apresentavam muta\u00E7\u00F5es no gene BRCA1. A efetiva localiza\u00E7\u00E3o do gene no cromossomo 13 e publica\u00E7\u00E3o da descoberta se deram no ano de 1995 na revista Nature. V\u00E1rios organismos possuem regi\u00F5es de homologia com a prote\u00EDna BRCA2 humana, das quais o dom\u00EDnio de liga\u00E7\u00E3o DSS1 (DBD) da regi\u00E3o C-terminal \u00E9 a por\u00E7\u00E3o mais conservada de BRCA2 entre seus ort\u00F3logos nos metazoas, plantas e fungos."@pt . . . . . . "BRCA2 (em ingl\u00EAs, breast cancer 2) \u00E9 um gene supressor de tumor e, assim como BRCA1, a identifica\u00E7\u00E3o de muta\u00E7\u00F5es nesse gene \u00E9 relevante para o diagn\u00F3stico de predisposi\u00E7\u00E3o ao c\u00E2ncer de mama e ov\u00E1rio. Muta\u00E7\u00F5es nesse gene tamb\u00E9m conferem risco aumentado para o muitos outros tipos de c\u00E2ncer, incluindo c\u00E2ncer de mama em homens, c\u00E2ncer de p\u00E2ncreas e c\u00E2ncer de pr\u00F3stata. Os produtos g\u00EAnicos de BRCA1 e BRCA2 atuam em uma via comum importante para a integridade do genoma e manuten\u00E7\u00E3o da estabilidade cromoss\u00F4mica."@pt . . . . . . . . . . . "RAD51"@uk . . . . . . . . . "BRCA2\uFF08breast cancer susceptibility gene II)\u3068\u306F\u3001\u304C\u3093\u6291\u5236\u907A\u4F1D\u5B50\u306E\u4E00\u7A2E\u3067\u3042\u308A\u3001\u305D\u306E\u5909\u7570\u306B\u3088\u308A\u907A\u4F1D\u5B50\u4E0D\u5B89\u5B9A\u6027\u3092\u751F\u3058\u3001\u6700\u7D42\u7684\u306B\u4E73\u764C\u3092\u5F15\u304D\u8D77\u3053\u3059\u3002"@ja . . . "BRCA2 (breast cancer 2, \u00ABc\u00E0ncer de mama 2\u00BB) \u00E9s un gen hum\u00E0 del tipus conegut com a gens o gens supressors de tumors, que regulen el cicle cel\u00B7lular i eviten la incontrolada. La prote\u00EFna BRCA2, producte d'aquest gen, forma part del sistema de detecci\u00F3 i reparaci\u00F3 de danys del DNA. Les mutacions d'aquest gen estan implicades en alguns tipus de c\u00E0ncer, especialment el c\u00E0ncer de mama, i en l'an\u00E8mia de Fanconi. El gen BRCA2 est\u00E0 situat al bra\u00E7 llarg (q) del cromosoma 13, a la posici\u00F3 12.3, des del parell de bases 31.787.616 fins al parell de bases 31.871.804."@ca . "BRCA2"@ca . "BRCA2 (\u0430\u043D\u0433\u043B. BRCA2, DNA repair associated) \u2013 \u0431\u0456\u043B\u043E\u043A, \u044F\u043A\u0438\u0439 \u043A\u043E\u0434\u0443\u0454\u0442\u044C\u0441\u044F \u043E\u0434\u043D\u043E\u0439\u043C\u0435\u043D\u043D\u0438\u043C \u0433\u0435\u043D\u043E\u043C, \u0440\u043E\u0437\u0442\u0430\u0448\u043E\u0432\u0430\u043D\u0438\u043C \u0443 \u043B\u044E\u0434\u0435\u0439 \u043D\u0430 \u043A\u043E\u0440\u043E\u0442\u043A\u043E\u043C\u0443 \u043F\u043B\u0435\u0447\u0456 13-\u0457 \u0445\u0440\u043E\u043C\u043E\u0441\u043E\u043C\u0438. \u0414\u043E\u0432\u0436\u0438\u043D\u0430 \u043F\u043E\u043B\u0456\u043F\u0435\u043F\u0442\u0438\u0434\u043D\u043E\u0433\u043E \u043B\u0430\u043D\u0446\u044E\u0433\u0430 \u0431\u0456\u043B\u043A\u0430 \u0441\u0442\u0430\u043D\u043E\u0432\u0438\u0442\u044C 3 418 \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442, \u0430 \u043C\u043E\u043B\u0435\u043A\u0443\u043B\u044F\u0440\u043D\u0430 \u043C\u0430\u0441\u0430 \u2014 384 202. \u041F\u043E\u0441\u043B\u0456\u0434\u043E\u0432\u043D\u0456\u0441\u0442\u044C \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442 A: \u0410\u043B\u0430\u043D\u0456\u043DC: \u0426\u0438\u0441\u0442\u0435\u0457\u043DD: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430E: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430F: \u0424\u0435\u043D\u0456\u043B\u0430\u043B\u0430\u043D\u0456\u043DG: \u0413\u043B\u0456\u0446\u0438\u043DH: \u0413\u0456\u0441\u0442\u0438\u0434\u0438\u043DI: \u0406\u0437\u043E\u043B\u0435\u0439\u0446\u0438\u043DK: \u041B\u0456\u0437\u0438\u043DL: \u041B\u0435\u0439\u0446\u0438\u043DM: \u041C\u0435\u0442\u0456\u043E\u043D\u0456\u043DN: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043DP: \u041F\u0440\u043E\u043B\u0456\u043DQ: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043DR: \u0410\u0440\u0433\u0456\u043D\u0456\u043DS: \u0421\u0435\u0440\u0438\u043DT: \u0422\u0440\u0435\u043E\u043D\u0456\u043DV: \u0412\u0430\u043B\u0456\u043DW: \u0422\u0440\u0438\u043F\u0442\u043E\u0444\u0430\u043D Y: \u0422\u0438\u0440\u043E\u0437\u0438\u043D \u041A\u043E\u0434\u043E\u0432\u0430\u043D\u0438\u0439 \u0433\u0435\u043D\u043E\u043C \u0431\u0456\u043B\u043E\u043A \u0437\u0430 \u0444\u0443\u043D\u043A\u0446\u0456\u0454\u044E \u043D\u0430\u043B\u0435\u0436\u0438\u0442\u044C \u0434\u043E \u0444\u043E\u0441\u0444\u043E\u043F\u0440\u043E\u0442\u0435\u0457\u043D\u0456\u0432. \u0417\u0430\u0434\u0456\u044F\u043D\u0438\u0439 \u0443 \u0442\u0430\u043A\u0438\u0445 \u0431\u0456\u043E\u043B\u043E\u0433\u0456\u0447\u043D\u0438\u0445 \u043F\u0440\u043E\u0446\u0435\u0441\u0430\u0445, \u044F\u043A \u043A\u043B\u0456\u0442\u0438\u043D\u043D\u0438\u0439 \u0446\u0438\u043A\u043B, \u043F\u043E\u0448\u043A\u043E\u0434\u0436\u0435\u043D\u043D\u044F \u0414\u041D\u041A, \u0440\u0435\u043F\u0430\u0440\u0430\u0446\u0456\u044F \u0414\u041D\u041A, \u0440\u0435\u043A\u043E\u043C\u0431\u0456\u043D\u0430\u0446\u0456\u044F \u0414\u041D\u041A. \u0411\u0456\u043B\u043E\u043A \u043C\u0430\u0454 \u0441\u0430\u0439\u0442 \u0434\u043B\u044F \u0437\u0432'\u044F\u0437\u0443\u0432\u0430\u043D\u043D\u044F \u0437 \u0414\u041D\u041A. \u041B\u043E\u043A\u0430\u043B\u0456\u0437\u043E\u0432\u0430\u043D\u0438\u0439 \u0443 \u0446\u0438\u0442\u043E\u043F\u043B\u0430\u0437\u043C\u0456, \u0446\u0438\u0442\u043E\u0441\u043A\u0435\u043B\u0435\u0442\u0456, \u044F\u0434\u0440\u0456."