. . . . "L\u2019inositol trisphosphate, souvent appel\u00E9 trisphosphoinositol et abr\u00E9g\u00E9 InsP3 ou IP3, est, avec les diacylglyc\u00E9rols (DAG), un messager secondaire de la transduction de signal et de la signalisation lipidique des cellules vivantes. Alors que le DAG, de nature aliphatique, demeure inclus dans la membrane cellulaire, l'IP3 est soluble et peut diffuser dans les cellules."@fr . "Inositoltrisfosf\u00E1t"@cs . . "L\u2019inositol trisphosphate, souvent appel\u00E9 trisphosphoinositol et abr\u00E9g\u00E9 InsP3 ou IP3, est, avec les diacylglyc\u00E9rols (DAG), un messager secondaire de la transduction de signal et de la signalisation lipidique des cellules vivantes. Alors que le DAG, de nature aliphatique, demeure inclus dans la membrane cellulaire, l'IP3 est soluble et peut diffuser dans les cellules. L'IP3 r\u00E9sulte de l'hydrolyse du phosphatidylinositol-4,5-bisphosphate (PIP2), un phospholipide de la membrane plasmique, par la phospholipase C (PLC). Il est dissous dans le cytosol et diffuse jusqu'\u00E0 atteindre des r\u00E9cepteurs de l'IP3, sur lesquels il agit pour accro\u00EEtre la concentration intracellulaire en cations Ca2+."@fr . . "Inositoltrisphosphat (auch Inositol-1,4,5-trisphosphat, kurz IP3) bezeichnet in der Biochemie ein Inositolphosphat mit drei Phosphatgruppen. Es wird aus einem Phospholipid freigesetzt und ist als sekund\u00E4rer Botenstoff f\u00FCr die Signal\u00FCbertragung (Signaltransduktion) in der Zelle von Bedeutung."@de . . "51596"^^ . . . "L'inositolo trifosfato, detto anche inositolo 1,4,5-trisfosfato (abbreviato in IP3) \u00E8, insieme al diacilglicerolo (abbreviato in DAG), un secondo messaggero utilizzato dalla cellula come molecola con la funzione di trasduzione del segnale. Mentre il DAG rimane all'interno della membrana, l'IP3 \u00E8 solubile ed \u00E8 in grado di diffondere attraverso la cellula."@it . . "Inositoltrisphosphat (auch Inositol-1,4,5-trisphosphat, kurz IP3) bezeichnet in der Biochemie ein Inositolphosphat mit drei Phosphatgruppen. Es wird aus einem Phospholipid freigesetzt und ist als sekund\u00E4rer Botenstoff f\u00FCr die Signal\u00FCbertragung (Signaltransduktion) in der Zelle von Bedeutung."@de . . . . . . . . "Inositol trisfosfato, inositol 1,4,5-trisfosfato o trifosfoinositol (abreviado InsP3 o IP3), es un segundo mensajero de la transducci\u00F3n de se\u00F1al celular. Se produce, junto con el diacilglicerol, por hidr\u00F3lisis catalizada mediante la fosfolipasa C del fosfatidilinositol 4,5-bifosfato (PIP2) , un fosfol\u00EDpido de membrana. Su efecto en el entorno celular es la movilizaci\u00F3n del Ca2+, almacenado en org\u00E1nulos como el ret\u00EDculo endoplasm\u00E1tico y en el aparato de Golgi.\u200B"@es . . "Inositol trisphosphate"@en . . . . . "Trisfosforan inozytolu (1,4,5-trisfosforan inozytolu, IP3) \u2013 organiczny zwi\u0105zek chemiczny z grupy estr\u00F3w, pochodna inozytolu zawieraj\u0105ca 3 reszty fosforanowe w pozycjach 1, 4 i 5. W organizmach jest mediatorem wewn\u0105trzkom\u00F3rkowym. Jest to przeka\u017Anik po\u015Brednicz\u0105cy w wymianie informacji chemicznej. Stymuluje wzrost st\u0119\u017Cenia jon\u00F3w Ca2+ w cytozolu."