. . "p"@en . "Q13185" . . . "13.13" . "NM_007276" . "Q13185"@en . "p" . "7" . . . . . "P83916" . "Heterochromatin-Protein 1"@de . "P45973"@en . "Heterochromatin protein 1"@en . . "1115906649"^^ . . "chromobox homolog 1"@en . "11335"^^ . "CBX1" . "604511"^^ . . . . . "P45973" . . "HP1-beta" . . . "604478"^^ . "NM_006807"@en . "604477"^^ . . "HP1\uFF08heterochromatin protein 1\uFF09\u30D5\u30A1\u30DF\u30EA\u30FC\u306F\u9AD8\u5EA6\u306B\u4FDD\u5B58\u3055\u308C\u305F\u30BF\u30F3\u30D1\u30AF\u8CEA\u304B\u3089\u69CB\u6210\u3055\u308C\u3001\u7D30\u80DE\u6838\u3067\u91CD\u8981\u306A\u6A5F\u80FD\u3092\u679C\u305F\u3059\u3002CBX\uFF08chromobox homolog\uFF09\u30D5\u30A1\u30DF\u30EA\u30FC\u3068\u3082\u547C\u3070\u308C\u308B\u3002\u305D\u306E\u6A5F\u80FD\u306F\u3001\u30D8\u30C6\u30ED\u30AF\u30ED\u30DE\u30C1\u30F3\u5F62\u6210\u306B\u3088\u308B\u907A\u4F1D\u5B50\u767A\u73FE\u6291\u5236\u3001\u8EE2\u5199\u6D3B\u6027\u5316\u3001\u30BB\u30F3\u30C8\u30ED\u30E1\u30A2\u3078\u306E\u63A5\u7740\u8907\u5408\u4F53\u306E\u7D50\u5408\u306E\u8ABF\u7BC0\u3001\u6838\u5468\u7E01\u90E8\u3078\u306E\u907A\u4F1D\u5B50\u306E\u9694\u96E2\u3001\u8EE2\u5199\u306E\u4E00\u6642\u505C\u6B62\u3001\u30D8\u30C6\u30ED\u30AF\u30ED\u30DE\u30C1\u30F3\u306E\u5B8C\u5168\u6027\u306E\u7DAD\u6301\u30011\u30CC\u30AF\u30EC\u30AA\u30BD\u30FC\u30E0\u30EC\u30D9\u30EB\u3067\u306E\u907A\u4F1D\u5B50\u306E\u6291\u5236\u3001\u30E6\u30FC\u30AF\u30ED\u30DE\u30C1\u30F3\u306E\u30D8\u30C6\u30ED\u30AF\u30ED\u30DE\u30C1\u30F3\u5316\u306B\u3088\u308B\u907A\u4F1D\u5B50\u6291\u5236\u3001DNA\u4FEE\u5FA9\u306A\u3069\u591A\u5C90\u306B\u308F\u305F\u308B\u3002HP1\u30BF\u30F3\u30D1\u30AF\u8CEA\u306F\u30D8\u30C6\u30ED\u30AF\u30ED\u30DE\u30C1\u30F3\u306E\u30D1\u30C3\u30B1\u30FC\u30B8\u30F3\u30B0\u306E\u57FA\u672C\u7684\u5358\u4F4D\u3067\u3042\u308A\u3001\u307B\u307C\u3059\u3079\u3066\u306E\u771F\u6838\u751F\u7269\u306E\u67D3\u8272\u4F53\u3067\u30BB\u30F3\u30C8\u30ED\u30E1\u30A2\u3068\u30C6\u30ED\u30E1\u30A2\u306B\u8C4A\u5BCC\u306B\u5B58\u5728\u3059\u308B\u3002\u7279\u7B46\u3059\u3079\u304D\u4F8B\u5916\u306F\u51FA\u82BD\u9175\u6BCD\u3067\u3042\u308A\u3001\u9175\u6BCD\u7279\u7570\u7684\u306A\u30B5\u30A4\u30EC\u30F3\u30B7\u30F3\u30B0\u8907\u5408\u4F53\u3067\u3042\u308BSIR\uFF08silent information regulatory\uFF09\u30BF\u30F3\u30D1\u30AF\u8CEA\u304C\u540C\u69D8\u306E\u6A5F\u80FD\u3092\u679C\u305F\u3057\u3066\u3044\u308B\u3002HP1\u30D5\u30A1\u30DF\u30EA\u30FC\u306E\u30E1\u30F3\u30D0\u30FC\u306FN\u672B\u7AEF\u306E\u3068C\u672B\u7AEF\u306E\u304C\u30D2\u30F3\u30B8\u9818\u57DF\u3067\u9694\u3066\u3089\u308C\u3066\u3044\u308B\u3053\u3068\u3067\u7279\u5FB4\u3065\u3051\u3089\u308C\u308B\u3002HP1\u306F\u30E6\u30FC\u30AF\u30ED\u30DE\u30C1\u30F3\u9818\u57DF\u306B\u3082\u5B58\u5728\u3057\u3001\u305D\u306E\u7D50\u5408\u306F\u907A\u4F1D\u5B50\u306E\u6291\u5236\u3068\u76F8\u95A2\u3057\u3066\u3044\u308B\u3002HP1\u306F1986\u5E74\u306BTharappel