@uk . "RAD51 \u00E9 um gene humano. A prote\u00EDna codificada por este gene \u00E9 um membro da fam\u00EDlia de prote\u00EDnas RAD51 que assistem na repara\u00E7\u00E3o de quebras na dupla cadeia de ADN. Os membros da fam\u00EDlia RAD51 s\u00E3o muito similares \u00E0 bacteriana e Rad51 de leveduras. A prote\u00EDna \u00E9 altamente conservada na maioria dos eucariotas, das leveduras a humanos."@pt . . . . . . . . . . . . . . "\u4E73\u817A\u764C\u4E8C\u53F7\u57FA\u56E0\uFF08BRCA2\uFF09\u662F\u4E00\u79CD\u5BFC\u81F4\u4E73\u817A\u764C\u7684\u86CB\u767D\u8D28\u57FA\u56E0\uFF0C\u5728\u4EBA\u4F53\u4E2D\u8868\u8FBE\u4E3A\u7F16\u7801BRCA2\u7684\u57FA\u56E0\u5176\u4E0EBRCA1\u4E00\u8D77\u6784\u6210\u4E86\u4E73\u817A\u764C\u7684\u4E3B\u8981\u81F4\u75C5\u57FA\u56E0\u3002 BRCA1\u4E0EBRCA2\u662F\u4E24\u79CD\u4E0D\u76F8\u5173\u7684\u86CB\u767D\u8D28\uFF0C\u4F46\u901A\u5E38\u90FD\u5728\u4E73\u623F\u4E0E\u5176\u4ED6\u7EC6\u80DE\u7EC4\u7EC7\u4E2D\u51FA\u73B0\u3002\u5B83\u4EEC\u53EF\u5E2E\u52A9\u4FEE\u590DDNA\uFF0C\u4E5F\u53EF\u5728\u65E0\u6CD5\u4FEE\u590DDNA\u7684\u60C5\u51B5\u4E0B\u7834\u574F\u7EC6\u80DE\u3002\u5B83\u4EEC\u53C2\u4E0E\u67D3\u8272\u4F53\u635F\u4F24\u7684\u4FEE\u590D\uFF0C\u5728DNA\u53CC\u94FE\u65AD\u88C2\u7684\u65E0\u9519\u4FEE\u590D\u4E2D\u8D77\u7740\u91CD\u8981\u4F5C\u7528\u3002\u5982\u679CBRCA1\u6216BRCA2\u672C\u8EAB\u56E0\u800C\u53D7\u635F\uFF0C\u5219\u53D7\u635F\u7684DNA\u65E0\u6CD5\u6B63\u786E\u4FEE\u590D\uFF0C\u8FD9\u4F1A\u589E\u52A0\u60A3\u4E73\u817A\u764C\u7684\u98CE\u9669\u3002BRCA1\u548CBRCA2\u88AB\u63CF\u8FF0\u4E3A\u201C\u4E73\u817A\u764C\u6613\u611F\u57FA\u56E0\u201D\u548C\u201C\u4E73\u817A\u764C\u6613\u611F\u86CB\u767D\u201D\u3002\u4E3B\u8981\u7684\u7B49\u4F4D\u57FA\u56E0\u5177\u6709\u6B63\u5E38\u7684\u80BF\u7624\u6291\u5236\u529F\u80FD\uFF0C\u800C\u8FD9\u4E9B\u57FA\u56E0\u4E2D\u7684\u9AD8\u6E17\u900F\u6027\u7A81\u53D8\u4F1A\u5BFC\u81F4\u80BF\u7624\u6291\u5236\u529F\u80FD\u7684\u4E27\u5931\uFF0C\u8FD9\u4E0E\u60A3\u4E73\u817A\u764C\u7684\u98CE\u9669\u589E\u52A0\u76F8\u5173\u3002 BRCA2\u57FA\u56E0\u4F4D\u4E8E\u7B2C\u5341\u4E09\u53F7\u67D3\u8272\u4F53\u7684\u957Fq\u81C212.3\u4F4D\uFF0813q12.3\uFF09\u3002\u4EBA\u7C7B\u53C2\u8003 BRCA 2 \u57FA\u56E0\u5305\u542B 27 \u4E2A\u5916\u663E\u5B50\uFF0C\u8BE5 cDNA \u6709 10,254 \u4E2A\u78B1\u57FA\u5BF9\u7F16\u7801 3418 \u4E2A\u6C28\u57FA\u9178\u7684\u86CB\u767D\u8D28\u3002"@zh . "BRCA2"@it . . . "Rad51 ist ein DNA-bindendes Protein in Eukaryonten und ein Mitglied der RAD51-Protein-Familie, die eine Funktion