. "Syndrome CLOVES"@fr . "140944" . . . "CLOVES syndrome is a rare overgrowth syndrome with complex vascular anomalies. CLOVES syndrome affects people with various symptoms, ranging from mild fatty soft-tissue tumors to vascular malformations encompassing the spine or internal organs. It is a genetic disorder that results from somatic, mosaic gain-of-function mutations of the PIK3CA gene, and belongs to the spectrum of PIK3CA-related overgrowth syndromes (PROS). This rare condition has no specific treatment and a poor survival rate. French doctor Guillaume Canaud published an article in Nature that demonstrate the efficacy of BYL719 (From cancer), an inhibitor of PIK3CA, in preventing and improving organ dysfunction. It seems this treatment is having tremendous and quick effects. CLOVES syndrome is closely linked to other overgrowth disorders like proteus syndrome, Klippel\u2013Tr\u00E9naunay syndrome, Sturge\u2013Weber syndrome, and hemihypertrophy, to name a few. 'CLOVES' is an acronym for: \n* C is for congenital. \n* L is for lipomatous, which means pertaining to or resembling a benign tumor made up of mature fat cells. Most CLOVES patients present with a soft fatty mass at birth, often visible on one or both sides of the back, legs and/or abdomen. \n* O is for overgrowth, because there is an abnormal increase in the size of the body or a body part that is often noted at birth. Patients with CLOVES may have affected areas of their bodies that grow faster than in other people. Overgrowth of extremities (usually arms or legs) is seen, with large wide hands or feet, large fingers or toes, wide space between fingers, and asymmetry of body parts. \n* V is for vascular malformations, which are blood vessel abnormalities. Patients with CLOVES have different venous, capillary, and lymphatic channels - typically capillary, venous and lymphatic malformations are known as \"slow flow\" lesions. Some patients with CLOVES have combined lesions (which are fast flow) and some have aggressive vascular malformation known as arteriovenous malformations (AVM). The effect of a vascular malformation varies per patient based on the type, size, and location of the malformation, and symptoms can vary. \n* E is for Epidermal naevi, which are sharply-circumscribed chronic lesions of the skin, and benign. These are often flesh-colored, raised or warty. \n* S is for Spinal/Skeletal Anomalies or scoliosis. Some patients with CLOVES have tethered spinal cord, vascular malformations in or around their spines, and other spinal differences. High-flow aggressive spinal lesions (like AVM) can cause serious neurological deficits/paralysis. The syndrome was first recognised by Saap and colleagues who recognised the spectrum of symptoms from a set of seven patients. In this initial description the syndrome is named CLOVE syndrome. It is believed that the first description of a case of CLOVES syndrome was written by Hermann Friedberg, a German physician, in 1867."