. "\u89E6\u5A92\u4E09\u6B8B\u57FA\uFF08\u3057\u3087\u304F\u3070\u3044\u3055\u3093\u3056\u3093\u304D\u3001\u82F1: Catalytic triad\uFF09\u3068\u306F\u3001\u3044\u304F\u3064\u304B\u306E\u9175\u7D20\u306E\u6D3B\u6027\u90E8\u4F4D\u306B\u898B\u3089\u308C\u308B3\u3064\u306E\u914D\u4F4D\u30A2\u30DF\u30CE\u9178\u306E\u4E00\u5F0F\u3067\u3042\u308B\u3002\u89E6\u5A92\u4E09\u6B8B\u57FA\u306F\u3001\u30D2\u30C9\u30ED\u30E9\u30FC\u30BC\u304A\u3088\u3073\u30C8\u30E9\u30F3\u30B9\u30D5\u30A7\u30E9\u30FC\u30BC\u9175\u7D20\uFF08\u4F8B\u3048\u3070\u3001\u30D7\u30ED\u30C6\u30A2\u30FC\u30BC\u3001\u30A2\u30DF\u30C0\u30FC\u30BC\u3001\u30A8\u30B9\u30C6\u30E9\u30FC\u30BC\u3001\u30A2\u30B7\u30EB\u30E9\u30FC\u30BC\u3001\u30EA\u30D1\u30FC\u30BC\u3001\u304A\u3088\u3073\u03B2-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC\uFF09\u3067\u6700\u3082\u4E00\u822C\u7684\u306B\u898B\u3089\u308C\u308B\u3002\u9178-\u5869\u57FA-\u6C42\u6838\u5264 \u4E09\u6B8B\u57FA\u306F\u3001\u5171\u6709\u7D50\u5408\u89E6\u5A92\u306E\u305F\u3081\u306E\u6C42\u6838\u6027\u6B8B\u57FA\u3092\u751F\u6210\u3059\u308B\u305F\u3081\u306E\u4E00\u822C\u7684\u306A\u30E2\u30C1\u30FC\u30D5\u3067\u3042\u308B\u3002\u3053\u306E\u6B8B\u57FA\u306F\u96FB\u8377\u30EA\u30EC\u30FC\u30CD\u30C3\u30C8\u30EF\u30FC\u30AF\u3092\u5F62\u6210\u3057\u3066\u6C42\u6838\u5264\u3092\u5206\u6975\u304A\u3088\u3073\u6D3B\u6027\u5316\u3057\u3001\u57FA\u8CEA\u3092\u653B\u6483\u3057\u3066\u5171\u6709\u7D50\u5408\u4E2D\u9593\u4F53\u3092\u5F62\u6210\u3057\u3001\u52A0\u6C34\u5206\u89E3\u3055\u308C\u3066\u3092\u653E\u51FA\u3057\u3001\u904A\u96E2\u9175\u7D20\u3092\u518D\u751F\u3059\u308B\u3002\u6C42\u6838\u5264\u306F\u3001\u6700\u3082\u4E00\u822C\u7684\u306B\u306F\u30BB\u30EA\u30F3\u3084\u30B7\u30B9\u30C6\u30A4\u30F3\u30A2\u30DF\u30CE\u9178\u3067\u3042\u308B\u304C\u3001\u6642\u306B\u306F\u30B9\u30EC\u30AA\u30CB\u30F3\u307E\u305F\u306F\u30BB\u30EC\u30CE\u30B7\u30B9\u30C6\u30A4\u30F3\u3082\u542B\u307E\u308C\u3066\u3044\u308B\u3002\u9175\u7D20\u306E\u4E09\u6B21\u5143\u69CB\u9020\u306F\u3001\u914D\u5217\u4E0A\uFF08\u4E00\u6B21\u69CB\u9020\uFF09\u3067\u306F\u96E2\u308C\u3066\u3044\u3066\u3082\u3001\u4E09\u6B8B\u57FA\u304C\u6B63\u78BA\u306A\u65B9\u5411\u306B\u307E\u3068\u307E\u3063\u3066\u3044\u308B\u3053\u3068\u3092\u793A\u3057\u3066\u3044\u308B\u3002 \u6A5F\u80FD\uFF08\u304A\u3088\u3073\u4E09\u6B8B\u57FA\u306E\u6C42\u6838\u5264\uFF09\u306E\u3068\u540C\u69D8\u306B\u3001\u89E6\u5A92\u4E09\u6B8B\u57FA\u306F\u53CE\u6582\u9032\u5316\u306E\u6700\u826F\u306E\u4F8B\u306E\u3044\u304F\u3064\u304B\u3092\u793A\u3057\u3066\u3044\u308B\u3002\u89E6\u5A92\u4F5C\u7528\u306B\u5BFE\u3059\u308B\u5316\u5B66\u7684\u5236\u7D04\u306B\u3088\u308A\u3001\u540C\u3058\u89E6\u5A92\u89E3\u660E\u304C\u3001\u5C11\u306A\u304F\u3068\u308223\u306E\u5225\u3005\u306E\u30B9\u30FC\u30D1\u30FC\u30D5\u30A1\u30DF\u30EA\u30FC\u3067\u72EC\u7ACB\u3057\u3066\u5C55\u958B\u3057\u3066\u3044\u308B\u3002\u305D\u306E\u4F5C\u7528\u6A5F\u5E8F\u306F\u3001\u751F\u5316\u5B66\u7684\u306B\u6700\u3082\u3088\u304F\u7814\u7A76\u3055\u308C\u3066\u3044\u308B\u3082\u306E\u306E\u4E00\u3064\u3067\u3042\u308B\u3002"@ja . . . . . . "A catalytic triad is a set of three coordinated amino acids that can be found in the active site of some enzymes. Catalytic triads are most commonly found in hydrolase and transferase enzymes (e.g. proteases, amidases, esterases, acylases, lipases and \u03B2-lactamases). An acid-base-nucleophile triad is a common motif for generating a nucleophilic residue for covalent catalysis. The residues form a charge-relay network to polarise and activate the nucleophile, which attacks the substrate, forming a covalent intermediate which is then hydrolysed to release the product and regenerate free enzyme. The nucleophile is most commonly a serine or cysteine amino acid, but occasionally threonine or even selenocysteine. The 3D structure of the enzyme brings together the triad residues in a precise orient"@en . . . . . . . . . . . . . . "\u041A\u0430\u0442\u0430\u043B\u0438\u0442\u0438\u0447\u0435\u0441\u043A\u0430\u044F \u0442\u0440\u0438\u0430\u0434\u0430"@ru . . . . . "Triad convergence ser cys.svg"@en . . . . . . "Tr\u00EDada catal\u00EDtica"@ca . . . . . . . . . . . . . . . "Uma tr\u00EDade catal\u00EDtica \u00E9 um conjunto de tr\u00EAs amino\u00E1cidos coordenados que podem ser encontrados no s\u00EDtio ativo de algumas enzimas. As tr\u00EDades catal\u00EDticas s\u00E3o mais comumente encontradas nas enzimas hidrolase e transferase (por exemplo, proteases, , esterases, acilases, lipases e \u03B2-lactamases). Uma tr\u00EDade \u00E1cido-base-nucle\u00F3filo \u00E9 um motivo comum para gerar um res\u00EDduo nucleof\u00EDlico para cat\u00E1lise covalente. Os res\u00EDduos formam uma rede de rel\u00E9 de carga para polarizar e ativar o nucle\u00F3filo, que ataca o substrato, formando um intermedi\u00E1rio covalente que \u00E9 ent\u00E3o hidrolisado para liberar o produto e regenerar a enzima livre. O nucle\u00F3filo \u00E9 mais comumente um amino\u00E1cido serina ou ciste\u00EDna, mas ocasionalmente treonina ou mesmo selenociste\u00EDna. A da enzima re\u00FAne os res\u00EDduos da tr\u00EDade em uma orienta\u00E7\u00E3o precisa, mesmo que eles possam estar distantes na sequ\u00EAncia (estrutura prim\u00E1ria). Bem como a evolu\u00E7\u00E3o divergente da fun\u00E7\u00E3o (e at\u00E9 mesmo o nucle\u00F3filo da tr\u00EDade), as tr\u00EDades catal\u00EDticas mostram alguns dos melhores exemplos de evolu\u00E7\u00E3o convergente. Restri\u00E7\u00F5es qu\u00EDmicas na cat\u00E1lise levaram \u00E0 mesma solu\u00E7\u00E3o catal\u00EDtica evoluindo independentemente em pelo menos 23 superfam\u00EDlias separadas. Seu mecanismo de a\u00E7\u00E3o \u00E9, conseq\u00FCentemente, um dos mais bem estudados em bioqu\u00EDmica."