. "Hemokromatos"@sv . . "Haemacr\u00F3mat\u00F3is cine\u00E1l 1"@ga . "Hemochromatose, pigmentcirrose, ijzerstapelingsziekte is een stofwisselingsziekte waarbij de opname van ijzer in de darm niet goed kan worden gereguleerd, hetgeen soms leidt tot ijzerstapeling in organen wat na lange tijd (soms ernstige) symptomen kan veroorzaken. De genetische aanleg is niet zeldzaam, maar het komt vaak voor dat de ziekte niet tot uiting komt, zie hieronder."@nl . "Iron accumulation demonstrated by Prussian blue staining in a patient with homozygous genetic haemochromatosis : Parts of normal pink tissue are scarcely present."@en . "275.0" . . . . . . "Galar \u00F3 oidhreacht \u00E9 an Haemachr\u00F3mat\u00F3is cine\u00E1l 1 n\u00F3 an Galar Ceilteach ina st\u00F3r\u00E1lann an cholainn an-iomarca iarainn \u00F3 aiste bia an othair. F\u00E1gann seo go mb\u00EDonn ard\u00FA paiteola\u00EDoch de na leibh\u00E9il iarainn sa cholainn. Feictear an cine\u00E1l \u00F3 oidhreacht is minice ina measc si\u00FAd a sh\u00EDolra\u00EDonn \u00F3 shliocht Thuaisceart na hEorpa, daoine de bhunadh na gCeilteach ach go h\u00E1irithe. T\u00E1 an tinneas seo an-fhairsing i measc mhuintir na h\u00C9ireann agus na gCeilteach."@ga . . . . . . . "HFE hereditary haemochromatosis HFE-related hereditary haemochromatosis"@en . . . . . . . . "235200"^^ . . . . . "Hereditary haemochromatosis"@en . . . . "HFE\u907A\u50B3\u6027\u8840\u8272\u75C5\uFF0C\u53C8\u540D\u8840\u8272\u6C89\u8457\u75C7\u7B2C1\u578B\u6216HFE\u76F8\u95DC\u907A\u50B3\u8840\u8272\u75C5\u662F\u4E00\u7A2E\u907A\u50B3\u75C5\uFF0C\u60A3\u8005\u904E\u5EA6\u651D\u53D6\u9435\u8CEA\uFF0C\u4EE4\u8EAB\u9AD4\u5167\u7684\u7E3D\u9435\u8CEA\u542B\u91CF\u9054\u81F3\u75C5\u7406\u6027\u7684\u6C34\u5E73\u3002\u4EBA\u985E\u8207\u53CA\u5176\u4ED6\u52D5\u7269\u90FD\u6C92\u6709\u65B9\u6CD5\u6392\u51FA\u591A\u9918\u7684\u9435\u8CEA\u3002\u591A\u9918\u7684\u9435\u8CEA\u6703\u7A4D\u805A\u5728\u7D44\u7E54\u53CA\u5668\u5B98\u5167\uFF0C\u5F71\u97FF\u5B83\u5011\u7684\u6B63\u5E38\u904B\u4F5C\u3002\u6700\u6613\u53D7\u5F71\u97FF\u7684\u5668\u5B98\u5305\u62EC\u809D\u81DF\u3001\u814E\u4E0A\u817A\u3001\u5FC3\u81DF\u53CA\u80F0\u81DF\uFF1B\u60A3\u8005\u53EF\u80FD\u51FA\u73FE\u809D\u786C\u5316\u3001\u3001\u5FC3\u8870\u7AED\u6216\u7CD6\u5C3F\u75C5\u3002\u9019\u7A2E\u75BE\u75C5\u5728\u5317\u6B50\u8B5C\u7CFB\u6700\u70BA\u666E\u904D\uFF0C\u5C24\u5176\u662F\u611B\u723E\u862D\u4EBA\u3002"@zh . "NBK1440" . . . . "275"^^ . . . . "975"@en . . . . . . . . . . . . . . "L'emocromatosi ereditaria (greco h\u00E0ima sangue, e chroma, -atos colore), in passato chiamato anche diabete bronzino, \u00E8 una malattia metabolica genetica dovuta all'accumulo di notevoli quantit\u00E0 di ferro in diversi organi e tessuti quali: fegato, pancreas, cute, cuore e alcune ghiandole endocrine. L'assorbimento intestinale del ferro negli alimenti \u00E8 aumentato.Ci\u00F2 \u00E8 causato, nella maggior parte dei casi, dalla mutazione genetica del gene , localizzato sul cromosoma 6 e strettamente associato al locus genico del complesso maggiore di istocompatibilit\u00E0."