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"Una organizaci\u00F3n de fabricaci\u00F3n por contrato (CMO), a veces llamada organizaci\u00F3n de desarrollo y fabricaci\u00F3n por contrato (CDMO), es una empresa que presta servicios a otras empresas de la industria farmac\u00E9utica en forma de contrato para proporcionar servicios integrales desde medicamentos hasta .\u200B Esto permite que las principales compa\u00F1\u00EDas farmac\u00E9uticas subcontraten esos aspectos del negocio, lo que puede ayudar con la escalabilidad o puede permitir que la compa\u00F1\u00EDa principal se centre en el descubrimiento de medicamentos y . Los servicios ofrecidos por los CMOs incluyen, entre otros: preformulaci\u00F3n, desarrollo de la formulaci\u00F3n, estudios de estabilidad, desarrollo de m\u00E9todos, materiales de ensayos cl\u00EDnicos pre-cl\u00EDnicos y de fase I, materiales de ensayos cl\u00EDnicos de etapa avanzada, estabilidad formal, ampliaci\u00F3n de escala, registro de lotes y producci\u00F3n comercial. Los CMO son fabricantes contratados, pero tambi\u00E9n pueden ser m\u00E1s que eso debido al aspecto de desarrollo. Sus clientes no solo esperan precios competitivos, sino tambi\u00E9n cumplimiento normativo, flexibilidad en la capacidad de producci\u00F3n y entrega a tiempo. En general, se requiere que el CMO cumpla con las buenas pr\u00E1cticas de fabricaci\u00F3n de sus clientes y organizaciones oficiales, como la Administraci\u00F3n de Alimentos y Medicamentos.\u200B"@es . . . "A contract manufacturing organization (CMO), more recently referred to (and more commonly used now) as a contract development and manufacturing organization (CDMO) to avoid the acronym confusion of Chief Medical Officer or Clinical Monitoring Organization in the pharma industry, is a company that serves other companies in the pharmaceutical industry on a contract basis to provide comprehensive services from drug development through drug manufacturing. This allows major pharmaceutical companies to outsource those aspects of the business, which can help with scalability or can allow the major company to focus on drug discovery and drug marketing instead."@en . . . . 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"A contract manufacturing organization (CMO), more recently referred to (and more commonly used now) as a contract development and manufacturing organization (CDMO) to avoid the acronym confusion of Chief Medical Officer or Clinical Monitoring Organization in the pharma industry, is a company that serves other companies in the pharmaceutical industry on a contract basis to provide comprehensive services from drug development through drug manufacturing. This allows major pharmaceutical companies to outsource those aspects of the business, which can help with scalability or can allow the major company to focus on drug discovery and drug marketing instead. Services offered by CDMOs include, but are not limited to: pre-formulation, formulation development, stability studies, method development, pre-clinical and Phase I clinical trial materials, late-stage clinical trial materials, formal stability, scale-up, registration batches and commercial production. CDMOs are contract manufacturers, yet they provide development as a standard part of their services. Their customers are not only expecting competitive pricing but also regulatory compliance, flexibility on the production capability and on time delivery. Overall it is required that CMO complies with good manufacturing practice from their client and regulatory bodies such as Food and Drug Administration."@en . "Un fa\u00E7onnier, en anglais Contract manufacturing organization (CMO), est une entreprise sous-traitante ou d'externalisation dans la fabrication de produits pharmaceutiques. On rencontre souvent les initiales CDMO pour \"commercial drug manufacturing organisation\" pour faire la diff\u00E9rence entre la production de lot en vue d'essais cliniques et de lot destin\u00E9 \u00E0 la commercialisation en ville ou \u00E0 l' h\u00F4pital. Le mot de fa\u00E7onnier recouvre les deux r\u00E9alit\u00E9s bien qu'en r\u00E9alit\u00E9 il s'agit de deux m\u00E9tiers diff\u00E9rents. Le fa\u00E7onnier de m\u00E9dicament pour essai clinique assure non seulement la fabrication mais aussi le conditionnement du placebo ou du m\u00E9dicament de r\u00E9f\u00E9rence . Il participe \u00E0 la randomisation et assure la logistique vers les exp\u00E9rimentateurs. \u00C0 ce titre il est soumis \u00E0 des inspections sp\u00E9cifi"@fr . . "Eine Contract Manufacturing Organization (CMO, engl.) wird in der pharmazeutischen Industrie ein Vertragshersteller genannt, der im Auftrag eines pharmazeutischen Unternehmens verschiedene Zwischenprodukte eines Arzneimittels oder das finale Produkt herstellt."