. "En inmunolog\u00EDa se denomina CD5 (del ingl\u00E9s cluster of differentiation) a un tipo de ant\u00EDgeno CD propio del sistema inmune de mam\u00EDferos. Se caracteriza por poseer un peso molecular de 55 kDa y su naturaleza bioqu\u00EDmica lo encuadra dentro de la familia de receptores basurero. Su funci\u00F3n biol\u00F3gica en la c\u00E9lula es: mediar en la transducci\u00F3n de se\u00F1al, mitigando la respuesta inmune ante sustancias que no deban desencadenar aquella. Se expresa espec\u00EDficamente en timocitos, c\u00E9lulas T y subpoblaciones de c\u00E9lulas B (las secretoras de IgM).\u200B"@es . "CD5 (protein)"@en . "La glicoproteina CD5 \u00E8 una proteina transmembrana di 67 kDa (58 se misurato in un non riducente) presente su Linfociti T e una piccola popolazione di linfociti B1 e timociti.Molecola costimolatoria accessoria, tramite la quale viene esercitata una modulazione sul segnale trasdotto dai complessi TCR e BCR. La proteina esercita un'azione diversa a seconda del tipo cellulare esercitando un'azione eccitatoria (B1 e timociti) o inibitoria (T mature) modulando la risposta di questi ultimi all'IL-1 \u00C8 anche conosciuta come: \n* Leu1 \n* T1 \n* Ly-1 (omologo murino) \n* Tp67"@it . . . . "CD5"@es . . "La glicoproteina CD5 \u00E8 una proteina transmembrana di 67 kDa (58 se misurato in un non riducente) presente su Linfociti T e una piccola popolazione di linfociti B1 e timociti.Molecola costimolatoria accessoria, tramite la quale viene esercitata una modulazione sul segnale trasdotto dai complessi TCR e BCR. La proteina esercita un'azione diversa a seconda del tipo cellulare esercitando un'azione eccitatoria (B1 e timociti) o inibitoria (T mature) modulando la risposta di questi ultimi all'IL-1 Fa parte della superfamiglia dei recettori scavenger possedendo nella parte extracitoplasmatica tre domini di questo tipo, che mostrano un basso grado di omologia tra le specie. Ha un dominio intracellulare altamente conservato che presenta molti siti per la fosforilazione inclusi in sequenze ITAM-like. Viene usato come marker per i linfociti B1 della leucemia a cellule capellute e per sottopopolazioni proliferanti di linfociti B autoreattivi nell'artrite reumatoide, sindrome di Sj\u00F6gren DM1, morbo di Graves. Nei linfociti T prelevati dopo un trapianto di midollo osseo viene persa la positivit\u00E0 per l'antigene e questo correla con una GVHD. La sua attivazione e fosforilazione conduce ad un rilascio di DAG e di Calcio che attiva la proteinchinasi C. \u00C8 anche conosciuta come: \n* Leu1 \n* T1 \n* Ly-1 (omologo murino) \n* Tp67"@it . "CD5 (ang. cluster of differentiation 5, synonimy: LEU1, T1) to bia\u0142ko wyst\u0119puj\u0105ce na limfocytach T oraz subpopulacji limfocyt\u00F3w B okre\u015Blanej nazw\u0105 . Gen koduj\u0105cy CD5 znajduje si\u0119 na chromosomie 11 w po\u0142o\u017Ceniu 11q23 . Sugerowanym ligandem dla CD5 jest cz\u0105steczka CD72. CD5 znajduje zastosowanie jako marker limfocyt\u00F3w T w badaniach immunohistochemicznych."