"CAV"@en . "25"^^ . . . . "858"^^ . "Caveolin"@en . "859"^^ . "857"^^ . . "Caveolin"@en . "Cav\u00E9oline"@fr . "P56539"@en . . . . "Caveolina"@es . . "NM_001234" . . . "Caveolin"@en . "8448"^^ . . "Le caveoline sono proteine di membrana principali costituenti delle caveole, invaginazioni delle membrane plasmatiche presenti in alcune zone delle membrane biologiche a doppio strato fosfolipidico.Le caveole sono coinvolte nell'endocitosi indipendente da recettori e, a differenza della clatrina, non destinano il materiale rivestito alla digestione ad opera dei lisosomi; infatti esse trasportano il materiale ad apparati cellulari (Es: Golgi) che lo modifichino. In tal modo ne permettono il riutilizzo. Hanno una tipica forma a fiasco, a differenza della forma a canestro delle clatrine. Le caveoline interagiscono con molecole segnale e costituiscono l'impalcatura per organizzare i preassemblati complessi della segnalazione intracellulare (Ras, , proteine G, PKC, ). Le caveoline sono codificate da almeno 3 geni nei vertebrati.In seguito a oligomerizzazione nel reticolo endoplasmatico, interagiscono con i glicosfingolipidi (lipidi di membrana). Presentano un dominio carbossi-terminale in grado di interagire con le membrane; un ; un e un dominio amino-terminale di interazione con le membrane, noto anche come CSD (Caveolin Scaffolding Domain). Le caveoline subiscono inoltre modificazioni post-traduzionali che vedono l'aggiunta di gruppi palmitoilici. Il CSD \u00E8 composto da 21 amminoacidi e pu\u00F2 essere considerata una sequenza \"velcro\" perch\u00E9 \u00E8 questa la parte della caveolina coinvolta nei processi di oligomerizzazione e nel riconoscimento di altre proteine e colesterolo."@it . "Caveoline sind die h\u00E4ufigsten membranst\u00E4ndigen Proteine der Caveolae, 50\u2013100 Nanometer gro\u00DFen sackf\u00F6rmigen Einbuchtungen der Plasmamembran auf der Oberfl\u00E4che von unterschiedlichen Zelltypen. Die Molek\u00FClmasse der Caveoline liegt zwischen 22 und 24 kDa. Bislang sind drei Caveoline bekannt, am besten untersucht ist Caveolin-1. Es wird als biochemischer Marker der Caveolae in den unterschiedlichen Zelltypen angesehen. Caveolin-1 bildet einen hochmolekularen Komplex und interagiert mit Caveolin-2. Die h\u00F6chste Expression von Caveolin-1 findet man in Fibroblasten, Endothelzellen, Pneumozyten Typ I und Fettzellen (Adipozyten). Caveolin-3 wird nur von Muskelzellen gebildet."@de . . . "p" . "Q03135"@en . . "Les caveolines s\u00F3n prote\u00EFnes integrals de membrana presents en estructures cel\u00B7lulars denominades caveoles. S\u00F3n prote\u00EFnes petites, amb un pes molecular de 20-23 kDa, amb una seq\u00FC\u00E8ncia altament conservada en l'evoluci\u00F3. Aquestes estructures, les caveoles, s\u00F3n invaginacions de la membrana plasm\u00E0tica de 50 a 100 nan\u00F2metres de di\u00E0metre, descrites per primera vegada el 1953 per George Palade. Les caveolines s'expressen en la majoria dels tipus cel\u00B7lulars dels vertebrats, per\u00F2 especialment en c\u00E8l\u00B7lules endotelials (superf\u00EDcie d'epitelis), adip\u00F2cits (c\u00E8l\u00B7lules grasses) i mi\u00F2cits (c\u00E8l\u00B7lules musculars)."