in der DNA-Reparatur bei Doppelstrangbr\u00FCchen hat. RAD51-Proteine sind Homologe zu den bakteriellen Proteinen RecA und zum Rad51 aus der B\u00E4ckerhefe. Die Proteinsequenz ist sehr stark konserviert, d. h. die Aminos\u00E4uresequenzen der jeweiligen Proteine \u00E4hneln sich von Hefen bis Menschen. Im Allgemeinen findet sich bei Eukaryoten (komplex-zellul\u00E4ren Organismen) neben Rad51 auch als homologes Protein, bei Archaeen dagegen und im Bakteriophagen T4 schlie\u00DFlich ."@de . . . . . . "BRCA2"@zh . . . . . . "RAD51"@pt . . . . . . . . . . "BRCA2"@en . . . . . . "La recombinase RAD51 fait partie de la famille des prot\u00E9ines RAD51. Chez les eucaryotes, elle est cod\u00E9e par le g\u00E8ne RAD51 qui, chez l'humain, se trouve sur le chromosome 15. Elle participe \u00E0 la r\u00E9paration de l'ADN, et plus particuli\u00E8rement des l\u00E9sions doubles brins. La famille RAD51 est homologue des prot\u00E9ines RecA chez les bact\u00E9ries, chez les arch\u00E9es et chez les levures. Cette prot\u00E9ines est hautement conserv\u00E9e chez la plupart des eucaryotes, depuis les levures jusqu'aux humains. La prot\u00E9ine RAD51 peut interagir avec la RPA, la BRCA2, la PALB2 et la (en)."@fr . . . . "La prote\u00EDna BRCA2 (de sus siglas en ingl\u00E9s \"Breast Cancer Type 2 susceptibility protein\") es una prote\u00EDna codificada en humanos por el gen BRCA2.\u200B Se han identificado ort\u00F3logos de BRCA2\u200B en la mayor\u00EDa de mam\u00EDferos para los cuales el genoma completo est\u00E1 disponible. BRCA2 pertenece a la familia de genes supresores de tumores\u200B\u200B y la prote\u00EDna codificada por este gen est\u00E1 implicada en reparaci\u00F3n de da\u00F1o cromos\u00F3mico con un importante papel en la reparaci\u00F3n libre de errores de cortes en la doble hebra de ADN.\u200B El gen BRCA2 est\u00E1 localizado en el brazo largo (q) del cromosoma 13 en la posici\u00F3n 12.3 (13q12.3), desde la base 31.787.616 a la base 31.871.804.\u200B Se han identificado cientos de mutaciones en este gen, muchas de las cuales causan un incremento en el riesgo de sufrir c\u00E1ncer de mama. Las mujeres que presentas estas mutaciones tienen un riesgo acumulado hasta los 70 a\u00F1os de entre 33- 95% para c\u00E1ncer de mama, y entre 4 y 47% para c\u00E1ncer de ovario.\u200B"@es . . . . . . "BRCA2"@fr . . . "Le g\u00E8ne BRCA2 (abr\u00E9viation de Breast Cancer 2, \u00AB cancer du sein 2 \u00BB) est un g\u00E8ne humain qui appartient \u00E0 une classe de g\u00E8nes suppresseurs de tumeur. Il est situ\u00E9 sur le chromosome 13 humain, et est impliqu\u00E9 dans environ 45 % des cancers familiaux et 10 \u00E0 20 % des cancers du sein et de l'ovaire."