@it . . ""@en . . . . . . "med"@en . . "235200"^^ . . . . . . . . . . . . . . . . . . "\u062F\u0627\u0621 \u0627\u0644\u0627\u0635\u0637\u0628\u0627\u063A \u0627\u0644\u062F\u0645\u0648\u064A \u0627\u0644\u0648\u0631\u0627\u062B\u064A"@ar . . . . . . . . . "HFE\u907A\u50B3\u6027\u8840\u8272\u75C5\uFF0C\u53C8\u540D\u8840\u8272\u6C89\u8457\u75C7\u7B2C1\u578B\u6216HFE\u76F8\u95DC\u907A\u50B3\u8840\u8272\u75C5\u662F\u4E00\u7A2E\u907A\u50B3\u75C5\uFF0C\u60A3\u8005\u904E\u5EA6\u651D\u53D6\u9435\u8CEA\uFF0C\u4EE4\u8EAB\u9AD4\u5167\u7684\u7E3D\u9435\u8CEA\u542B\u91CF\u9054\u81F3\u75C5\u7406\u6027\u7684\u6C34\u5E73\u3002\u4EBA\u985E\u8207\u53CA\u5176\u4ED6\u52D5\u7269\u90FD\u6C92\u6709\u65B9\u6CD5\u6392\u51FA\u591A\u9918\u7684\u9435\u8CEA\u3002\u591A\u9918\u7684\u9435\u8CEA\u6703\u7A4D\u805A\u5728\u7D44\u7E54\u53CA\u5668\u5B98\u5167\uFF0C\u5F71\u97FF\u5B83\u5011\u7684\u6B63\u5E38\u904B\u4F5C\u3002\u6700\u6613\u53D7\u5F71\u97FF\u7684\u5668\u5B98\u5305\u62EC\u809D\u81DF\u3001\u814E\u4E0A\u817A\u3001\u5FC3\u81DF\u53CA\u80F0\u81DF\uFF1B\u60A3\u8005\u53EF\u80FD\u51FA\u73FE\u809D\u786C\u5316\u3001\u3001\u5FC3\u8870\u7AED\u6216\u7CD6\u5C3F\u75C5\u3002\u9019\u7A2E\u75BE\u75C5\u5728\u5317\u6B50\u8B5C\u7CFB\u6700\u70BA\u666E\u904D\uFF0C\u5C24\u5176\u662F\u611B\u723E\u862D\u4EBA\u3002"@zh . . . . . . "D006432" . . "Haemochromatosis type 1"@en . "Hemochromatose"@nl . . . . . "5490"^^ . . . . "\u0627\u0644\u0627\u0635\u0637\u0628\u0627\u063A \u0627\u0644\u062F\u0645\u0648\u064A \u0627\u0644\u0646\u0648\u0639 1 \u0623\u0648 \u0627\u0644\u0627\u0635\u0637\u0628\u0627\u063A \u0627\u0644\u062F\u0645\u0648\u0649 \u0627\u0644\u0648\u0631\u0627\u062B\u0649 \u0623\u0648 \u0627\u0644\u0635\u0628\u0627\u063A \u0627\u0644\u062F\u0645\u0648\u0649 \u0630\u0648 \u0627\u0644\u0635\u0644\u0629 \u0627\u0644\u0648\u0631\u0627\u062B\u064A\u0647 \u0647\u0648 \u0645\u0631\u0636 \u0648\u0631\u0627\u062B\u064A \u064A\u062A\u0645\u064A\u0632 \u0628\u0641\u0631\u0637 \u0627\u0645\u062A\u0635\u0627\u0635 \u0627\u0644\u062D\u062F\u064A\u062F\u0645\u0646 \u0627\u0644\u063A\u0630\u0627\u0621 \u0645\u0645\u0627 \u064A\u0624\u062F\u064A \u0625\u0644\u0649 \u0632\u064A\u0627\u062F\u0629 \u0645\u062E\u0632\u0648\u0646 \u0627\u0644\u062D\u062F\u064A\u062F \u0641\u064A \u0627\u0644\u062C\u0633\u0645 \u0645\u0633\u0628\u0628\u0627 \u062D\u0627\u0644\u0629 \u0645\u0631\u0636\u064A\u0647. \u0648\u0627\u0644\u0625\u0646\u0633\u0627\u0646 \u0645\u062B\u0644 \u0633\u0627\u0626\u0631\u0627\u0644\u062D\u064A\u0648\u0627\u0646\u0627\u062A \u0644\u0627\u064A\u0645\u062A\u0644\u0643 \u0648\u0633\u064A\u0644\u0629 \u062A\u062E\u0644\u0635\u0647 \u0645\u0646 \u0627\u0644\u062D\u062F\u064A\u062F \u0627\u0644\u0632\u0627\u0626\u062F \u0639\u0646 \u062D\u0627\u062C\u062A\u0629. \u062A\u0631\u0627\u0643\u0645 \u0627\u0644\u062D\u062F\u064A\u062F \u0627\u0644\u0632\u0627\u0626\u062F\u0641\u064A \u0627\u0644\u0623\u0646\u0633\u062C\u0629 \u0648\u0627\u0644\u0623\u0639\u0636\u0627\u0621 \u064A\u0624\u062F\u0649 \u0625\u0644\u0649 \u062A\u0639\u0637\u064A\u0644 \u0648\u0638\u0627\u0626\u0641\u0647\u0627 \u0627\u0644\u0637\u0628\u064A\u0639\u064A\u0629. \u0645\u0639\u0638\u0645 \u0627\u0644\u0623\u062C\u0647\u0632\u0629 \u0639\u0631\u0636\u0629 \u0644\u0647 \u0647\u064A:- \u0627\u0644\u0643\u0628\u062F\u060C \u0627\u0644\u063A\u062F\u0629 \u0627\u0644\u0643\u0638\u0631\u064A\u0629\u060C \u0627\u0644\u0642\u0644\u0628.\u0627\u0644\u062C\u0644\u062F.\u0627\u0644\u063A\u062F\u062F \u0627\u0644\u062A\u0646\u0627\u0633\u0644\u064A\u0629\u060C \u0627\u0644\u0645\u0641\u0627\u0635\u0644 \u0648\u0627\u0644\u0628\u0646\u0643\u0631\u064A\u0627\u0633 \u0648\u064A\u0645\u0643\u0646 \u0623\u0646 \u064A\u0635\u0627\u0628 \u0627\u0644\u0645\u0631\u064A\u0636 \u0628\u0627\u0644\u062A\u0644\u064A\u0641 \u0627\u0644\u0643\u0628\u062F\u064A \u0648\u0642\u0635\u0648\u0631 \u0627\u0644\u063A\u062F\u0629 \u0627\u0644\u0643\u0638\u0631\u064A\u0629\u060C \u0648\u0641\u0634\u0644 \u0627\u0644\u0642\u0644\u0628 \u0623\u0648 \u062F\u0627\u0621\u0627\u0644\u0633\u0643\u0631\u064A. \u0648\u064A\u0648\u062C\u062F \u0627\u0644\u0645\u0631\u0636 \u0628\u0634\u0643\u0644 \u0648\u0631\u0627\u062B\u064A \u0628\u0635\u0648\u0631\u0629 \u0639\u0627\u0645\u0647 \u0628\u064A\u0646 \u0623\u0648\u0644\u0626\u0643 \u0627\u0644\u0630\u064A\u0646 \u064A\u0646\u062D\u062F\u0631\u0648\u0646 \u0645\u0646 \u0623\u0635\u0644 \u0623\u0648\u0631\u0648\u0628\u0627 \u0627\u0644\u0634\u0645\u0627\u0644\u064A\u0629\u060C \u0648\u0644\u0627 \u0633\u064A\u0645\u0627 \u062A\u0644\u0643 \u0627\u0644\u062A\u064A \u0645\u0646 \u0623\u0635\u0644 \u0627\u0644\u0633\u0644\u062A\u064A\u0643."@ar . "Hemokromatos, \u00E4ven kallat bronsdiabetes eller j\u00E4mtlandssjuka, \u00E4r en genetisk sjukdom d\u00E4r kroppens naturliga reglering av j\u00E4rnupptag inte fungerar. F\u00F6r mycket j\u00E4rn tas upp i tunntarmen och inlagras i kroppens v\u00E4vnader och organ. Kroppen kan inte g\u00F6ra sig av med \u00F6verskottsj\u00E4rnet och de onormalt stora och successivt \u00F6kande j\u00E4rndep\u00E5erna medf\u00F6r en f\u00F6rh\u00F6jd oxidativ stress. Detta leder till en \u00F6kad risk att p\u00E5 sikt utveckla olika f\u00F6ljdsjukdomar s\u00E5som levercirros, diabetes och artrit. Tr\u00F6tthet \u00E4r ofta ett tidigt tecken vid hemokromatos. M\u00E4n insjuknar snabbare eftersom kvinnor kan uts\u00F6ndra j\u00E4rn i stor omfattning med mensen. Det \u00E4r en sjukdom av st\u00F6rre omfattning \u00E4n hemosideros som har liknande uppkomst. Liknande symtom kan \u00E4ven uppst\u00E5 vid andra former av j\u00E4rn\u00F6verskott, till exempel orsakat av upprepade blodtransfusioner."