. . . . . . . "1116721915"^^ . . . . . . . . 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"20836"^^ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Cell theory has its origins in seventeenth century microscopy observations, but it was nearly two hundred years before a complete cell membrane theory was developed to explain what separates cells from the outside world. By the 19th century it was accepted that some form of semi-permeable barrier must exist around a cell. Studies of the action of anesthetic molecules led to the theory that this barrier might be made of some sort of fat (lipid), but the structure was still unknown. A series of pioneering experiments in 1925 indicated that this barrier membrane consisted of two molecular layers of lipids\u2014a lipid bilayer. New tools over the next few decades confirmed this theory, but controversy remained regarding the role of proteins in the cell membrane. Eventually the fluid mosaic model wa"@en . 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"\u062A\u0627\u0631\u064A\u062E \u0646\u0638\u0631\u064A\u0629 \u063A\u0634\u0627\u0621 \u0627\u0644\u062E\u0644\u064A\u0629"@ar . . . . "La historia de la teor\u00EDa celular se inicia con las primeras observaciones de c\u00E9lulas de organismos por microscopio en el siglo XVII; en el siglo XIX la ciencia concluy\u00F3 que deb\u00EDa existir una barrera semipermeable alrededor de la c\u00E9lula que separara a esta del ambiente exterior. El estudio del mecanismo de acci\u00F3n de las mol\u00E9culas anest\u00E9sicas condujo a la hip\u00F3tesis de que la barrera o membrana celular deb\u00EDa estar compuesta de alg\u00FAn tipo de l\u00EDpido, pero la estructura permaneci\u00F3 desconocida hasta una serie de experimentos en 1925, que indicaron que la membrana consist\u00EDa en dos capas moleculares de l\u00EDpidos, es decir, una bicapa lip\u00EDdica."@es . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Historia de la teor\u00EDa de la membrana celular"@es . . . . . . . "Cell theory has its origins in seventeenth century microscopy observations, but it was nearly two hundred years before a complete cell membrane theory was developed to explain what separates cells from the outside world. By the 19th century it was accepted that some form of semi-permeable barrier must exist around a cell. Studies of the action of anesthetic molecules led to the theory that this barrier might be made of some sort of fat (lipid), but the structure was still unknown. A series of pioneering experiments in 1925 indicated that this barrier membrane consisted of two molecular layers of lipids\u2014a lipid bilayer. New tools over the next few decades confirmed this theory, but controversy remained regarding the role of proteins in the cell membrane. Eventually the fluid mosaic model was composed in which proteins \u201Cfloat\u201D in a fluid lipid bilayer \"sea\". Although simplistic and incomplete, this model is still widely referenced today."@en . . . . . . "History of cell membrane theory"@en . . . . "21400587"^^ . . . . . "La historia de la teor\u00EDa celular se inicia con las primeras observaciones de c\u00E9lulas de organismos por microscopio en el siglo XVII; en el siglo XIX la ciencia concluy\u00F3 que deb\u00EDa existir una barrera semipermeable alrededor de la c\u00E9lula que separara a esta del ambiente exterior. El estudio del mecanismo de acci\u00F3n de las mol\u00E9culas anest\u00E9sicas condujo a la hip\u00F3tesis de que la barrera o membrana celular deb\u00EDa estar compuesta de alg\u00FAn tipo de l\u00EDpido, pero la estructura permaneci\u00F3 desconocida hasta una serie de experimentos en 1925, que indicaron que la membrana consist\u00EDa en dos capas moleculares de l\u00EDpidos, es decir, una bicapa lip\u00EDdica. Durante las d\u00E9cadas siguientes del siglo XX, nuevos experimentos descubrieron la presencia de prote\u00EDnas asociadas a la membrana celular, aunque hubo desacuerdos acerca de su funci\u00F3n. En la d\u00E9cada de los 70 apareci\u00F3 el modelo de mosaico fluido, seg\u00FAn el cual las prote\u00EDnas \u00ABflotan\u00BB libremente en la bicapa lip\u00EDdica, abarcando la mitad o el espesor entero de la membrana. Este modelo, aun siendo simplista e incompleto, se usa ampliamente desde entonces."@es .