@pl . . . "\u30A4\u30CE\u30B7\u30C8\u30FC\u30EB\u30C8\u30EA\u30B9\u30EA\u30F3\u9178\uFF08\u82F1: Inositol trisphosphate, IP3\uFF09\u306F\u3001\u30A4\u30CE\u30B7\u30C8\u30FC\u30EB\u306B3\u3064\u306E\u30EA\u30F3\u9178\u304C\u30A8\u30B9\u30C6\u30EB\u7D50\u5408\u3057\u305F\u5316\u5B66\u7269\u8CEA\u3002\u30B8\u30A2\u30B7\u30EB\u30B0\u30EA\u30BB\u30ED\u30FC\u30EB\u3068\u5171\u306B\u3001\u7D30\u80DE\u306E\u30B7\u30B0\u30CA\u30EB\u4F1D\u9054\u306B\u304A\u3044\u3066\u30BB\u30AB\u30F3\u30C9\u30E1\u30C3\u30BB\u30F3\u30B8\u30E3\u30FC\u306E1\u3064\u3068\u3057\u3066\u751F\u4F53\u306B\u5229\u7528\u3055\u308C\u3066\u3044\u308B\u3002\u307E\u305F\u3001\u8102\u8CEA\u30E1\u30C7\u30A3\u30A8\u30FC\u30BF\u30FC\u3068\u3057\u3066\u3082\u4F7F\u308F\u308C\u308B\u3002 \u7D30\u80DE\u819C\u306B\u5B58\u5728\u3059\u308B\u30EA\u30F3\u8102\u8CEA\u3067\u3042\u308B\u30DB\u30B9\u30D5\u30A1\u30C1\u30B8\u30EB\u30A4\u30CE\u30B7\u30C8\u30FC\u30EB4,5-\u30D3\u30B9\u30EA\u30F3\u9178\u304C\u30DB\u30B9\u30DB\u30EA\u30D1\u30FC\u30BCC\u306B\u3088\u3063\u3066\u52A0\u6C34\u5206\u89E3\u3055\u308C\u308B\u3068\u3001IP3\u3068\u30B8\u30A2\u30B7\u30EB\u30B0\u30EA\u30BB\u30ED\u30FC\u30EB\u304C\u751F\u6210\u3059\u308B\u3002\u3053\u306E\u3046\u3061\u3001\u6BD4\u8F03\u7684\u8102\u6EB6\u6027\u306E\u9AD8\u3044\u30B8\u30A2\u30B7\u30EB\u30B0\u30EA\u30BB\u30ED\u30FC\u30EB\u306F\u7D30\u80DE\u819C\u306E\u4E2D\u306B\u5B58\u5728\u3059\u308B\u306E\u306B\u5BFE\u3057\u3001IP3\u306F\u6C34\u6EB6\u6027\u3067\u3042\u308B\u305F\u3081\u7D30\u80DE\u8CEA\u306B\u62E1\u6563\u3059\u308B\u3002"@ja . . . . . . . . "Inositol trifosfato"@es . . . . . . . . . . . . "200"^^ . . "1123409508"^^ . . . . . "Inositoltrisphosphat"@de . "O inositol 1,2,4 trisfosfato ou IP3, juntamente com o diacilglicerol, \u00E9 um mensageiro secund\u00E1rio envolvido na transdu\u00E7\u00E3o de sinal em c\u00E9lulas biol\u00F3gicas. \u00C9 formado por hidr\u00F3lise de (PIP2), um fosfol\u00EDpido que est\u00E1 localizado na membrana plasm\u00E1tica, pela fosfolipase C. A sua principal fun\u00E7\u00E3o consiste na mobiliza\u00E7\u00E3o de Ca2+ a partir de organelos onde este est\u00E1 armazenado, e na regula\u00E7\u00E3o da , entre outras reac\u00E7\u00E3o celulares. Por exemplo, na mosca-da-fruta, Drosophila, o IP3 \u00E9 usado na transdu\u00E7\u00E3o intracelular do reconhecimento de luz por c\u00E9lulas do olho."@pt . . . . "[-2,3,5-trihydroxy-4,6-diphosphonooxycyclohexyl] dihydrogen phosphate"@en . . . . . . . . . "Inositol trisphosphate or inositol 1,4,5-trisphosphate abbreviated InsP3 or Ins3P or IP3 is an inositol phosphate signaling molecule. It is made by hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2), a phospholipid that is located in the plasma membrane, by phospholipase C (PLC).Together with diacylglycerol (DAG), IP3 is a second messenger molecule used in signal transduction in biological cells. While DAG stays inside the membrane, IP3 is soluble and diffuses through the cell, where it binds to its receptor, which is a calcium channel located in the endoplasmic reticulum. When IP3 binds its receptor, calcium is released into the cytosol, thereby activating various calcium regulated intracellular signals."