@pl . . "CD5 (\u0431\u0435\u043B\u043E\u043A)"@ru . . . . . . . . "10628"^^ . . . "CD5 is a cluster of differentiation expressed on the surface of T cells (various species) and in a subset of murine B cells known as B-1a. The expression of this receptor in human B cells has been a controversial topic and to date there is no consensus regarding the role of this receptor as a marker of human B cells. B-1 cells have limited diversity of their B-cell receptor due to their lack of the enzyme terminal deoxynucleotidyl transferase (TdT) and are potentially self-reactive. CD5 serves to mitigate activating signals from the BCR so that the B-1 cells can only be activated by very strong stimuli (such as bacterial proteins) and not by normal tissue proteins. CD5 was used as a T-cell marker until monoclonal antibodies against CD3 were developed."@en . . . "CD5 is a cluster of differentiation expressed on the surface of T cells (various species) and in a subset of murine B cells known as B-1a. The expression of this receptor in human B cells has been a controversial topic and to date there is no consensus regarding the role of this receptor as a marker of human B cells. B-1 cells have limited diversity of their B-cell receptor due to their lack of the enzyme terminal deoxynucleotidyl transferase (TdT) and are potentially self-reactive. CD5 serves to mitigate activating signals from the BCR so that the B-1 cells can only be activated by very strong stimuli (such as bacterial proteins) and not by normal tissue proteins. CD5 was used as a T-cell marker until monoclonal antibodies against CD3 were developed. In humans, the gene is located on the long arm of chromosome 11. There is no confirmed ligand for CD5 but there is evidence that CD72, a C-type lectin, may be a ligand or that CD5 may be homophilic, binding CD5 on the surface of other cells. CD5 includes a scavenger receptor cysteine-rich protein domain. T cells express higher levels of CD5 than B cells. CD5 is upregulated on T cells upon strong activation. In the thymus, there is a correlation with CD5 expression and strength of the interaction of the T cell towards self-peptides."@en . "CD5 (Cluster de diff\u00E9renciation 5) est une prot\u00E9ine exprim\u00E9e \u00E0 la surface des lymphocytes T ainsi que par une sous-classe de lymphocytes B s\u00E9cr\u00E9tant des IgM ( (en)). CD5 est \u00E9galement appel\u00E9e Leu1. CD5 fut utilis\u00E9 comme marqueur des lymphocytes T jusqu'\u00E0 ce que des anticorps monoclonaux dirig\u00E9s contre CD3 soient d\u00E9velopp\u00E9s."@fr . . . . "CD5 \u043B\u0438\u043C\u0444\u043E\u0446\u0438\u0442\u0430\u0440\u043D\u044B\u0439 \u0440\u0435\u0446\u0435\u043F\u0442\u043E\u0440 (T1) \u2014 \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u043D\u044B\u0439 \u0431\u0435\u043B\u043E\u043A, \u0440\u0435\u0446\u0435\u043F\u0442\u043E\u0440, \u044D\u043A\u0441\u043F\u0440\u0435\u0441\u0441\u0438\u0440\u043E\u0432\u0430\u043D \u043D\u0430 \u043F\u043E\u0432\u0435\u0440\u0445\u043D\u043E\u0441\u0442\u0438 T-\u043B\u0438\u043C\u0444\u043E\u0446\u0438\u0442\u043E\u0432 \u0438 B-\u043B\u0438\u043C\u0444\u043E\u0446\u0438\u0442\u043E\u0432 \u043F\u043E\u0434\u0433\u0440\u0443\u043F\u043F\u044B B-1\u0430. \u0420\u0435\u0433\u0443\u043B\u0438\u0440\u0443\u0435\u0442 \u043F\u0440\u043E\u043B\u0438\u0444\u0435\u0440\u0430\u0446\u0438\u044E T-\u043B\u0438\u043C\u0444\u043E\u0446\u0438\u0442\u043E\u0432. \u041E\u0442\u043D\u043E\u0441\u0438\u0442\u0441\u044F \u043A \u0441\u0443\u043F\u0435\u0440\u0441\u0435\u043C\u0435\u0439\u0441\u0442\u0432\u0430 SRCR."