@sv . . . . . "Emocromatosi ereditaria"@it . . . . "E83.1"@en . . . . "\u0627\u0644\u0627\u0635\u0637\u0628\u0627\u063A \u0627\u0644\u062F\u0645\u0648\u064A \u0627\u0644\u0646\u0648\u0639 1 \u0623\u0648 \u0627\u0644\u0627\u0635\u0637\u0628\u0627\u063A \u0627\u0644\u062F\u0645\u0648\u0649 \u0627\u0644\u0648\u0631\u0627\u062B\u0649 \u0623\u0648 \u0627\u0644\u0635\u0628\u0627\u063A \u0627\u0644\u062F\u0645\u0648\u0649 \u0630\u0648 \u0627\u0644\u0635\u0644\u0629 \u0627\u0644\u0648\u0631\u0627\u062B\u064A\u0647 \u0647\u0648 \u0645\u0631\u0636 \u0648\u0631\u0627\u062B\u064A \u064A\u062A\u0645\u064A\u0632 \u0628\u0641\u0631\u0637 \u0627\u0645\u062A\u0635\u0627\u0635 \u0627\u0644\u062D\u062F\u064A\u062F\u0645\u0646 \u0627\u0644\u063A\u0630\u0627\u0621 \u0645\u0645\u0627 \u064A\u0624\u062F\u064A \u0625\u0644\u0649 \u0632\u064A\u0627\u062F\u0629 \u0645\u062E\u0632\u0648\u0646 \u0627\u0644\u062D\u062F\u064A\u062F \u0641\u064A \u0627\u0644\u062C\u0633\u0645 \u0645\u0633\u0628\u0628\u0627 \u062D\u0627\u0644\u0629 \u0645\u0631\u0636\u064A\u0647. \u0648\u0627\u0644\u0625\u0646\u0633\u0627\u0646 \u0645\u062B\u0644 \u0633\u0627\u0626\u0631\u0627\u0644\u062D\u064A\u0648\u0627\u0646\u0627\u062A \u0644\u0627\u064A\u0645\u062A\u0644\u0643 \u0648\u0633\u064A\u0644\u0629 \u062A\u062E\u0644\u0635\u0647 \u0645\u0646 \u0627\u0644\u062D\u062F\u064A\u062F \u0627\u0644\u0632\u0627\u0626\u062F \u0639\u0646 \u062D\u0627\u062C\u062A\u0629. \u062A\u0631\u0627\u0643\u0645 \u0627\u0644\u062D\u062F\u064A\u062F \u0627\u0644\u0632\u0627\u0626\u062F\u0641\u064A \u0627\u0644\u0623\u0646\u0633\u062C\u0629 \u0648\u0627\u0644\u0623\u0639\u0636\u0627\u0621 \u064A\u0624\u062F\u0649 \u0625\u0644\u0649 \u062A\u0639\u0637\u064A\u0644 \u0648\u0638\u0627\u0626\u0641\u0647\u0627 \u0627\u0644\u0637\u0628\u064A\u0639\u064A\u0629. \u0645\u0639\u0638\u0645 \u0627\u0644\u0623\u062C\u0647\u0632\u0629 \u0639\u0631\u0636\u0629 \u0644\u0647 \u0647\u064A:- \u0627\u0644\u0643\u0628\u062F\u060C \u0627\u0644\u063A\u062F\u0629 \u0627\u0644\u0643\u0638\u0631\u064A\u0629\u060C \u0627\u0644\u0642\u0644\u0628.\u0627\u0644\u062C\u0644\u062F.\u0627\u0644\u063A\u062F\u062F \u0627\u0644\u062A\u0646\u0627\u0633\u0644\u064A\u0629\u060C \u0627\u0644\u0645\u0641\u0627\u0635\u0644 \u0648\u0627\u0644\u0628\u0646\u0643\u0631\u064A\u0627\u0633 \u0648\u064A\u0645\u0643\u0646 \u0623\u0646 \u064A\u0635\u0627\u0628 \u0627\u0644\u0645\u0631\u064A\u0636 \u0628\u0627\u0644\u062A\u0644\u064A\u0641 \u0627\u0644\u0643\u0628\u062F\u064A \u0648\u0642\u0635\u0648\u0631 \u0627\u0644\u063A\u062F\u0629 \u0627\u0644\u0643\u0638\u0631\u064A\u0629\u060C \u0648\u0641\u0634\u0644 \u0627\u0644\u0642\u0644\u0628 \u0623\u0648 \u062F\u0627\u0621\u0627\u0644\u0633\u0643\u0631\u064A. \u0648\u064A\u0648\u062C\u062F \u0627\u0644\u0645\u0631\u0636 \u0628\u0634\u0643\u0644 \u0648\u0631\u0627\u062B\u064A \u0628\u0635\u0648\u0631\u0629 \u0639\u0627\u0645\u0647 \u0628\u064A\u0646 \u0623\u0648\u0644\u0626\u0643 \u0627\u0644\u0630\u064A\u0646 \u064A\u0646\u062D\u062F\u0631\u0648\u0646 \u0645\u0646 \u0623\u0635\u0644 \u0623\u0648\u0631\u0648\u0628\u0627 \u0627\u0644\u0634\u0645\u0627\u0644\u064A\u0629\u060C \u0648\u0644\u0627 \u0633\u064A\u0645\u0627 \u062A\u0644\u0643 \u0627\u0644\u062A\u064A \u0645\u0646 \u0623\u0635\u0644 \u0627\u0644\u0633\u0644\u062A\u064A\u0643."@ar . . . . . . "Haemochromatosis type 1"@en . . . "HFE\u907A\u50B3\u6027\u8840\u8272\u75C5"@zh . . . . . "med"@en . . "E83.1" . . . . . "Hereditary haemochromatosis type 1 (HFE-related Hemochromatosis) is a genetic disorder characterized by excessive intestinal absorption of dietary iron, resulting in a pathological increase in total body iron stores. Humans, like most animals, have no means to excrete excess iron, with the exception of menstruation which, for the average woman, results in a loss of 3.2 mg of iron. Excess iron accumulates in tissues and organs, disrupting their normal function. The most susceptible organs include the liver, heart, pancreas, skin, joints, gonads, thyroid and pituitary gland; patients can present with cirrhosis, polyarthropathy, hypogonadism, heart failure, or diabetes. There are 5 types of hereditary hemochromatosis: type 1, 2 (2A, 2B), 3, 4 and 5, all caused by mutated genes. Hereditary hemochromatosis is the most frequent, and unique related to the HFE gene. It is most common among those of Northern European ancestry, in particular those of Celtic descent. The disease is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. Most often, the parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but do not express signs or symptoms of the condition. In this situation, the otherwise unaffected parents are referred to as carriers."@en . . . . . . . . . . . . . . . . . . . . "L'emocromatosi ereditaria (greco h\u00E0ima sangue, e chroma, -atos colore), in passato chiamato anche diabete bronzino, \u00E8 una malattia metabolica genetica dovuta all'accumulo di notevoli quantit\u00E0 di ferro in diversi organi e tessuti quali: fegato, pancreas, cute, cuore e alcune ghiandole endocrine. L'assorbimento intestinale del ferro negli alimenti \u00E8 aumentato.Ci\u00F2 \u00E8 causato, nella maggior parte dei casi, dalla mutazione genetica del gene , localizzato sul cromosoma 6 e strettamente associato al locus genico del complesso maggiore di istocompatibilit\u00E0."