@en . . . . . . . . . . . . . . . . . . . . . "Inositoltrisfosf\u00E1t (IP3, p\u0159esn\u011Bji inositol-1,4,5-trisfosf\u00E1t) je ve vod\u011B rozpustn\u00FD cukern\u00FD alkohol esterifikovan\u00FD na t\u0159ech m\u00EDstech fosf\u00E1tov\u00FDmi skupinami. Je to v\u00FDznamn\u00FD druh\u00FD posel v bun\u011B\u010Dn\u00E9 signalizaci, kter\u00FD vznik\u00E1 \u010Dinnost\u00ED fosfolip\u00E1zy C z jist\u00E9ho vz\u00E1cn\u011Bj\u0161\u00EDho membr\u00E1nov\u00E9ho fosfolipidu (konkr\u00E9tn\u011B z PIP2). Druh\u00FDm produktem t\u00E9to enzymatick\u00E9 reakce je 1,2-diacylglycerol (DAG), rovn\u011B\u017E druh\u00FD posel, ten v\u0161ak na rozd\u00EDl od inositoltrifosf\u00E1tu z\u016Fst\u00E1v\u00E1 ukotven ve fosfolipidov\u00E9 membr\u00E1n\u011B."@cs . . . . . . "\u808C\u9187\u4E09\u78F7\u9178\uFF08\u82F1\u8A9E\uFF1AInositol trisphosphate\uFF0C\u6216\u79F0\u4E3A\u808C\u9187-1,4,5-\u4E09\u78F7\u9178\u6216\u4E09\u78F7\u9178\u808C\u9187\uFF0C\u7B80\u5199\u4E3AInsP3\u6216IP3\uFF09\u5728\u7EC6\u80DE\u4E2D\u4E0E\u7518\u6CB9\u4E8C\u916F\u4E00\u8D77\u88AB\u4F5C\u4E3A\u4FE1\u53F7\u8F6C\u5BFC\u4E0E\u8FC7\u7A0B\u7684\u7B2C\u4E8C\u4FE1\u4F7F\u5206\u5B50\u3002\u808C\u9187\u4E09\u78F7\u9178\u7531\u78F7\u8102\u9176C\u50AC\u5316\uFF08PIP2\uFF09\u6C34\u89E3\u800C\u4EA7\u751F\uFF0C\u6C34\u89E3\u540E\u5269\u4E0B\u7684\u7518\u6CB9\u4E8C\u916F\u505C\u7559\u5728\u7EC6\u80DE\u819C\u4E0A\uFF0C\u800C\u808C\u9187\u4E09\u78F7\u9178\u5219\u662F\u53EF\u6EB6\u6027\u7684\u5E76\u6269\u6563\u5230\u6574\u4E2A\u7EC6\u80DE\u4E4B\u4E2D\u3002"@zh . . . "Inositoltrisfosf\u00E1t (IP3, p\u0159esn\u011Bji inositol-1,4,5-trisfosf\u00E1t) je ve vod\u011B rozpustn\u00FD cukern\u00FD alkohol esterifikovan\u00FD na t\u0159ech m\u00EDstech fosf\u00E1tov\u00FDmi skupinami. Je to v\u00FDznamn\u00FD druh\u00FD posel v bun\u011B\u010Dn\u00E9 signalizaci, kter\u00FD vznik\u00E1 \u010Dinnost\u00ED fosfolip\u00E1zy C z jist\u00E9ho vz\u00E1cn\u011Bj\u0161\u00EDho membr\u00E1nov\u00E9ho fosfolipidu (konkr\u00E9tn\u011B z PIP2). Druh\u00FDm produktem t\u00E9to enzymatick\u00E9 reakce je 1,2-diacylglycerol (DAG), rovn\u011B\u017E druh\u00FD posel, ten v\u0161ak na rozd\u00EDl od inositoltrifosf\u00E1tu z\u016Fst\u00E1v\u00E1 ukotven ve fosfolipidov\u00E9 membr\u00E1n\u011B. IP3 difunduje po sv\u00E9m vzniku po cel\u00E9 bu\u0148ce a v\u00E1\u017Ee se na endoplazmatick\u00E9 retikulum, konkr\u00E9tn\u011B na ligandem \u0159\u00EDzen\u00FD iontov\u00FD kan\u00E1l. Jedn\u00E1 se o IP3-dependentn\u00ED v\u00E1pn\u00EDkov\u00FD kan\u00E1l, kter\u00FD se po nav\u00E1z\u00E1n\u00ED IP3 otev\u0159e a do cytosolu za\u010Dnou proudit v\u00E1pn\u00EDkov\u00E9 ionty. To zp\u016Fsob\u00ED dal\u0161\u00ED p\u0159enos sign\u00E1lu, obvykle pomoc\u00ED v\u00E1pn\u00EDku a DAG toti\u017E dojde k aktivaci proteinkin\u00E1zy C, kter\u00E1 m\u016F\u017Ee m\u00EDt r\u016Fznou funkci v z\u00E1vislosti na typu bu\u0148ky. N\u00E1sledn\u011B je inositoltrifosf\u00E1t rychle bu\u010F fosforylov\u00E1n na , nebo defosforylov\u00E1n na , aby \u00FAnik v\u00E1pn\u00EDku z ER nepokra\u010Doval."@cs . . . "\u0625\u064A\u0646\u0648\u0632\u064A\u062A\u0648\u0644 \u062B\u0644\u0627\u062B\u064A \u0627\u0644\u0641\u0633\u0641\u0627\u062A \u0623\u0648 \u0625\u064A\u0646\u0648\u0632\u064A\u062A\u0648\u0644 5,4,1 \u062B\u0644\u0627\u062B\u064A \u0627\u0644\u0641\u0648\u0633\u0641\u0627\u062A \u0648\u0627\u062E\u062A\u0635\u0627\u0631\u0627 (IP3) \u0647\u0648 \u062C\u0632\u064A\u0621 \u0625\u064A\u0646\u0648\u0632\u064A\u062A\u0648\u0644 \u0641\u0648\u0633\u0641\u0627\u062A\u064A \u0644\u0647 \u062F\u0648\u0631 \u0641\u064A \u0645\u0633\u0627\u0631 \u0646\u0642\u0644 \u0627\u0644\u0625\u0634\u0627\u0631\u0629. \u064A\u062A\u0645 \u062A\u062E\u0644\u064A\u0642\u0647 \u0639\u0628\u0631 \u062D\u0644\u0645\u0623\u0629 (PIP2) -\u0648\u0647\u0648 \u062F\u0647\u0646 \u0641\u0633\u0641\u0648\u0631\u064A \u064A\u062A\u0648\u0627\u062C\u062F \u0641\u064A \u0627\u0644\u063A\u0634\u0627\u0621 \u0627\u0644\u062E\u0644\u0648\u064A- \u0628\u0648\u0627\u0633\u0637\u0629 \u0641\u0648\u0633\u0641\u0648\u0644\u064A\u0628\u0627\u0632 C\u200F (PLC). \u064A\u064F\u0633\u062A\u062E\u062F\u0645 \u0627\u0644\u0625\u064A\u0646\u0648\u0632\u064A\u062A\u0648\u0644 \u062B\u0644\u0627\u062B\u064A \u0627\u0644\u0641\u0633\u0641\u0627\u062A \u0645\u0639 (DAG) \u0643\u0631\u0633\u0648\u0644\u064A\u0646 \u062B\u0627\u0646\u0648\u064A\u064A\u0646 \u0641\u064A \u062A\u0648\u0635\u064A\u0644 \u0627\u0644\u0625\u0634\u0627\u0631\u0629 \u0641\u064A \u0627\u0644\u062E\u0644\u0627\u064A\u0627 \u0627\u0644\u0628\u064A\u0648\u0644\u0648\u062C\u064A\u0629. \u064A\u0628\u0642\u0649 \u062B\u0646\u0627\u0626\u064A \u0627\u0644\u063A\u0644\u064A\u0633\u0631\u064A\u062F \u062F\u0627\u062E\u0644 \u0627\u0644\u063A\u0634\u0627\u0621\u060C \u0623\u0645\u0627 \u0627\u0644\u0625\u064A\u0646\u0648\u0632\u064A\u062A\u0648\u0644 \u062B\u0644\u0627\u062B\u064A \u0627\u0644\u0641\u0633\u0641\u0627\u062A \u0641\u0647\u0648 \u0642\u0627\u0628\u0644 \u0644\u0644\u0627\u0646\u062D\u0644\u0627\u0644 \u0648\u064A\u0646\u062A\u0634\u0631 \u0639\u0628\u0631 \u0627\u0644\u062E\u0644\u064A\u0629\u060C \u0623\u064A\u0646 \u064A\u0631\u062A\u0628\u0637 \u0648\u0647\u0648 \u0642\u0646\u0627\u0629 \u0643\u0627\u0644\u0633\u064A\u0648\u0645 \u0645\u062A\u0648\u0627\u062C\u062F\u0629 \u0639\u0644\u0649 \u063A\u0634\u0627\u0621 \u0627\u0644\u0634\u0628\u0643\u0629 \u0627\u0644\u0625\u0646\u062F\u0648\u0628\u0644\u0627\u0632\u0645\u064A\u0629. \u062D\u064A\u0646 \u064A\u0631\u062A\u0628\u0637 \u0627\u0644\u0625\u064A\u0646\u0648\u0632\u064A\u062A\u0648\u0644 \u062B\u0644\u0627\u062B\u064A \u0627\u0644\u0641\u0633\u0641\u0627\u062A \u0628\u0645\u0633\u062A\u0642\u0628\u0644\u0647\u060C \u064A\u064F\u062D\u0631\u0631 \u0627\u0644\u0643\u0627\u0644\u0633\u064A\u0648\u0645 \u0625\u0644\u0649 \u0627\u0644\u0639\u0635\u0627\u0631\u0629 \u0627\u0644\u062E\u0644\u0648\u064A\u0629 \u0645\u0646\u0634\u0637\u0627 \u0645\u062E\u062A\u0644\u0641 \u0627\u0644\u0625\u0634\u0627\u0631\u0627\u062A \u062F\u0627\u062E\u0644 \u0627\u0644\u062E\u0644\u0648\u064A\u0629 \u0627\u0644\u0645\u0646\u0638\u064E\u0651\u0645\u064E\u0629 \u0628\u0627\u0644\u0643\u0627\u0644\u0633\u064A\u0648\u0645."@ar . "Inositolo trifosfato"@it . . . "Trisfosforan inozytolu (1,4,5-trisfosforan inozytolu, IP3) \u2013 organiczny zwi\u0105zek chemiczny z grupy estr\u00F3w, pochodna inozytolu zawieraj\u0105ca 3 reszty fosforanowe w pozycjach 1, 4 i 5. W organizmach jest mediatorem wewn\u0105trzkom\u00F3rkowym. Jest to przeka\u017Anik po\u015Brednicz\u0105cy w wymianie informacji chemicznej. Stymuluje wzrost st\u0119\u017Cenia jon\u00F3w Ca2+ w cytozolu."