@fr . . . . . . . "RAD51"@zh . . "RAD51 \u00E9 um gene humano. A prote\u00EDna codificada por este gene \u00E9 um membro da fam\u00EDlia de prote\u00EDnas RAD51 que assistem na repara\u00E7\u00E3o de quebras na dupla cadeia de ADN. Os membros da fam\u00EDlia RAD51 s\u00E3o muito similares \u00E0 bacteriana e Rad51 de leveduras. A prote\u00EDna \u00E9 altamente conservada na maioria dos eucariotas, das leveduras a humanos."@pt . . "BRCA2 and BRCA2 (/\u02CCbr\u00E6k\u0259\u02C8tu\u02D0/) are a human gene and its protein product, respectively. The official symbol (BRCA2, italic for the gene, nonitalic for the protein) and the official name (originally breast cancer 2; currently BRCA2, DNA repair associated) are maintained by the HUGO Gene Nomenclature Committee. One alternative symbol, FANCD1, recognizes its association with the FANC protein complex. Orthologs, styled Brca2 and Brca2, are common in other vertebrate species. BRCA2 is a human tumor suppressor gene (specifically, a caretaker gene), found in all humans; its protein, also called by the synonym breast cancer type 2 susceptibility protein, is responsible for repairing DNA."@en . . . "BRCA2"@de . "RAD51"@ar . "BRCA2 (breast cancer 2, \u00ABc\u00E0ncer de mama 2\u00BB) \u00E9s un gen hum\u00E0 del tipus conegut com a gens o gens supressors de tumors, que regulen el cicle cel\u00B7lular i eviten la incontrolada. La prote\u00EFna BRCA2, producte d'aquest gen, forma part del sistema de detecci\u00F3 i reparaci\u00F3 de danys del DNA. Les mutacions d'aquest gen estan implicades en alguns tipus de c\u00E0ncer, especialment el c\u00E0ncer de mama, i en l'an\u00E8mia de Fanconi. El gen BRCA2 est\u00E0 situat al bra\u00E7 llarg (q) del cromosoma 13, a la posici\u00F3 12.3, des del parell de bases 31.787.616 fins al parell de bases 31.871.804."@ca . . . "BRCA2 repeat"@en . . . . . "72129"^^ . . "Rad51 \u306F\u3001\u5358\u7D30\u80DE\u771F\u6838\u751F\u7269\u304B\u3089\u30D2\u30C8\u307E\u3067\u306E\u77E5\u3089\u308C\u3066\u3044\u308B\u9650\u308A\u3059\u3079\u3066\u306E\u771F\u6838\u751F\u7269\u306B\u5B58\u5728\u3059\u308B\u3001\u907A\u4F1D\u5B50\u3042\u308B\u3044\u306F\u305D\u308C\u306B\u30B3\u30FC\u30C9\u3055\u308C\u308B\u30BF\u30F3\u30D1\u30AF\u8CEA\u3067\u3042\u308B\u3002DNA\u4E8C\u91CD\u9396\u5207\u65AD\u306E\u4FEE\u5FA9\u306B\u95A2\u4E0E\u3059\u308B\u3002\u539F\u6838\u751F\u7269\u306ERecA\u30BF\u30F3\u30D1\u30AF\u8CEA\u3068\u914D\u5217\u306E\u76F8\u540C\u6027\u3092\u6709\u3059\u308B\u3002"@ja . . . . . . . . . "BRCA2 ist ein Protein in den Zellkernen der meisten Eukaryoten, das als Untereinheit mehrerer Proteinkomplexe eine Schl\u00FCsselrolle bei der DNA-Reparatur und der homologen Rekombination einnimmt. Beim Menschen wird BRCA2 haupts\u00E4chlich in Brust- und Thymusdr\u00FCse, sowie in der Lunge, den Eierst\u00F6cken und der Milz produziert. Homozygote Mutationen im BRCA2-Gen sind f\u00FCr erh\u00F6htes Risiko f\u00FCr Bauchspeicheldr\u00FCsenkrebs, Brust- und Eierstockkrebs verantwortlich. Das Gen wird daher zur (veralteten) Klasse der Tumorsuppressorgene gez\u00E4hlt."