@ru . . . "CD5 (ang. cluster of differentiation 5, synonimy: LEU1, T1) to bia\u0142ko wyst\u0119puj\u0105ce na limfocytach T oraz subpopulacji limfocyt\u00F3w B okre\u015Blanej nazw\u0105 . Gen koduj\u0105cy CD5 znajduje si\u0119 na chromosomie 11 w po\u0142o\u017Ceniu 11q23 . Sugerowanym ligandem dla CD5 jest cz\u0105steczka CD72. CD5 znajduje zastosowanie jako marker limfocyt\u00F3w T w badaniach immunohistochemicznych."@pl . . . . . . . "10794560"^^ . "O CD5 (Cluster of Differentiation 5) \u00E9 uma mol\u00E9cula de superf\u00EDcie celular encontrada em um sutipo de c\u00E9lulas B secretoras de imunoglobulina chamadas de c\u00E9lulas B-1, e tamb\u00E9m em linf\u00F3citos T. As c\u00E9lulas B-1 possuem diversidade limitada de seu receptor de c\u00E9lulas B (BCR) devido \u00E0 falta da enzima deoxinucleotidil transferase terminal (TdT) e s\u00E3o potencialmente auto-reativas. O CD5 serve para mitigar sinais do BCR de forma que as c\u00E9lulas B-1 podem sem ativadas apenas por est\u00EDmulos intensos (como prote\u00EDnas bacterianas) e n\u00E3o por prote\u00EDnas tissulares normais. O CD5 era utilizado como marcador de c\u00E9lulas T at\u00E9 o advento de anticorpos monoclonais espec\u00EDficos contra o CD3."@pt . . . . . . . "CD5"@pl . . "En inmunolog\u00EDa se denomina CD5 (del ingl\u00E9s cluster of differentiation) a un tipo de ant\u00EDgeno CD propio del sistema inmune de mam\u00EDferos. Se caracteriza por poseer un peso molecular de 55 kDa y su naturaleza bioqu\u00EDmica lo encuadra dentro de la familia de receptores basurero. Su funci\u00F3n biol\u00F3gica en la c\u00E9lula es: mediar en la transducci\u00F3n de se\u00F1al, mitigando la respuesta inmune ante sustancias que no deban desencadenar aquella. Se expresa espec\u00EDficamente en timocitos, c\u00E9lulas T y subpoblaciones de c\u00E9lulas B (las secretoras de IgM).\u200B"@es . . . . . . "1091265470"^^ . . . . . . . "O CD5 (Cluster of Differentiation 5) \u00E9 uma mol\u00E9cula de superf\u00EDcie celular encontrada em um sutipo de c\u00E9lulas B secretoras de imunoglobulina chamadas de c\u00E9lulas B-1, e tamb\u00E9m em linf\u00F3citos T. As c\u00E9lulas B-1 possuem diversidade limitada de seu receptor de c\u00E9lulas B (BCR) devido \u00E0 falta da enzima deoxinucleotidil transferase terminal (TdT) e s\u00E3o potencialmente auto-reativas. O CD5 serve para mitigar sinais do BCR de forma que as c\u00E9lulas B-1 podem sem ativadas apenas por est\u00EDmulos intensos (como prote\u00EDnas bacterianas) e n\u00E3o por prote\u00EDnas tissulares normais. O CD5 era utilizado como marcador de c\u00E9lulas T at\u00E9 o advento de anticorpos monoclonais espec\u00EDficos contra o CD3. Nos humanos, o gene que codifica esta prote\u00EDna est\u00E1 localizado no bra\u00E7o longo do cromossomo 11. N\u00E3o h\u00E1 ligante conhecido para o CD5. As c\u00E9lulas T expressam n\u00EDveis mais altos de CD5 que as c\u00E9lulas B. As doen\u00E7as neopl\u00E1sicas de c\u00E9lulas do manto e a leucemia linfoc\u00EDtica cr\u00F4nica expressam, de forma an\u00F4mala, o marcador CD5 na superf\u00EDcie de suas c\u00E9lulas."