@en . "Le syndrome CLOVES est un des syndromes hypertrophiques li\u00E9s au g\u00E8ne PIK3CA. Il est caract\u00E9ris\u00E9 par la pr\u00E9sence d'excroissances de tissus graisseux, de malformations vasculaires, de n\u00E6vi, d'une scoliose, et de d\u00E9formations osseuses."@fr . . . "\u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0643\u0644\u0648\u0641\u0632 \u0647\u064A \u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0641\u0631\u0637 \u0646\u0645\u0648 \u0646\u0627\u062F\u0631\u0629 \u0645\u062A\u0631\u0627\u0641\u0642\u0629 \u0645\u0639 \u062A\u0634\u0648\u0647\u0627\u062A \u0648\u0639\u0627\u0626\u064A\u0629 \u0645\u0639\u0642\u062F\u0629. \u062A\u062A\u0631\u0627\u0648\u062D \u0623\u0639\u0631\u0627\u0636 \u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0643\u0644\u0648\u0641\u0632 \u0645\u0646 \u0627\u0644\u062E\u0641\u064A\u0641\u0629\u060C \u0639\u0644\u0649 \u0634\u0643\u0644 \u0623\u0648\u0631\u0627\u0645 \u0646\u0633\u064A\u062C \u0631\u062E\u0648 \u0634\u062D\u0645\u064A\u0629\u060C \u0625\u0644\u0649 \u062A\u0634\u0648\u0647\u0627\u062A \u0648\u0639\u0627\u0626\u064A\u0629 \u062A\u0634\u0645\u0644 \u0627\u0644\u0646\u062E\u0627\u0639 \u0627\u0644\u0634\u0648\u0643\u064A \u0648\u0627\u0644\u0623\u0639\u0636\u0627\u0621 \u0627\u0644\u062F\u0627\u062E\u0644\u064A\u0629. \u062A\u0631\u062A\u0628\u0637 \u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0643\u0644\u0648\u0641\u0632 \u0645\u0639 \u0645\u062A\u0644\u0627\u0632\u0645\u0627\u062A \u0641\u0631\u0637 \u0646\u0645\u0648 \u0623\u062E\u0631\u0649 \u0645\u062B\u0644: \u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0628\u0631\u0648\u062A\u064A\u0648\u0633\u060C \u0648\u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0643\u0644\u064A\u0628\u0644-\u062A\u0631\u064A\u0646\u0648\u0646\u0627\u064A\u060C \u0648\u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0633\u062A\u064A\u0631\u062C \u0648\u064A\u0628\u0631\u060C \u0648\u0627\u0644\u0636\u062E\u0627\u0645\u0629 \u0627\u0644\u0634\u0642\u0651\u064A\u0629. \u0648\u0642\u062F \u062A\u0633\u0628\u0651\u0628 \u0641\u064A \u0628\u0639\u0636 \u0627\u0644\u062D\u0627\u0644\u0627\u062A \u0639\u062F\u0645 \u0646\u0632\u0648\u0644 \u0627\u0644\u062E\u0635\u064A\u062A\u064A\u0646 (\u062E\u0635\u064A\u062A\u064A\u0646 \u0647\u0627\u062C\u0631\u062A\u064A\u0646). CLOVES (\u0643\u0644\u0648\u0641\u0632) \u0647\u0648 \u0627\u062E\u062A\u0635\u0627\u0631 \u064A\u0634\u0645\u0644 \u0627\u0644\u0623\u062D\u0631\u0641 \u0627\u0644\u0623\u0648\u0644\u0649 \u0645\u0646 \u0627\u0644\u0643\u0644\u0645\u0627\u062A \u0627\u0644\u0625\u0646\u062C\u0644\u064A\u0632\u064A\u0629 \u0627\u0644\u062A\u0627\u0644\u064A\u0629:"@ar . "Q87.3" . . . . . "La sindrome CLOVES \u00E8 una sindrome estremamente rara che si presenta con crescita eccessiva ed anomalie vascolari complesse. Il termine CLOVES \u00E8 mutuato dalla lingua inglese ed \u00E8 l'acronimo dei sintomi pi\u00F9 rilevanti. La sindrome CLOVES colpisce le persone con vari sintomi che vanno da lievi tumori adiposi dei tessuti molli a malformazioni vascolari che comprendono la colonna vertebrale o gli organi interni. La sindrome CLOVES \u00E8 strettamente collegato ad altre malattie come la sindrome di Proteo, sindrome di Klippel-Trenaunay, sindrome di Sturge-Weber e l'emiipertrofia. Come accennato, CLOVES \u00E8 l'anagramma delle parole inglesi relative ai sintomi principali: \n* C: congenital (congenita) \n* L: lipomatous (lipomatosa), che significa pertinenza o simile a un tumore benigno costituito da cellule grasse mature. La maggior parte dei pazienti CLOVES presentano una massa grassa morbida alla nascita, spesso visibili su uno o entrambi i lati della schiena, gambe e o addome. \n* O: overgrowth (proliferazione), perch\u00E9 c'\u00E8 un aumento anomalo della dimensione del corpo o di una parte del corpo, osservabile spesso fin dalla nascita. Crescita eccessiva delle estremit\u00E0 (di solito braccia o gambe), con grandi mani o piedi larghi, grandi dita, ampio spazio tra le dita e l'asimmetria di parti del corpo. \n* V: vascular malformations (malformazioni vascolari), quindi anormalit\u00E0 dei vasi sanguigni. I pazienti CLOVES presentano vasi venosi, capillari e linfatici anomali. \n* E: Epidermal naevi (nei epidermici), formazioni benigne, spesso di aspetto verrucoso. \n* S: Spinal/Skeletal Anomalies or scoliosis (anormalit\u00E0 spinali/scheletriche o scoliosi)."@it . "Congenital Lipomatous Overgrowth-Vascular malformation-Epidermal nevi-Skeletal anomaly syndrome"@en . . . . "CLOVES syndrome is a rare overgrowth syndrome with complex vascular anomalies. CLOVES syndrome affects people with various symptoms, ranging from mild fatty soft-tissue tumors to vascular malformations encompassing the spine or internal organs. It is a genetic disorder that results from somatic, mosaic gain-of-function mutations of the PIK3CA gene, and belongs to the spectrum of PIK3CA-related overgrowth syndromes (PROS). This rare condition has no specific treatment and a poor survival rate. 