@de . . . "BRCA2 (\u0430\u043D\u0433\u043B. BRCA2, DNA repair associated) \u2013 \u0431\u0456\u043B\u043E\u043A, \u044F\u043A\u0438\u0439 \u043A\u043E\u0434\u0443\u0454\u0442\u044C\u0441\u044F \u043E\u0434\u043D\u043E\u0439\u043C\u0435\u043D\u043D\u0438\u043C \u0433\u0435\u043D\u043E\u043C, \u0440\u043E\u0437\u0442\u0430\u0448\u043E\u0432\u0430\u043D\u0438\u043C \u0443 \u043B\u044E\u0434\u0435\u0439 \u043D\u0430 \u043A\u043E\u0440\u043E\u0442\u043A\u043E\u043C\u0443 \u043F\u043B\u0435\u0447\u0456 13-\u0457 \u0445\u0440\u043E\u043C\u043E\u0441\u043E\u043C\u0438. \u0414\u043E\u0432\u0436\u0438\u043D\u0430 \u043F\u043E\u043B\u0456\u043F\u0435\u043F\u0442\u0438\u0434\u043D\u043E\u0433\u043E \u043B\u0430\u043D\u0446\u044E\u0433\u0430 \u0431\u0456\u043B\u043A\u0430 \u0441\u0442\u0430\u043D\u043E\u0432\u0438\u0442\u044C 3 418 \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442, \u0430 \u043C\u043E\u043B\u0435\u043A\u0443\u043B\u044F\u0440\u043D\u0430 \u043C\u0430\u0441\u0430 \u2014 384 202. \u041F\u043E\u0441\u043B\u0456\u0434\u043E\u0432\u043D\u0456\u0441\u0442\u044C \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442 A: \u0410\u043B\u0430\u043D\u0456\u043DC: \u0426\u0438\u0441\u0442\u0435\u0457\u043DD: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430E: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430F: \u0424\u0435\u043D\u0456\u043B\u0430\u043B\u0430\u043D\u0456\u043DG: \u0413\u043B\u0456\u0446\u0438\u043DH: \u0413\u0456\u0441\u0442\u0438\u0434\u0438\u043DI: \u0406\u0437\u043E\u043B\u0435\u0439\u0446\u0438\u043DK: \u041B\u0456\u0437\u0438\u043DL: \u041B\u0435\u0439\u0446\u0438\u043DM: \u041C\u0435\u0442\u0456\u043E\u043D\u0456\u043DN: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043DP: \u041F\u0440\u043E\u043B\u0456\u043DQ: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043DR: \u0410\u0440\u0433\u0456\u043D\u0456\u043DS: \u0421\u0435\u0440\u0438\u043DT: \u0422\u0440\u0435\u043E\u043D\u0456\u043DV: \u0412\u0430\u043B\u0456\u043DW: \u0422\u0440\u0438\u043F\u0442\u043E\u0444\u0430\u043D Y: \u0422\u0438\u0440\u043E\u0437\u0438\u043D"@uk . . "BRCA2"@pl . . . . "RAD51 es un gen eucariota que codifica una prote\u00EDna que pertenece a la familia de la prote\u00EDna RAD51, que ayuda a la reparaci\u00F3n de roturas de doble hebra en el ADN. Los miembros de la familia de RAD51 son hom\u00F3logos de la prote\u00EDna bacteriana RecA y de la Rad51 de la levadura Saccharomyces cerevisiae. La prote\u00EDna est\u00E1 muy conservada en la mayor\u00EDa de los eucariotas, desde las levaduras a los humanos."