. "Indukowane pluripotencjalne kom\u00F3rki macierzyste, kom\u00F3rki iPS, IPSC (ang. induced pluripotent stem cells) \u2013 typ pluripotencjalnych kom\u00F3rek macierzystych, kt\u00F3re zosta\u0142y sztucznie uzyskane z niepluripotentnych kom\u00F3rek (przewa\u017Cnie kom\u00F3rek somatycznych doros\u0142ego cz\u0142owieka) przez wymuszenie ekspresji odpowiednich gen\u00F3w w tych kom\u00F3rkach. Kom\u00F3rki iPS s\u0105 podobne do naturalnych pluripotencjalnych kom\u00F3rek macierzystych (na przyk\u0142ad kom\u00F3rek zarodkowych) pod wieloma wzgl\u0119dami \u2013 ekspresja gen\u00F3w, bia\u0142ek i receptor\u00F3w, okres podzia\u0142u, morfologia oraz mo\u017Cliwo\u015Bci r\u00F3\u017Cnicowania \u2013 przy czym ich w\u0142a\u015Bciwo\u015Bci s\u0105 wci\u0105\u017C analizowane. Pierwotnie otrzymano je poprzez wprowadzenie do kom\u00F3rek sk\u00F3ry gen\u00F3w koduj\u0105cych bia\u0142ka KLF4, SOX2, OCT4 oraz c-MYC. Pos\u0142u\u017Cono si\u0119 w tym celu retrowirusem. Indukowane kom\u00F3rki pluripotencjalne pierwszy raz zosta\u0142y wyhodowane w roku 2006 z kom\u00F3rek mysich, a w 2007 z ludzkich, przez Shin\u2019y\u0119 Yamanak\u0119.W lipcu 2010 pojawi\u0142y si\u0119 informacje, \u017Ce kom\u00F3rki mezenchymalne znajduj\u0105ce si\u0119 w miazdze trzecich z\u0119b\u00F3w trzonowych daj\u0105 nadziej\u0119 uzyskiwania kom\u00F3rek iPS, gdy\u017C zabieg odr\u00F3\u017Cnicowywania z ich udzia\u0142em przebiega z wydajno\u015Bci\u0105 do 100 razy wi\u0119ksz\u0105 ni\u017C z udzia\u0142em fibroblast\u00F3w sk\u00F3ry."@pl . . . . . . . . . . . . . . . "\u8BF1\u5BFC\u6027\u591A\u80FD\u5E72\u7EC6\u80DE\uFF08\u82F1\u8A9E\uFF1AInduced pluripotent stem cell\uFF09\uFF0C\u53C8\u7A31\u4EBA\u5DE5\u8A98\u5C0E\u591A\u80FD\u5E79\u7D30\u80DE\uFF0C\u5E38\u7C21\u7A31\u7232iPS\u7D30\u80DE\uFF08iPSC\uFF09\uFF0C\u662F\u4E00\u7A2E\u7531\u54FA\u4E73\u52D5\u7269\u6210\u9AD4\u7D30\u80DE\u7D93\u8F49\u5165\u8F49\u9304\u56E0\u5B50\u7B49\u624B\u6BB5\u812B\u5206\u5316\u5F62\u6210\u7684\u591A\u80FD\u5E79\u7D30\u80DE\uFF0C\u6700\u65E9\u7531\u65E5\u672C\u5B78\u8005\u5C71\u4E2D\u4F38\u5F4C\u7684\u7814\u7A76\u5718\u968A\u65BC2006\u5E74\u767C\u73FE\u3002\u5C71\u4E2D\u4F38\u5F4C\u5718\u968A\u5728\u767C\u8868iPS\u8A98\u5C0E\u6280\u8853\u6642\u4F7F\u7528\u5BE6\u9A57\u6750\u6599\u7232\u5C0F\u9F20\u7D30\u80DE\u30022007\u5E74\uFF0C\u7814\u7A76\u4EBA\u54E1\u53C8\u8B49\u660EiPS\u8A98\u5C0E\u6280\u8853\u53EF\u4EE5\u61C9\u7528\u65BC\u4EBA\u9AD4\u7D30\u80DE\u3002\u6700\u521D\u7531\u5C71\u4E2D\u4F38\u5F4C\u5718\u968A\u767C\u73FE\u7684\u8A98\u5C0E\u65B9\u6CD5\u662F\u901A\u904E\u6162\u75C5\u6BD2\u8F09\u9AD4\u5C07Oct4\u3001Sox2\u3001c-Myc\u3001Klf4\u56DB\u7A2E\u8F49\u9304\u56E0\u5B50\u57FA\u56E0\u8F49\u5165\u6210\u9AD4\u7D30\u80DE\u5C07\u5176\u8F49\u5316\u7232\u985E\u4F3C\u65BC\u80DA\u80CE\u5E79\u7D30\u80DE\u7684\u591A\u80FD\u5E79\u7D30\u80DE\u3002\u5176\u5F8C\uFF0C\u7814\u7A76\u4EBA\u54E1\u53C8\u5148\u5F8C\u767C\u73FE\u4E86\u66F4\u512A\u5316\u7684\u8A98\u5C0E\u65B9\u6CD5\uFF0C\u5982\u4F7F\u7528\u8CEA\u7C92\u8F09\u9AD4\u8F49\u67D3\u3001\u817A\u75C5\u6BD2\u611F\u67D3\u3001\u8102\u8CEA\u9AD4\u5C0E\u5165\u7B49\u975E\u57FA\u56E0\u7D44\u6574\u5408\u7684\u65B9\u6CD5\u9032\u884C\u8A98\u5C0E\u3001\u901A\u904E\u7D30\u80DE\u878D\u5408\u8A98\u5C0E\u3001\u4F7F\u7528\u5C0F\u5206\u5B50\u85E5\u7269\u9032\u884C\u8A98\u5C0E\u3001\u8F49\u5165miRNA\uFF08\u5FAE\u5E72\u64FERNA\uFF09\u9032\u884C\u8A98\u5C0E\u7B49\u3002 iPS\u7D30\u80DE\u8207\u80DA\u80CE\u5E79\u7D30\u80DE\u64C1\u6709\u76F8\u4F3C\u7684\u518D\u751F\u80FD\u529B\uFF0C\u7406\u8AD6\u4E0A\u53EF\u4EE5\u5206\u5316\u7232\u6210\u9AD4\u7684\u6240\u6709\u5668\u5B98\u3001\u7D44\u7E54\u3002\u800C\u76F8\u6BD4\u80DA\u80CE\u5E79\u7D30\u80DE\uFF0CiPS\u7D30\u80DE\u9762\u81E8\u7684\u502B\u7406\u9053\u5FB7\u722D\u8B70\u8F03\u5C0F\uFF0C\u4E14\u61C9\u7528\u8A72\u6280\u8853\u53EF\u4EE5\u7522\u751F\u57FA\u56E0\u578B\u8207\u79FB\u690D\u53D7\u9AD4\u5B8C\u5168\u76F8\u540C\u7684\u5E79\u7D30\u80DE\uFF0C\u898F\u907F\u4E86\u6392\u7570\u53CD\u61C9\u7684\u98A8\u96AA\uFF0C\u56E0\u800CiPS\u7D30\u80DE\u5728\u4E00\u5B9A\u7A0B\u5EA6\u4E0A\u885D\u64CA\u4E86\u80DA\u80CE\u5E79\u7D30\u80DE\u5728\u518D\u751F\u91AB\u5B78\u4E2D\u7684\u5730\u4F4D\uFF0C\u88AB\u8A8D\u7232\u5728\u518D\u751F\u91AB\u5B78\u53CA\u7D44\u7E54\u5DE5\u7A0B\u65B9\u9762\u64C1\u6709\u8F03\u7232\u5EE3\u95CA\u7684\u61C9\u7528\u524D\u666F\uFF0C\u6709\u671B\u7232\u6CBB\u7652\u7CD6\u5C3F\u75C5\u3001\u95DC\u7BC0\u708E\u7B49\u75BE\u75C5\u63D0\u4F9B\u65B0\u7684\u601D\u8DEF\u3002\u540C\u6642\uFF0CiPS\u7D30\u80DE\u5728\u65B0\u85E5\u958B\u767C\u3001\u75BE\u75C5\u6A21\u578B\u69CB\u5EFA\u9818\u57DF\u4E5F\u6709\u671B\u5F97\u5230\u61C9\u7528\u3002\u4F46iPS\u8A98\u5C0E\u6280\u8853\u540C\u6A23\u9762\u81E8\u7740\u8A98\u5C0E\u6548\u7387\u4F4E\u3001\u7528\u65BC\u6CBB\u7642\u53EF\u80FD\u5B58\u5728\u9577\u671F\u98A8\u96AA\u7B49\u6311\u6230\u3002 iPS\u6280\u8853\u7684\u767C\u660E\u4EBA\u5C71\u4E2D\u4F38\u5F4C\u65BC2012\u5E74\u8207\u6838\u79FB\u690D\u53CA\u514B\u9686\u6280\u8853\u7814\u7A76\u7684\u5148\u9A45\u8005\u7D04\u7FF0\u00B7\u683C\u767B\u7235\u58EB\u4E00\u540C\u7372\u8AFE\u8C9D\u723E\u751F\u7406\u91AB\u5B78\u734E\u3002"@zh . "Las c\u00E9lulas madre pluripotentes inducidas (normalmente abreviadas como c\u00E9lulas iPS, por sus siglas en ingl\u00E9s: \"induced Pluripotent Stem\" ) son un tipo de c\u00E9lulas madre con caracter\u00EDsticas pluripotenciales (capaces de generar la mayor\u00EDa de los tejidos) derivadas artificialmente de una c\u00E9lula que inicialmente no era pluripotencial.\u200B Por lo general se utiliza como una c\u00E9lula adulta diferenciada (diferenciaci\u00F3n celular) procedente de un tejido, sobre la que se induce la expresi\u00F3n de varios genes ex\u00F3genos, tales como Oct4, Sox2, c-Myc y Klf4, capaces de des-diferenciarla.