@de . . . . . . "\u0645\u0646\u0638\u0645\u0629 \u0627\u0644\u062A\u0635\u0646\u064A\u0639 \u0628\u0627\u0644\u062A\u0639\u0627\u0642\u062F"@ar . "Contract manufacturing organization"@en . . "Una organizaci\u00F3n de fabricaci\u00F3n por contrato (CMO), a veces llamada organizaci\u00F3n de desarrollo y fabricaci\u00F3n por contrato (CDMO), es una empresa que presta servicios a otras empresas de la industria farmac\u00E9utica en forma de contrato para proporcionar servicios integrales desde medicamentos hasta .\u200B Esto permite que las principales compa\u00F1\u00EDas farmac\u00E9uticas subcontraten esos aspectos del negocio, lo que puede ayudar con la escalabilidad o puede permitir que la compa\u00F1\u00EDa principal se centre en el descubrimiento de medicamentos y ."@es . . . . . . . . . "19034659"^^ . . . "Organizaci\u00F3n de fabricaci\u00F3n por contrato"@es . . "Contract Manufacturing Organization"@de . . . . . . . . "13839"^^ . . "1101349523"^^ . . . . . . . "Eine Contract Manufacturing Organization (CMO, engl.) wird in der pharmazeutischen Industrie ein Vertragshersteller genannt, der im Auftrag eines pharmazeutischen Unternehmens verschiedene Zwischenprodukte eines Arzneimittels oder das finale Produkt herstellt. Contract Manufacturing Organizations haben sich neben der Contract Research Organization (engl. f\u00FCr Auftragsforschungsinstitut) in der pharmazeutischen Industrie etabliert und werden dazu genutzt, um verschiedene Verfahrensschritte in der Herstellung eines Arzneiproduktes auszulagern. Neben der reinen Herstellung eines Produktes bieten einige Firmen bereits Unterst\u00FCtzung in der Forschung und Entwicklung wie Synthese, Formulierungsentwicklung, Stabilit\u00E4tsstudien oder im Transfer vom Laborprozess in die gro\u00DFtechnische Anlage (engl. scale-up) an. Diese werden Contract Development and Manufacturing Organization (CDMO, engl. f\u00FCr Vertragshersteller und -entwickler) genannt.Im Jahr 2011 lag der weltweite Umsatz von Vertragsherstellern f\u00FCr die pharmazeutische Industrie bei 31,9 Mrd. USD, w\u00E4hrend f\u00FCr das Jahr 2017 ein Anwachsen auf 63 Mrd. USD prognostiziert wird.Zu den nach Umsatz (2020) gr\u00F6\u00DFten CMOs z\u00E4hlen unter anderem Samsung Biologics, Lonza oder Boehringer Ingelheim."@de . . . . . "Un fa\u00E7onnier, en anglais Contract manufacturing organization (CMO), est une entreprise sous-traitante ou d'externalisation dans la fabrication de produits pharmaceutiques. On rencontre souvent les initiales CDMO pour \"commercial drug manufacturing organisation\" pour faire la diff\u00E9rence entre la production de lot en vue d'essais cliniques et de lot destin\u00E9 \u00E0 la commercialisation en ville ou \u00E0 l' h\u00F4pital. Le mot de fa\u00E7onnier recouvre les deux r\u00E9alit\u00E9s bien qu'en r\u00E9alit\u00E9 il s'agit de deux m\u00E9tiers diff\u00E9rents. Le fa\u00E7onnier de m\u00E9dicament pour essai clinique assure non seulement la fabrication mais aussi le conditionnement du placebo ou du m\u00E9dicament de r\u00E9f\u00E9rence . Il participe \u00E0 la randomisation et assure la logistique vers les exp\u00E9rimentateurs. \u00C0 ce titre il est soumis \u00E0 des inspections sp\u00E9cifiques de la part des agences de r\u00E9gulation. La place des fa\u00E7onniers a pris de l'importance notamment durant les p\u00E9riodes de fin des brevets industriels sur les m\u00E9dicaments, o\u00F9 les principales entreprises pharmaceutiques ont pr\u00E9f\u00E9r\u00E9 vendre leur site industriel associ\u00E9 \u00E0 ces m\u00E9dicaments dont les ventes ont chut\u00E9 plut\u00F4t que de les restructurer, elles-m\u00EAmes. Les principaux fa\u00E7onniers \u00E0 l'\u00E9chelle mondiale sont : CDM Lavoisier, Catalent, Lonza, Evonik DSM, Patheon, Baxter, Delpharm, Fareva, , Teva,PCAS."@fr . . . . . "Fa\u00E7onnier"@fr . . . . . .