@pt . . "Tr\u00EDada catal\u00EDtica en biologia es refereix als tres residus qu\u00EDmics d'amino\u00E0cids que funcionen en conjunt al centre del lloc actiu d'alguns enzims hidrolasa i transferasa (per exemple, els de proteasa, , , , lipasa i \u03B2-lactamases). Una tr\u00EDada \u00C0cid-Base-Nucle\u00F2fil \u00E9s un motiu com\u00FA per a la generaci\u00F3 d'un residu nucleof\u00EDlic per a la cat\u00E0lisi covalent. Els residus formen una xarxa de c\u00E0rregues que polaritzen i activen el nucle\u00F2fil, aquest ataca els substrat formant un intermediari covalent que posteriorment \u00E9s hidrolitzat per a generar un enzim lliure. El residu nucleof\u00EDlic generalment \u00E9s serina o una ciste\u00EFna per\u00F2 de vegades pot ser una treonina."@ca . . "\u041A\u0430\u0442\u0430\u043B\u0438\u0442\u0438\u0447\u0435\u0441\u043A\u0430\u044F \u0442\u0440\u0438\u0430\u0434\u0430 \u2014 \u044D\u0442\u043E \u043D\u0430\u0431\u043E\u0440 \u0438\u0437 \u0442\u0440\u0435\u0445 \u0441\u043A\u043E\u043E\u0440\u0434\u0438\u043D\u0438\u0440\u043E\u0432\u0430\u043D\u043D\u044B\u0445 \u0430\u043C\u0438\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442, \u043A\u043E\u0442\u043E\u0440\u044B\u0435 \u043C\u043E\u0436\u043D\u043E \u043D\u0430\u0439\u0442\u0438 \u0432 \u0430\u043A\u0442\u0438\u0432\u043D\u043E\u043C \u0446\u0435\u043D\u0442\u0440\u0435 \u043D\u0435\u043A\u043E\u0442\u043E\u0440\u044B\u0445 \u0444\u0435\u0440\u043C\u0435\u043D\u0442\u043E\u0432. \u041A\u0430\u0442\u0430\u043B\u0438\u0442\u0438\u0447\u0435\u0441\u043A\u0438\u0435 \u0442\u0440\u0438\u0430\u0434\u044B \u0447\u0430\u0449\u0435 \u0432\u0441\u0435\u0433\u043E \u0432\u0441\u0442\u0440\u0435\u0447\u0430\u044E\u0442\u0441\u044F \u0432 \u0444\u0435\u0440\u043C\u0435\u043D\u0442\u0430\u0445 \u0433\u0438\u0434\u0440\u043E\u043B\u0430\u0437 \u0438 \u0442\u0440\u0430\u043D\u0441\u0444\u0435\u0440\u0430\u0437 (\u043D\u0430\u043F\u0440\u0438\u043C\u0435\u0440, \u043F\u0440\u043E\u0442\u0435\u0430\u0437\u044B, , \u044D\u0441\u0442\u0435\u0440\u0430\u0437\u044B, \u0430\u0446\u0438\u043B\u0430\u0437\u044B, \u043B\u0438\u043F\u0430\u0437\u044B \u0438 \u03B2-\u043B\u0430\u043A\u0442\u0430\u043C\u0430\u0437\u044B). \u0422\u0440\u0438\u0430\u0434\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430-\u043E\u0441\u043D\u043E\u0432\u0430\u043D\u0438\u0435-\u043D\u0443\u043A\u043B\u0435\u043E\u0444\u0438\u043B \u044F\u0432\u043B\u044F\u0435\u0442\u0441\u044F \u0440\u0430\u0441\u043F\u0440\u043E\u0441\u0442\u0440\u0430\u043D\u0435\u043D\u043D\u044B\u043C \u043C\u043E\u0442\u0438\u0432\u043E\u043C \u0434\u043B\u044F \u043E\u0431\u0440\u0430\u0437\u043E\u0432\u0430\u043D\u0438\u044F \u043D\u0443\u043A\u043B\u0435\u043E\u0444\u0438\u043B\u044C\u043D\u043E\u0433\u043E \u043E\u0441\u0442\u0430\u0442\u043A\u0430 \u0434\u043B\u044F . \u041E\u0441\u0442\u0430\u0442\u043A\u0438 \u043E\u0431\u0440\u0430\u0437\u0443\u044E\u0442 \u0441\u0435\u0442\u044C \u0440\u0435\u043B\u0435 \u0437\u0430\u0440\u044F\u0434\u0430 \u0434\u043B\u044F \u043F\u043E\u043B\u044F\u0440\u0438\u0437\u0430\u0446\u0438\u0438 \u0438 \u0430\u043A\u0442\u0438\u0432\u0430\u0446\u0438\u0438 \u043D\u0443\u043A\u043B\u0435\u043E\u0444\u0438\u043B\u0430, \u043A\u043E\u0442\u043E\u0440\u044B\u0439 \u0430\u0442\u0430\u043A\u0443\u0435\u0442 \u0441\u0443\u0431\u0441\u0442\u0440\u0430\u0442, \u043E\u0431\u0440\u0430\u0437\u0443\u044F \u043A\u043E\u0432\u0430\u043B\u0435\u043D\u0442\u043D\u044B\u0439 \u043F\u0440\u043E\u043C\u0435\u0436\u0443\u0442\u043E\u0447\u043D\u044B\u0439 \u043F\u0440\u043E\u0434\u0443\u043A\u0442, \u043A\u043E\u0442\u043E\u0440\u044B\u0439 \u0437\u0430\u0442\u0435\u043C \u0433\u0438\u0434\u0440\u043E\u043B\u0438\u0437\u0443\u0435\u0442\u0441\u044F \u0441 \u0432\u044B\u0441\u0432\u043E\u0431\u043E\u0436\u0434\u0435\u043D\u0438\u0435\u043C \u043F\u0440\u043E\u0434\u0443\u043A\u0442\u0430 \u0438 \u0440\u0435\u0433\u0435\u043D\u0435\u0440\u0430\u0446\u0438\u0435\u0439 \u0441\u0432\u043E\u0431\u043E\u0434\u043D\u043E\u0433\u043E \u0444\u0435\u0440\u043C\u0435\u043D\u0442\u0430. \u041D\u0443\u043A\u043B\u0435\u043E\u0444\u0438\u043B\u043E\u043C \u0447\u0430\u0449\u0435 \u0432\u0441\u0435\u0433\u043E \u044F\u0432\u043B\u044F\u0435\u0442\u0441\u044F \u0430\u043C\u0438\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442\u0430 \u0441\u0435\u0440\u0438\u043D \u0438\u043B\u0438 \u0446\u0438\u0441\u0442\u0435\u0438\u043D, \u043D\u043E \u0438\u043D\u043E\u0433\u0434\u0430 \u0442\u0440\u0435\u043E\u043D\u0438\u043D \u0438\u043B\u0438 \u0434\u0430\u0436\u0435 \u0441\u0435\u043B\u0435\u043D\u043E\u0446\u0438\u0441\u0442\u0435\u0438\u043D. \u0422\u0440\u0435\u0445\u043C\u0435\u0440\u043D\u0430\u044F \u0441\u0442\u0440\u0443\u043A\u0442\u0443\u0440\u0430 \u0444\u0435\u0440\u043C\u0435\u043D\u0442\u0430 \u043E\u0431\u044A\u0435\u0434\u0438\u043D\u044F\u0435\u0442 \u0442\u0440\u0438\u0430\u0434\u043D\u044B\u0435 \u043E\u0441\u0442\u0430\u0442\u043A\u0438 \u0432 \u0442\u043E\u0447\u043D\u043E\u0439 \u043E\u0440\u0438\u0435\u043D\u0442\u0430\u0446\u0438\u0438, \u0434\u0430\u0436\u0435 \u0435\u0441\u043B\u0438 \u043E\u043D\u0438 \u043C\u043E\u0433\u0443\u0442 \u043D\u0430\u0445\u043E\u0434\u0438\u0442\u044C\u0441\u044F \u0434\u0430\u043B\u0435\u043A\u043E \u0434\u0440\u0443\u0433 \u043E\u0442 \u0434\u0440\u0443\u0433\u0430 \u0432 \u043F\u043E\u0441\u043B\u0435\u0434\u043E\u0432\u0430\u0442\u0435\u043B\u044C\u043D\u043E\u0441\u0442\u0438 (\u043F\u0435\u0440\u0432\u0438\u0447\u043D\u0430\u044F \u0441\u0442\u0440\u0443\u043A\u0442\u0443\u0440\u0430). \u041F\u043E\u043C\u0438\u043C\u043E \u0434\u0438\u0432\u0435\u0440\u0433\u0435\u043D\u0442\u043D\u043E\u0439 \u044D\u0432\u043E\u043B\u044E\u0446\u0438\u0438 \u0444\u0443\u043D\u043A\u0446\u0438\u0438 (\u0438 \u0434\u0430\u0436\u0435 \u043D\u0443\u043A\u043B\u0435\u043E\u0444\u0438\u043B\u0430 \u0442\u0440\u0438\u0430\u0434\u044B), \u043A\u0430\u0442\u0430\u043B\u0438\u0442\u0438\u0447\u0435\u0441\u043A\u0438\u0435 \u0442\u0440\u0438\u0430\u0434\u044B \u0434\u0435\u043C\u043E\u043D\u0441\u0442\u0440\u0438\u0440\u0443\u044E\u0442 \u043E\u0434\u043D\u0438 \u0438\u0437 \u043B\u0443\u0447\u0448\u0438\u0445 \u043F\u0440\u0438\u043C\u0435\u0440\u043E\u0432 \u043A\u043E\u043D\u0432\u0435\u0440\u0433\u0435\u043D\u0442\u043D\u043E\u0439 \u044D\u0432\u043E\u043B\u044E\u0446\u0438\u0438. \u0425\u0438\u043C\u0438\u0447\u0435\u0441\u043A\u0438\u0435 \u043E\u0433\u0440\u0430\u043D\u0438\u0447\u0435\u043D\u0438\u044F \u043A\u0430\u0442\u0430\u043B\u0438\u0437\u0430 \u043F\u0440\u0438\u0432\u0435\u043B\u0438 \u043A \u0442\u043E\u043C\u0443, \u0447\u0442\u043E \u043E\u0434\u043D\u043E \u0438 \u0442\u043E \u0436\u0435 \u0441\u0442\u0440\u043E\u0435\u043D\u0438\u0435 \u043A\u0430\u0442\u0430\u043B\u0438\u0442\u0438\u0447\u0435\u0441\u043A\u0438\u0445 \u0446\u0435\u043D\u0442\u0440\u043E\u0432 \u0440\u0430\u0437\u0432\u0438\u043B\u043E\u0441\u044C \u043D\u0435\u0437\u0430\u0432\u0438\u0441\u0438\u043C\u043E \u043F\u043E \u043A\u0440\u0430\u0439\u043D\u0435\u0439 \u043C\u0435\u0440\u0435 \u0432 23 \u043E\u0442\u0434\u0435\u043B\u044C\u043D\u044B\u0445 \u0441\u0443\u043F\u0435\u0440\u0441\u0435\u043C\u0435\u0439\u0441\u0442\u0432\u0430\u0445. \u0412\u0441\u043B\u0435\u0434\u0441\u0442\u0432\u0438\u0435 \u044D\u0442\u043E\u0433\u043E, \u0438\u0445 \u043C\u0435\u0445\u0430\u043D\u0438\u0437\u043C \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044F \u044F\u0432\u043B\u044F\u0435\u0442\u0441\u044F \u043E\u0434\u043D\u0438\u043C \u0438\u0437 \u043D\u0430\u0438\u0431\u043E\u043B\u0435\u0435 \u0438\u0437\u0443\u0447\u0435\u043D\u043D\u044B\u0445 \u0432 \u0431\u0438\u043E\u0445\u0438\u043C\u0438\u0438."@ru . . . . . . . . . . . . . . . . . . . . . "Evolutionary convergence of serine and cysteine protease towards the same catalytic triads organisation of acid-base-nucleophile in different protease superfamilies. Shown are the triads of subtilisin, prolyl oligopeptidase, TEV protease, and papain."@en . . . . . . "58391"^^ . . "Tr\u00EDada catal\u00EDtica"@es . . . . "\uCD09\uB9E4 \uC0BC\uC794\uAE30(\u89F8\u5A92\u4E09\u6B98\u57FA, \uC601\uC5B4: catalytic triad)\uB294 \uC77C\uBD80 \uD6A8\uC18C\uC758 \uD65C\uC131 \uBD80\uC704\uC5D0\uC11C \uBC1C\uACAC\uD560 \uC218 \uC788\uB294 3\uAC1C\uC758 \uBC30\uC704 \uC544\uBBF8\uB178\uC0B0\uB4E4\uC758 \uC138\uD2B8\uC774\uB2E4. \uCD09\uB9E4 \uC0BC\uC794\uAE30\uB294 \uAC00\uC218\uBD84\uD574\uD6A8\uC18C(\uC608: \uB2E8\uBC31\uC9C8\uAC00\uC218\uBD84\uD574\uD6A8\uC18C, , \uC5D0\uC2A4\uD130\uAC00\uC218\uBD84\uD574\uD6A8\uC18C, , \uC9C0\uC9C8\uAC00\uC218\uBD84\uD574\uD6A8\uC18C, \u03B2-\uB77D\uD0C0\uBA54\uC774\uC2A4) \uBC0F \uC804\uC774\uD6A8\uC18C\uC5D0\uC11C \uAC00\uC7A5 \uC77C\uBC18\uC801\uC73C\uB85C \uBC1C\uACAC\uB41C\uB2E4. \uC0B0-\uC5FC\uAE30-\uCE5C\uD575\uCCB4 \uC0BC\uC794\uAE30\uB294 \uACF5\uC720\uACB0\uD569\uC131 \uCD09\uB9E4\uC791\uC6A9\uC744 \uC704\uD55C \uCE5C\uD575\uC131 \uC794\uAE30\uB97C \uC0DD\uC131\uD558\uAE30 \uC704\uD55C \uC77C\uBC18\uC801\uC778 \uBAA8\uD2F0\uD504\uC774\uB2E4. \uC794\uAE30\uB294 \uC804\uD558 \uB9B4\uB808\uC774 \uB124\uD2B8\uC6CC\uD06C\uB97C \uD615\uC131\uD558\uC5EC \uCE5C\uD575\uCCB4\uB97C \uBD84\uADF9\uD654\uD558\uACE0 \uD65C\uC131\uD654\uC2DC\uCF1C \uAE30\uC9C8\uC744 \uACF5\uACA9\uD558\uC5EC \uACF5\uC720\uACB0\uD569\uC131 \uC911\uAC04\uC0DD\uC131\uBB3C\uC744 \uD615\uC131\uD558\uACE0 \uAC00\uC218\uBD84\uD574\uB418\uC5B4 \uC0DD\uC131\uBB3C\uC744 \uBC29\uCD9C\uD558\uACE0 \uC720\uB9AC \uD6A8\uC18C\uB97C \uC7AC\uC0DD\uD55C\uB2E4. \uC5EC\uAE30\uC11C \uCE5C\uD575\uCCB4\uB294 \uAC00\uC7A5 \uC77C\uBC18\uC801\uC73C\uB85C \uC544\uBBF8\uB178\uC0B0\uC778 \uC138\uB9B0 \uB610\uB294 \uC2DC\uC2A4\uD14C\uC778\uC774\uC9C0\uB9CC \uB54C\uB54C\uB85C \uD2B8\uB808\uC624\uB2CC \uB610\uB294 \uC140\uB808\uB178\uC2DC\uC2A4\uD14C\uC778\uC77C \uC218\uB3C4 \uC788\uB2E4. \uD6A8\uC18C\uC758 3\uCC28 \uAD6C\uC870\uB294 \uB2E8\uBC31\uC9C8 1\uCC28 \uAD6C\uC870\uC758 \uC11C\uC5F4\uC0C1 \uBA40\uB9AC \uB5A8\uC5B4\uC838 \uC704\uCE58\uD560 \uC218 \uC788\uC74C\uC5D0\uB3C4 \uBD88\uAD6C\uD558\uACE0 \uC815\uD655\uD55C \uBC29\uD5A5\uC73C\uB85C 3\uAC1C\uC758 \uC794\uAE30\uAC00 \uC704\uCE58\uD55C\uB2E4."