\u200B Se denomina reprogramaci\u00F3n a esta desdiferenciaci\u00F3n. Las c\u00E9lulas iPS son capaces: a) de diferenciarse en c\u00E9lulas de tejidos pertenecientes a las tres capas germinales de un embri\u00F3n natural (ver embriog\u00E9nesis humana): endoderm"@es . . . . . . . . . . . . . . . . . . . . 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\u043B\u0438\u0448\u0435 4 \u0442\u0440\u0430\u043D\u0441\u043A\u0440\u0438\u043F\u0446\u0456\u0439\u043D\u0456 \u0444\u0430\u043A\u0442\u043E\u0440\u0438, \u0430 \u0441\u0430\u043C\u0435 OCT4, c-MYC, SOX2, KLF4."@uk . . . "\u8BF1\u5BFC\u6027\u591A\u80FD\u5E72\u7EC6\u80DE"@zh . "C\u00E9lulas tronco pluripotente induzidas (do ingl\u00EAs, induced pluripotent stem cells, IPS), s\u00E3o c\u00E9lulas de organismos adultos que, atrav\u00E9s da express\u00E3o de fatores de transcri\u00E7\u00E3o espec\u00EDficos, ganham uma caracter\u00EDstica bastante particular de c\u00E9lula embrion\u00E1ria, a pluripot\u00EAncia. Por conta de tal capacidade \u00E9 esperado que as c\u00E9lulas-tronco pluripotente induzidas revolucionem a medicina regenerativa num futuro pr\u00F3ximo . A tecnologia capaz de obter c\u00E9lulas-tronco pluripotentes foi uma grande descoberta realizada por Takahashi e Yamanaka, que demonstraram a indu\u00E7\u00E3o de pluripot\u00EAncia em c\u00E9lulas embrion\u00E1rias de rato ou fibroblastos adultos atrav\u00E9s da introdu\u00E7\u00E3o de quatro fatores de transcri\u00E7\u00E3o . Por conta desta descoberta, Yamanaka foi o ganhador do Pr\u00EAmio Nobel de Fisiologia do ano de 2012, junto com John B. Gurdon, que demonstrou a reversibilidade da diferencia\u00E7\u00E3o celular transferindo o n\u00FAcleo do epit\u00E9lio intestinal de um sapo para um zigoto, que originou um sapo adulto normalmente . O estudo feito por Takahashi abre uma nova gama de possibilidades n\u00E3o s\u00F3 no campo de pesquisa da Biologia do Desenvolvimento, ajudando a elucidar detalhes do processo de diferencia\u00E7\u00E3o e desdiferencia\u00E7\u00E3o celular, mas tamb\u00E9m no campo da medicina. Para realiza\u00E7\u00E3o de pesquisas, a obten\u00E7\u00E3o de c\u00E9lulas-tronco embrion\u00E1rias exige a destrui\u00E7\u00E3o, ou pelo menos algum tipo de manipula\u00E7\u00E3o de embri\u00F5es ainda n\u00E3o implantados , o que acaba gerando debates \u00E9ticos. Entretanto, como a t\u00E9cnica de Takahashi n\u00E3o exige tais manipula\u00E7\u00F5es de embri\u00F5es humanos, o debate acerca de quest\u00F5es \u00E9ticas n\u00E3o \u00E9 gerado. Assim, abrem-se portas para diversas pesquisas a fim de entender melhor os mecanismos de diferencia\u00E7\u00E3o celular, bem como aplica\u00E7\u00F5es pr\u00E1ticas no campo da medicina, uma vez que h\u00E1 a possibilidade de gerar c\u00E9lulas pluripotentes atrav\u00E9s da desdiferencia\u00E7\u00E3o de c\u00E9lulas do pr\u00F3prio paciente, o que eliminaria problemas de rejei\u00E7\u00E3o e potencialmente facilitaria tratamentos como por exemplo, les\u00F5es na espinha ."@pt . . . "Induzierte pluripotente Stammzellen (iPS-Zellen) sind pluripotente Stammzellen, die durch k\u00FCnstliche Reprogrammierung von nicht-pluripotenten somatischen Zellen entstanden sind. Die Umwandlung wird durch von au\u00DFen angeregte Expression spezieller Gene (Transkriptionsfaktoren) in der K\u00F6rperzelle angesto\u00DFen, f\u00FCr die verschiedene Techniken existieren. iPS-Zellen \u00E4hneln nat\u00FCrlichen Stammzellen in vielen Eigenschaften stark, ob die heutigen iPS-Zellen in allen Eigenschaften mit nat\u00FCrlichen Stammzellen \u00FCbereinstimmen, ist eine ungekl\u00E4rte Frage. Induzierte pluripotente Stammzellen haben ein hohes medizinisches Potential, da die Forschung an ihnen weniger ethische Probleme mit sich zieht als die an Embryonalen Stammzellen. Au\u00DFerdem lassen sich speziell auf Patienten angepasste iPS-Zellen erzeugen. Nachdem 2006 im Labor des japanischen Stammzellenforschers Shin\u2019ya Yamanaka die ersten iPS-Zellen hergestellt wurden, ist die Forschung an iPS-Zellen heute eines der sich am schnellsten weiterentwickelnden Gebiete der Biologie.F\u00FCr die Entwicklung induzierter pluripotenter Stammzellen erhielt Shin\u2019ya Yamanaka 2012 den Nobelpreis f\u00FCr Physiologie oder Medizin."@de . . . . . . . . "Sel induk pluripoten diinduksi atau Sel iPS atau Sel iPSC (bahasa Inggris: Induced pluripotent stem cells) adalah sejenis sel punca yang dapat dihasilkan langsung dari sel dewasa. Teknologi iPSC dipelopori oleh laboratorium Shinya Yamanaka di Kyoto, Jepang, ilmuwan yang pada 2006 memasukkan empat gen spesifik yang menyandi faktor transkripsi dapat mengubah sel dewasa menjadi sel punca pluripoten. Ia dianugerahi Hadiah Nobel 2012 bersama dengan Sir John Gurdon \"untuk penemuan bahwa sel dewasa dapat diprogram ulang untuk menjadi pluripoten\". Sel punca pluripoten menjanjikan di bidang pengobatan regeneratif. Karena mereka dapat berkembang biak tanpa batas waktu, serta dapat membentuk setiap jenis sel lain dalam tubuh (seperti sel-sel neuron, jantung, pankreas, dan hati), mereka mewakili satu sumber sel yang dapat digunakan untuk menggantikan sel yang hilang yang rusak atau penyakit. Jenis sel punca pluripoten yang paling terkenal adalah sel punca embrionik (embryonic stem cell, ESC). Namun, karena generasi sel punca embrionik melibatkan penghancuran (atau setidaknya manipulasi) dari embrio tahap pra-implantasi, ada banyak kontroversi seputar penggunaannya. Lebih lanjut, karena sel-sel punca embrionik hanya dapat berasal dari embrio, sejauh ini tidak layak untuk membuat sel punca embrionik yang cocok dengan pasien. Karena iPSC dapat diturunkan langsung dari jaringan dewasa, mereka tidak membutuhkan embrio, tetapi dapat dibuat dengan cara yang sesuai dengan pasien, yang berarti bahwa setiap individu dapat memiliki garis sel punca pluripoten sendiri. Pasokan sel autolog yang tidak terbatas ini dapat digunakan untuk menghasilkan transplantasi tanpa risiko penolakan imun. Sementara teknologi iPSC belum maju ke tahap di mana transplantasi terapeutik telah dianggap aman, iPSC siap digunakan dalam upaya penemuan obat yang dipersonalisasi dan memahami dasar penyakit spesifik pasien. Yamanaka menamakan iPSC dengan huruf kecil \"i\" karena popularitas iPod dan produk lainnya."