C. James\u3068Sarah Elgin\u306B\u3088\u3063\u3066\u3001\u30AD\u30A4\u30ED\u30B7\u30E7\u30A6\u30B8\u30E7\u30A6\u30D0\u30A8Drosophila melanogaster\u3067\uFF08position-effect variegation\uFF09\u3068\u547C\u3070\u308C\u308B\u73FE\u8C61\u306B\u95A2\u3059\u308B\u56E0\u5B50\u3068\u3057\u3066\u767A\u898B\u3055\u308C\u305F\u3002"@ja . . . . "1553"^^ . "1555"^^ . . "NM_007276"@en . . "CBX5" . . . . . . . . . "NM_012117" . "1551"^^ . . "HP1-alpha"@en . . . "q"@en . "13.13"^^ . "HP1\uFF08heterochromatin protein 1\uFF09\u30D5\u30A1\u30DF\u30EA\u30FC\u306F\u9AD8\u5EA6\u306B\u4FDD\u5B58\u3055\u308C\u305F\u30BF\u30F3\u30D1\u30AF\u8CEA\u304B\u3089\u69CB\u6210\u3055\u308C\u3001\u7D30\u80DE\u6838\u3067\u91CD\u8981\u306A\u6A5F\u80FD\u3092\u679C\u305F\u3059\u3002CBX\uFF08chromobox homolog\uFF09\u30D5\u30A1\u30DF\u30EA\u30FC\u3068\u3082\u547C\u3070\u308C\u308B\u3002\u305D\u306E\u6A5F\u80FD\u306F\u3001\u30D8\u30C6\u30ED\u30AF\u30ED\u30DE\u30C1\u30F3\u5F62\u6210\u306B\u3088\u308B\u907A\u4F1D\u5B50\u767A\u73FE\u6291\u5236\u3001\u8EE2\u5199\u6D3B\u6027\u5316\u3001\u30BB\u30F3\u30C8\u30ED\u30E1\u30A2\u3078\u306E\u63A5\u7740\u8907\u5408\u4F53\u306E\u7D50\u5408\u306E\u8ABF\u7BC0\u3001\u6838\u5468\u7E01\u90E8\u3078\u306E\u907A\u4F1D\u5B50\u306E\u9694\u96E2\u3001\u8EE2\u5199\u306E\u4E00\u6642\u505C\u6B62\u3001\u30D8\u30C6\u30ED\u30AF\u30ED\u30DE\u30C1\u30F3\u306E\u5B8C\u5168\u6027\u306E\u7DAD\u6301\u30011\u30CC\u30AF\u30EC\u30AA\u30BD\u30FC\u30E0\u30EC\u30D9\u30EB\u3067\u306E\u907A\u4F1D\u5B50\u306E\u6291\u5236\u3001\u30E6\u30FC\u30AF\u30ED\u30DE\u30C1\u30F3\u306E\u30D8\u30C6\u30ED\u30AF\u30ED\u30DE\u30C1\u30F3\u5316\u306B\u3088\u308B\u907A\u4F1D\u5B50\u6291\u5236\u3001DNA\u4FEE\u5FA9\u306A\u3069\u591A\u5C90\u306B\u308F\u305F\u308B\u3002HP1\u30BF\u30F3\u30D1\u30AF\u8CEA\u306F\u30D8\u30C6\u30ED\u30AF\u30ED\u30DE\u30C1\u30F3\u306E\u30D1\u30C3\u30B1\u30FC\u30B8\u30F3\u30B0\u306E\u57FA\u672C\u7684\u5358\u4F4D\u3067\u3042\u308A\u3001\u307B\u307C\u3059\u3079\u3066\u306E\u771F\u6838\u751F\u7269\u306E\u67D3\u8272\u4F53\u3067\u30BB\u30F3\u30C8\u30ED\u30E1\u30A2\u3068\u30C6\u30ED\u30E1\u30A2\u306B\u8C4A\u5BCC\u306B\u5B58\u5728\u3059\u308B\u3002\u7279\u7B46\u3059\u3079\u304D\u4F8B\u5916\u306F\u51FA\u82BD\u9175\u6BCD\u3067\u3042\u308A\u3001\u9175\u6BCD\u7279\u7570\u7684\u306A\u30B5\u30A4\u30EC\u30F3\u30B7\u30F3\u30B0\u8907\u5408\u4F53\u3067\u3042\u308BSIR\uFF08silent information