@ca . . . . . "\u041A\u0430\u0432\u0435\u043E\u043B\u0438\u043D\u044B \u2014 \u0433\u0440\u0443\u043F\u043F\u0430 \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u043D\u044B\u0445 \u0431\u0435\u043B\u043A\u043E\u0432 \u0440\u0435\u0446\u0435\u043F\u0442\u043E\u0440-\u043D\u0435\u0437\u0430\u0432\u0438\u0441\u0438\u043C\u043E\u0433\u043E \u044D\u043D\u0434\u043E\u0446\u0438\u0442\u043E\u0437\u0430. \u0423 \u043F\u043E\u0437\u0432\u043E\u043D\u043E\u0447\u043D\u044B\u0445 \u0436\u0438\u0432\u043E\u0442\u043D\u044B\u0445 \u0441\u0443\u0449\u0435\u0441\u0442\u0432\u0443\u0435\u0442 3 \u0442\u0438\u043F\u0430 \u043A\u0430\u0432\u0435\u043E\u043B\u0438\u043D\u0430 \u0441\u043E \u0441\u0445\u043E\u0434\u043D\u043E\u0439 \u0441\u0442\u0440\u0443\u043A\u0442\u0443\u0440\u043E\u0439: , \u0438 . \u0412 \u043A\u043B\u0435\u0442\u043A\u0435 \u043A\u0430\u0432\u0435\u043E\u043B\u0438\u043D \u0441\u043E\u0431\u0438\u0440\u0430\u0435\u0442\u0441\u044F \u0432 \u043E\u043B\u0438\u0433\u043E\u043C\u0435\u0440\u044B, \u0441\u0432\u044F\u0437\u044B\u0432\u0430\u0435\u0442 \u0445\u043E\u043B\u0435\u0441\u0442\u0435\u0440\u0438\u043D \u0438 \u0441\u0444\u0438\u043D\u0433\u043E\u043B\u0438\u043F\u0438\u0434\u044B \u0432 \u043E\u043F\u0440\u0435\u0434\u0435\u043B\u0451\u043D\u043D\u044B\u0445 \u0443\u0447\u0430\u0441\u0442\u043A\u0430\u0445 \u043A\u043B\u0435\u0442\u043E\u0447\u043D\u043E\u0439 \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u044B, \u0447\u0442\u043E \u043F\u0440\u0438\u0432\u043E\u0434\u0438\u0442 \u043A \u0444\u043E\u0440\u043C\u0438\u0440\u043E\u0432\u0430\u043D\u0438\u044E \u043A\u0430\u0432\u0435\u043E\u043B\u044B."@ru . . . . "CAV3" . . . "2036817"^^ . "NM_001753" . "PDOC00930"@en . "25" . . "Les caveolines s\u00F3n prote\u00EFnes integrals de membrana presents en estructures cel\u00B7lulars denominades caveoles. S\u00F3n prote\u00EFnes petites, amb un pes molecular de 20-23 kDa, amb una seq\u00FC\u00E8ncia altament conservada en l'evoluci\u00F3. Aquestes estructures, les caveoles, s\u00F3n invaginacions de la membrana plasm\u00E0tica de 50 a 100 nan\u00F2metres de di\u00E0metre, descrites per primera vegada el 1953 per George Palade. Les caveolines s'expressen en la majoria dels tipus cel\u00B7lulars dels vertebrats, per\u00F2 especialment en c\u00E8l\u00B7lules endotelials (superf\u00EDcie d'epitelis), adip\u00F2cits (c\u00E8l\u00B7lules grasses) i mi\u00F2cits (c\u00E8l\u00B7lules musculars). Les caveoles tamb\u00E9 estan presents, tot i que en menor quantitat, en c\u00E8l\u00B7lules del sistema immunitari i del sistema nervi\u00F3s. El nombre de caveoles \u00E9s molt redu\u00EFt o estan completament absents en moltes l\u00EDnies cel\u00B7lulars transformades oncog\u00E8nica o viricament i en moltes c\u00E8l\u00B7lules canceroses humanes. La caveola est\u00E0 normalment estabilitzades a la membrana plasm\u00E0tica mitjan\u00E7ant el citoesquelet d'actina. A partir d'estudis basats en la t\u00E8cnica de doble hibridaci\u00F3 en llevats es va detectar que la filamina era un lligand de la caveolina-1. Als adip\u00F2cits les caveoles representen el 30% de la superf\u00EDcie de la membrana plasm\u00E0tica.A m\u00E9s, en la l\u00EDnia 3T3L1, un model \u00E0mpliament utilitzat per estudiar l'adipog\u00E8nesi, el nombre de caveoles i els nivells de caveolina-1 augmenten 10 i 20 vegades, respectivament, durant el proc\u00E9s de diferenciaci\u00F3 de l'adip\u00F2cit."