@in . . . . . "Induzierte pluripotente Stammzelle"@de . . . . . . . . "C\u00E9lula-tronco pluripotente induzida"@pt . . . . . . "Inducerade pluripotenta stamceller (f\u00F6rkortat iPS eller PS) \u00E4r en form av vanliga celler som omprogrammeras i en process som kallas \"dedifferentiering\" och \u00E5terg\u00E5r till en liknande version av sin ursprungliga form, allts\u00E5 stamceller. Stamceller \u00E4r speciella celler som kan differentieras till andra celler som \u00E4r specialiserade att g\u00F6ra speciella uppgifter(t.ex. stamceller som differentierats till en hudcell \u00E4r specialiserad att bara dela sig till hudceller). Pluripotenta stamceller \u00E4r i princip identiska till embryonala stamceller och den enda skillnaden \u00E4r att pluripotenta stamceller ej kan ge upphov till placenta. Pluripotenta stamceller \u00E4r ocks\u00E5 i princip identisk till inducerade pluripotenta stamceller d\u00E5 den enda skillnaden \u00E4r uppkomsten av stamcellerna."@sv . . . . "\uC720\uB3C4\uB9CC\uB2A5\uC904\uAE30\uC138\uD3EC"@ko . . . "Induced pluripotent stem cells (also known as iPS cells or iPSCs) are a type of pluripotent stem cell that can be generated directly from a somatic cell. The iPSC technology was pioneered by Shinya Yamanaka's lab in Kyoto, Japan, who showed in 2006 that the introduction of four specific genes (named Myc, Oct3/4, Sox2 and Klf4), collectively known as Yamanaka factors, encoding transcription factors could convert somatic cells into pluripotent stem cells. He was awarded the 2012 Nobel Prize along with Sir John Gurdon \"for the discovery that mature cells can be reprogrammed to become pluripotent.\" Pluripotent stem cells hold promise in the field of regenerative medicine. Because they can propagate indefinitely, as well as give rise to every other cell type in the body (such as neurons, heart, pancreatic, and liver cells), they represent a single source of cells that could be used to replace those lost to damage or disease. The most well-known type of pluripotent stem cell is the embryonic stem cell. However, since the generation of embryonic stem cells involves destruction (or at least manipulation) of the pre-implantation stage embryo, there has been much controversy surrounding their use. Patient-matched embryonic stem cell lines can now be derived using somatic cell nuclear transfer (SCNT). Since iPSCs can be derived directly from adult tissues, they not only bypass the need for embryos, but can be made in a patient-matched manner, which means that each individual could have their own pluripotent stem cell line. These unlimited supplies of autologous cells could be used to generate transplants without the risk of immune rejection. While the iPSC technology has not yet advanced to a stage where therapeutic transplants have been deemed safe, iPSCs are readily being used in personalized drug discovery efforts and understanding the patient-specific basis of disease. Yamanaka named iPSCs with a lower case \"i\" due to the popularity of the iPod and other products. In his Nobel seminar, Yamanaka cited the earlier seminal work of Harold Weintraub on the role of myoblast determination protein 1 (MyoD) in reprogramming cell fate to a muscle lineage as an important precursor to the discovery of iPSCs."@en . . . . "Las c\u00E9lulas madre pluripotentes inducidas (normalmente abreviadas como c\u00E9lulas iPS, por sus siglas en ingl\u00E9s: \"induced Pluripotent Stem\" ) son un tipo de c\u00E9lulas madre con caracter\u00EDsticas pluripotenciales (capaces de generar la mayor\u00EDa de los tejidos) derivadas artificialmente de una c\u00E9lula que inicialmente no era pluripotencial.\u200B Por lo general se utiliza como una c\u00E9lula adulta diferenciada (diferenciaci\u00F3n celular) procedente de un tejido, sobre la que se induce la expresi\u00F3n de varios genes ex\u00F3genos, tales como Oct4, Sox2, c-Myc y Klf4, capaces de des-diferenciarla.\u200B Se denomina reprogramaci\u00F3n a esta desdiferenciaci\u00F3n. Las c\u00E9lulas iPS son capaces: a) de diferenciarse en c\u00E9lulas de tejidos pertenecientes a las tres capas germinales de un embri\u00F3n natural (ver embriog\u00E9nesis humana): endodermo, mesodermo y ectodermo, b) de formar teratomas, y c) ratones quim\u00E9ricos o quimeras (quimerismo).\u200B\u200B\u200B Se ha demostrado que las c\u00E9lulas iPS son id\u00E9nticas en muchos aspectos, y similares en otros, a las (normalmente abreviadas como ES, por sus siglas en ingl\u00E9s: \"Embryonic Stem\"). Por ejemplo, son iguales en morfolog\u00EDa, expresi\u00F3n de ciertos genes y prote\u00EDnas, patrones de metilaci\u00F3n del ADN, tiempo de duplicaci\u00F3n celular y capacidad de diferenciaci\u00F3n a c\u00E9lulas de otros tejidos. Sin embargo, el mecanismo mediante el cual se inducen y su relaci\u00F3n con las c\u00E9lulas ES sigue a\u00FAn en investigaci\u00F3n (Liu, et al. 2011). Las c\u00E9lulas iPS se obtuvieron por primera vez en el a\u00F1o 2006 a partir de c\u00E9lulas de ratones (Takahashi & Yamanaka, 2006), y en 2007 a partir de c\u00E9lulas humanas (Takahashi, et al. 2007). En 2006, se describi\u00F3 por primera vez este proceso a partir de fibroblastos de rat\u00F3n utilizando retrovirus que vehiculizaban e induc\u00EDan la expresi\u00F3n de varios genes ex\u00F3genos. En 2011 se public\u00F3 una revisi\u00F3n sobre esta primera metodolog\u00EDa (Miller & Schlaeger, 2011). Este logro se considera uno de los avances m\u00E1s importantes de la investigaci\u00F3n con c\u00E9lulas madre, ya que permite obtener c\u00E9lulas madres pluripotenciales a partir de c\u00E9lulas adultas. Las iPS tienen aplicaciones como modelos para estudio de enfermedades, posibles usos terap\u00E9uticos (disminuyendo el rechazo en los trasplantes y sin la controversia del uso de embriones que tiene las c\u00E9lulas ES), y en investigaciones b\u00E1sicas. Shinya Yamanaka y John Gurdon fueron galardonados en 2012 con el premio nobel de Fisiolog\u00EDa o Medicina.