@it . . "Galar \u00F3 oidhreacht \u00E9 an Haemachr\u00F3mat\u00F3is cine\u00E1l 1 n\u00F3 an Galar Ceilteach ina st\u00F3r\u00E1lann an cholainn an-iomarca iarainn \u00F3 aiste bia an othair. F\u00E1gann seo go mb\u00EDonn ard\u00FA paiteola\u00EDoch de na leibh\u00E9il iarainn sa cholainn. Feictear an cine\u00E1l \u00F3 oidhreacht is minice ina measc si\u00FAd a sh\u00EDolra\u00EDonn \u00F3 shliocht Thuaisceart na hEorpa, daoine de bhunadh na gCeilteach ach go h\u00E1irithe. T\u00E1 an tinneas seo an-fhairsing i measc mhuintir na h\u00C9ireann agus na gCeilteach."@ga . . "L\u2019h\u00E9mochromatose de type 1 ou h\u00E9mochromatose classique, par mutation du g\u00E8ne HFE, est une maladie g\u00E9n\u00E9tique caract\u00E9ris\u00E9e par une hyperabsorption du fer par l'intestin entra\u00EEnant son accumulation dans l'organisme, pr\u00E9f\u00E9rentiellement au niveau de certains tissus et organes. C'est l'une des maladies g\u00E9n\u00E9tiques les plus fr\u00E9quentes dans les populations originaires d'Europe du Nord. Il existe d'autres formes d'h\u00E9mochromatose (types 2a, 2b, 3 et 4), en particulier des formes pouvant s'exprimer d\u00E8s l'enfance (h\u00E9mochromatoses dites \u00AB juv\u00E9niles \u00BB) mais il s'agit de maladies rarissimes."@fr . . . . "68349"^^ . . . . . . . "HFE-Associated Hereditary Hemochromatosis"@en . . . . . . . . . . . . . "Hemokromatos, \u00E4ven kallat bronsdiabetes eller j\u00E4mtlandssjuka, \u00E4r en genetisk sjukdom d\u00E4r kroppens naturliga reglering av j\u00E4rnupptag inte fungerar. F\u00F6r mycket j\u00E4rn tas upp i tunntarmen och inlagras i kroppens v\u00E4vnader och organ. Kroppen kan inte g\u00F6ra sig av med \u00F6verskottsj\u00E4rnet och de onormalt stora och successivt \u00F6kande j\u00E4rndep\u00E5erna medf\u00F6r en f\u00F6rh\u00F6jd oxidativ stress. Detta leder till en \u00F6kad risk att p\u00E5 sikt utveckla olika f\u00F6ljdsjukdomar s\u00E5som levercirros, diabetes och artrit. Tr\u00F6tthet \u00E4r ofta ett tidigt tecken vid hemokromatos. M\u00E4n insjuknar snabbare eftersom kvinnor kan uts\u00F6ndra j\u00E4rn i stor omfattning med mensen. Det \u00E4r en sjukdom av st\u00F6rre omfattning \u00E4n hemosideros som har liknande uppkomst."@sv . . . . . . . . . . "NBK1440"@en . . . . . "Die H\u00E4mochromatose Typ 1 ist die klassische und mit etwa 80 % bei weitem h\u00E4ufigste Form der H\u00E4mochromatose, einer Erkrankung, bei der zu viel Eisen aus dem D\u00FCnndarm aufgenommen wird. Synonyme sind: Symptomatische Form der klassischen H\u00E4mochromatose ; Symptomatische Form der HFE-Gen-assoziierten heredit\u00E4ren H\u00E4mochromatose; englisch HFE-Associated Hemochromatosis; HFE-HH Mitunter wird der Begriff \u201EH\u00E4mochromatose\u201C als Synonym f\u00FCr diesen Typ 1 verwendet. Eine US-amerikanische Forschungsgruppe sequenzierte 1996 das HFE-Gen und stellte dessen Verbindung zur H\u00E4mochromatose dar."