@ko . . . . . . . . "Triad convergence thr.svg"@en . "\u89E6\u5A92\u4E09\u6B8B\u57FA"@ja . . . . . . . "2533237"^^ . . . . "En biologie mol\u00E9culaire, on d\u00E9signe g\u00E9n\u00E9ralement par triade catalytique les trois r\u00E9sidus d'acides amin\u00E9s qui interviennent ensemble dans le site actif de certaines hydrolases et transf\u00E9rases telles que des peptidases, des amidases, des est\u00E9rases, des lipases et des \u03B2-lactamases. Une fa\u00E7on courante de produire des r\u00E9sidus nucl\u00E9ophiles pour une catalyse covalente consiste \u00E0 faire intervenir une triade acide\u2013base\u2013nucl\u00E9ophile. Ces r\u00E9sidus forment un r\u00E9seau de transfert de charges qui polarise et active le r\u00E9sidu nucl\u00E9ophile, lequel attaque le substrat en formant un interm\u00E9diaire covalent hydrolys\u00E9 ensuite pour lib\u00E9rer \u00E0 nouveau l'enzyme. Le nucl\u00E9ophile d'une telle triade est g\u00E9n\u00E9ralement la s\u00E9rine ou la cyst\u00E9ine, mais peut \u00E9galement \u00EAtre la thr\u00E9onine. Les r\u00E9sidus constituant la triade catalytique peuvent \u00EAtre tr\u00E8s \u00E9loign\u00E9s les uns des autres le long de la s\u00E9quence peptidique (structure primaire) des enzymes consid\u00E9r\u00E9es, mais se retrouver \u00E0 proximit\u00E9 les uns des autres en raison du repliement des polypeptides en une structure tertiaire tridimensionnelle complexe. Les triades catalytiques constituent l'un des meilleurs exemples de convergence \u00E9volutive : la nature m\u00EAme des r\u00E9actions chimiques catalys\u00E9es ont conduit de fa\u00E7on ind\u00E9pendante aux m\u00EAmes types de sites actifs \u00E0 partir d'au moins 23 superfamilles distinctes. Leur m\u00E9canisme r\u00E9actionnel est par cons\u00E9quent l'un des mieux compris de toute la biochimie."@fr . . . . . . . . . . . . . . . . . "El t\u00E9rmino tr\u00EDada catal\u00EDtica refiere a los tres residuos de amino\u00E1cidos que funcionan en conjunto en el centro del sitio activo de algunas enzimas hidrolasas y transferasas (por ejemplo, proteasas, amidasas, esterasas, , lipasas y \u03B2-lactamasas). Una tr\u00EDada \u00C1cido-Base-Nucle\u00F3filo es un motivo com\u00FAn para la generaci\u00F3n de un residuo nucleof\u00EDlico para la cat\u00E1lisis covalente.\u200B\u200B Los residuos aminoac\u00EDdicos forman una red de relevamiento de cargas que polarizan y activan al nucle\u00F3filo, el cual ataca al sustrato, formando un intermediario covalente el cual es luego hidrolizado para regenerar la enzima libre. El residuo nucleof\u00EDlico es por lo general una serina o una ciste\u00EDna pero algunas veces puede ser una treonina. Debido a que las enzimas se pliegan en complejas estructuras tridimensionales, los residuos de la tr\u00EDada catal\u00EDtica pueden estar muy alejados unos de otros sobre la secuencia primaria, sin embargo, se encuentran estrechamente relacionados en el plegamiento final. Adem\u00E1s de ejemplificar a la perfecci\u00F3n la evoluci\u00F3n divergente de funci\u00F3n (incluso con el nucle\u00F3filo de la tr\u00EDada), las tr\u00EDadas catal\u00EDticas muestran algunos de los mejores ejemplos de evoluci\u00F3n convergente. Las limitaciones qu\u00EDmicas del proceso catal\u00EDtico han conducido a la misma soluci\u00F3n catal\u00EDtica para al menos 23 diferentes de enzimas que evolucionaron en forma independiente.\u200B Su es por lo tanto uno de los mejor estudiados en toda la bioqu\u00EDmica.\u200B\u200B"@es . . . . . . . . . . . "\uCD09\uB9E4 \uC0BC\uC794\uAE30(\u89F8\u5A92\u4E09\u6B98\u57FA, \uC601\uC5B4: catalytic triad)\uB294 \uC77C\uBD80 \uD6A8\uC18C\uC758 \uD65C\uC131 \uBD80\uC704\uC5D0\uC11C \uBC1C\uACAC\uD560 \uC218 \uC788\uB294 3\uAC1C\uC758 \uBC30\uC704 \uC544\uBBF8\uB178\uC0B0\uB4E4\uC758 \uC138\uD2B8\uC774\uB2E4. \uCD09\uB9E4 \uC0BC\uC794\uAE30\uB294 \uAC00\uC218\uBD84\uD574\uD6A8\uC18C(\uC608: \uB2E8\uBC31\uC9C8\uAC00\uC218\uBD84\uD574\uD6A8\uC18C, , \uC5D0\uC2A4\uD130\uAC00\uC218\uBD84\uD574\uD6A8\uC18C, , \uC9C0\uC9C8\uAC00\uC218\uBD84\uD574\uD6A8\uC18C, \u03B2-\uB77D\uD0C0\uBA54\uC774\uC2A4) \uBC0F \uC804\uC774\uD6A8\uC18C\uC5D0\uC11C \uAC00\uC7A5 \uC77C\uBC18\uC801\uC73C\uB85C \uBC1C\uACAC\uB41C\uB2E4. \uC0B0-\uC5FC\uAE30-\uCE5C\uD575\uCCB4 \uC0BC\uC794\uAE30\uB294 \uACF5\uC720\uACB0\uD569\uC131 \uCD09\uB9E4\uC791\uC6A9\uC744 \uC704\uD55C \uCE5C\uD575\uC131 \uC794\uAE30\uB97C \uC0DD\uC131\uD558\uAE30 \uC704\uD55C \uC77C\uBC18\uC801\uC778 \uBAA8\uD2F0\uD504\uC774\uB2E4. \uC794\uAE30\uB294 \uC804\uD558 \uB9B4\uB808\uC774 \uB124\uD2B8\uC6CC\uD06C\uB97C \uD615\uC131\uD558\uC5EC \uCE5C\uD575\uCCB4\uB97C \uBD84\uADF9\uD654\uD558\uACE0 \uD65C\uC131\uD654\uC2DC\uCF1C \uAE30\uC9C8\uC744 \uACF5\uACA9\uD558\uC5EC \uACF5\uC720\uACB0\uD569\uC131 \uC911\uAC04\uC0DD\uC131\uBB3C\uC744 \uD615\uC131\uD558\uACE0 \uAC00\uC218\uBD84\uD574\uB418\uC5B4 \uC0DD\uC131\uBB3C\uC744 \uBC29\uCD9C\uD558\uACE0 \uC720\uB9AC \uD6A8\uC18C\uB97C \uC7AC\uC0DD\uD55C\uB2E4. \uC5EC\uAE30\uC11C \uCE5C\uD575\uCCB4\uB294 \uAC00\uC7A5 \uC77C\uBC18\uC801\uC73C\uB85C \uC544\uBBF8\uB178\uC0B0\uC778 \uC138\uB9B0 \uB610\uB294 \uC2DC\uC2A4\uD14C\uC778\uC774\uC9C0\uB9CC \uB54C\uB54C\uB85C \uD2B8\uB808\uC624\uB2CC \uB610\uB294 \uC140\uB808\uB178\uC2DC\uC2A4\uD14C\uC778\uC77C \uC218\uB3C4 \uC788\uB2E4. \uD6A8\uC18C\uC758 3\uCC28 \uAD6C\uC870\uB294 \uB2E8\uBC31\uC9C8 1\uCC28 \uAD6C\uC870\uC758 \uC11C\uC5F4\uC0C1 \uBA40\uB9AC \uB5A8\uC5B4\uC838 \uC704\uCE58\uD560 \uC218 \uC788\uC74C\uC5D0\uB3C4 \uBD88\uAD6C\uD558\uACE0 \uC815\uD655\uD55C \uBC29\uD5A5\uC73C\uB85C 3\uAC1C\uC758 \uC794\uAE30\uAC00 \uC704\uCE58\uD55C\uB2E4."