\u200B"@es . . . . . . . . . . . . . . . . . "Induzierte pluripotente Stammzellen (iPS-Zellen) sind pluripotente Stammzellen, die durch k\u00FCnstliche Reprogrammierung von nicht-pluripotenten somatischen Zellen entstanden sind. Die Umwandlung wird durch von au\u00DFen angeregte Expression spezieller Gene (Transkriptionsfaktoren) in der K\u00F6rperzelle angesto\u00DFen, f\u00FCr die verschiedene Techniken existieren. iPS-Zellen \u00E4hneln nat\u00FCrlichen Stammzellen in vielen Eigenschaften stark, ob die heutigen iPS-Zellen in allen Eigenschaften mit nat\u00FCrlichen Stammzellen \u00FCbereinstimmen, ist eine ungekl\u00E4rte Frage. Induzierte pluripotente Stammzellen haben ein hohes medizinisches Potential, da die Forschung an ihnen weniger ethische Probleme mit sich zieht als die an Embryonalen Stammzellen. Au\u00DFerdem lassen sich speziell auf Patienten angepasste iPS-Zellen erzeugen."@de . . . "\u4EBA\u5DE5\u591A\u80FD\u6027\u5E79\u7D30\u80DE\uFF08\u3058\u3093\u3053\u3046\u305F\u306E\u3046\u305B\u3044\u304B\u3093\u3055\u3044\u307C\u3046\u3001\u82F1: induced pluripotent stem cells\uFF09\u306F\u3001\u4F53\u7D30\u80DE\u30784\u7A2E\u985E\u306E\u907A\u4F1D\u5B50\u3092\u5C0E\u5165\u3059\u308B\u3053\u3068\u306B\u3088\u308A\u3001ES\u7D30\u80DE\uFF08\u80DA\u6027\u5E79\u7D30\u80DE\uFF09\u306E\u3088\u3046\u306B\u975E\u5E38\u306B\u591A\u304F\u306E\u7D30\u80DE\u306B\u5206\u5316\u3067\u304D\u308B\u5206\u5316\u4E07\u80FD\u6027 (pluripotency)\u3068\u3001\u5206\u88C2\u5897\u6B96\u3092\u7D4C\u3066\u3082\u305D\u308C\u3092\u7DAD\u6301\u3067\u304D\u308B\u81EA\u5DF1\u8907\u88FD\u80FD\u3092\u6301\u305F\u305B\u305F\u7D30\u80DE\u306E\u3053\u3068\u30022006\u5E74\uFF08\u5E73\u621018\u5E74\uFF09\u3001\u5C71\u4E2D\u4F38\u5F25\u7387\u3044\u308B\u4EAC\u90FD\u5927\u5B66\u306E\u7814\u7A76\u30B0\u30EB\u30FC\u30D7\u306B\u3088\u3063\u3066\u30DE\u30A6\u30B9\u306E\u7DDA\u7DAD\u82BD\u7D30\u80DE\uFF08\u76AE\u819A\u7D30\u80DE\uFF09\u304B\u3089\u521D\u3081\u3066\u4F5C\u3089\u308C\u305F\u3002 \u82F1\u8A9E\u540D\u306E\u982D\u6587\u5B57\u3092\u3068\u3063\u3066\u3001iPS\u7D30\u80DE\uFF08\u30A2\u30A4\u30D4\u30FC\u30A8\u30B9\u3055\u3044\u307C\u3046\u3001iPS cells\uFF09\u3068\u547C\u3070\u308C\u308B\u3002\u547D\u540D\u8005\u306E\u5C71\u4E2D\u304C\u6700\u521D\u3092\u5C0F\u6587\u5B57\u306E\u300Ci\u300D\u306B\u3057\u305F\u306E\u306F\u3001\u5F53\u6642\u4E16\u754C\u7684\u306B\u5927\u6D41\u884C\u3057\u3066\u3044\u305F\u7C73Apple\u306E\u643A\u5E2F\u97F3\u697D\u30D7\u30EC\u30FC\u30E4\u30FC\u3067\u3042\u308B\u300EiPod\u300F\u306E\u3088\u3046\u306B\u666E\u53CA\u3057\u3066\u307B\u3057\u3044\u3068\u306E\u9858\u3044\u304C\u8FBC\u3081\u3089\u308C\u3066\u3044\u308B\u3002\u4EE5\u4E0B\u3001\u300CiPS\u7D30\u80DE\u300D\u3068\u3044\u3046\u8868\u8A18\u3092\u7528\u3044\u308B\u3002"@ja . "Cellule souche pluripotente induite"@fr . . . "Sel induk pluripoten diinduksi atau Sel iPS atau Sel iPSC (bahasa Inggris: Induced pluripotent stem cells) adalah sejenis sel punca yang dapat dihasilkan langsung dari sel dewasa. Teknologi iPSC dipelopori oleh laboratorium Shinya Yamanaka di Kyoto, Jepang, ilmuwan yang pada 2006 memasukkan empat gen spesifik yang menyandi faktor transkripsi dapat mengubah sel dewasa menjadi sel punca pluripoten. Ia dianugerahi Hadiah Nobel 2012 bersama dengan Sir John Gurdon \"untuk penemuan bahwa sel dewasa dapat diprogram ulang untuk menjadi pluripoten\"."@in . . . "C\u00E9lula madre pluripotente inducida"@es . . "Indukovan\u00E1 pluripotentn\u00ED kmenov\u00E1 bu\u0148ka"@cs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Una cellula staminale pluripotente indotta (conosciuta anche come iPS o iPSC dall'inglese Induced Pluripotent Stem Cell) \u00E8 un tipo di cellula staminale generata artificialmente a partire da una terminalmente differenziata (in genere una cellula somatica adulta), mediante l'introduzione di quattro geni specifici codificanti determinati fattori di trascrizione che ne inducono la conversione in cellula staminale di una specifica linea cellulare, che a sua volta potr\u00E0 svilupparsi in cellula differenziata."@it . . . "\u8BF1\u5BFC\u6027\u591A\u80FD\u5E72\u7EC6\u80DE\uFF08\u82F1\u8A9E\uFF1AInduced pluripotent stem cell\uFF09\uFF0C\u53C8\u7A31\u4EBA\u5DE5\u8A98\u5C0E\u591A\u80FD\u5E79\u7D30\u80DE\uFF0C\u5E38\u7C21\u7A31\u7232iPS\u7D30\u80DE\uFF08iPSC\uFF09\uFF0C\u662F\u4E00\u7A2E\u7531\u54FA\u4E73\u52D5\u7269\u6210\u9AD4\u7D30\u80DE\u7D93\u8F49\u5165\u8F49\u9304\u56E0\u5B50\u7B49\u624B\u6BB5\u812B\u5206\u5316\u5F62\u6210\u7684\u591A\u80FD\u5E79\u7D30\u80DE\uFF0C\u6700\u65E9\u7531\u65E5\u672C\u5B78\u8005\u5C71\u4E2D\u4F38\u5F4C\u7684\u7814\u7A76\u5718\u968A\u65BC2006\u5E74\u767C\u73FE\u3002\u5C71\u4E2D\u4F38\u5F4C\u5718\u968A\u5728\u767C\u8868iPS\u8A98\u5C0E\u6280\u8853\u6642\u4F7F\u7528\u5BE6\u9A57\u6750\u6599\u7232\u5C0F\u9F20\u7D30\u80DE\u30022007\u5E74\uFF0C\u7814\u7A76\u4EBA\u54E1\u53C8\u8B49\u660EiPS\u8A98\u5C0E\u6280\u8853\u53EF\u4EE5\u61C9\u7528\u65BC\u4EBA\u9AD4\u7D30\u80DE\u3002\u6700\u521D\u7531\u5C71\u4E2D\u4F38\u5F4C\u5718\u968A\u767C\u73FE\u7684\u8A98\u5C0E\u65B9\u6CD5\u662F\u901A\u904E\u6162\u75C5\u6BD2\u8F09\u9AD4\u5C07Oct4\u3001Sox2\u3001c-Myc\u3001Klf4\u56DB\u7A2E\u8F49\u9304\u56E0\u5B50\u57FA\u56E0\u8F49\u5165\u6210\u9AD4\u7D30\u80DE\u5C07\u5176\u8F49\u5316\u7232\u985E\u4F3C\u65BC\u80DA\u80CE\u5E79\u7D30\u80DE\u7684\u591A\u80FD\u5E79\u7D30\u80DE\u3002\u5176\u5F8C\uFF0C\u7814\u7A76\u4EBA\u54E1\u53C8\u5148\u5F8C\u767C\u73FE\u4E86\u66F4\u512A\u5316\u7684\u8A98\u5C0E\u65B9\u6CD5\uFF0C\u5982\u4F7F\u7528\u8CEA\u7C92\u8F09\u9AD4\u8F49\u67D3\u3001\u817A\u75C5\u6BD2\u611F\u67D3\u3001\u8102\u8CEA\u9AD4\u5C0E\u5165\u7B49\u975E\u57FA\u56E0\u7D44\u6574\u5408\u7684\u65B9\u6CD5\u9032\u884C\u8A98\u5C0E\u3001\u901A\u904E\u7D30\u80DE\u878D\u5408\u8A98\u5C0E\u3001\u4F7F\u7528\u5C0F\u5206\u5B50\u85E5\u7269\u9032\u884C\u8A98\u5C0E\u3001\u8F49\u5165miRNA\uFF08\u5FAE\u5E72\u64FERNA\uFF09\u9032\u884C\u8A98\u5C0E\u7B49\u3002 