@ca . "\u041A\u0430\u0432\u0435\u043E\u043B\u0456\u043D"@uk . "IPR001612"@en . "Caveolin 1, caveolae protein, 22kDa"@en . . . . . . "601253"^^ . . . . . "Las caveolinas son prote\u00EDnas integrales de la membrana plasm\u00E1tica presentes en estructuras celulares denominadas caveolas. Estas estructuras son invaginaciones de la membrana plasm\u00E1tica de 50 a 100 nan\u00F3metros de di\u00E1metro, descritas por primera vez en 1953 por George Palade. Las caveolinas se expresan en la mayor\u00EDa de los tipos celulares de los vertebrados, pero especialmente en c\u00E9lulas endoteliales (superficies de epitelios), adipocitos (c\u00E9lulas grasas) y miocitos (c\u00E9lulas musculares). La caveolina se localiza en las denominadas \"balsas lip\u00EDdicas\" de las membranas celulares."@es . "NM_001234"@en . "601047"^^ . "859" . . . . "31" . "601048"^^ . . "601048"^^ . "1527"^^ . "1528"^^ . "1529"^^ . . "1528" . . . "601047"^^ . . "Les cav\u00E9olines forment une famille de prot\u00E9ines membranaires constitutives des cav\u00E9oles et impliqu\u00E9es dans le ph\u00E9nom\u00E8ne d'endocytose."@fr . "Le caveoline sono proteine di membrana principali costituenti delle caveole, invaginazioni delle membrane plasmatiche presenti in alcune zone delle membrane biologiche a doppio strato fosfolipidico.Le caveole sono coinvolte nell'endocitosi indipendente da recettori e, a differenza della clatrina, non destinano il materiale rivestito alla digestione ad opera dei lisosomi; infatti esse trasportano il materiale ad apparati cellulari (Es: Golgi) che lo modifichino. In tal modo ne permettono il riutilizzo. Hanno una tipica forma a fiasco, a differenza della forma a canestro delle clatrine."@it . . . . "1116938698"^^ . "7" . . "Caveolina"@it . . . . . . . . . "NM_001233" . . "CAV1" . . . "NM_001753"@en . "Caveolin 3"@en . . . . . . "P51636" . "Les cav\u00E9olines forment une famille de prot\u00E9ines membranaires constitutives des cav\u00E9oles et impliqu\u00E9es dans le ph\u00E9nom\u00E8ne d'endocytose."@fr . . . . . "In molecular biology, caveolins are a family of integral membrane proteins that are the principal components of caveolae membranes and involved in receptor-independent endocytosis. Caveolins may act as scaffolding proteins within caveolar membranes by compartmentalizing and concentrating signaling molecules. They also induce positive (inward) membrane curvature by way of oligomerization, and hairpin insertion. Various classes of signaling molecules, including G-protein subunits, receptor and non-receptor tyrosine kinases, endothelial nitric oxide synthase (eNOS), and small GTPases, bind Cav-1 through its 'caveolin-scaffolding domain'."