@pl . "Inositol trifosfato"@pt . "IP3; Triphosphoinositol; Inositol 1,4,5-trisphosphate"@en . . . . . "IP3; Triphosphoinositol; Inositol 1,4,5-trisphosphate"@en . "\u30A4\u30CE\u30B7\u30C8\u30FC\u30EB\u30C8\u30EA\u30B9\u30EA\u30F3\u9178"@ja . . "Inositol 1,4,5-trisphosphate.svg"@en . . . "O inositol 1,2,4 trisfosfato ou IP3, juntamente com o diacilglicerol, \u00E9 um mensageiro secund\u00E1rio envolvido na transdu\u00E7\u00E3o de sinal em c\u00E9lulas biol\u00F3gicas. \u00C9 formado por hidr\u00F3lise de (PIP2), um fosfol\u00EDpido que est\u00E1 localizado na membrana plasm\u00E1tica, pela fosfolipase C. A sua principal fun\u00E7\u00E3o consiste na mobiliza\u00E7\u00E3o de Ca2+ a partir de organelos onde este est\u00E1 armazenado, e na regula\u00E7\u00E3o da , entre outras reac\u00E7\u00E3o celulares. Por exemplo, na mosca-da-fruta, Drosophila, o IP3 \u00E9 usado na transdu\u00E7\u00E3o intracelular do reconhecimento de luz por c\u00E9lulas do olho. Em c\u00E9lulas da musculatura lisa, o IP3 liga-se e activa o receptor de IP3 existente na membrana do ret\u00EDculo sarcoplasm\u00E1tico, fazendo abrir canais de c\u00E1lcio, resultando na liberta\u00E7\u00E3o de Ca2+ para o sarcoplasma. Este aumento de Ca2+ activa o canal operado pelo receptor de rianodina no reticulo sarcoplasm\u00E1tico, levando ao progressivo aumento da concentra\u00E7\u00E3o de Ca2+ na c\u00E9lula muscular e promovendo a contrac\u00E7\u00E3o da c\u00E9lula muscular."@pt . . . "Trisfosforan inozytolu"@pl . . . . "\u0418\u043D\u043E\u0437\u0438\u0442\u043E\u043B\u0442\u0440\u0438\u0444\u043E\u0441\u0444\u0430\u0442 (IP3) \u2014 \u044D\u0442\u043E \u0432\u043E\u0434\u043E\u0440\u0430\u0441\u0442\u0432\u043E\u0440\u0438\u043C\u044B\u0439 \u0432\u0442\u043E\u0440\u0438\u0447\u043D\u044B\u0439 \u043F\u043E\u0441\u0440\u0435\u0434\u043D\u0438\u043A. IP3 \u043E\u0431\u0440\u0430\u0437\u0443\u0435\u0442\u0441\u044F \u0432 \u0440\u0435\u0437\u0443\u043B\u044C\u0442\u0430\u0442\u0435 \u0440\u0430\u0441\u043F\u0430\u0434\u0430 \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u043D\u044B\u0445 \u0444\u043E\u0441\u0444\u043E\u043B\u0438\u043F\u0438\u0434\u043E\u0432 \u043F\u043E\u0434 \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435\u043C \u0444\u0435\u0440\u043C\u0435\u043D\u0442\u0430 \u0444\u043E\u0441\u0444\u043E\u043B\u0438\u043F\u0430\u0437\u044B \u0421. \u0418\u043D\u043E\u0437\u0438\u0442\u043E\u043B\u0442\u0440\u0438\u0444\u043E\u0441\u0444\u0430\u0442 \u0432\u043C\u0435\u0441\u0442\u0435 \u0441 \u0434\u0438\u0430\u0446\u0438\u043B\u0433\u043B\u0438\u0446\u0435\u0440\u0438\u043D\u043E\u043C \u043F\u0440\u0438\u043D\u0438\u043C\u0430\u0435\u0442 \u0443\u0447\u0430\u0441\u0442\u0438\u0435 \u0432 \u043F\u0435\u0440\u0435\u0434\u0430\u0447\u0435 \u0441\u0438\u0433\u043D\u0430\u043B\u0430 \u0432 \u043A\u043B\u0435\u0442\u043A\u0435. IP3 \u0432\u0437\u0430\u0438\u043C\u043E\u0434\u0435\u0439\u0441\u0442\u0432\u0443\u0435\u0442 \u0441 Ca2+-\u043A\u0430\u043D\u0430\u043B\u0430\u043C\u0438 \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u044B \u044D\u043D\u0434\u043E\u043F\u043B\u0430\u0437\u043C\u0430\u0442\u0438\u0447\u0435\u0441\u043A\u043E\u0433\u043E \u0440\u0435\u0442\u0438\u043A\u0443\u043B\u0443\u043C\u0430, \u0432 \u0440\u0435\u0437\u0443\u043B\u044C\u0442\u0430\u0442\u0435 \u0447\u0435\u0433\u043E \u043F\u0440\u043E\u0438\u0441\u0445\u043E\u0434\u0438\u0442 \u0432\u044B\u0434\u0435\u043B\u0435\u043D\u0438\u0435 \u0438\u043E\u043D\u043E\u0432 \u043A\u0430\u043B\u044C\u0446\u0438\u044F \u0438\u0437 \u042D\u041F\u0420. IP3 \u0442\u0430\u043A\u0436\u0435 \u043F\u0440\u0438\u043D\u0438\u043C\u0430\u0435\u0442 \u0443\u0447\u0430\u0441\u0442\u0438\u0435 \u0432 \u0440\u0435\u0433\u0443\u043B\u044F\u0442\u043E\u0440\u043D\u044B\u0445 \u043F\u0440\u043E\u0446\u0435\u0441\u0441\u0430\u0445, \u0441\u043E\u043F\u0440\u043E\u0432\u043E\u0436\u0434\u0430\u044E\u0449\u0438\u0445 \u043E\u043F\u043B\u043E\u0434\u043E\u0442\u0432\u043E\u0440\u0435\u043D\u0438\u0435 \u044F\u0439\u0446\u0435\u043A\u043B\u0435\u0442\u043A\u0438. \u0410\u0433\u043E\u043D\u0438\u0441\u0442 \u0440\u0435\u0446\u0435\u043F\u0442\u043E\u0440\u0430 IP3 \u2014 \u0430\u0434\u0435\u043D\u043E\u0444\u043E\u0441\u0442\u0438\u043D."@ru . . "Inositol 1,4,5\u2010trisfosfat"@ca . . "1D-myo-inositol 1,4,5-trisphosphate"@en . . . "\u808C\u9187\u4E09\u78F7\u9178"@zh . . . . . . . . . "\u0418\u043D\u043E\u0437\u0438\u0442\u043E\u043B\u0442\u0440\u0438\u0444\u043E\u0441\u0444\u0430\u0442"@ru . . . . . "L'inositolo trifosfato, detto anche inositolo 1,4,5-trisfosfato (abbreviato in IP3) \u00E8, insieme al diacilglicerolo (abbreviato in DAG), un secondo messaggero utilizzato dalla cellula come molecola con la funzione di trasduzione del segnale. Mentre il DAG rimane all'interno della membrana, l'IP3 \u00E8 solubile ed \u00E8 in grado di diffondere attraverso la cellula. L'IP3 \u00E8 prodotto dall'idrolisi, per azione della fosfolipasi C, del fosfatidilinositolo 4,5-bisfosfato (PIP2), un fosfolipide localizzato all'interno della membrana cellulare. L'IP3, una volta prodotto, lega ed attiva il recettore dell'inositolo trifosfato, una grossa proteina canale che si trova sulla superficie del reticolo endoplasmatico. Il suo legame con questa proteina permette la sua apertura ed il rilascio di calcio che fluisce all'interno del citoplasma.Le azioni molecolari che ne derivano sono molteplici. Basti pensare che tramite il suo legame con una singola molecola effettrice, la proteina calmodulina, lo ione calcio \u00E8 capace di condizionare pi\u00F9 di trenta enzimi intracellulari legati al metabolismo, alla trasduzione del segnale o alla produzione di energia. Sono molti gli ormoni ed i neurotrasmettitori che innescano la produzione di IP3 dopo interazione con i loro recettori. Esempi classici includono la serotonina, la noradrenalina, l'istamina, la colecistochinina, la bradichinina e l'angiotensina."@it . "1"^^ . . . . . . . . . . . . . . . . . . . "\u0625\u064A\u0646\u0648\u0632\u064A\u062A\u0648\u0644 \u062B\u0644\u0627\u062B\u064A \u0627\u0644\u0641\u0633\u0641\u0627\u062A \u0623\u0648 \u0625\u064A\u0646\u0648\u0632\u064A\u062A\u0648\u0644 5,4,1 \u062B\u0644\u0627\u062B\u064A \u0627\u0644\u0641\u0648\u0633\u0641\u0627\u062A \u0648\u0627\u062E\u062A\u0635\u0627\u0631\u0627 (IP3) \u0647\u0648 \u062C\u0632\u064A\u0621 \u0625\u064A\u0646\u0648\u0632\u064A\u062A\u0648\u0644 \u0641\u0648\u0633\u0641\u0627\u062A\u064A \u0644\u0647 \u062F\u0648\u0631 \u0641\u064A \u0645\u0633\u0627\u0631 \u0646\u0642\u0644 \u0627\u0644\u0625\u0634\u0627\u0631\u0629. \u064A\u062A\u0645 \u062A\u062E\u0644\u064A\u0642\u0647 \u0639\u0628\u0631 \u062D\u0644\u0645\u0623\u0629 (PIP2) -\u0648\u0647\u0648 \u062F\u0647\u0646 \u0641\u0633\u0641\u0648\u0631\u064A \u064A\u062A\u0648\u0627\u062C\u062F \u0641\u064A \u0627\u0644\u063A\u0634\u0627\u0621 \u0627\u0644\u062E\u0644\u0648\u064A- \u0628\u0648\u0627\u0633\u0637\u0629 \u0641\u0648\u0633\u0641\u0648\u0644\u064A\u0628\u0627\u0632 