@ko . "Als katalytische Triade bezeichnet man in der Biochemie eine spezielle Anordnung von drei Aminos\u00E4uren im aktiven Zentrum einiger Enzyme. Mit der katalytischen Triade kann in Hydrolasen die Spaltung eines Substrats und in Transferasen der Transfer eines Substratteils auf ein zweites Substrat katalysiert werden. Die drei Aminos\u00E4uren fungieren dabei als S\u00E4ure, Base und Nukleophil und erm\u00F6glichen eine kovalente Katalyse."@de . . . . . . . "Tr\u00EDade catal\u00EDtica"@pt . "Katalytische Triade"@de . . . . "vertical"@en . . . . . . . "\u50AC\u5316\u4E09\u8054\u4F53"@zh . . . . . . . . . . . . "Triade catalytique"@fr . . "Katalytische triade"@nl . . . . . . . . . . . "Tr\u00EDada catal\u00EDtica en biologia es refereix als tres residus qu\u00EDmics d'amino\u00E0cids que funcionen en conjunt al centre del lloc actiu d'alguns enzims hidrolasa i transferasa (per exemple, els de proteasa, , , , lipasa i \u03B2-lactamases). Una tr\u00EDada \u00C0cid-Base-Nucle\u00F2fil \u00E9s un motiu com\u00FA per a la generaci\u00F3 d'un residu nucleof\u00EDlic per a la cat\u00E0lisi covalent. Els residus formen una xarxa de c\u00E0rregues que polaritzen i activen el nucle\u00F2fil, aquest ataca els substrat formant un intermediari covalent que posteriorment \u00E9s hidrolitzat per a generar un enzim lliure. El residu nucleof\u00EDlic generalment \u00E9s serina o una ciste\u00EFna per\u00F2 de vegades pot ser una treonina. Pel fet que els enzims es pleguen en estructures estructures tridimensionals, els residus a la tr\u00EDada catal\u00EDtica poden estar molt allunyats els uns dels altres sobre la seq\u00FC\u00E8ncia prim\u00E0ria, tanmateix, es troben estretament relacionats amb el plegament final. Les triades catal\u00EDtiques s\u00F3n un exemple de l'evoluci\u00F3 divergent de funci\u00F3 (fins i tot amb el nucle\u00F2fil de la tr\u00EDada), per\u00F2 tamb\u00E9 les tr\u00EDades catal\u00EDtiques mostren alguns dels exemples de l'evoluci\u00F3 convergent. Les limitacions qu\u00EDmiques del proc\u00E9s catal\u00EDtic han condu\u00EFt a la mateixa soluci\u00F3 catal\u00EDtic com a m\u00EDnim per a 23 diferents d'enzims que van evolucionar de forma independent. Per tant, el seu \u00E9s un dels m\u00E9s ben estudiats de tota la bioqu\u00EDmica."@ca . "\u50AC\u5316\u4E09\u8054\u4F53\uFF0C\u53C8\u7A31\u50AC\u5316\u91D1\u4E09\u89D2\uFF0C\u901A\u5E38\u6307\u5728\u6C34\u89E3\u9176\u548C\u8F6C\u79FB\u9176\u7684\u6D3B\u6027\u4F4D\u70B9\u4E2D\u5FC3\u540C\u65F6\u4F5C\u7528\u7684\u4E09\u4E2A\u6C28\u57FA\u9178\u6B8B\u57FA\uFF08\u5982\u86CB\u767D\u9176\u3001\u3001\u916F\u9176\u3001\u3001\u8102\u9176\u548C\u03B2-\u5185\u9170\u80FA\u9176\uFF09\u3002\u7528\u4E8E\u5171\u4EF7\u50AC\u5316\u7684\u4EB2\u6838\u6B8B\u57FA\u4E00\u822C\u662F\u9178-\u78B1-\u4EB2\u6838\u4E09\u8054\u4F53\u3002\u6B8B\u57FA\u4F1A\u5F62\u6210\u4E00\u4E2A\u7535\u8377\u4E2D\u7EE7\u7F51\u7EDC\uFF0C\u4EE5\u6781\u5316\u548C\u6D3B\u5316\u4EB2\u6838\u8BD5\u5242\uFF0C\u6765\u8FDB\u653B\u5E95\u7269\u5F62\u6210\u5171\u4EF7\u4E2D\u95F4\u4F53\uFF0C\u7136\u540E\u4E2D\u95F4\u4F53\u6C34\u89E3\uFF0C\u518D\u751F\u51FA\u6E38\u79BB\u7684\u9176\u3002\u4EB2\u6838\u8BD5\u5242\u5927\u591A\u662F\u4E1D\u6C28\u9178\u6216\u534A\u80F1\u6C28\u9178\uFF0C\u4E5F\u6709\u5C11\u91CF\u662F\u82CF\u6C28\u9178\u3002 \u56E0\u4E3A\u9176\u4F1A\u6298\u53E0\u6210\u590D\u6742\u7684\u4E09\u7EF4\u7ED3\u6784\uFF0C\u50AC\u5316\u4E09\u8054\u4F53\u7684\u6B8B\u57FA\u53EF\u80FD\u5728\u5176\u6240\u5728\u7684\u6C28\u57FA\u9178\u5E8F\u5217\uFF08\u4E00\u7EA7\u7ED3\u6784\uFF09\u4E2D\u79BB\u5F97\u5F88\u8FDC\uFF0C\u4F46\u6700\u540E\u5B83\u4EEC\u5C06\u4F1A\u6298\u53E0\u5230\u4E00\u8D77\u3002 \u867D\u7136\u5728\u529F\u80FD\u4E0A\uFF08\u751A\u81F3\u662F\u4E09\u8054\u4F53\u4E2D\u7684\u4EB2\u6838\u4F53\uFF09\u8FDB\u5316\u8D8B\u5F02\uFF0C\u50AC\u5316\u4E09\u8054\u4F53\u5374\u662F\u8D8B\u540C\u8FDB\u5316\u7684\u6700\u597D\u6848\u4F8B\u3002\u5BF9\u50AC\u5316\u7684\u5316\u5B66\u7EA6\u675F\u4F7F\u5F97\u81F3\u5C1123\u4E2A\u72EC\u7ACB\u7684\u86CB\u767D\u8D28\u8D85\u5BB6\u65CF\u8FDB\u5316\u51FA\u4E86\u76F8\u540C\u7684\u50AC\u5316\u65B9\u6CD5\u3002\u751F\u7269\u5316\u5B66\u4E2D\uFF0C\u7814\u7A76\u5F97\u6700\u900F\u5F7B\u4E4B\u4E00\u7684\u5C31\u662F\u8FD9\u4E9B\u53CD\u5E94\u7684\u4F5C\u7528\u673A\u7406\u3002"@zh . . "En biologie mol\u00E9culaire, on d\u00E9signe g\u00E9n\u00E9ralement par triade catalytique les trois r\u00E9sidus d'acides amin\u00E9s qui interviennent ensemble dans le site actif de certaines hydrolases et transf\u00E9rases telles que des peptidases, des amidases, des est\u00E9rases, des lipases et des \u03B2-lactamases. Une fa\u00E7on courante de produire des r\u00E9sidus nucl\u00E9ophiles pour une catalyse covalente consiste \u00E0 faire intervenir une triade acide\u2013base\u2013nucl\u00E9ophile. Ces r\u00E9sidus forment un r\u00E9seau de transfert de charges qui polarise et active le r\u00E9sidu nucl\u00E9ophile, lequel attaque le substrat en formant un interm\u00E9diaire covalent hydrolys\u00E9 ensuite pour lib\u00E9rer \u00E0 nouveau l'enzyme. Le nucl\u00E9ophile d'une telle triade est g\u00E9n\u00E9ralement la s\u00E9rine ou la cyst\u00E9ine, mais peut \u00E9galement \u00EAtre la thr\u00E9onine."