@en . . "p"@en . . "P51636"@en . "\u041A\u0430\u0432\u0435\u043E\u043B\u0438\u043D\u044B \u2014 \u0433\u0440\u0443\u043F\u043F\u0430 \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u043D\u044B\u0445 \u0431\u0435\u043B\u043A\u043E\u0432 \u0440\u0435\u0446\u0435\u043F\u0442\u043E\u0440-\u043D\u0435\u0437\u0430\u0432\u0438\u0441\u0438\u043C\u043E\u0433\u043E \u044D\u043D\u0434\u043E\u0446\u0438\u0442\u043E\u0437\u0430. \u0423 \u043F\u043E\u0437\u0432\u043E\u043D\u043E\u0447\u043D\u044B\u0445 \u0436\u0438\u0432\u043E\u0442\u043D\u044B\u0445 \u0441\u0443\u0449\u0435\u0441\u0442\u0432\u0443\u0435\u0442 3 \u0442\u0438\u043F\u0430 \u043A\u0430\u0432\u0435\u043E\u043B\u0438\u043D\u0430 \u0441\u043E \u0441\u0445\u043E\u0434\u043D\u043E\u0439 \u0441\u0442\u0440\u0443\u043A\u0442\u0443\u0440\u043E\u0439: , \u0438 . \u0412 \u043A\u043B\u0435\u0442\u043A\u0435 \u043A\u0430\u0432\u0435\u043E\u043B\u0438\u043D \u0441\u043E\u0431\u0438\u0440\u0430\u0435\u0442\u0441\u044F \u0432 \u043E\u043B\u0438\u0433\u043E\u043C\u0435\u0440\u044B, \u0441\u0432\u044F\u0437\u044B\u0432\u0430\u0435\u0442 \u0445\u043E\u043B\u0435\u0441\u0442\u0435\u0440\u0438\u043D \u0438 \u0441\u0444\u0438\u043D\u0433\u043E\u043B\u0438\u043F\u0438\u0434\u044B \u0432 \u043E\u043F\u0440\u0435\u0434\u0435\u043B\u0451\u043D\u043D\u044B\u0445 \u0443\u0447\u0430\u0441\u0442\u043A\u0430\u0445 \u043A\u043B\u0435\u0442\u043E\u0447\u043D\u043E\u0439 \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u044B, \u0447\u0442\u043E \u043F\u0440\u0438\u0432\u043E\u0434\u0438\u0442 \u043A \u0444\u043E\u0440\u043C\u0438\u0440\u043E\u0432\u0430\u043D\u0438\u044E \u043A\u0430\u0432\u0435\u043E\u043B\u044B."@ru . . . "Las caveolinas son prote\u00EDnas integrales de la membrana plasm\u00E1tica presentes en estructuras celulares denominadas caveolas. Estas estructuras son invaginaciones de la membrana plasm\u00E1tica de 50 a 100 nan\u00F3metros de di\u00E1metro, descritas por primera vez en 1953 por George Palade. Las caveolinas se expresan en la mayor\u00EDa de los tipos celulares de los vertebrados, pero especialmente en c\u00E9lulas endoteliales (superficies de epitelios), adipocitos (c\u00E9lulas grasas) y miocitos (c\u00E9lulas musculares). La caveolina se localiza en las denominadas \"balsas lip\u00EDdicas\" de las membranas celulares."@es . . "In molecular biology, caveolins are a family of integral membrane proteins that are the principal components of caveolae membranes and involved in receptor-independent endocytosis. Caveolins may act as scaffolding proteins within caveolar membranes by compartmentalizing and concentrating signaling molecules. They also induce positive (inward) membrane curvature by way of oligomerization, and hairpin insertion. Various classes of signaling molecules, including G-protein subunits, receptor and non-receptor tyrosine kinases, endothelial nitric oxide synthase (eNOS), and small GTPases, bind Cav-1 through its 'caveolin-scaffolding domain'. The caveolin gene family has three members in vertebrates: CAV1, CAV2, and CAV3, coding for the proteins caveolin-1, caveolin-2, and caveolin-3, respectively. All three members are membrane proteins with similar structure. Caveolin forms oligomers and associates with cholesterol and sphingolipids in certain areas of the cell membrane, leading to the formation of caveolae."