'CLOVES' is an acronym for:"@en . . "6977"^^ . . . . . . "140944"^^ . . . . . . . "Das CLOVE-Syndrom, Akronym f\u00FCr Congenital Lipomatous Overgrowth, Vaskul\u00E4re Fehlbildung und Epidermaler N\u00E4vus, ist ein sehr seltenes angeborenes Fehlbildungssyndrom mit den namensgebenden Hauptmerkmalen.Das Syndrom geh\u00F6rt zur Untergruppe der Gro\u00DFwuchssyndrome PIK3CA-assoziiertes Gro\u00DFwuchssyndrom (PROS). Synonyme sind: CLOVES-Syndrom (mit Skoliose); Kongenitaler lipomat\u00F6ser \u00DCberwuchs - vaskul\u00E4re Fehlbildung - epidermale Naevi \u2013 Skelettanomalien; Kongenitaler lipomat\u00F6ser \u00DCberwuchs - vaskul\u00E4re Fehlbildung - epidermale N\u00E4vi. Die Erstbeschreibung stammt wohl aus dem Jahre 1867 durch Hermann Friedberg. Das Akronym wurde im Jahr 2007 durch die US-amerikanische Humangenetikerin Julie C. Sapp und Mitarbeiter gepr\u00E4gt."@de . . . "La sindrome CLOVES \u00E8 una sindrome estremamente rara che si presenta con crescita eccessiva ed anomalie vascolari complesse. Il termine CLOVES \u00E8 mutuato dalla lingua inglese ed \u00E8 l'acronimo dei sintomi pi\u00F9 rilevanti. La sindrome CLOVES colpisce le persone con vari sintomi che vanno da lievi tumori adiposi dei tessuti molli a malformazioni vascolari che comprendono la colonna vertebrale o gli organi interni. La sindrome CLOVES \u00E8 strettamente collegato ad altre malattie come la sindrome di Proteo, sindrome di Klippel-Trenaunay, sindrome di Sturge-Weber e l'emiipertrofia."@it . . . . . . "Le syndrome CLOVES est un des syndromes hypertrophiques li\u00E9s au g\u00E8ne PIK3CA. Il est caract\u00E9ris\u00E9 par la pr\u00E9sence d'excroissances de tissus graisseux, de malformations vasculaires, de n\u00E6vi, d'une scoliose, et de d\u00E9formations osseuses."@fr . . . . "CLOVE-Syndrom"@de . . . "612918"^^ . "46218322"^^ . . "\u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0643\u0644\u0648\u0641\u0632"@ar . . "Mutations affecting PI3kinase are involved in the cause of this condition"@en . "Q87.3"@en . . . "Sindrome CLOVES"@it . "\u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0643\u0644\u0648\u0641\u0632 \u0647\u064A \u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0641\u0631\u0637 \u0646\u0645\u0648 \u0646\u0627\u062F\u0631\u0629 \u0645\u062A\u0631\u0627\u0641\u0642\u0629 \u0645\u0639 \u062A\u0634\u0648\u0647\u0627\u062A \u0648\u0639\u0627\u0626\u064A\u0629 \u0645\u0639\u0642\u062F\u0629. \u062A\u062A\u0631\u0627\u0648\u062D \u0623\u0639\u0631\u0627\u0636 \u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0643\u0644\u0648\u0641\u0632 \u0645\u0646 \u0627\u0644\u062E\u0641\u064A\u0641\u0629\u060C \u0639\u0644\u0649 \u0634\u0643\u0644 \u0623\u0648\u0631\u0627\u0645 \u0646\u0633\u064A\u062C \u0631\u062E\u0648 \u0634\u062D\u0645\u064A\u0629\u060C \u0625\u0644\u0649 \u062A\u0634\u0648\u0647\u0627\u062A \u0648\u0639\u0627\u0626\u064A\u0629 \u062A\u0634\u0645\u0644 \u0627\u0644\u0646\u062E\u0627\u0639 \u0627\u0644\u0634\u0648\u0643\u064A \u0648\u0627\u0644\u0623\u0639\u0636\u0627\u0621 \u0627\u0644\u062F\u0627\u062E\u0644\u064A\u0629. \u062A\u0631\u062A\u0628\u0637 \u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0643\u0644\u0648\u0641\u0632 \u0645\u0639 \u0645\u062A\u0644\u0627\u0632\u0645\u0627\u062A \u0641\u0631\u0637 \u0646\u0645\u0648 \u0623\u062E\u0631\u0649 \u0645\u062B\u0644: \u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0628\u0631\u0648\u062A\u064A\u0648\u0633\u060C \u0648\u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0643\u0644\u064A\u0628\u0644-\u062A\u0631\u064A\u0646\u0648\u0646\u0627\u064A\u060C \u0648\u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0633\u062A\u064A\u0631\u062C \u0648\u064A\u0628\u0631\u060C \u0648\u0627\u0644\u0636\u062E\u0627\u0645\u0629 \u0627\u0644\u0634\u0642\u0651\u064A\u0629. \u0648\u0642\u062F \u062A\u0633\u0628\u0651\u0628 \u0641\u064A \u0628\u0639\u0636 \u0627\u0644\u062D\u0627\u0644\u0627\u062A \u0639\u062F\u0645 \u0646\u0632\u0648\u0644 \u0627\u0644\u062E\u0635\u064A\u062A\u064A\u0646 (\u062E\u0635\u064A\u062A\u064A\u0646 \u0647\u0627\u062C\u0631\u062A\u064A\u0646). CLOVES (\u0643\u0644\u0648\u0641\u0632) \u0647\u0648 \u0627\u062E\u062A\u0635\u0627\u0631 \u064A\u0634\u0645\u0644 \u0627\u0644\u0623\u062D\u0631\u0641 \u0627\u0644\u0623\u0648\u0644\u0649 \u0645\u0646 \u0627\u0644\u0643\u0644\u0645\u0627\u062A \u0627\u0644\u0625\u0646\u062C\u0644\u064A\u0632\u064A\u0629 \u0627\u0644\u062A\u0627\u0644\u064A\u0629: \n* \u0633\u064A C: \u0645\u0646 \u0627\u0644\u0643\u0644\u0645\u0629 \u0627\u0644\u0625\u0646\u062C\u0644\u064A\u0632\u064A\u0629 \u00ABCongenital\u00BB \u0623\u064A \u00AB\u062E\u064E\u0644\u0642\u064A\u00BB. \n* \u0625\u0644 L: \u0645\u0646 \u0627\u0644\u0643\u0644\u0645\u0629 \u0627\u0644\u0625\u0646\u062C\u0644\u064A\u0632\u064A\u0629 \u00ABLipomatous\u00BB \u0623\u064A \u00AB\u0645\u062A\u0639\u0644\u0650\u0651\u0642 \u0628\u0627\u0644\u0648\u0631\u0645 \u0627\u0644\u0634\u062D\u0645\u064A\u00BB\u060C \u0627\u0644\u062A\u064A \u062A\u0639\u0646\u064A \u0645\u0627 \u064A\u0634\u0628\u0647 \u0627\u0644\u0648\u0631\u0645 \u0627\u0644\u062D\u0645\u064A\u062F \u0627\u0644\u0645\u0643\u0648\u0646 \u0645\u0646 \u062E\u0644\u0627\u064A\u0627 \u0634\u062D\u0645\u064A\u0629 \u0646\u0627\u0636\u062C\u0629. \u062A\u062A\u0638\u0627\u0647\u0631 \u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0643\u0644\u0648\u0641\u0632 \u0644\u062F\u0649 \u0645\u0639\u0638\u0645 \u0627\u0644\u0645\u0631\u0636\u0649 \u0639\u0644\u0649 \u0634\u0643\u0644 \u0643\u062A\u0644 \u062F\u0647\u0646\u064A\u0629 \u0644\u064A\u0646\u0629 \u0639\u0646\u062F \u0627\u0644\u0648\u0644\u0627\u062F\u0629\u060C \u0648\u063A\u0627\u0644\u0628\u064B\u0627 \u0645\u0627 \u062A\u0643\u0648\u0646 \u0645\u0648\u062C\u0648\u062F\u0629 \u0639\u0644\u0649 \u0623\u062D\u062F \u062C\u0627\u0646\u0628\u064A \u0627\u0644\u0638\u0647\u0631 \u0623\u0648 \u0643\u0644\u064A\u0647\u0645\u0627\u060C \u0623\u0648 \u0627\u0644\u0633\u0627\u0642\u060C \u0623\u0648 \u0627\u0644\u0628\u0637\u0646. \n* \u0623\u0648 