@de . . . . . "Hereditary haemochromatosis type 1 (HFE-related Hemochromatosis) is a genetic disorder characterized by excessive intestinal absorption of dietary iron, resulting in a pathological increase in total body iron stores. Humans, like most animals, have no means to excrete excess iron, with the exception of menstruation which, for the average woman, results in a loss of 3.2 mg of iron."@en . "D006432"@en . . . . . . . . . . . . . . "Hemochromatose, pigmentcirrose, ijzerstapelingsziekte is een stofwisselingsziekte waarbij de opname van ijzer in de darm niet goed kan worden gereguleerd, hetgeen soms leidt tot ijzerstapeling in organen wat na lange tijd (soms ernstige) symptomen kan veroorzaken. De genetische aanleg is niet zeldzaam, maar het komt vaak voor dat de ziekte niet tot uiting komt, zie hieronder."@nl . . . . "Die H\u00E4mochromatose Typ 1 ist die klassische und mit etwa 80 % bei weitem h\u00E4ufigste Form der H\u00E4mochromatose, einer Erkrankung, bei der zu viel Eisen aus dem D\u00FCnndarm aufgenommen wird. Synonyme sind: Symptomatische Form der klassischen H\u00E4mochromatose ; Symptomatische Form der HFE-Gen-assoziierten heredit\u00E4ren H\u00E4mochromatose; englisch HFE-Associated Hemochromatosis; HFE-HH Mitunter wird der Begriff \u201EH\u00E4mochromatose\u201C als Synonym f\u00FCr diesen Typ 1 verwendet. Eine US-amerikanische Forschungsgruppe sequenzierte 1996 das HFE-Gen und stellte dessen Verbindung zur H\u00E4mochromatose dar."@de . . . . . . . . . . "61506"^^ . . . . . . . "975"^^ . . . . . . . . . . . "HFE-Associated Hereditary Hemochromatosis"@en . . . . . . . . . . . . . . . . . "Haemochromatosis type 2, 3, 4, and 5. Secondary haemochromatosis. Aceruloplasminemia. Atransferrinemia"@en . . . . . "Hemocromatosis hereditaria"@es . . . . . . "H\u00E9mochromatose de type 1"@fr . . . . . "1116511670"^^ . . "H\u00E4mochromatose Typ 1"@de . . . . . . "La hemocromatosis hereditaria HFE o hemocromatosis hereditaria (del griego \u03B1\u1F37\u03BC\u03B1, haima: sangre y \u03C7\u03C1\u03CE\u03BC\u03B1, chr\u00F3ma: color)\u200B es una enfermedad hereditaria que afecta al metabolismo humano del hierro, provocando un ac\u00FAmulo excesivo e incorrecto de este metal en los \u00F3rganos y sistemas del organismo. No se debe confundir con la hemosiderosis,\u200B afecci\u00F3n caracterizada por el exceso de hemosiderina en los tejidos, que no llega a producir da\u00F1o org\u00E1nico. Cuando el dep\u00F3sito de hierro es tal que ocasiona perjuicio a los \u00F3rganos en los que se acumula (especialmente el h\u00EDgado y los pulmones), se habla de hemocromatosis. En concentraciones fisiol\u00F3gicas, el hierro es un elemento vital para el organismo gracias a su capacidad de recibir y ceder electrones. Sin embargo, cuando se encuentra en grandes cantidades pierde esta funci\u00F3n y genera radicales libres,\u200B causantes del da\u00F1o org\u00E1nico presente en la enfermedad."