@fr . . . . . . . . . . . . . . . "1121642889"^^ . "500"^^ . . . . "Catalytic triad"@en . . . . . . . "\u50AC\u5316\u4E09\u8054\u4F53\uFF0C\u53C8\u7A31\u50AC\u5316\u91D1\u4E09\u89D2\uFF0C\u901A\u5E38\u6307\u5728\u6C34\u89E3\u9176\u548C\u8F6C\u79FB\u9176\u7684\u6D3B\u6027\u4F4D\u70B9\u4E2D\u5FC3\u540C\u65F6\u4F5C\u7528\u7684\u4E09\u4E2A\u6C28\u57FA\u9178\u6B8B\u57FA\uFF08\u5982\u86CB\u767D\u9176\u3001\u3001\u916F\u9176\u3001\u3001\u8102\u9176\u548C\u03B2-\u5185\u9170\u80FA\u9176\uFF09\u3002\u7528\u4E8E\u5171\u4EF7\u50AC\u5316\u7684\u4EB2\u6838\u6B8B\u57FA\u4E00\u822C\u662F\u9178-\u78B1-\u4EB2\u6838\u4E09\u8054\u4F53\u3002\u6B8B\u57FA\u4F1A\u5F62\u6210\u4E00\u4E2A\u7535\u8377\u4E2D\u7EE7\u7F51\u7EDC\uFF0C\u4EE5\u6781\u5316\u548C\u6D3B\u5316\u4EB2\u6838\u8BD5\u5242\uFF0C\u6765\u8FDB\u653B\u5E95\u7269\u5F62\u6210\u5171\u4EF7\u4E2D\u95F4\u4F53\uFF0C\u7136\u540E\u4E2D\u95F4\u4F53\u6C34\u89E3\uFF0C\u518D\u751F\u51FA\u6E38\u79BB\u7684\u9176\u3002\u4EB2\u6838\u8BD5\u5242\u5927\u591A\u662F\u4E1D\u6C28\u9178\u6216\u534A\u80F1\u6C28\u9178\uFF0C\u4E5F\u6709\u5C11\u91CF\u662F\u82CF\u6C28\u9178\u3002 \u56E0\u4E3A\u9176\u4F1A\u6298\u53E0\u6210\u590D\u6742\u7684\u4E09\u7EF4\u7ED3\u6784\uFF0C\u50AC\u5316\u4E09\u8054\u4F53\u7684\u6B8B\u57FA\u53EF\u80FD\u5728\u5176\u6240\u5728\u7684\u6C28\u57FA\u9178\u5E8F\u5217\uFF08\u4E00\u7EA7\u7ED3\u6784\uFF09\u4E2D\u79BB\u5F97\u5F88\u8FDC\uFF0C\u4F46\u6700\u540E\u5B83\u4EEC\u5C06\u4F1A\u6298\u53E0\u5230\u4E00\u8D77\u3002 \u867D\u7136\u5728\u529F\u80FD\u4E0A\uFF08\u751A\u81F3\u662F\u4E09\u8054\u4F53\u4E2D\u7684\u4EB2\u6838\u4F53\uFF09\u8FDB\u5316\u8D8B\u5F02\uFF0C\u50AC\u5316\u4E09\u8054\u4F53\u5374\u662F\u8D8B\u540C\u8FDB\u5316\u7684\u6700\u597D\u6848\u4F8B\u3002\u5BF9\u50AC\u5316\u7684\u5316\u5B66\u7EA6\u675F\u4F7F\u5F97\u81F3\u5C1123\u4E2A\u72EC\u7ACB\u7684\u86CB\u767D\u8D28\u8D85\u5BB6\u65CF\u8FDB\u5316\u51FA\u4E86\u76F8\u540C\u7684\u50AC\u5316\u65B9\u6CD5\u3002\u751F\u7269\u5316\u5B66\u4E2D\uFF0C\u7814\u7A76\u5F97\u6700\u900F\u5F7B\u4E4B\u4E00\u7684\u5C31\u662F\u8FD9\u4E9B\u53CD\u5E94\u7684\u4F5C\u7528\u673A\u7406\u3002"@zh . . . . . . . . . . . . . . . . "Evolutionary convergence of threonine proteases towards the same N-terminal active site organisation. Shown are the catalytic threonine of the proteasome and ornithine acetyltransferase."@en . . . . . . . . . . "Een katalytische triade is een benaming voor een bijeengeschakeld drietal aminozuren in het actieve centrum van bepaalde enzymen. Katalytische triaden komen voor in hydrolasen en transferasen: twee grote groepen enzymen waartoe onder andere de proteasen, , esterasen, en lipasen behoren. In een katalytische triade bevinden zich gewoonlijk drie aminozuurresiduen, die samenwerken om een chemische reactie te katalyseren. Meestal bevat de triade een zuur, basisch en nucleofiel aminozuur die tijdelijk een (covalente) binding aangaan met het substraat. In een dergelijke situatie vormen de residuen samen een ladingsnetwerk die het nucleofiele residu activeren, waardoor het substraat wordt aangevallen. Hierbij ontstaat een covalent tussenproduct dat gehydrolyseerd wordt om het enzym weer vrij te maken. Het nucleofiele residu is meestal serine of cyste\u00EFne, maar ook zijn gevallen bekend waarin threonine of zelfs selenocyste\u00EFne in de triade voorkwamen. De aminozuurresiduen van een katalytische triade kunnen ver uit elkaar liggen in de aminozuursequentie (primaire structuur), maar ze worden bij elkaar gebracht door specifieke eiwitvouwing; de complexe driedimensionale structuur."@nl . . . . . . . . . . . . . . "Uma tr\u00EDade catal\u00EDtica \u00E9 um conjunto de tr\u00EAs amino\u00E1cidos coordenados que podem ser encontrados no s\u00EDtio ativo de algumas enzimas. As tr\u00EDades catal\u00EDticas s\u00E3o mais comumente encontradas nas enzimas hidrolase e transferase (por exemplo, proteases, , esterases, acilases, lipases e \u03B2-lactamases). Uma tr\u00EDade \u00E1cido-base-nucle\u00F3filo \u00E9 um motivo comum para gerar um res\u00EDduo nucleof\u00EDlico para cat\u00E1lise covalente. Os res\u00EDduos formam uma rede de rel\u00E9 de carga para polarizar e ativar o nucle\u00F3filo, que ataca o substrato, formando um intermedi\u00E1rio covalente que \u00E9 ent\u00E3o hidrolisado para liberar o produto e regenerar a enzima livre. O nucle\u00F3filo \u00E9 mais comumente um amino\u00E1cido serina ou ciste\u00EDna, mas ocasionalmente treonina ou mesmo selenociste\u00EDna. A da enzima re\u00FAne os res\u00EDduos da tr\u00EDade em uma orienta\u00E7\u00E3o prec"@pt . . . "\uCD09\uB9E4 \uC0BC\uC794\uAE30"@ko . . . "Als katalytische Triade bezeichnet man in der Biochemie eine spezielle Anordnung von drei Aminos\u00E4uren im aktiven Zentrum einiger Enzyme. Mit der katalytischen Triade kann in Hydrolasen die Spaltung eines Substrats und in Transferasen der Transfer eines Substratteils auf ein zweites Substrat katalysiert werden. Die drei Aminos\u00E4uren fungieren dabei als S\u00E4ure, Base und Nukleophil und erm\u00F6glichen eine kovalente Katalyse. Die Aminos\u00E4urereste der katalytischen Triade k\u00F6nnen in der Aminos\u00E4uresequenz (Prim\u00E4rstruktur) weit auseinanderliegen und erst durch die Enzymfaltung, der Ausbildung einer komplexen dreidimensionalen Struktur, in r\u00E4umliche N\u00E4he gebracht werden."