regulatory\uFF09\u30BF\u30F3\u30D1\u30AF\u8CEA\u304C\u540C\u69D8\u306E\u6A5F\u80FD\u3092\u679C\u305F\u3057\u3066\u3044\u308B\u3002HP1\u30D5\u30A1\u30DF\u30EA\u30FC\u306E\u30E1\u30F3\u30D0\u30FC\u306FN\u672B\u7AEF\u306E\u3068C\u672B\u7AEF\u306E\u304C\u30D2\u30F3\u30B8\u9818\u57DF\u3067\u9694\u3066\u3089\u308C\u3066\u3044\u308B\u3053\u3068\u3067\u7279\u5FB4\u3065\u3051\u3089\u308C\u308B\u3002HP1\u306F\u30E6\u30FC\u30AF\u30ED\u30DE\u30C1\u30F3\u9818\u57DF\u306B\u3082\u5B58\u5728\u3057\u3001\u305D\u306E\u7D50\u5408\u306F\u907A\u4F1D\u5B50\u306E\u6291\u5236\u3068\u76F8\u95A2\u3057\u3066\u3044\u308B\u3002HP1\u306F1986\u5E74\u306BTharappel C. James\u3068Sarah Elgin\u306B\u3088\u3063\u3066\u3001\u30AD\u30A4\u30ED\u30B7\u30E7\u30A6\u30B8\u30E7\u30A6\u30D0\u30A8Drosophila melanogaster\u3067\uFF08position-effect variegation\uFF09\u3068\u547C\u3070\u308C\u308B\u73FE\u8C61\u306B\u95A2\u3059\u308B\u56E0\u5B50\u3068\u3057\u3066\u767A\u898B\u3055\u308C\u305F\u3002"@ja . . . "P83916"@en . "10951"^^ . "Bei der Familie der Heterochromatin-Proteine 1 (HP1) (auch \u201EChromobox-Homolog\u201C, CBX) handelt es sich um hochkonservierte Adaptermolek\u00FCle, die eine Vielzahl essentieller Funktionen im Zellkern \u00FCbernehmen. Hierzu z\u00E4hlen die epigenetische Genregulation, die Aufrechterhaltung der Genomstabilit\u00E4t und die Ausbildung einer \u201EPlattform\u201C f\u00FCr den Wiederaufbau der Zellkerne in der Endphase der Mitose. Erstmals beschrieben wurde es 1986 von Sarah Elgin in Drosophila melanogaster als ein Protein, welches als mutierte Form mit der Unterdr\u00FCckung der Positionseffekt-Variegation verbunden ist. 1991 wurde von Prim Singh nachgewiesen, dass HP1 ein hochkonserviertes Protein des Heterochromatin ist und eine fundamentale Rolle in der epigenetischen Regulation spielt."@de . . . . "1555" . . "17"^^ . . . "12"^^ . . . "8828948"^^ . . . "The family of heterochromatin protein 1 (HP1) (\"Chromobox Homolog\", CBX) consists of highly conserved proteins, which have important functions in the cell nucleus. These functions include gene repression by heterochromatin formation, transcriptional activation, regulation of binding of cohesion complexes to centromeres, sequestration of genes to the nuclear periphery, transcriptional arrest, maintenance of heterochromatin integrity, gene repression at the single nucleosome level, gene repression by heterochromatization of euchromatin, and DNA repair. HP1 proteins are fundamental units of heterochromatin packaging that are enriched at the centromeres and telomeres of nearly all eukaryotic chromosomes with the notable exception of budding yeast, in