@es . "Rad51\u662F\u771F\u6838\u751F\u7269\u9AD4\u5167\u7684\u4E00\u7A2E\u86CB\u767D\u8CEA\uFF0C\u4E0E\u539F\u6838\u751F\u7269\u7684\u540C\u6E90\uFF0C\u662F\u4E00\u79CD\u9AD8\u5EA6\u4FDD\u5B88\u7684\u86CB\u767D\uFF0C\u5F9E\u9175\u6BCD\u83CC\u5230\u4EBA\u985E\u4E4B\u9593\u7684\u8B8A\u7570\u4E0D\u5927\u3002\u4EBA\u985E\u7684Rad51\u542B\u6709339\u500B\u6C28\u57FA\u9178\uFF0C\u65BC\u540C\u6E90\u91CD\u7D44\u4E2D\u626E\u6F14\u4E3B\u8981\u89D2\u8272\uFF0C\u53C3\u8207\u641C\u5C0B\u540C\u6E90\u90E8\u4F4D\u8207DNA\u7684\u914D\u5C0D\u904E\u7A0B\u3002 \u4EBA\u985E\u7684Rad51\u7684\u57FA\u56E0\u4F4D\u65BC\u7B2C15\u865F\u67D3\u8272\u9AD4\u3002\u5305\u62EC\u6B64\u57FA\u56E0\u5728\u5167\uFF0C\u54FA\u4E73\u985E\u5171\u6709\u4E03\u7A2E\u985E\u4F3CrecA\u7684\u57FA\u56E0\uFF0C\u5305\u62ECRad51\u3001Rad51L1/B\u3001Rad51L2/C\u3001Rad51L3/D\u3001XRCC2\u3001XRCC3\u4EE5\u53CADMC1\u3002"@zh . . . "BRCA2"@uk . "La prote\u00EDna BRCA2 (de sus siglas en ingl\u00E9s \"Breast Cancer Type 2 susceptibility protein\") es una prote\u00EDna codificada en humanos por el gen BRCA2.\u200B Se han identificado ort\u00F3logos de BRCA2\u200B en la mayor\u00EDa de mam\u00EDferos para los cuales el genoma completo est\u00E1 disponible. BRCA2 pertenece a la familia de genes supresores de tumores\u200B\u200B y la prote\u00EDna codificada por este gen est\u00E1 implicada en reparaci\u00F3n de da\u00F1o cromos\u00F3mico con un importante papel en la reparaci\u00F3n libre de errores de cortes en la doble hebra de ADN.\u200B"@es . "PF00634"@en . . . . . "BRCA2"@ja . "BRCA2\uFF08breast cancer susceptibility gene II)\u3068\u306F\u3001\u304C\u3093\u6291\u5236\u907A\u4F1D\u5B50\u306E\u4E00\u7A2E\u3067\u3042\u308A\u3001\u305D\u306E\u5909\u7570\u306B\u3088\u308A\u907A\u4F1D\u5B50\u4E0D\u5B89\u5B9A\u6027\u3092\u751F\u3058\u3001\u6700\u7D42\u7684\u306B\u4E73\u764C\u3092\u5F15\u304D\u8D77\u3053\u3059\u3002"@ja . "Rad51"@de . . . "1116707483"^^ . . . . . . . . . . . . . "RAD51"@es . . . . . . . . . . . . "BRCA2 ist ein Protein in den Zellkernen der meisten Eukaryoten, das als Untereinheit mehrerer Proteinkomplexe eine Schl\u00FCsselrolle bei der DNA-Reparatur und der homologen Rekombination einnimmt. Beim Menschen wird BRCA2 haupts\u00E4chlich in Brust- und Thymusdr\u00FCse, sowie in der Lunge, den Eierst\u00F6cken und der Milz produziert. Homozygote Mutationen im BRCA2-Gen sind f\u00FCr erh\u00F6htes Risiko f\u00FCr Bauchspeicheldr\u00FCsenkrebs, Brust- und Eierstockkrebs verantwortlich. Das Gen wird daher zur (veralteten) Klasse der Tumorsuppressorgene gez\u00E4hlt."