iPS\u6280\u8853\u7684\u767C\u660E\u4EBA\u5C71\u4E2D\u4F38\u5F4C\u65BC2012\u5E74\u8207\u6838\u79FB\u690D\u53CA\u514B\u9686\u6280\u8853\u7814\u7A76\u7684\u5148\u9A45\u8005\u7D04\u7FF0\u00B7\u683C\u767B\u7235\u58EB\u4E00\u540C\u7372\u8AFE\u8C9D\u723E\u751F\u7406\u91AB\u5B78\u734E\u3002"@zh . . . . . . . . . "Ge\u00EFnduceerde pluripotente stamcellen (afgekort als iPSC) zijn stamcellen die rechtstreeks uit lichaamscellen worden gemaakt. De iPSC-technologie werd ontwikkeld in 2006, toen de Japanse onderzoeker Shinya Yamanaka ontdekte dat gewone lichaamscellen, zoals fibroblasten, met behulp van vier transcriptiefactoren (Myc, Oct3/4, Sox2 and Klf4) geherprogrammeerd kunnen worden tot pluripotente stamcellen. Voor zijn ontdekking ontving hij in 2012 de Nobelprijs voor de geneeskunde."@nl . . . "Les cellules souches pluripotentes induites (CSPi) (en anglais Induced pluripotent stem cells soit iPS ou iPSCs) sont des cellules souches pluripotentes g\u00E9n\u00E9r\u00E9es en laboratoire \u00E0 partir de cellules somatiques. Ces cellules souches induites ont le potentiel de se diff\u00E9rencier en n'importe quelle cellule du corps humain et ont donc des applications tr\u00E8s vari\u00E9es en th\u00E9rapie et en recherche biom\u00E9dicale. Elles sont consid\u00E9r\u00E9es comme l'une des avanc\u00E9es majeures de la biotechnologie puisqu'elles permettent de constituer une alternative \u00E0 l'utilisation de cellules souches embryonnaires humaines, permettant ainsi de d\u00E9passer les probl\u00E8mes \u00E9thiques li\u00E9s \u00E0 ces derni\u00E8res."@fr . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "\u4EBA\u5DE5\u591A\u80FD\u6027\u5E79\u7D30\u80DE\uFF08\u3058\u3093\u3053\u3046\u305F\u306E\u3046\u305B\u3044\u304B\u3093\u3055\u3044\u307C\u3046\u3001\u82F1: induced pluripotent stem cells\uFF09\u306F\u3001\u4F53\u7D30\u80DE\u30784\u7A2E\u985E\u306E\u907A\u4F1D\u5B50\u3092\u5C0E\u5165\u3059\u308B\u3053\u3068\u306B\u3088\u308A\u3001ES\u7D30\u80DE\uFF08\u80DA\u6027\u5E79\u7D30\u80DE\uFF09\u306E\u3088\u3046\u306B\u975E\u5E38\u306B\u591A\u304F\u306E\u7D30\u80DE\u306B\u5206\u5316\u3067\u304D\u308B\u5206\u5316\u4E07\u80FD\u6027 (pluripotency)\u3068\u3001\u5206\u88C2\u5897\u6B96\u3092\u7D4C\u3066\u3082\u305D\u308C\u3092\u7DAD\u6301\u3067\u304D\u308B\u81EA\u5DF1\u8907\u88FD\u80FD\u3092\u6301\u305F\u305B\u305F\u7D30\u80DE\u306E\u3053\u3068\u30022006\u5E74\uFF08\u5E73\u621018\u5E74\uFF09\u3001\u5C71\u4E2D\u4F38\u5F25\u7387\u3044\u308B\u4EAC\u90FD\u5927\u5B66\u306E\u7814\u7A76\u30B0\u30EB\u30FC\u30D7\u306B\u3088\u3063\u3066\u30DE\u30A6\u30B9\u306E\u7DDA\u7DAD\u82BD\u7D30\u80DE\uFF08\u76AE\u819A\u7D30\u80DE\uFF09\u304B\u3089\u521D\u3081\u3066\u4F5C\u3089\u308C\u305F\u3002 \u82F1\u8A9E\u540D\u306E\u982D\u6587\u5B57\u3092\u3068\u3063\u3066\u3001iPS\u7D30\u80DE\uFF08\u30A2\u30A4\u30D4\u30FC\u30A8\u30B9\u3055\u3044\u307C\u3046\u3001iPS cells\uFF09\u3068\u547C\u3070\u308C\u308B\u3002\u547D\u540D\u8005\u306E\u5C71\u4E2D\u304C\u6700\u521D\u3092\u5C0F\u6587\u5B57\u306E\u300Ci\u300D\u306B\u3057\u305F\u306E\u306F\u3001\u5F53\u6642\u4E16\u754C\u7684\u306B\u5927\u6D41\u884C\u3057\u3066\u3044\u305F\u7C73Apple\u306E\u643A\u5E2F\u97F3\u697D\u30D7\u30EC\u30FC\u30E4\u30FC\u3067\u3042\u308B\u300EiPod\u300F\u306E\u3088\u3046\u306B\u666E\u53CA\u3057\u3066\u307B\u3057\u3044\u3068\u306E\u9858\u3044\u304C\u8FBC\u3081\u3089\u308C\u3066\u3044\u308B\u3002\u4EE5\u4E0B\u3001\u300CiPS\u7D30\u80DE\u300D\u3068\u3044\u3046\u8868\u8A18\u3092\u7528\u3044\u308B\u3002"@ja . . "Una cellula staminale pluripotente indotta (conosciuta anche come iPS o iPSC dall'inglese Induced Pluripotent Stem Cell) \u00E8 un tipo di cellula staminale generata artificialmente a partire da una terminalmente differenziata (in genere una cellula somatica adulta), mediante l'introduzione di quattro geni specifici codificanti determinati fattori di trascrizione che ne inducono la conversione in cellula staminale di una specifica linea cellulare, che a sua volta potr\u00E0 svilupparsi in cellula differenziata. Sulla base di tali propriet\u00E0, le iPSC offrono grandi speranze nel campo della medicina rigenerativa: la possibilit\u00E0 di indurne la differenziazione nella maggior parte dei tipi cellulari di un organismo (come ad esempio cellule neuronali, pancreatiche, cardiache ed epatiche), pu\u00F2 essere sfruttata nella rigenerazione di tessuti o organi danneggiati."