@en . . . . . . . "\u041A\u0430\u0432\u0435\u043E\u043B\u0438\u043D"@ru . . "P56539" . . "Q03135" . . . "857" . "Caveolina"@ca . . . "\u041A\u0430\u0432\u0435\u043E\u043B\u0456\u043D\u0438 \u2014 \u0446\u0435 \u0440\u043E\u0434\u0438\u043D\u0430 \u0456\u043D\u0442\u0435\u0433\u0440\u0430\u043B\u044C\u043D\u0438\u0445 \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u043D\u0438\u0445 \u043F\u0440\u043E\u0442\u0435\u0457\u043D\u0456\u0432, \u044F\u043A\u0456 \u0454 \u0433\u043E\u043B\u043E\u0432\u043D\u0438\u043C \u043A\u043E\u043C\u043F\u043E\u043D\u0435\u043D\u0442\u043E\u043C \u043C\u0435\u043C\u0431\u0440\u0430\u043D \u0456 \u0437\u0430\u043B\u0443\u0447\u0435\u043D\u0456 \u0432 \u0431\u0435\u0437\u0440\u0435\u0446\u0435\u043F\u0442\u043E\u0440\u043D\u0438\u0439 \u0435\u043D\u0434\u043E\u0446\u0438\u0442\u043E\u0437. \u041A\u0430\u0432\u0435\u043E\u043B\u0456\u043D\u0438 \u043C\u043E\u0436\u0443\u0442\u044C \u0434\u0456\u044F\u0442\u0438 \u044F\u043A \u0441\u043A\u0430\u0444\u0444\u043E\u043B\u0434\u043D\u0456 \u043F\u0440\u043E\u0442\u0435\u0457\u043D\u0438 \u0432 \u043C\u0435\u0436\u0430\u0445 \u043A\u0430\u0432\u0435\u043E\u043B\u044F\u0440\u043D\u043E\u0457 \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u0438, \u043A\u043E\u043C\u043F\u0430\u0440\u0442\u043C\u0435\u043D\u0442\u0430\u043B\u0456\u0437\u0443\u044E\u0447\u0438 \u0442\u0430 \u043A\u043E\u043D\u0446\u0435\u043D\u0442\u0440\u0443\u044E\u0447\u0438 \u0441\u0438\u0433\u043D\u0430\u043B\u044C\u043D\u0456 \u043C\u043E\u043B\u0435\u043A\u0443\u043B\u0438. \u0420\u0456\u0437\u043D\u043E\u043C\u0430\u043D\u0456\u0442\u043D\u0456 \u043A\u043B\u0430\u0441\u0438 \u0441\u0438\u0433\u043D\u0430\u043B\u044C\u043D\u0438\u0445 \u043C\u043E\u043B\u0435\u043A\u0443\u043B, \u0432\u043A\u043B\u044E\u0447\u0430\u044E\u0447\u0438 \u0441\u0443\u0431\u043E\u0434\u0438\u043D\u0438\u0446\u0456 G-\u0431\u0456\u043B\u043A\u0430, \u0440\u0435\u0446\u0435\u043F\u0442\u043E\u0440\u043D\u0456 \u0456 \u0431\u0435\u0437\u0440\u0435\u0446\u0435\u043F\u0442\u043E\u0440\u043D\u0456 \u0442\u0438\u0440\u043E\u0437\u0438\u043D\u043E\u0432\u0456 \u043A\u0456\u043D\u0430\u0437\u0438, \u0435\u043D\u0434\u043E\u0442\u0435\u043B\u0456\u0430\u043B\u044C\u043D\u0443 NO-\u0441\u0438\u043D\u0442\u0430\u0437\u0443 (eNOS) \u0456 \u043C\u0430\u043B\u0456 \u0413\u0422\u0424\u0430\u0437\u0438, \u0437\u0432\u044F\u0437\u0443\u044E\u0442\u044C Cav-1 \u0447\u0435\u0440\u0435\u0437 \u043A\u0430\u0432\u0435\u043E\u043B\u0456\u043D-\u0441\u043A\u0430\u0444\u0444\u043E\u043B\u0434\u043D\u0438\u0439 \u0434\u043E\u043C\u0435\u043D.\u0420\u043E\u0434\u0438\u043D\u0430 \u0433\u0435\u043D\u0456\u0432 \u043A\u0430\u0432\u0435\u043E\u043B\u0456\u043D\u0456\u0432 \u0443 \u0445\u0440\u0435\u0431\u0435\u0442\u043D\u0438\u0445 \u043C\u0430\u0454 \u0442\u0440\u0438 \u0441\u043A\u043B\u0430\u0434\u043E\u0432\u0456 CAV1, CAV2 \u0456 CAV3, \u044F\u043A\u0456 \u043A\u043E\u0434\u0443\u044E\u0442\u044C \u0432\u0456\u0434\u043F\u043E\u0432\u0456\u0434\u043D\u0456 \u043F\u0440\u043E\u0442\u0435\u0457\u043D\u0438 \u043A\u0430\u0432\u0435\u043E\u043B\u0456\u043D-1, \u043A\u0430\u0432\u0435\u043E\u043B\u0456\u043D-2, \u0456 \u043A\u0430\u0432\u0435\u043E\u043B\u0456\u043D-3. \u0412\u0441\u0456 \u0442\u0440\u0438 \u0447\u0430\u0441\u0442\u0438\u043D\u0438 \u043A\u043E\u0434\u0443\u044E\u0442\u044C \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u043D\u0456 \u043F\u0440\u043E\u0442\u0435\u0457\u043D\u0438 \u0437 \u043F\u043E\u0434\u0456\u0431\u043D\u043E\u044E \u0441\u0442\u0440\u0443\u043A\u0442\u0443\u0440\u043E\u044E. \u041A\u0430\u0432\u0435\u043E\u043B\u0456\u043D \u0444\u043E\u0440\u043C\u0443\u0454 \u043E\u043B\u0456\u0433\u043E\u043C\u0435\u0440\u0438 \u0456 \u0430\u0441\u043E\u0446\u0456\u0430\u0442\u0438 \u0437 \u0445\u043E\u043B\u0435\u0441\u0442\u0435\u0440\u043E\u043B\u043E\u043C \u0456 \u0441\u0444\u0456\u043D\u0433\u043E\u043B\u0456\u043F\u0456\u0434\u0430\u043C\u0438 \u0432 \u043A\u043E\u043D\u043A\u0440\u0435\u0442\u043D\u0438\u0445 \u0434\u0456\u043B\u044F\u043D\u043A\u0430\u0445 \u043A\u043B\u0456\u0442\u0438\u043D\u043D\u043E\u0457 \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u0438, \u0449\u043E \u043F\u0440\u0438\u0437"@uk . "Caveoline sind die h\u00E4ufigsten membranst\u00E4ndigen Proteine der Caveolae, 50\u2013100 Nanometer gro\u00DFen sackf\u00F6rmigen Einbuchtungen der Plasmamembran auf der Oberfl\u00E4che von unterschiedlichen Zelltypen. Die Molek\u00FClmasse der Caveoline liegt zwischen 22 und 24 kDa. Bislang sind drei Caveoline bekannt, am besten untersucht ist Caveolin-1. Es wird als biochemischer Marker der Caveolae in den unterschiedlichen Zelltypen angesehen. Caveolin-1 bildet einen hochmolekularen Komplex und interagiert mit Caveolin-2. Die h\u00F6chste Expression von Caveolin-1 findet man in Fibroblasten, Endothelzellen, Pneumozyten Typ I und Fettzellen (Adipozyten). Caveolin-3 wird nur von Muskelzellen gebildet. Mutationen im CAV1-Gen k\u00F6nnen zu einer (seltenen) erblichen Form von Lipodystrophie f\u00FChren. Mutationen in CAV3 haben eine ganze Reihe m\u00F6glicher erblicher Krankheiten zur Folge, je nachdem, welcher Teil des Gens (und damit des Proteins) ver\u00E4ndert ist: Gliederg\u00FCrteldystrophie Typ 1C; permanent \u00FCberh\u00F6hte Werte von Creatinkinase im Plasma; \u00FCberm\u00E4\u00DFige Reizbarkeit, Kontraktionen der Muskeln; hypertrophe Kardiomyopathie; Long-QT-Syndrom Typ 9; pl\u00F6tzlicher Kindstod. Viele Zellfunktionen werden mit den Caveolae und Caveolin-1 in Verbindung gebracht: Membrantransport, Endozytose, Regulation des Calciumstoffwechsels, Lipidstoffwechsel sowie Signaltransduktion bei Zellvermehrung und programmiertem Zelltod. Caveolin-1 bildet das Ger\u00FCst der Caveolae und interagiert mit vielen Signalmolek\u00FClen und reguliert deren Aktivierung. So hemmt Caveolin-1 die Aktivierung von Rezeptoren f\u00FCr Epidermal Growth Factor und Platelet Derived Growth Factor. Dies f\u00FChrt zu einer Verminderung von Zellwachstum und verst\u00E4rkter Apoptose. Bei Patienten mit idiopathischer Lungenfibrose ist die Expression von Caveolin-1 im Lungengewebe deutlich vermindert. Transforming growth factor \u03B21 (TGF-\u03B21), ein Zytokin, welches die Vermehrung von Bindegewebe f\u00F6rdert, hemmt die Expression von Caveolin-1 in Fibroblasten der menschlichen Lunge. Umgekehrt hemmt Caveolin-1 in kultivierten Fibroblasten die durch TGF-\u03B21 induzierte Produktion von extrazellul\u00E4rer Matrix."