@de . . . . . . . "Rad51"@ja . "1"^^ . . 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"Rad51 ist ein DNA-bindendes Protein in Eukaryonten und ein Mitglied der RAD51-Protein-Familie, die eine Funktion in der DNA-Reparatur bei Doppelstrangbr\u00FCchen hat. RAD51-Proteine sind Homologe zu den bakteriellen Proteinen RecA und zum Rad51 aus der B\u00E4ckerhefe. Die Proteinsequenz ist sehr stark konserviert, d. h. die Aminos\u00E4uresequenzen der jeweiligen Proteine \u00E4hneln sich von Hefen bis Menschen. Im Allgemeinen findet sich bei Eukaryoten (komplex-zellul\u00E4ren Organismen) neben Rad51 auch als homologes Protein, bei Archaeen dagegen und im Bakteriophagen T4 schlie\u00DFlich ."@de . "La recombinase RAD51 fait partie de la famille des prot\u00E9ines RAD51. Chez les eucaryotes, elle est cod\u00E9e par le g\u00E8ne RAD51 qui, chez l'humain, se trouve sur le chromosome 15. Elle participe \u00E0 la r\u00E9paration de l'ADN, et plus particuli\u00E8rement des l\u00E9sions doubles brins. La famille RAD51 est homologue des prot\u00E9ines RecA chez les bact\u00E9ries, chez les arch\u00E9es et chez les levures. Cette prot\u00E9ines est hautement conserv\u00E9e chez la plupart des eucaryotes, depuis les levures jusqu'aux humains. Il existe de deux produits de transcription de ce g\u00E8ne distincts, r\u00E9sultant d'un m\u00E9canisme d'\u00E9pissage alternatif, tandis que des variantes suppl\u00E9mentaires r\u00E9sultent par ailleurs d'une polyad\u00E9nylation alternative. Sept g\u00E8nes apparent\u00E9s au g\u00E8ne recA ont \u00E9t\u00E9 recens\u00E9s chez les mammif\u00E8res : Rad51, Rad51L1/B, Rad51L2/C, Rad51L3/D, XRCC2, XRCC3 et DMC1/Lim15. Hormis la DMC1, sp\u00E9cifique \u00E0 la m\u00E9iose, toutes ces prot\u00E9ines sont indispensables au d\u00E9veloppement des mammif\u00E8res. Chez l'humain, la prot\u00E9ine RAD51 compte 339 r\u00E9sidus d'acides amin\u00E9s et joue un r\u00F4le essentiel dans la recombinaison homologue lors de la r\u00E9paration de l'ADN \u00E0 la suite de l\u00E9sions doubles brins. Au cours de ce processus, des brins d'ADN sont \u00E9chang\u00E9s moyennant l'hydrolyse de mol\u00E9cules d'ATP, et la prot\u00E9ine RAD51 intervient dans la recherche d'homologie entre ces brins, et leur appariement par compl\u00E9mentarit\u00E9. Contrairement aux autres prot\u00E9ines qui interagissent avec l'ADN, celles de la famille Rec1/Rad51 forment un filament h\u00E9lico\u00EFdal de nucl\u00E9oprot\u00E9ine sur l'ADN. La prot\u00E9ine RAD51 peut interagir avec la RPA, la BRCA2, la PALB2 et la (en)."@fr .