@pt . . . . . . . . "CD5 (\u0430\u043D\u0433\u043B. CD5 molecule) \u2013 \u0431\u0456\u043B\u043E\u043A, \u044F\u043A\u0438\u0439 \u043A\u043E\u0434\u0443\u0454\u0442\u044C\u0441\u044F \u043E\u0434\u043D\u043E\u0439\u043C\u0435\u043D\u043D\u0438\u043C \u0433\u0435\u043D\u043E\u043C, \u0440\u043E\u0437\u0442\u0430\u0448\u043E\u0432\u0430\u043D\u0438\u043C \u0443 \u043B\u044E\u0434\u0435\u0439 \u043D\u0430 \u043A\u043E\u0440\u043E\u0442\u043A\u043E\u043C\u0443 \u043F\u043B\u0435\u0447\u0456 11-\u0457 \u0445\u0440\u043E\u043C\u043E\u0441\u043E\u043C\u0438. \u0414\u043E\u0432\u0436\u0438\u043D\u0430 \u043F\u043E\u043B\u0456\u043F\u0435\u043F\u0442\u0438\u0434\u043D\u043E\u0433\u043E \u043B\u0430\u043D\u0446\u044E\u0433\u0430 \u0431\u0456\u043B\u043A\u0430 \u0441\u0442\u0430\u043D\u043E\u0432\u0438\u0442\u044C 495 \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442, \u0430 \u043C\u043E\u043B\u0435\u043A\u0443\u043B\u044F\u0440\u043D\u0430 \u043C\u0430\u0441\u0430 \u2014 54 578. \u041F\u043E\u0441\u043B\u0456\u0434\u043E\u0432\u043D\u0456\u0441\u0442\u044C \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442 A: \u0410\u043B\u0430\u043D\u0456\u043DC: \u0426\u0438\u0441\u0442\u0435\u0457\u043DD: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430E: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430F: \u0424\u0435\u043D\u0456\u043B\u0430\u043B\u0430\u043D\u0456\u043DG: \u0413\u043B\u0456\u0446\u0438\u043DH: \u0413\u0456\u0441\u0442\u0438\u0434\u0438\u043DI: \u0406\u0437\u043E\u043B\u0435\u0439\u0446\u0438\u043DK: \u041B\u0456\u0437\u0438\u043DL: \u041B\u0435\u0439\u0446\u0438\u043DM: \u041C\u0435\u0442\u0456\u043E\u043D\u0456\u043DN: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043DP: \u041F\u0440\u043E\u043B\u0456\u043DQ: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043DR: \u0410\u0440\u0433\u0456\u043D\u0456\u043DS: \u0421\u0435\u0440\u0438\u043DT: \u0422\u0440\u0435\u043E\u043D\u0456\u043DV: \u0412\u0430\u043B\u0456\u043DW: \u0422\u0440\u0438\u043F\u0442\u043E\u0444\u0430\u043D Y: \u0422\u0438\u0440\u043E\u0437\u0438\u043D \u041A\u043E\u0434\u043E\u0432\u0430\u043D\u0438\u0439 \u0433\u0435\u043D\u043E\u043C \u0431\u0456\u043B\u043E\u043A \u0437\u0430 \u0444\u0443\u043D\u043A\u0446\u0456\u0454\u044E \u043D\u0430\u043B\u0435\u0436\u0438\u0442\u044C \u0434\u043E \u0444\u043E\u0441\u0444\u043E\u043F\u0440\u043E\u0442\u0435\u0457\u043D\u0456\u0432. \u041B\u043E\u043A\u0430\u043B\u0456\u0437\u043E\u0432\u0430\u043D\u0438\u0439 \u0443 \u043A\u043B\u0456\u0442\u0438\u043D\u043D\u0456\u0439 \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u0456, \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u0456."@uk . "CD5"@uk . . . . . . "CD5"@fr . "CD5 \u043B\u0438\u043C\u0444\u043E\u0446\u0438\u0442\u0430\u0440\u043D\u044B\u0439 \u0440\u0435\u0446\u0435\u043F\u0442\u043E\u0440 (T1) \u2014 \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u043D\u044B\u0439 \u0431\u0435\u043B\u043E\u043A, \u0440\u0435\u0446\u0435\u043F\u0442\u043E\u0440, \u044D\u043A\u0441\u043F\u0440\u0435\u0441\u0441\u0438\u0440\u043E\u0432\u0430\u043D \u043D\u0430 \u043F\u043E\u0432\u0435\u0440\u0445\u043D\u043E\u0441\u0442\u0438 T-\u043B\u0438\u043C\u0444\u043E\u0446\u0438\u0442\u043E\u0432 \u0438 B-\u043B\u0438\u043C\u0444\u043E\u0446\u0438\u0442\u043E\u0432 \u043F\u043E\u0434\u0433\u0440\u0443\u043F\u043F\u044B B-1\u0430. \u0420\u0435\u0433\u0443\u043B\u0438\u0440\u0443\u0435\u0442 \u043F\u0440\u043E\u043B\u0438\u0444\u0435\u0440\u0430\u0446\u0438\u044E T-\u043B\u0438\u043C\u0444\u043E\u0446\u0438\u0442\u043E\u0432. \u041E\u0442\u043D\u043E\u0441\u0438\u0442\u0441\u044F \u043A \u0441\u0443\u043F\u0435\u0440\u0441\u0435\u043C\u0435\u0439\u0441\u0442\u0432\u0430 SRCR."