@de . . . "As caveolinas comp\u00F5em uma fam\u00EDlia de prote\u00EDnas transmembrana (ou integrais) incomum, que inserem, cada uma, uma al\u00E7a hidrof\u00F3bica na por\u00E7\u00E3o citos\u00F3lica da membrana celular, mas que n\u00E3o se estende atrav\u00E9s desta. Elas estar\u00E3o envolvidas em processos forma\u00E7\u00E3o invaginante e/ou ves\u00EDcula das cav\u00E9olas e est\u00E3o envolvidas na endocitose independente do receptor . Elas s\u00E3o expressas de forma onipresente em mam\u00EDferos, mas seus n\u00EDveis de express\u00E3o variam consideravelmente entre os tecidos . A fam\u00EDlia do gene da caveolina possui tr\u00EAs membros em vertebrados: CAV1, CAV2 e CAV3, codificando as prote\u00EDnas caveolina-1, caveolina-2 e caveolina-3, respectivamente. Atuando todas como prote\u00EDnas de membrana de estrutura semelhante, que formam olig\u00F4meros ao se associar ao colesterol e esfingolip\u00EDdios em regi\u00F5es espec\u00EDficas da membrana celular dando origem \u00E0s ."@pt . . "NM_001233"@en . "Caveolin"@de . "601253"^^ . "3"^^ . . . . . "7"^^ . "Caveolin" . . "q" . . . . "1527" . . . "3" . "As caveolinas comp\u00F5em uma fam\u00EDlia de prote\u00EDnas transmembrana (ou integrais) incomum, que inserem, cada uma, uma al\u00E7a hidrof\u00F3bica na por\u00E7\u00E3o citos\u00F3lica da membrana celular, mas que n\u00E3o se estende atrav\u00E9s desta. Elas estar\u00E3o envolvidas em processos forma\u00E7\u00E3o invaginante e/ou ves\u00EDcula das cav\u00E9olas e est\u00E3o envolvidas na endocitose independente do receptor . Elas s\u00E3o expressas de forma onipresente em mam\u00EDferos, mas seus n\u00EDveis de express\u00E3o variam consideravelmente entre os tecidos . A fam\u00EDlia do gene da caveolina possui tr\u00EAs membros em vertebrados: CAV1, CAV2 e CAV3, codificando as prote\u00EDnas caveolina-1, caveolina-2 e caveolina-3, respectivamente. Atuando todas como prote\u00EDnas de membrana de estrutura semelhante, que formam olig\u00F4meros ao se associar ao colesterol e esfingolip\u00EDdios em regi\u00F5es espec"@pt . . . . . "q"@en . . "858" . "\u041A\u0430\u0432\u0435\u043E\u043B\u0456\u043D\u0438 \u2014 \u0446\u0435 \u0440\u043E\u0434\u0438\u043D\u0430 \u0456\u043D\u0442\u0435\u0433\u0440\u0430\u043B\u044C\u043D\u0438\u0445 \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u043D\u0438\u0445 \u043F\u0440\u043E\u0442\u0435\u0457\u043D\u0456\u0432, \u044F\u043A\u0456 \u0454 \u0433\u043E\u043B\u043E\u0432\u043D\u0438\u043C \u043A\u043E\u043C\u043F\u043E\u043D\u0435\u043D\u0442\u043E\u043C \u043C\u0435\u043C\u0431\u0440\u0430\u043D \u0456 \u0437\u0430\u043B\u0443\u0447\u0435\u043D\u0456 \u0432 \u0431\u0435\u0437\u0440\u0435\u0446\u0435\u043F\u0442\u043E\u0440\u043D\u0438\u0439 \u0435\u043D\u0434\u043E\u0446\u0438\u0442\u043E\u0437. \u041A\u0430\u0432\u0435\u043E\u043B\u0456\u043D\u0438 \u043C\u043E\u0436\u0443\u0442\u044C \u0434\u0456\u044F\u0442\u0438 \u044F\u043A \u0441\u043A\u0430\u0444\u0444\u043E\u043B\u0434\u043D\u0456 \u043F\u0440\u043E\u0442\u0435\u0457\u043D\u0438 \u0432 \u043C\u0435\u0436\u0430\u0445 \u043A\u0430\u0432\u0435\u043E\u043B\u044F\u0440\u043D\u043E\u0457 \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u0438, \u043A\u043E\u043C\u043F\u0430\u0440\u0442\u043C\u0435\u043D\u0442\u0430\u043B\u0456\u0437\u0443\u044E\u0447\u0438 \u0442\u0430 \u043A\u043E\u043D\u0446\u0435\u043D\u0442\u0440\u0443\u044E\u0447\u0438 \u0441\u0438\u0433\u043D\u0430\u043B\u044C\u043D\u0456 \u043C\u043E\u043B\u0435\u043A\u0443\u043B\u0438. \u0420\u0456\u0437\u043D\u043E\u043C\u0430\u043D\u0456\u0442\u043D\u0456 \u043A\u043B\u0430\u0441\u0438 \u0441\u0438\u0433\u043D\u0430\u043B\u044C\u043D\u0438\u0445 \u043C\u043E\u043B\u0435\u043A\u0443\u043B, \u0432\u043A\u043B\u044E\u0447\u0430\u044E\u0447\u0438 \u0441\u0443\u0431\u043E\u0434\u0438\u043D\u0438\u0446\u0456 G-\u0431\u0456\u043B\u043A\u0430, \u0440\u0435\u0446\u0435\u043F\u0442\u043E\u0440\u043D\u0456 \u0456 \u0431\u0435\u0437\u0440\u0435\u0446\u0435\u043F\u0442\u043E\u0440\u043D\u0456 \u0442\u0438\u0440\u043E\u0437\u0438\u043D\u043E\u0432\u0456 \u043A\u0456\u043D\u0430\u0437\u0438, \u0435\u043D\u0434\u043E\u0442\u0435\u043B\u0456\u0430\u043B\u044C\u043D\u0443 NO-\u0441\u0438\u043D\u0442\u0430\u0437\u0443 (eNOS) \u0456 \u043C\u0430\u043B\u0456 \u0413\u0422\u0424\u0430\u0437\u0438, \u0437\u0432\u044F\u0437\u0443\u044E\u0442\u044C Cav-1 \u0447\u0435\u0440\u0435\u0437 \u043A\u0430\u0432\u0435\u043E\u043B\u0456\u043D-\u0441\u043A\u0430\u0444\u0444\u043E\u043B\u0434\u043D\u0438\u0439 \u0434\u043E\u043C\u0435\u043D.\u0420\u043E\u0434\u0438\u043D\u0430 \u0433\u0435\u043D\u0456\u0432 \u043A\u0430\u0432\u0435\u043E\u043B\u0456\u043D\u0456\u0432 \u0443 \u0445\u0440\u0435\u0431\u0435\u0442\u043D\u0438\u0445 \u043C\u0430\u0454 \u0442\u0440\u0438 \u0441\u043A\u043B\u0430\u0434\u043E\u0432\u0456 CAV1, CAV2 \u0456 CAV3, \u044F\u043A\u0456 \u043A\u043E\u0434\u0443\u044E\u0442\u044C \u0432\u0456\u0434\u043F\u043E\u0432\u0456\u0434\u043D\u0456 \u043F\u0440\u043E\u0442\u0435\u0457\u043D\u0438 \u043A\u0430\u0432\u0435\u043E\u043B\u0456\u043D-1, \u043A\u0430\u0432\u0435\u043E\u043B\u0456\u043D-2, \u0456 \u043A\u0430\u0432\u0435\u043E\u043B\u0456\u043D-3. \u0412\u0441\u0456 \u0442\u0440\u0438 \u0447\u0430\u0441\u0442\u0438\u043D\u0438 \u043A\u043E\u0434\u0443\u044E\u0442\u044C \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u043D\u0456 \u043F\u0440\u043E\u0442\u0435\u0457\u043D\u0438 \u0437 \u043F\u043E\u0434\u0456\u0431\u043D\u043E\u044E \u0441\u0442\u0440\u0443\u043A\u0442\u0443\u0440\u043E\u044E. \u041A\u0430\u0432\u0435\u043E\u043B\u0456\u043D \u0444\u043E\u0440\u043C\u0443\u0454 \u043E\u043B\u0456\u0433\u043E\u043C\u0435\u0440\u0438 \u0456 \u0430\u0441\u043E\u0446\u0456\u0430\u0442\u0438 \u0437 \u0445\u043E\u043B\u0435\u0441\u0442\u0435\u0440\u043E\u043B\u043E\u043C \u0456 \u0441\u0444\u0456\u043D\u0433\u043E\u043B\u0456\u043F\u0456\u0434\u0430\u043C\u0438 \u0432 \u043A\u043E\u043D\u043A\u0440\u0435\u0442\u043D\u0438\u0445 \u0434\u0456\u043B\u044F\u043D\u043A\u0430\u0445 \u043A\u043B\u0456\u0442\u0438\u043D\u043D\u043E\u0457 \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u0438, \u0449\u043E \u043F\u0440\u0438\u0437\u0432\u043E\u0434\u0438\u0442\u044C \u0434\u043E \u0444\u043E\u0440\u043C\u0443\u0432\u0430\u043D\u043D\u044F ."@uk . . . "PF01146"@en . . "CAV2" . . . . "Caveolin 2"@en . . "Caveolinas"@pt . "31"^^ . "CAV" . . "1529" . .