@de . . "A catalytic triad is a set of three coordinated amino acids that can be found in the active site of some enzymes. Catalytic triads are most commonly found in hydrolase and transferase enzymes (e.g. proteases, amidases, esterases, acylases, lipases and \u03B2-lactamases). An acid-base-nucleophile triad is a common motif for generating a nucleophilic residue for covalent catalysis. The residues form a charge-relay network to polarise and activate the nucleophile, which attacks the substrate, forming a covalent intermediate which is then hydrolysed to release the product and regenerate free enzyme. The nucleophile is most commonly a serine or cysteine amino acid, but occasionally threonine or even selenocysteine. The 3D structure of the enzyme brings together the triad residues in a precise orientation, even though they may be far apart in the sequence (primary structure). As well as divergent evolution of function (and even the triad's nucleophile), catalytic triads show some of the best examples of convergent evolution. Chemical constraints on catalysis have led to the same catalytic solution independently evolving in at least 23 separate superfamilies. Their mechanism of action is consequently one of the best studied in biochemistry."@en . . . . . "\u041A\u0430\u0442\u0430\u043B\u0438\u0442\u0438\u0447\u0435\u0441\u043A\u0430\u044F \u0442\u0440\u0438\u0430\u0434\u0430 \u2014 \u044D\u0442\u043E \u043D\u0430\u0431\u043E\u0440 \u0438\u0437 \u0442\u0440\u0435\u0445 \u0441\u043A\u043E\u043E\u0440\u0434\u0438\u043D\u0438\u0440\u043E\u0432\u0430\u043D\u043D\u044B\u0445 \u0430\u043C\u0438\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442, \u043A\u043E\u0442\u043E\u0440\u044B\u0435 \u043C\u043E\u0436\u043D\u043E \u043D\u0430\u0439\u0442\u0438 \u0432 \u0430\u043A\u0442\u0438\u0432\u043D\u043E\u043C \u0446\u0435\u043D\u0442\u0440\u0435 \u043D\u0435\u043A\u043E\u0442\u043E\u0440\u044B\u0445 \u0444\u0435\u0440\u043C\u0435\u043D\u0442\u043E\u0432. \u041A\u0430\u0442\u0430\u043B\u0438\u0442\u0438\u0447\u0435\u0441\u043A\u0438\u0435 \u0442\u0440\u0438\u0430\u0434\u044B \u0447\u0430\u0449\u0435 \u0432\u0441\u0435\u0433\u043E \u0432\u0441\u0442\u0440\u0435\u0447\u0430\u044E\u0442\u0441\u044F \u0432 \u0444\u0435\u0440\u043C\u0435\u043D\u0442\u0430\u0445 \u0433\u0438\u0434\u0440\u043E\u043B\u0430\u0437 \u0438 \u0442\u0440\u0430\u043D\u0441\u0444\u0435\u0440\u0430\u0437 (\u043D\u0430\u043F\u0440\u0438\u043C\u0435\u0440, \u043F\u0440\u043E\u0442\u0435\u0430\u0437\u044B, , \u044D\u0441\u0442\u0435\u0440\u0430\u0437\u044B, \u0430\u0446\u0438\u043B\u0430\u0437\u044B, \u043B\u0438\u043F\u0430\u0437\u044B \u0438 \u03B2-\u043B\u0430\u043A\u0442\u0430\u043C\u0430\u0437\u044B). \u0422\u0440\u0438\u0430\u0434\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430-\u043E\u0441\u043D\u043E\u0432\u0430\u043D\u0438\u0435-\u043D\u0443\u043A\u043B\u0435\u043E\u0444\u0438\u043B \u044F\u0432\u043B\u044F\u0435\u0442\u0441\u044F \u0440\u0430\u0441\u043F\u0440\u043E\u0441\u0442\u0440\u0430\u043D\u0435\u043D\u043D\u044B\u043C \u043C\u043E\u0442\u0438\u0432\u043E\u043C \u0434\u043B\u044F \u043E\u0431\u0440\u0430\u0437\u043E\u0432\u0430\u043D\u0438\u044F \u043D\u0443\u043A\u043B\u0435\u043E\u0444\u0438\u043B\u044C\u043D\u043E\u0433\u043E \u043E\u0441\u0442\u0430\u0442\u043A\u0430 \u0434\u043B\u044F . \u041E\u0441\u0442\u0430\u0442\u043A\u0438 \u043E\u0431\u0440\u0430\u0437\u0443\u044E\u0442 \u0441\u0435\u0442\u044C \u0440\u0435\u043B\u0435 \u0437\u0430\u0440\u044F\u0434\u0430 \u0434\u043B\u044F \u043F\u043E\u043B\u044F\u0440\u0438\u0437\u0430\u0446\u0438\u0438 \u0438 \u0430\u043A\u0442\u0438\u0432\u0430\u0446\u0438\u0438 \u043D\u0443\u043A\u043B\u0435\u043E\u0444\u0438\u043B\u0430, \u043A\u043E\u0442\u043E\u0440\u044B\u0439 \u0430\u0442\u0430\u043A\u0443\u0435\u0442 \u0441\u0443\u0431\u0441\u0442\u0440\u0430\u0442, \u043E\u0431\u0440\u0430\u0437\u0443\u044F \u043A\u043E\u0432\u0430\u043B\u0435\u043D\u0442\u043D\u044B\u0439 \u043F\u0440\u043E\u043C\u0435\u0436\u0443\u0442\u043E\u0447\u043D\u044B\u0439 \u043F\u0440\u043E\u0434\u0443\u043A\u0442, \u043A\u043E\u0442\u043E\u0440\u044B\u0439 \u0437\u0430\u0442\u0435\u043C \u0433\u0438\u0434\u0440\u043E\u043B\u0438\u0437\u0443\u0435\u0442\u0441\u044F \u0441 \u0432\u044B\u0441\u0432\u043E\u0431\u043E\u0436\u0434\u0435\u043D\u0438\u0435\u043C \u043F\u0440\u043E\u0434\u0443\u043A\u0442\u0430 \u0438 \u0440\u0435\u0433\u0435\u043D\u0435\u0440\u0430\u0446\u0438\u0435\u0439 \u0441\u0432\u043E\u0431\u043E\u0434\u043D\u043E\u0433\u043E \u0444\u0435\u0440\u043C\u0435\u043D\u0442\u0430. \u041D\u0443\u043A\u043B\u0435\u043E\u0444\u0438\u043B\u043E\u043C \u0447\u0430\u0449\u0435 \u0432\u0441\u0435\u0433\u043E \u044F\u0432\u043B\u044F\u0435\u0442\u0441\u044F \u0430\u043C\u0438\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442\u0430 \u0441\u0435\u0440\u0438\u043D \u0438\u043B\u0438 \u0446\u0438\u0441\u0442\u0435\u0438\u043D, \u043D\u043E \u0438\u043D\u043E\u0433\u0434\u0430 \u0442\u0440\u0435\u043E\u043D\u0438\u043D \u0438\u043B\u0438 \u0434\u0430\u0436\u0435 \u0441\u0435\u043B\u0435\u043D\u043E\u0446\u0438\u0441\u0442\u0435\u0438\u043D. \u0422\u0440\u0435\u0445\u043C\u0435\u0440\u043D\u0430\u044F \u0441\u0442\u0440\u0443\u043A\u0442\u0443\u0440\u0430 \u0444\u0435\u0440\u043C\u0435\u043D\u0442\u0430 \u043E\u0431\u044A\u0435\u0434\u0438\u043D\u044F\u0435\u0442 \u0442\u0440\u0438\u0430\u0434\u043D\u044B\u0435 \u043E\u0441\u0442\u0430\u0442\u043A\u0438 \u0432 \u0442\u043E\u0447\u043D\u043E\u0439 \u043E\u0440\u0438\u0435"@ru . . "\u89E6\u5A92\u4E09\u6B8B\u57FA\uFF08\u3057\u3087\u304F\u3070\u3044\u3055\u3093\u3056\u3093\u304D\u3001\u82F1: Catalytic triad\uFF09\u3068\u306F\u3001\u3044\u304F\u3064\u304B\u306E\u9175\u7D20\u306E\u6D3B\u6027\u90E8\u4F4D\u306B\u898B\u3089\u308C\u308B3\u3064\u306E\u914D\u4F4D\u30A2\u30DF\u30CE\u9178\u306E\u4E00\u5F0F\u3067\u3042\u308B\u3002\u89E6\u5A92\u4E09\u6B8B\u57FA\u306F\u3001\u30D2\u30C9\u30ED\u30E9\u30FC\u30BC\u304A\u3088\u3073\u30C8\u30E9\u30F3\u30B9\u30D5\u30A7\u30E9\u30FC\u30BC\u9175\u7D20\uFF08\u4F8B\u3048\u3070\u3001\u30D7\u30ED\u30C6\u30A2\u30FC\u30BC\u3001\u30A2\u30DF\u30C0\u30FC\u30BC\u3001\u30A8\u30B9\u30C6\u30E9\u30FC\u30BC\u3001\u30A2\u30B7\u30EB\u30E9\u30FC\u30BC\u3001\u30EA\u30D1\u30FC\u30BC\u3001\u304A\u3088\u3073\u03B2-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC\uFF09\u3067\u6700\u3082\u4E00\u822C\u7684\u306B\u898B\u3089\u308C\u308B\u3002\u9178-\u5869\u57FA-\u6C42\u6838\u5264 \u4E09\u6B8B\u57FA\u306F\u3001\u5171\u6709\u7D50\u5408\u89E6\u5A92\u306E\u305F\u3081\u306E\u6C42\u6838\u6027\u6B8B\u57FA\u3092\u751F\u6210\u3059\u308B\u305F\u3081\u306E\u4E00\u822C\u7684\u306A\u30E2\u30C1\u30FC\u30D5\u3067\u3042\u308B\u3002\u3053\u306E\u6B8B\u57FA\u306F\u96FB\u8377\u30EA\u30EC\u30FC\u30CD\u30C3\u30C8\u30EF\u30FC\u30AF\u3092\u5F62\u6210\u3057\u3066\u6C42\u6838\u5264\u3092\u5206\u6975\u304A\u3088\u3073\u6D3B\u6027\u5316\u3057\u3001\u57FA\u8CEA\u3092\u653B\u6483\u3057\u3066\u5171\u6709\u7D50\u5408\u4E2D\u9593\u4F53\u3092\u5F62\u6210\u3057\u3001\u52A0\u6C34\u5206\u89E3\u3055\u308C\u3066\u3092\u653E\u51FA\u3057\u3001\u904A\u96E2\u9175\u7D20\u3092\u518D\u751F\u3059\u308B\u3002\u6C42\u6838\u5264\u306F\u3001\u6700\u3082\u4E00\u822C\u7684\u306B\u306F\u30BB\u30EA\u30F3\u3084\u30B7\u30B9\u30C6\u30A4\u30F3\u30A2\u30DF\u30CE\u9178\u3067\u3042\u308B\u304C\u3001\u6642\u306B\u306F\u30B9\u30EC\u30AA\u30CB\u30F3\u307E\u305F\u306F\u30BB\u30EC\u30CE\u30B7\u30B9\u30C6\u30A4\u30F3\u3082\u542B\u307E\u308C\u3066\u3044\u308B\u3002\u9175\u7D20\u306E\u4E09\u6B21\u5143\u69CB\u9020\u306F\u3001\u914D\u5217\u4E0A\uFF08\u4E00\u6B21\u69CB\u9020\uFF09\u3067\u306F\u96E2\u308C\u3066\u3044\u3066\u3082\u3001\u4E09\u6B8B\u57FA\u304C\u6B63\u78BA\u306A\u65B9\u5411\u306B\u307E\u3068\u307E\u3063\u3066\u3044\u308B\u3053\u3068\u3092\u793A\u3057\u3066\u3044\u308B\u3002 \u6A5F\u80FD\uFF08\u304A\u3088\u3073\u4E09\u6B8B\u57FA\u306E\u6C42\u6838\u5264\uFF09\u306E\u3068\u540C\u69D8\u306B\u3001\u89E6\u5A92\u4E09\u6B8B\u57FA\u306F\u53CE\u6582\u9032\u5316\u306E\u6700\u826F\u306E\u4F8B\u306E\u3044\u304F\u3064\u304B\u3092\u793A\u3057\u3066\u3044\u308B\u3002\u89E6\u5A92\u4F5C\u7528\u306B\u5BFE\u3059\u308B\u5316\u5B66\u7684\u5236\u7D04\u306B\u3088\u308A\u3001\u540C\u3058\u89E6\u5A92\u89E3\u660E\u304C\u3001\u5C11\u306A\u304F\u3068\u308223\u306E\u5225\u3005\u306E\u30B9\u30FC\u30D1\u30FC\u30D5\u30A1\u30DF\u30EA\u30FC\u3067\u72EC\u7ACB\u3057\u3066\u5C55\u958B\u3057\u3066\u3044\u308B\u3002\u305D\u306E\u4F5C\u7528\u6A5F\u5E8F\u306F\u3001\u751F\u5316\u5B66\u7684\u306B\u6700\u3082\u3088\u304F\u7814\u7A76\u3055\u308C\u3066\u3044\u308B\u3082\u306E\u306E\u4E00\u3064\u3067\u3042\u308B\u3002"@ja . . . . . . . . . . "Een katalytische triade is een benaming voor een bijeengeschakeld drietal aminozuren in het actieve centrum van bepaalde enzymen. Katalytische triaden komen voor in hydrolasen en transferasen: twee grote groepen enzymen waartoe onder andere de proteasen, , esterasen, en lipasen behoren. De aminozuurresiduen van een katalytische triade kunnen ver uit elkaar liggen in de aminozuursequentie (primaire structuur), maar ze worden bij elkaar gebracht door specifieke eiwitvouwing; de complexe driedimensionale structuur."@nl . . . . . . . . . "El t\u00E9rmino tr\u00EDada catal\u00EDtica refiere a los tres residuos de amino\u00E1cidos que funcionan en conjunto en el centro del sitio activo de algunas enzimas hidrolasas y transferasas (por ejemplo, proteasas, amidasas, esterasas, , lipasas y \u03B2-lactamasas). Una tr\u00EDada \u00C1cido-Base-Nucle\u00F3filo es un motivo com\u00FAn para la generaci\u00F3n de un residuo nucleof\u00EDlico para la cat\u00E1lisis covalente.\u200B\u200B Los residuos aminoac\u00EDdicos forman una red de relevamiento de cargas que polarizan y activan al nucle\u00F3filo, el cual ataca al sustrato, formando un intermediario covalente el cual es luego hidrolizado para regenerar la enzima libre. El residuo nucleof\u00EDlico es por lo general una serina o una ciste\u00EDna pero algunas veces puede ser una treonina."@es . . . .