@it . . . . . . . "Ge\u00EFnduceerde pluripotente stamcellen (afgekort als iPSC) zijn stamcellen die rechtstreeks uit lichaamscellen worden gemaakt. De iPSC-technologie werd ontwikkeld in 2006, toen de Japanse onderzoeker Shinya Yamanaka ontdekte dat gewone lichaamscellen, zoals fibroblasten, met behulp van vier transcriptiefactoren (Myc, Oct3/4, Sox2 and Klf4) geherprogrammeerd kunnen worden tot pluripotente stamcellen. Voor zijn ontdekking ontving hij in 2012 de Nobelprijs voor de geneeskunde. Ge\u00EFnduceerde pluripotente stamcellen hebben het vermogen om zich te differenti\u00EBren (specialiseren) tot bijna ieder gewenst celtype van het menselijk lichaam, zoals hartcellen of levercellen. Dit is van grote betekenis voor de regeneratieve geneeskunde en weefseltechnologie, omdat uit deze stamcellen een compleet weefsel kan worden geproduceerd voor medische doeleinden. IPSC's kunnen in vitro uitrijpen tot alle drie de kiemlagen, en gedragen zich dus als embryonale stamcellen. Het isoleren van stamcellen uit menselijke embryo's ligt ethisch zeer gevoelig. Bij ge\u00EFnduceerde pluripotente stamcellen spelen deze ethische gevoeligheden niet. Met behulp van de iPSC-technologie kunnen weefsels of orgaandelen worden gemaakt die zonder afstotingsgevaar in een pati\u00EBnt kunnen worden getransplanteerd, aangezien de cellen oorspronkelijk uit de pati\u00EBnt zelf afkomstig zijn. Ondanks het grote potentieel van ge\u00EFnduceerde pluripotente stamcellen, zijn er nog geen klinisch toepasbare producten gerealiseerd."@nl . . . "\u0406\u043D\u0434\u0443\u043A\u043E\u0432\u0430\u043D\u0456 \u043F\u043B\u044E\u0440\u0438\u043F\u043E\u0442\u0435\u043D\u0442\u043D\u0456 \u0441\u0442\u043E\u0432\u0431\u0443\u0440\u043E\u0432\u0456 \u043A\u043B\u0456\u0442\u0438\u043D\u0438 (\u0406\u041F\u0421\u041A) \u044F\u0432\u043B\u044F\u044E\u0442\u044C \u0441\u043E\u0431\u043E\u044E \u0442\u0438\u043F \u0441\u0442\u043E\u0432\u0431\u0443\u0440\u043E\u0432\u0438\u0445 \u043A\u043B\u0456\u0442\u0438\u043D, \u043E\u0442\u0440\u0438\u043C\u0430\u043D\u0438\u0445 \u0448\u0442\u0443\u0447\u043D\u043E \u0432 \u043B\u0430\u0431\u043E\u0440\u0430\u0442\u043E\u0440\u043D\u0438\u0445 \u0443\u043C\u043E\u0432\u0430\u0445 \u0437\u0456 \u0437\u0440\u0456\u043B\u0438\u0445 \u0434\u0438\u0444\u0435\u0440\u0435\u043D\u0446\u0456\u0439\u043E\u0432\u0430\u043D\u0438\u0445 \u043A\u043B\u0456\u0442\u0438\u043D \u043E\u0440\u0433\u0430\u043D\u0456\u0437\u043C\u0443 \u0441\u0441\u0430\u0432\u0446\u0456\u0432, \u0437\u043E\u043A\u0440\u0435\u043C\u0430 \u043B\u044E\u0434\u0438\u043D\u0438. \u0406\u041F\u0421\u041A \u043E\u0442\u0440\u0438\u043C\u0443\u044E\u0442\u044C \u0437\u0430 \u0434\u043E\u043F\u043E\u043C\u043E\u0433\u043E\u044E \u0448\u0442\u0443\u0447\u043D\u043E\u0433\u043E \u0432\u0432\u0435\u0434\u0435\u043D\u043D\u044F \u0443 \u043A\u043B\u0456\u0442\u0438\u043D\u0443 \u0431\u0456\u043B\u043A\u0456\u0432 \u0442\u0440\u0430\u043D\u0441\u043A\u0440\u0438\u043F\u0446\u0456\u0439\u043D\u0438\u0445 \u0444\u0430\u043A\u0442\u043E\u0440\u0456\u0432 \u0430\u0431\u043E \u043C\u0456\u043A\u0440\u043E\u0420\u041D\u041A, \u0432\u043D\u0430\u0441\u043B\u0456\u0434\u043E\u043A \u044F\u043A\u043E\u0433\u043E \u0437\u0430\u043F\u0443\u0441\u043A\u0430\u0454\u0442\u044C\u0441\u044F \u043F\u0440\u043E\u0433\u0440\u0430\u043C\u0430 \u043F\u0435\u0440\u0435\u0442\u0432\u043E\u0440\u0435\u043D\u043D\u044F \u043A\u043B\u0456\u0442\u0438\u043D\u0438 \u043D\u0430 \u043D\u0435\u0434\u0438\u0444\u0435\u0440\u0435\u043D\u0446\u0456\u0439\u043E\u0432\u0430\u043D\u0443 \u0441\u0442\u043E\u0432\u0431\u0443\u0440\u043E\u0432\u0443. \u0414\u043B\u044F \u0456\u043D\u0434\u0443\u043A\u0443\u0432\u0430\u043D\u043D\u044F \u0442\u0430\u043A\u0438\u0445 \u043A\u043B\u0456\u0442\u0438\u043D \u0437\u0430\u0437\u0432\u0438\u0447\u0430\u0439 \u0432\u0438\u043A\u043E\u0440\u0438\u0441\u0442\u043E\u0432\u0443\u044E\u0442\u044C\u0441\u044F \u0444\u0456\u0431\u0440\u043E\u0431\u043B\u0430\u0441\u0442\u0438 \u0448\u043A\u0456\u0440\u0438. \u041E\u0442\u0440\u0438\u043C\u0430\u043D\u0456 \u0406\u041F\u0421\u041A \u0434\u0438\u0444\u0435\u0440\u0435\u043D\u0446\u0456\u044E\u044E\u0442\u044C\u0441\u044F \u0437\u0430 \u0434\u043E\u043F\u043E\u043C\u043E\u0433\u043E\u044E \u0456\u043D\u0448\u0438\u0445 \u0442\u0440\u0430\u043D\u0441\u043A\u0440\u0438\u043F\u0446\u0456\u0439\u043D\u0438\u0445 \u0444\u0430\u043A\u0442\u043E\u0440\u0456\u0432 \u0443 \u0440\u0456\u0437\u043D\u0456 \u0442\u0438\u043F\u0438 \u043A\u043B\u0456\u0442\u0438\u043D, \u0437\u043E\u043A\u0440\u0435\u043C\u0430 \u043D\u0435\u0439\u0440\u043E\u043D\u0438 \u0442\u0430 \u043A\u0430\u0440\u0434\u0456\u043E\u043C\u0456\u043E\u0446\u0438\u0442\u0438."@uk . . . . . "1122136477"^^ . . "Inducerad pluripotent stamcell"@sv . . "\uC720\uB3C4\uB9CC\uB2A5\uC904\uAE30\uC138\uD3EC(\u8A98\u5C0E\u842C\u80FD - \u7D30\u80DE, \uC601\uC5B4: induced pluripotent stem cell, iPS cell/iPSC) \uB610\uB294 \uC5ED\uBD84\uD654 \uC904\uAE30\uC138\uD3EC\uB294 \uB2E4\uB2A5\uC131\uC774 \uC5C6\uB294 \uC131\uC778\uC758 \uD53C\uBD80\uC138\uD3EC\uC640 \uAC19\uC740 \uCCB4\uC138\uD3EC\uC5D0 \uC5ED\uBD84\uD654\uB97C \uC77C\uC73C\uD0A4\uB294 4\uAC00\uC9C0 \uD2B9\uC815 \uC720\uC804\uC790\uB97C \uB3C4\uC785\uD55C \uD6C4 \uBC1C\uD604\uC2DC\uD0A4\uAC70\uB098 \uC5ED\uBD84\uD654\uB97C \uC77C\uC73C\uD0A4\uB294 4\uAC00\uC9C0 \uC720\uC804\uC790\uAC00 \uB3C4\uC785\uB41C \uC138\uD3EC\uC5D0\uC11C \uB9CC\uB4E4\uC5B4\uC9C4 \uC5ED\uBD84\uD654 \uC720\uB3C4 \uB2E8\uBC31\uC9C8\uC744 \uCD94\uCD9C\uD558\uC5EC \uC774\uB97C \uB2E4\uC2DC \uCCB4\uC138\uD3EC\uC5D0 \uC8FC\uC785\uD568\uC73C\uB85C\uC368 \uBC30\uC544 \uC904\uAE30\uC138\uD3EC\uC640 \uAC19\uC740 \uB2E4\uB2A5\uC131\uC744 \uAC16\uB294 \uC904\uAE30\uC138\uD3EC\uB97C \uB9CC\uB4E4 \uC218 \uC788\uB294\uB370 \uC774\uB97C \uC720\uB3C4 \uB9CC\uB2A5 \uC904\uAE30\uC138\uD3EC \uB610\uB294 \uC5ED\uBD84\uD654 \uC904\uAE30\uC138\uD3EC\uB77C\uACE0 \uD55C\uB2E4. 