which a yeast-specific silencing complex of"@en . "7"^^ . . "21"^^ . . "NM_006807" . "q" . . "HP1-alpha" . . . . "23468" . . . "CBX3" . "12" . . . . "21.32" . "chromobox homolog 5"@en . "1553" . . "HP1"@ja . . . . . . "NM_012117"@en . . . "21-15" . . . . "chromobox homolog 3"@en . . . . "21.32"^^ . . "16807"^^ . . . . . "1551" . "17" . . . . "HP1-beta"@en . "604477"^^ . "604478"^^ . . "23468"^^ . . "604511"^^ . . . . . . "11335" . . "The family of heterochromatin protein 1 (HP1) (\"Chromobox Homolog\", CBX) consists of highly conserved proteins, which have important functions in the cell nucleus. These functions include gene repression by heterochromatin formation, transcriptional activation, regulation of binding of cohesion complexes to centromeres, sequestration of genes to the nuclear periphery, transcriptional arrest, maintenance of heterochromatin integrity, gene repression at the single nucleosome level, gene repression by heterochromatization of euchromatin, and DNA repair. HP1 proteins are fundamental units of heterochromatin packaging that are enriched at the centromeres and telomeres of nearly all eukaryotic chromosomes with the notable exception of budding yeast, in which a yeast-specific silencing complex of SIR (silent information regulatory) proteins serve a similar function. Members of the HP1 family are characterized by an N-terminal chromodomain and a C-terminal chromoshadow domain, separated by a hinge region. HP1 is also found at some euchromatic sites, where its binding can correlate with either gene repression or gene activation. HP1 was originally discovered by Tharappel C James and Sarah Elgin in 1986 as a factor in the phenomenon known as position effect variegation in Drosophila melanogaster."@en . . "HP1-gamma" . . . . "Bei der Familie der Heterochromatin-Proteine 1 (HP1) (auch \u201EChromobox-Homolog\u201C, CBX) handelt es sich um hochkonservierte Adaptermolek\u00FCle, die eine Vielzahl essentieller Funktionen im Zellkern \u00FCbernehmen. Hierzu z\u00E4hlen die epigenetische Genregulation, die Aufrechterhaltung der Genomstabilit\u00E4t und die Ausbildung einer \u201EPlattform\u201C f\u00FCr den Wiederaufbau der Zellkerne in der Endphase der Mitose. Erstmals beschrieben wurde es 1986 von Sarah Elgin in Drosophila melanogaster als ein Protein, welches als mutierte Form mit der Unterdr\u00FCckung der Positionseffekt-Variegation verbunden ist. 1991 wurde von Prim Singh nachgewiesen, dass HP1 ein hochkonserviertes Protein des Heterochromatin ist und eine fundamentale Rolle in der epigenetischen Regulation spielt."@de . . . . "10951" . "HP1-gamma"@en . . . . . .