O: \u0645\u0646 \u0627\u0644\u0643\u0644\u0645\u0629 \u0627\u0644\u0625\u0646\u062C\u0644\u064A\u0632\u064A\u0629 \u00ABOvergrowth\u00BB \u0623\u064A \u00AB\u0641\u0631\u0637 \u0646\u0645\u0648\u00BB\u060C \u0625\u0630 \u062A\u0648\u062C\u062F \u0632\u064A\u0627\u062F\u0629 \u0648\u0627\u0636\u062D\u0629 \u063A\u064A\u0631 \u0637\u0628\u064A\u0639\u064A\u0629 \u0641\u064A \u062D\u062C\u0645 \u0627\u0644\u062C\u0633\u0645 \u0623\u0648 \u062C\u0632\u0621 \u0645\u0646\u0647 \u062A\u064F\u0644\u0627\u062D\u064E\u0638 \u0639\u0646\u062F \u0627\u0644\u0648\u0644\u0627\u062F\u0629. \u0642\u062F \u064A\u0645\u062A\u0644\u0643 \u0627\u0644\u0623\u0634\u062E\u0627\u0635 \u0627\u0644\u0645\u0635\u0627\u0628\u0648\u0646 \u0628\u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0643\u0644\u0648\u0641\u0632 \u0623\u062C\u0632\u0627\u0621 \u0645\u0646 \u062C\u0633\u062F\u0647\u0645 \u062A\u0646\u0645\u0648 \u0628\u0633\u0631\u0639\u0629 \u0645\u062E\u062A\u0644\u0641\u0629 \u0639\u0646 \u0627\u0644\u0623\u062C\u0632\u0627\u0621 \u0627\u0644\u0623\u062E\u0631\u0649. \u0646\u0644\u0627\u062D\u0638 \u0639\u0646\u062F \u0627\u0644\u0628\u0639\u0636 \u0641\u0631\u0637 \u0646\u0645\u0648 \u0627\u0644\u0623\u0637\u0631\u0627\u0641 (\u063A\u0627\u0644\u0628\u064B\u0627 \u0627\u0644\u0630\u0631\u0627\u0639\u064A\u0646 \u0623\u0648 \u0627\u0644\u0633\u0627\u0642\u064A\u0646)\u060C \u0645\u0639 \u0642\u062F\u0645\u064A\u0646 \u0648\u064A\u062F\u064A\u0646 \u0645\u0641\u0631\u0637\u062A\u064A \u0627\u0644\u062D\u062C\u0645\u060C \u0648\u0623\u0635\u0627\u0628\u0639 \u064A\u062F\u064A\u0646 \u0648\u0642\u062F\u0645\u064A\u0646 \u0643\u0628\u064A\u0631\u0629 \u0627\u0644\u062D\u062C\u0645\u060C \u0648\u0639\u062F\u0645 \u062A\u0646\u0627\u0638\u0631 \u062C\u0627\u0646\u0628\u064A \u0627\u0644\u062C\u0633\u0645. \n* \u06A4\u064A V: \u0645\u0646 \u0627\u0644\u0643\u0644\u0645\u0629 \u0627\u0644\u0625\u0646\u062C\u0644\u064A\u0632\u064A\u0629 \u00ABVascular abnormalities\u00BB \u0627\u0644\u062A\u064A \u062A\u0639\u0646\u064A \u00AB\u062A\u0634\u0648\u0647\u0627\u062A \u0648\u0639\u0627\u0626\u064A\u0629\u00BB\u060C \u0623\u064A \u0647\u0646\u0627\u0643 \u0634\u0630\u0648\u0630\u0627\u062A \u0641\u064A \u0627\u0644\u0623\u0648\u0639\u064A\u0629 \u0627\u0644\u062F\u0645\u0648\u064A\u0629. \u064A\u0645\u062A\u0644\u0643 \u0645\u0631\u0636\u0649 \u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0643\u0644\u0648\u0641\u0632 \u062A\u0634\u0648\u0647\u0627\u062A \u0634\u0639\u0631\u064A\u0629 \u0648\u0648\u0631\u064A\u062F\u064A\u0629 \u0648\u0644\u0645\u0641\u0627\u0648\u064A\u0629 \u0645\u062E\u062A\u0644\u0641\u0629 \u062A\u0633\u0645\u0649 \u00AB\u0627\u0644\u0622\u0641\u0627\u062A \u0628\u0637\u064A\u0626\u0629 \u0627\u0644\u062C\u0631\u064A\u0627\u0646\u00BB. \u0646\u0634\u0627\u0647\u062F \u0644\u062F\u0649 \u0628\u0639\u0636 \u0627\u0644\u0645\u0631\u0636\u0649 \u0622\u0641\u0627\u062A \u0645\u0634\u062A\u0631\u0643\u0629 (\u062A\u0643\u0648\u0646 \u0645\u0646 \u0627\u0644\u0646\u0648\u0639 \u0633\u0631\u064A\u0639 \u0627\u0644\u062C\u0631\u064A\u0627\u0646)\u060C \u0648\u062A\u0634\u0648\u0647\u0627\u062A \u0648\u0639\u0627\u0626\u064A\u0629 \u062E\u0637\u064A\u0631\u0629 \u062A\u062F\u0639\u0649 \u0627\u0644\u062A\u0634\u0648\u0647\u0627\u062A \u0627\u0644\u0634\u0631\u064A\u0627\u0646\u064A\u0629 \u0627\u0644\u0648\u0631\u064A\u062F\u064A\u0629. \u064A\u062E\u062A\u0644\u0641 \u062A\u0623\u062B\u064A\u0631 \u0627\u0644\u062A\u0634\u0648\u0647 \u0627\u0644\u0648\u0639\u0627\u0626\u064A \u0639\u0644\u0649 \u0627\u0644\u0645\u0631\u064A\u0636 \u062D\u0633\u0628 \u0627\u0644\u0646\u0648\u0639 \u0648\u0627\u0644\u062D\u062C\u0645 \u0648\u0627\u0644\u0645\u0643\u0627\u0646\u060C \u0648\u062A\u062A\u0646\u0648\u0639 \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0623\u064A\u0636\u064B\u0627 \u062D\u0633\u0628 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0622\u0646\u0641\u0629 \u0627\u0644\u0630\u0643\u0631. \n* \u0625\u064A E: \u0645\u0646 \u0627\u0644\u0643\u0644\u0645\u0629 \u0627\u0644\u0625\u0646\u062C\u0644\u064A\u0632\u064A\u0629 \u00ABEpidermal naevi\u00BB \u0623\u064A \u00AB\u0648\u062D\u0645\u0627\u062A \u062C\u0644\u062F\u064A\u0629\u00BB\u060C \u0648\u0647\u064A \u0622\u0641\u0627\u062A \u062C\u0644\u062F\u064A\u0629 \u0645\u0632\u0645\u0646\u0629 \u0645\u062D\u062F\u062F\u0629 \u0627\u0644\u062D\u0648\u0627\u0641 \u0628\u0634\u0643\u0644 \u062C\u064A\u062F\u060C \u0648\u0633\u0644\u064A\u0645\u0629\u060C \u0648\u0628\u0644\u0648\u0646 \u0627\u0644\u062C\u0644\u062F\u060C \u0648\u0645\u0631\u062A\u0641\u0639\u0629 \u0623\u0648 \u062B\u0624\u0644\u0648\u0644\u064A\u0629 \u0627\u0644\u0634\u0643\u0644. \n* \u0625\u0633 S: \u0645\u0646 \u0627\u0644\u0643\u0644\u0645\u0629 \u0627\u0644\u0625\u0646\u062C\u0644\u064A\u0632\u064A\u0629 \u00ABScoliosis\u00BB \u0623\u064A \u00AB\u0627\u0644\u062C\u0646\u0641\u00BB \u0623\u0648 \u0627\u0644\u0645\u064A\u0644\u0627\u0646 \u0627\u0644\u062C\u0627\u0646\u0628\u064A \u0644\u0644\u0639\u0645\u0648\u062F \u0627\u0644\u0641\u0642\u0631\u064A. \u064A\u0645\u062A\u0644\u0643 \u0628\u0639\u0636 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u0635\u0627\u0628\u064A\u0646 \u0628\u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0643\u0644\u0648\u0641\u0632 \u062D\u0628\u0644\u064B\u0627 \u0634\u0648\u0643\u064A\u064B\u0627 \u0645\u0634\u062F\u0648\u062F\u064B\u0627\u060C \u0648\u062A\u0634\u0648\u0647\u0627\u062A \u0648\u0639\u0627\u0626\u064A\u0629 \u062F\u0627\u062E\u0644 \u0627\u0644\u062D\u0628\u0644 \u0627\u0644\u0634\u0648\u0643\u064A \u0623\u0648 \u062D\u0648\u0644\u0647\u060C \u0648\u0627\u062E\u062A\u0644\u0627\u0641\u0627\u062A \u0623\u062E\u0631\u0649 \u0639\u0646 \u0627\u0644\u0634\u0643\u0644 \u0627\u0644\u0637\u0628\u064A\u0639\u064A. \u0642\u062F \u062A\u0633\u0628\u0628 \u0627\u0644\u0622\u0641\u0627\u062A \u0627\u0644\u0634\u0648\u0643\u064A\u0629 \u0633\u0631\u064A\u0639\u0629 \u0627\u0644\u062C\u0631\u064A\u0627\u0646 \u0648\u0634\u062F\u064A\u062F\u0629 \u0627\u0644\u0639\u062F\u0648\u0627\u0646\u064A\u0629 (\u0645\u062B\u0644 \u0627\u0644\u062A\u0634\u0648\u0647\u0627\u062A \u0627\u0644\u0634\u0631\u064A\u0627\u0646\u064A\u0629 \u0627\u0644\u0648\u0631\u064A\u062F\u064A\u0629) \u0645\u0634\u0627\u0643\u0644 \u0639\u0635\u0628\u064A\u0629 \u062E\u0637\u064A\u0631\u0629 \u0648\u0634\u0644\u0644\u064B\u0627 \u0639\u0635\u0628\u064A\u064B\u0627. \u0648\u0635\u0641 \u0633\u0627\u0628 \u0648\u0632\u0645\u0644\u0627\u0624\u0647 \u0627\u0644\u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0644\u0623\u0648\u0644 \u0645\u0631\u0629\u060C \u0625\u0630 \u0644\u0627\u062D\u0638\u0648\u0627 \u0637\u064A\u0641 \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0641\u064A \u0645\u062C\u0645\u0648\u0639\u0629 \u0645\u0643\u0648\u0646\u0629 \u0645\u0646 \u0633\u0628\u0639\u0629 \u0645\u0631\u0636\u0649\u060C \u0648\u0633\u064F\u0645\u064A\u062A \u0627\u0644\u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u062D\u064A\u0646\u0647\u0627 \u062D\u0633\u0628 \u0627\u0644\u0623\u062D\u0631\u0641 \u0627\u0644\u0623\u0648\u0644\u0649 \u0644\u0644\u0623\u0639\u0631\u0627\u0636 \u0627\u0644\u0645\u064F\u0644\u0627\u062D\u064E\u0638\u0629. \u064A\u064F\u0639\u062A\u0642\u064E\u062F \u0623\u0646 \u0623\u0648\u0644 \u0648\u0635\u0641\u064D \u0644\u0645\u062A\u0644\u0627\u0632\u0645\u0629 \u0643\u0644\u0648\u0641\u0632 \u0642\u062F \u0643\u062A\u0628\u0647 \u0627\u0644\u0637\u0628\u064A\u0628 \u0627\u0644\u0623\u0644\u0645\u0627\u0646\u064A \u0647\u064A\u0631\u0645\u0627\u0646 \u0641\u0631\u064A\u062F\u0628\u064A\u0631\u063A \u0641\u064A \u0639\u0627\u0645 1867."@ar . . . "612918"^^ . "CLOVES syndrome"@en . "Congenital Lipomatous Overgrowth-Vascular malformation-Epidermal nevi-Spinal anomaly syndrome"@en . . "Das CLOVE-Syndrom, Akronym f\u00FCr Congenital Lipomatous Overgrowth, Vaskul\u00E4re Fehlbildung und Epidermaler N\u00E4vus, ist ein sehr seltenes angeborenes Fehlbildungssyndrom mit den namensgebenden Hauptmerkmalen.Das Syndrom geh\u00F6rt zur Untergruppe der Gro\u00DFwuchssyndrome PIK3CA-assoziiertes Gro\u00DFwuchssyndrom (PROS). Synonyme sind: CLOVES-Syndrom (mit Skoliose); Kongenitaler lipomat\u00F6ser \u00DCberwuchs - vaskul\u00E4re Fehlbildung - epidermale Naevi \u2013 Skelettanomalien; Kongenitaler lipomat\u00F6ser \u00DCberwuchs - vaskul\u00E4re Fehlbildung - epidermale N\u00E4vi."@de . "1092142378"^^ .