2006\uB144 \uC77C\uBCF8 \uAD50\uD1A0\uB300 \uC57C\uB9C8\uB098\uCE74 \uC2E0\uC57C \uAD50\uC218\uD300\uC740 \uC0DD\uC950\uC758 \uD53C\uBD80 \uC12C\uC720\uC544\uC138\uD3EC\uC5D0 \uBA87 \uAC00\uC9C0 \uC720\uC804\uC790\uB97C \uB3C4\uC785\uD558\uC5EC \uBC30\uC544\uC904\uAE30\uC138\uD3EC\uCC98\uB7FC \uB9CC\uB2A5\uC131\uC744 \uAC00\uC9C4 \uC904\uAE30\uC138\uD3EC\uB97C \uB9CC\uB4DC\uB294\uB370 \uC131\uACF5\uD588\uB2E4. \uC774\uB4EC\uD574\uC778 2007\uB144\uC5D0 \uC57C\uB9C8\uB098\uCE74 \uAD50\uC218\uD300\uC740 \uC131\uC778\uC758 \uD53C\uBD80\uC138\uD3EC\uC5D0 \uC720\uC804\uC790\uB97C \uB3C4\uC785\uD558\uC5EC \uC720\uB3C4\uB9CC\uB2A5\uC904\uAE30\uC138\uD3EC\uB97C \uB9CC\uB4DC\uB294\uB370 \uC131\uACF5\uD558\uC600\uB2E4. \uC774\uBBF8 \uC131\uC219\uD558\uACE0 \uBD84\uD654\uB41C \uC138\uD3EC\uB97C \uBBF8\uC131\uC219\uD55C \uC138\uD3EC\uB85C \uC5ED\uBD84\uD654\uC2DC\uCF1C\uC11C \uB2E4\uC2DC \uBAA8\uB4E0 \uC870\uC9C1\uC73C\uB85C \uBC1C\uC804\uC2DC\uD0AC \uC218 \uC788\uB2E4\uB294 \uC0AC\uC2E4\uC744 \uBC1C\uACAC\uD558\uACE0 \uC99D\uBA85\uD55C \uACF5\uB85C\uAC00 \uC778\uC815\uB418\uC5B4, \uC57C\uB9C8\uB098\uCE74 \uC2E0\uC57C \uAD50\uC218\uB294 \uC874 \uAC70\uB4E0 \uAD50\uC218\uC640 \uD568\uAED8 \uD558\uBA70 2012\uB144 \uB178\uBCA8 \uC0DD\uB9AC\uD559\u00B7\uC758\uD559\uC0C1 \uC218\uC0C1\uC790\uB85C \uC120\uC815\uB418\uC5C8\uB2E4."@ko . . "Les c\u00E8l\u00B7lules mare Pluripotents Indu\u00EFdes o c\u00E8l\u00B7lules IPS (en angl\u00E8s: Induced Pluripotent Stem Cells) s\u00F3n un nou tipus de c\u00E8l\u00B7lules adultes multipotents elevades a un estat superior, c\u00E8l\u00B7lules pluripotents. Aquestes c\u00E8l\u00B7lules s\u00F3n capaces de generar la majoria de les c\u00E8l\u00B7lules de la resta del cos."@ca . . . . "Indukowane pluripotencjalne kom\u00F3rki macierzyste, kom\u00F3rki iPS, IPSC (ang. induced pluripotent stem cells) \u2013 typ pluripotencjalnych kom\u00F3rek macierzystych, kt\u00F3re zosta\u0142y sztucznie uzyskane z niepluripotentnych kom\u00F3rek (przewa\u017Cnie kom\u00F3rek somatycznych doros\u0142ego cz\u0142owieka) przez wymuszenie ekspresji odpowiednich gen\u00F3w w tych kom\u00F3rkach."@pl . "Indukovan\u00E1 pluripotentn\u00ED kmenov\u00E1 bu\u0148ka (iPSC) je odvozena z dosp\u011Bl\u00E9 (somatick\u00E9) bu\u0148ky in vitro indukc\u00ED pluripotence, \u010D\u00EDm\u017E se obch\u00E1z\u00ED etick\u00E1 dilemata kolem pou\u017Eit\u00ED embryon\u00E1ln\u00EDch kmenov\u00FDch bun\u011Bk; bu\u0148ky jsou skl\u00EDzeny neinvazivn\u011B a mohou b\u00FDt transplantov\u00E1ny autologn\u011B, co\u017E sni\u017Euje imunitn\u00ED odpov\u011B\u010F a odm\u00EDtnut\u00ED. Laicky \u0159e\u010Deno, iPSC je um\u011Ble p\u0159ipraven\u00E1 kmenov\u00E1 bu\u0148ka, vytvo\u0159en\u00E1 z p\u016Fvodn\u011B zcela oby\u010Dejn\u00E9 bu\u0148ky z\u00EDskan\u00E9 typicky z t\u011Bla dosp\u011Blce. Zat\u00EDmco p\u016Fvodn\u00ED bu\u0148ka byla diferencovan\u00E1 (m\u011Bla ur\u010Den sv\u016Fj bun\u011B\u010Dn\u00FD osud), indukovan\u00E1 pluripotentn\u00ED bu\u0148ka je pluripotentn\u00ED, co\u017E znamen\u00E1, \u017Ee z n\u00ED m\u016F\u017Ee vzniknout jak\u00E1koliv bu\u0148ka v t\u011Ble dosp\u011Blce (diferenciac\u00ED). To zvy\u0161uje jej\u00ED potenci\u00E1l pro vyu\u017Eit\u00ED u r\u016Fzn\u00FDch chorobn\u00FDch proces\u016F. Vzhledem k tomu, \u017Ee iPSC lze v z\u00E1sad\u011B z\u00EDskat z jak\u00E9koli dosp\u011Bl\u00E9 tk\u00E1n\u011B v\u010Detn\u011B k\u016F\u017Ee, potenci\u00E1ln\u00ED z\u00E1soba zdrojov\u00FDch bun\u011Bk je o mnoho \u0159\u00E1d\u016F v\u011Bt\u0161\u00ED ne\u017E u jin\u00FDch typ\u016F kmenov\u00FDch bun\u011Bk."@cs . . . "\uC720\uB3C4\uB9CC\uB2A5\uC904\uAE30\uC138\uD3EC(\u8A98\u5C0E\u842C\u80FD - \u7D30\u80DE, \uC601\uC5B4: induced pluripotent stem cell, iPS cell/iPSC) \uB610\uB294 \uC5ED\uBD84\uD654 \uC904\uAE30\uC138\uD3EC\uB294 \uB2E4\uB2A5\uC131\uC774 \uC5C6\uB294 \uC131\uC778\uC758 \uD53C\uBD80\uC138\uD3EC\uC640 \uAC19\uC740 \uCCB4\uC138\uD3EC\uC5D0 \uC5ED\uBD84\uD654\uB97C \uC77C\uC73C\uD0A4\uB294 4\uAC00\uC9C0 \uD2B9\uC815 \uC720\uC804\uC790\uB97C \uB3C4\uC785\uD55C \uD6C4 \uBC1C\uD604\uC2DC\uD0A4\uAC70\uB098 \uC5ED\uBD84\uD654\uB97C \uC77C\uC73C\uD0A4\uB294 4\uAC00\uC9C0 \uC720\uC804\uC790\uAC00 \uB3C4\uC785\uB41C \uC138\uD3EC\uC5D0\uC11C \uB9CC\uB4E4\uC5B4\uC9C4 \uC5ED\uBD84\uD654 \uC720\uB3C4 \uB2E8\uBC31\uC9C8\uC744 \uCD94\uCD9C\uD558\uC5EC \uC774\uB97C \uB2E4\uC2DC \uCCB4\uC138\uD3EC\uC5D0 \uC8FC\uC785\uD568\uC73C\uB85C\uC368 \uBC30\uC544 \uC904\uAE30\uC138\uD3EC\uC640 \uAC19\uC740 \uB2E4\uB2A5\uC131\uC744 \uAC16\uB294 \uC904\uAE30\uC138\uD3EC\uB97C \uB9CC\uB4E4 \uC218 \uC788\uB294\uB370 \uC774\uB97C \uC720\uB3C4 \uB9CC\uB2A5 \uC904\uAE30\uC138\uD3EC \uB610\uB294 \uC5ED\uBD84\uD654 \uC904\uAE30\uC138\uD3EC\uB77C\uACE0 \uD55C\uB2E4. 2006\uB144 \uC77C\uBCF8 \uAD50\uD1A0\uB300 \uC57C\uB9C8\uB098\uCE74 \uC2E0\uC57C \uAD50\uC218\uD300\uC740 \uC0DD\uC950\uC758 \uD53C\uBD80 \uC12C\uC720\uC544\uC138\uD3EC\uC5D0 \uBA87 \uAC00\uC9C0 \uC720\uC804\uC790\uB97C \uB3C4\uC785\uD558\uC5EC \uBC30\uC544\uC904\uAE30\uC138\uD3EC\uCC98\uB7FC \uB9CC\uB2A5\uC131\uC744 \uAC00\uC9C4 \uC904\uAE30\uC138\uD3EC\uB97C \uB9CC\uB4DC\uB294\uB370 \uC131\uACF5\uD588\uB2E4. \uC774\uB4EC\uD574\uC778 2007\uB144\uC5D0 \uC57C\uB9C8\uB098\uCE74 \uAD50\uC218\uD300\uC740 \uC131\uC778\uC758 \uD53C\uBD80\uC138\uD3EC\uC5D0 \uC720\uC804\uC790\uB97C \uB3C4\uC785\uD558\uC5EC \uC720\uB3C4\uB9CC\uB2A5\uC904\uAE30\uC138\uD3EC\uB97C \uB9CC\uB4DC\uB294\uB370 \uC131\uACF5\uD558\uC600\uB2E4. \uC774\uBBF8 \uC131\uC219\uD558\uACE0 \uBD84\uD654\uB41C \uC138\uD3EC\uB97C \uBBF8\uC131\uC219\uD55C \uC138\uD3EC\uB85C \uC5ED\uBD84\uD654\uC2DC\uCF1C\uC11C \uB2E4\uC2DC \uBAA8\uB4E0 \uC870\uC9C1\uC73C\uB85C \uBC1C\uC804\uC2DC\uD0AC \uC218 \uC788\uB2E4\uB294 \uC0AC\uC2E4\uC744 \uBC1C\uACAC\uD558\uACE0 \uC99D\uBA85\uD55C \uACF5\uB85C\uAC00 \uC778\uC815\uB418\uC5B4, \uC57C\uB9C8\uB098\uCE74 \uC2E0\uC57C \uAD50\uC218\uB294 \uC874 \uAC70\uB4E0 \uAD50\uC218\uC640 \uD568\uAED8 \uD558\uBA70 2012\uB144 \uB178\uBCA8 \uC0DD\uB9AC\uD559\u00B7\uC758\uD559\uC0C1 \uC218\uC0C1\uC790\uB85C \uC120\uC815\uB418\uC5C8\uB2E4."