@es . "La hemocromatosis hereditaria HFE o hemocromatosis hereditaria (del griego \u03B1\u1F37\u03BC\u03B1, haima: sangre y \u03C7\u03C1\u03CE\u03BC\u03B1, chr\u00F3ma: color)\u200B es una enfermedad hereditaria que afecta al metabolismo humano del hierro, provocando un ac\u00FAmulo excesivo e incorrecto de este metal en los \u00F3rganos y sistemas del organismo. No se debe confundir con la hemosiderosis,\u200B afecci\u00F3n caracterizada por el exceso de hemosiderina en los tejidos, que no llega a producir da\u00F1o org\u00E1nico. Cuando el dep\u00F3sito de hierro es tal que ocasiona perjuicio a los \u00F3rganos en los que se acumula (especialmente el h\u00EDgado y los pulmones), se habla de hemocromatosis."@es . "5490" . . "Hemochromatoza dziedziczna"@pl . . . . "Hemochromatoza dziedziczna (ang. hereditary hemochromatosis, HH), syn. wrodzona lub pierwotna, dawniej stosowane nazwy to: cukrzyca brunatna i cukrzyca br\u0105zowa (diabetes bronze) \u2013 genetycznie uwarunkowana choroba metabolizmu \u017Celaza, w kt\u00F3rej dochodzi do nadmiernego wch\u0142aniania tego pierwiastka z po\u017Cywienia i nadmiernego gromadzenia w tkankach, co prowadzi do objaw\u00F3w chorobowych. Najcz\u0119stsz\u0105 przyczyn\u0105 hemochromatozy pierwotnej jest mutacja homozygotyczna genu HFE, kt\u00F3ry znajduje si\u0119 na chromosomie 6. Stosuje si\u0119 w\u00F3wczas niekiedy r\u00F3wnie\u017C nazw\u0119 hemochromatoza HFE lub HFE-zale\u017Cna."@pl . . . . . "Hemochromatoza dziedziczna (ang. hereditary hemochromatosis, HH), syn. wrodzona lub pierwotna, dawniej stosowane nazwy to: cukrzyca brunatna i cukrzyca br\u0105zowa (diabetes bronze) \u2013 genetycznie uwarunkowana choroba metabolizmu \u017Celaza, w kt\u00F3rej dochodzi do nadmiernego wch\u0142aniania tego pierwiastka z po\u017Cywienia i nadmiernego gromadzenia w tkankach, co prowadzi do objaw\u00F3w chorobowych. Najcz\u0119stsz\u0105 przyczyn\u0105 hemochromatozy pierwotnej jest mutacja homozygotyczna genu HFE, kt\u00F3ry znajduje si\u0119 na chromosomie 6. Stosuje si\u0119 w\u00F3wczas niekiedy r\u00F3wnie\u017C nazw\u0119 hemochromatoza HFE lub HFE-zale\u017Cna."@pl . . . . . . . . "L\u2019h\u00E9mochromatose de type 1 ou h\u00E9mochromatose classique, par mutation du g\u00E8ne HFE, est une maladie g\u00E9n\u00E9tique caract\u00E9ris\u00E9e par une hyperabsorption du fer par l'intestin entra\u00EEnant son accumulation dans l'organisme, pr\u00E9f\u00E9rentiellement au niveau de certains tissus et organes. C'est l'une des maladies g\u00E9n\u00E9tiques les plus fr\u00E9quentes dans les populations originaires d'Europe du Nord. Il existe d'autres formes d'h\u00E9mochromatose (types 2a, 2b, 3 et 4), en particulier des formes pouvant s'exprimer d\u00E8s l'enfance (h\u00E9mochromatoses dites \u00AB juv\u00E9niles \u00BB) mais il s'agit de maladies rarissimes."@fr .