@ru . . "CD5 (Cluster de diff\u00E9renciation 5) est une prot\u00E9ine exprim\u00E9e \u00E0 la surface des lymphocytes T ainsi que par une sous-classe de lymphocytes B s\u00E9cr\u00E9tant des IgM ( (en)). CD5 est \u00E9galement appel\u00E9e Leu1. CD5 fut utilis\u00E9 comme marqueur des lymphocytes T jusqu'\u00E0 ce que des anticorps monoclonaux dirig\u00E9s contre CD3 soient d\u00E9velopp\u00E9s."@fr . . . . "CD5 (\u0430\u043D\u0433\u043B. CD5 molecule) \u2013 \u0431\u0456\u043B\u043E\u043A, \u044F\u043A\u0438\u0439 \u043A\u043E\u0434\u0443\u0454\u0442\u044C\u0441\u044F \u043E\u0434\u043D\u043E\u0439\u043C\u0435\u043D\u043D\u0438\u043C \u0433\u0435\u043D\u043E\u043C, \u0440\u043E\u0437\u0442\u0430\u0448\u043E\u0432\u0430\u043D\u0438\u043C \u0443 \u043B\u044E\u0434\u0435\u0439 \u043D\u0430 \u043A\u043E\u0440\u043E\u0442\u043A\u043E\u043C\u0443 \u043F\u043B\u0435\u0447\u0456 11-\u0457 \u0445\u0440\u043E\u043C\u043E\u0441\u043E\u043C\u0438. \u0414\u043E\u0432\u0436\u0438\u043D\u0430 \u043F\u043E\u043B\u0456\u043F\u0435\u043F\u0442\u0438\u0434\u043D\u043E\u0433\u043E \u043B\u0430\u043D\u0446\u044E\u0433\u0430 \u0431\u0456\u043B\u043A\u0430 \u0441\u0442\u0430\u043D\u043E\u0432\u0438\u0442\u044C 495 \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442, \u0430 \u043C\u043E\u043B\u0435\u043A\u0443\u043B\u044F\u0440\u043D\u0430 \u043C\u0430\u0441\u0430 \u2014 54 578. \u041F\u043E\u0441\u043B\u0456\u0434\u043E\u0432\u043D\u0456\u0441\u0442\u044C \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442 A: \u0410\u043B\u0430\u043D\u0456\u043DC: \u0426\u0438\u0441\u0442\u0435\u0457\u043DD: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430E: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430F: \u0424\u0435\u043D\u0456\u043B\u0430\u043B\u0430\u043D\u0456\u043DG: \u0413\u043B\u0456\u0446\u0438\u043DH: \u0413\u0456\u0441\u0442\u0438\u0434\u0438\u043DI: \u0406\u0437\u043E\u043B\u0435\u0439\u0446\u0438\u043DK: \u041B\u0456\u0437\u0438\u043DL: \u041B\u0435\u0439\u0446\u0438\u043DM: \u041C\u0435\u0442\u0456\u043E\u043D\u0456\u043DN: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043DP: \u041F\u0440\u043E\u043B\u0456\u043DQ: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043DR: \u0410\u0440\u0433\u0456\u043D\u0456\u043DS: \u0421\u0435\u0440\u0438\u043DT: \u0422\u0440\u0435\u043E\u043D\u0456\u043DV: \u0412\u0430\u043B\u0456\u043DW: \u0422\u0440\u0438\u043F\u0442\u043E\u0444\u0430\u043D Y: \u0422\u0438\u0440\u043E\u0437\u0438\u043D \u041A\u043E\u0434\u043E\u0432\u0430\u043D\u0438\u0439 \u0433\u0435\u043D\u043E\u043C \u0431\u0456\u043B\u043E\u043A \u0437\u0430 \u0444\u0443\u043D\u043A\u0446\u0456\u0454\u044E \u043D\u0430\u043B\u0435\u0436\u0438\u0442\u044C \u0434\u043E \u0444\u043E\u0441\u0444\u043E\u043F\u0440\u043E\u0442\u0435\u0457\u043D\u0456\u0432. \u041B\u043E\u043A\u0430\u043B\u0456\u0437\u043E\u0432\u0430\u043D\u0438\u0439 \u0443 \u043A\u043B\u0456\u0442\u0438\u043D\u043D\u0456\u0439 \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u0456, \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u0456."@uk . "CD5"@it . . "CD5"@pt .