@ko . . . . "89000"^^ . . . . . . . "Sel iPS"@in . "Induced pluripotent stem cell"@en . . "Les c\u00E8l\u00B7lules mare Pluripotents Indu\u00EFdes o c\u00E8l\u00B7lules IPS (en angl\u00E8s: Induced Pluripotent Stem Cells) s\u00F3n un nou tipus de c\u00E8l\u00B7lules adultes multipotents elevades a un estat superior, c\u00E8l\u00B7lules pluripotents. Aquestes c\u00E8l\u00B7lules s\u00F3n capaces de generar la majoria de les c\u00E8l\u00B7lules de la resta del cos. Nom\u00E9s per aquest motiu ja s\u00F3n eines molt \u00FAtils per al desenvolupament de medicaments i a la modificaci\u00F3 de malalties. Per\u00F2 el que realment es busca \u00E9s la creaci\u00F3 d'\u00F2rgans mitjan\u00E7ant impressores 3D. Per exemple una empresa anomenada Organovo, va aconseguir crear una l\u00E0mina de fetge completament funcional."@ca . . . . . "Indukowane pluripotencjalne kom\u00F3rki macierzyste"@pl . "Ge\u00EFnduceerde pluripotente stamcel"@nl . . . . . . "\u0406\u043D\u0434\u0443\u043A\u043E\u0432\u0430\u043D\u0456 \u043F\u043B\u044E\u0440\u0438\u043F\u043E\u0442\u0435\u043D\u0442\u043D\u0456 \u0441\u0442\u043E\u0432\u0431\u0443\u0440\u043E\u0432\u0456 \u043A\u043B\u0456\u0442\u0438\u043D\u0438"@uk . "Inducerade pluripotenta stamceller (f\u00F6rkortat iPS eller PS) \u00E4r en form av vanliga celler som omprogrammeras i en process som kallas \"dedifferentiering\" och \u00E5terg\u00E5r till en liknande version av sin ursprungliga form, allts\u00E5 stamceller. Stamceller \u00E4r speciella celler som kan differentieras till andra celler som \u00E4r specialiserade att g\u00F6ra speciella uppgifter(t.ex. stamceller som differentierats till en hudcell \u00E4r specialiserad att bara dela sig till hudceller). Pluripotenta stamceller \u00E4r i princip identiska till embryonala stamceller och den enda skillnaden \u00E4r att pluripotenta stamceller ej kan ge upphov till placenta. Pluripotenta stamceller \u00E4r ocks\u00E5 i princip identisk till inducerade pluripotenta stamceller d\u00E5 den enda skillnaden \u00E4r uppkomsten av stamcellerna. Till skillnad fr\u00E5n pluripotenta stamceller som redan finns f\u00F6r att kunna differentieras till olika kroppsceller som t.ex. fosterstamceller som finns i omogna k\u00F6nsceller, s\u00E5 \u00E4r inducerade pluripotenta stamceller stamceller gjorda fr\u00E5n t.ex. helt vanliga adulta stamceller som redan \u00E4r kroppsceller."@sv . . . "Induced pluripotent stem cells (also known as iPS cells or iPSCs) are a type of pluripotent stem cell that can be generated directly from a somatic cell. The iPSC technology was pioneered by Shinya Yamanaka's lab in Kyoto, Japan, who showed in 2006 that the introduction of four specific genes (named Myc, Oct3/4, Sox2 and Klf4), collectively known as Yamanaka factors, encoding transcription factors could convert somatic cells into pluripotent stem cells. He was awarded the 2012 Nobel Prize along with Sir John Gurdon \"for the discovery that mature cells can be reprogrammed to become pluripotent.\""@en . . . . . . . "C\u00E8l\u00B7lules IPS"@ca . . . "12223532"^^ . . . . "C\u00E9lulas tronco pluripotente induzidas (do ingl\u00EAs, induced pluripotent stem cells, IPS), s\u00E3o c\u00E9lulas de organismos adultos que, atrav\u00E9s da express\u00E3o de fatores de transcri\u00E7\u00E3o espec\u00EDficos, ganham uma caracter\u00EDstica bastante particular de c\u00E9lula embrion\u00E1ria, a pluripot\u00EAncia. Por conta de tal capacidade \u00E9 esperado que as c\u00E9lulas-tronco pluripotente induzidas revolucionem a medicina regenerativa num futuro pr\u00F3ximo ."@pt . . . . . . . . . "Les cellules souches pluripotentes induites (CSPi) (en anglais Induced pluripotent stem cells soit iPS ou iPSCs) sont des cellules souches pluripotentes g\u00E9n\u00E9r\u00E9es en laboratoire \u00E0 partir de cellules somatiques. Ces cellules souches induites ont le potentiel de se diff\u00E9rencier en n'importe quelle cellule du corps humain et ont donc des applications tr\u00E8s vari\u00E9es en th\u00E9rapie et en recherche biom\u00E9dicale. Elles sont consid\u00E9r\u00E9es comme l'une des avanc\u00E9es majeures de la biotechnologie puisqu'elles permettent de constituer une alternative \u00E0 l'utilisation de cellules souches embryonnaires humaines, permettant ainsi de d\u00E9passer les probl\u00E8mes \u00E9thiques li\u00E9s \u00E0 ces derni\u00E8res."@fr . . . . "Indukovan\u00E1 pluripotentn\u00ED kmenov\u00E1 bu\u0148ka (iPSC) je odvozena z dosp\u011Bl\u00E9 (somatick\u00E9) bu\u0148ky in vitro indukc\u00ED pluripotence, \u010D\u00EDm\u017E se obch\u00E1z\u00ED etick\u00E1 dilemata kolem pou\u017Eit\u00ED embryon\u00E1ln\u00EDch kmenov\u00FDch bun\u011Bk; bu\u0148ky jsou skl\u00EDzeny neinvazivn\u011B a mohou b\u00FDt transplantov\u00E1ny autologn\u011B, co\u017E sni\u017Euje imunitn\u00ED odpov\u011B\u010F a odm\u00EDtnut\u00ED. Laicky \u0159e\u010Deno, iPSC je um\u011Ble p\u0159ipraven\u00E1 kmenov\u00E1 bu\u0148ka, vytvo\u0159en\u00E1 z p\u016Fvodn\u011B zcela oby\u010Dejn\u00E9 bu\u0148ky z\u00EDskan\u00E9 typicky z t\u011Bla dosp\u011Blce. Zat\u00EDmco p\u016Fvodn\u00ED bu\u0148ka byla diferencovan\u00E1 (m\u011Bla ur\u010Den sv\u016Fj bun\u011B\u010Dn\u00FD osud), indukovan\u00E1 pluripotentn\u00ED bu\u0148ka je pluripotentn\u00ED, co\u017E znamen\u00E1, \u017Ee z n\u00ED m\u016F\u017Ee vzniknout jak\u00E1koliv bu\u0148ka v t\u011Ble dosp\u011Blce (diferenciac\u00ED). To zvy\u0161uje jej\u00ED potenci\u00E1l pro vyu\u017Eit\u00ED u r\u016Fzn\u00FDch chorobn\u00FDch proces\u016F. Vzhledem k tomu, \u017Ee iPSC lze v z\u00E1sad\u011B z\u00EDskat z jak\u00E9koli dosp\u011Bl\u00E9 tk\u00E1n\u011B v\u010Detn\u011B k\u016F\u017Ee, potenci"@cs . . "\u4EBA\u5DE5\u591A\u80FD\u6027\u5E79\u7D30\u80DE"@ja . . . . . . . . "Cellula staminale pluripotente indotta"@it . . . . . . . . . .