C\u200F (PLC). \u064A\u064F\u0633\u062A\u062E\u062F\u0645 \u0627\u0644\u0625\u064A\u0646\u0648\u0632\u064A\u062A\u0648\u0644 \u062B\u0644\u0627\u062B\u064A \u0627\u0644\u0641\u0633\u0641\u0627\u062A \u0645\u0639 (DAG) \u0643\u0631\u0633\u0648\u0644\u064A\u0646 \u062B\u0627\u0646\u0648\u064A\u064A\u0646 \u0641\u064A \u062A\u0648\u0635\u064A\u0644 \u0627\u0644\u0625\u0634\u0627\u0631\u0629 \u0641\u064A \u0627\u0644\u062E\u0644\u0627\u064A\u0627 \u0627\u0644\u0628\u064A\u0648\u0644\u0648\u062C\u064A\u0629. \u064A\u0628\u0642\u0649 \u062B\u0646\u0627\u0626\u064A \u0627\u0644\u063A\u0644\u064A\u0633\u0631\u064A\u062F \u062F\u0627\u062E\u0644 \u0627\u0644\u063A\u0634\u0627\u0621\u060C \u0623\u0645\u0627 \u0627\u0644\u0625\u064A\u0646\u0648\u0632\u064A\u062A\u0648\u0644 \u062B\u0644\u0627\u062B\u064A \u0627\u0644\u0641\u0633\u0641\u0627\u062A \u0641\u0647\u0648 \u0642\u0627\u0628\u0644 \u0644\u0644\u0627\u0646\u062D\u0644\u0627\u0644 \u0648\u064A\u0646\u062A\u0634\u0631 \u0639\u0628\u0631 \u0627\u0644\u062E\u0644\u064A\u0629\u060C \u0623\u064A\u0646 \u064A\u0631\u062A\u0628\u0637 \u0648\u0647\u0648 \u0642\u0646\u0627\u0629 \u0643\u0627\u0644\u0633\u064A\u0648\u0645 \u0645\u062A\u0648\u0627\u062C\u062F\u0629 \u0639\u0644\u0649 \u063A\u0634\u0627\u0621 \u0627\u0644\u0634\u0628\u0643\u0629 \u0627\u0644\u0625\u0646\u062F\u0648\u0628\u0644\u0627\u0632\u0645\u064A\u0629. \u062D\u064A\u0646 \u064A\u0631\u062A\u0628\u0637 \u0627\u0644\u0625\u064A\u0646\u0648\u0632\u064A\u062A\u0648\u0644 \u062B\u0644\u0627\u062B\u064A \u0627\u0644\u0641\u0633\u0641\u0627\u062A \u0628\u0645\u0633\u062A\u0642\u0628\u0644\u0647\u060C \u064A\u064F\u062D\u0631\u0631 \u0627\u0644\u0643\u0627\u0644\u0633\u064A\u0648\u0645 \u0625\u0644\u0649 \u0627\u0644\u0639\u0635\u0627\u0631\u0629 \u0627\u0644\u062E\u0644\u0648\u064A\u0629 \u0645\u0646\u0634\u0637\u0627 \u0645\u062E\u062A\u0644\u0641 \u0627\u0644\u0625\u0634\u0627\u0631\u0627\u062A \u062F\u0627\u062E\u0644 \u0627\u0644\u062E\u0644\u0648\u064A\u0629 \u0627\u0644\u0645\u0646\u0638\u064E\u0651\u0645\u064E\u0629 \u0628\u0627\u0644\u0643\u0627\u0644\u0633\u064A\u0648\u0645."@ar . . "\u30A4\u30CE\u30B7\u30C8\u30FC\u30EB\u30C8\u30EA\u30B9\u30EA\u30F3\u9178\uFF08\u82F1: Inositol trisphosphate, IP3\uFF09\u306F\u3001\u30A4\u30CE\u30B7\u30C8\u30FC\u30EB\u306B3\u3064\u306E\u30EA\u30F3\u9178\u304C\u30A8\u30B9\u30C6\u30EB\u7D50\u5408\u3057\u305F\u5316\u5B66\u7269\u8CEA\u3002\u30B8\u30A2\u30B7\u30EB\u30B0\u30EA\u30BB\u30ED\u30FC\u30EB\u3068\u5171\u306B\u3001\u7D30\u80DE\u306E\u30B7\u30B0\u30CA\u30EB\u4F1D\u9054\u306B\u304A\u3044\u3066\u30BB\u30AB\u30F3\u30C9\u30E1\u30C3\u30BB\u30F3\u30B8\u30E3\u30FC\u306E1\u3064\u3068\u3057\u3066\u751F\u4F53\u306B\u5229\u7528\u3055\u308C\u3066\u3044\u308B\u3002\u307E\u305F\u3001\u8102\u8CEA\u30E1\u30C7\u30A3\u30A8\u30FC\u30BF\u30FC\u3068\u3057\u3066\u3082\u4F7F\u308F\u308C\u308B\u3002 \u7D30\u80DE\u819C\u306B\u5B58\u5728\u3059\u308B\u30EA\u30F3\u8102\u8CEA\u3067\u3042\u308B\u30DB\u30B9\u30D5\u30A1\u30C1\u30B8\u30EB\u30A4\u30CE\u30B7\u30C8\u30FC\u30EB4,5-\u30D3\u30B9\u30EA\u30F3\u9178\u304C\u30DB\u30B9\u30DB\u30EA\u30D1\u30FC\u30BCC\u306B\u3088\u3063\u3066\u52A0\u6C34\u5206\u89E3\u3055\u308C\u308B\u3068\u3001IP3\u3068\u30B8\u30A2\u30B7\u30EB\u30B0\u30EA\u30BB\u30ED\u30FC\u30EB\u304C\u751F\u6210\u3059\u308B\u3002\u3053\u306E\u3046\u3061\u3001\u6BD4\u8F03\u7684\u8102\u6EB6\u6027\u306E\u9AD8\u3044\u30B8\u30A2\u30B7\u30EB\u30B0\u30EA\u30BB\u30ED\u30FC\u30EB\u306F\u7D30\u80DE\u819C\u306E\u4E2D\u306B\u5B58\u5728\u3059\u308B\u306E\u306B\u5BFE\u3057\u3001IP3\u306F\u6C34\u6EB6\u6027\u3067\u3042\u308B\u305F\u3081\u7D30\u80DE\u8CEA\u306B\u62E1\u6563\u3059\u308B\u3002"@ja . . "The inositol trisphosphate trianion"@en . . . "Inositol trisphosphate"@fr . "Inositol trisphosphate or inositol 1,4,5-trisphosphate abbreviated InsP3 or Ins3P or IP3 is an inositol phosphate signaling molecule. It is made by hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2), a phospholipid that is located in the plasma membrane, by phospholipase C (PLC).Together with diacylglycerol (DAG), IP3 is a second messenger molecule used in signal transduction in biological cells. While DAG stays inside the membrane, IP3 is soluble and diffuses through the cell, where it binds to its receptor, which is a calcium channel located in the endoplasmic reticulum. When IP3 binds its receptor, calcium is released into the cytosol, thereby activating various calcium regulated intracellular signals."@en . . "\u0625\u064A\u0646\u0648\u0632\u064A\u062A\u0648\u0644 \u062B\u0644\u0627\u062B\u064A \u0627\u0644\u0641\u0633\u0641\u0627\u062A"@ar . "L'inositol 1,4,5\u2010trisfosfat o trifosfoinositol (abreujat insp\u2083 o IP\u2083), \u00E9s un segon missatger de la transducci\u00F3 de senyal cel\u00B7lular. Es produeix, juntament amb el diacilglicerol, per hidr\u00F2lisi catalitzada mitjan\u00E7ant la fosfolipasa C del (PIP 2 ), un fosfol\u00EDpid de membrana. El seu efecte en l'entorn cel\u00B7lular \u00E9s la mobilitzaci\u00F3 del Ca 2 + , emmagatzemat en org\u00E0nuls com el reticle endoplasm\u00E0tic."@ca . . . . . . . . . . . . "\u808C\u9187\u4E09\u78F7\u9178\uFF08\u82F1\u8A9E\uFF1AInositol trisphosphate\uFF0C\u6216\u79F0\u4E3A\u808C\u9187-1,4,5-\u4E09\u78F7\u9178\u6216\u4E09\u78F7\u9178\u808C\u9187\uFF0C\u7B80\u5199\u4E3AInsP3\u6216IP3\uFF09\u5728\u7EC6\u80DE\u4E2D\u4E0E\u7518\u6CB9\u4E8C\u916F\u4E00\u8D77\u88AB\u4F5C\u4E3A\u4FE1\u53F7\u8F6C\u5BFC\u4E0E\u8FC7\u7A0B\u7684\u7B2C\u4E8C\u4FE1\u4F7F\u5206\u5B50\u3002\u808C\u9187\u4E09\u78F7\u9178\u7531\u78F7\u8102\u9176C\u50AC\u5316\uFF08PIP2\uFF09\u6C34\u89E3\u800C\u4EA7\u751F\uFF0C\u6C34\u89E3\u540E\u5269\u4E0B\u7684\u7518\u6CB9\u4E8C\u916F\u505C\u7559\u5728\u7EC6\u80DE\u819C\u4E0A\uFF0C\u800C\u808C\u9187\u4E09\u78F7\u9178\u5219\u662F\u53EF\u6EB6\u6027\u7684\u5E76\u6269\u6563\u5230\u6574\u4E2A\u7EC6\u80DE\u4E4B\u4E2D\u3002"@zh . . . "18871"^^ . "\u0418\u043D\u043E\u0437\u0438\u0442\u043E\u043B\u0442\u0440\u0438\u0444\u043E\u0441\u0444\u0430\u0442 (IP3) \u2014 \u044D\u0442\u043E \u0432\u043E\u0434\u043E\u0440\u0430\u0441\u0442\u0432\u043E\u0440\u0438\u043C\u044B\u0439 \u0432\u0442\u043E\u0440\u0438\u0447\u043D\u044B\u0439 \u043F\u043E\u0441\u0440\u0435\u0434\u043D\u0438\u043A. IP3 \u043E\u0431\u0440\u0430\u0437\u0443\u0435\u0442\u0441\u044F \u0432 \u0440\u0435\u0437\u0443\u043B\u044C\u0442\u0430\u0442\u0435 \u0440\u0430\u0441\u043F\u0430\u0434\u0430 \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u043D\u044B\u0445 \u0444\u043E\u0441\u0444\u043E\u043B\u0438\u043F\u0438\u0434\u043E\u0432 \u043F\u043E\u0434 \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435\u043C \u0444\u0435\u0440\u043C\u0435\u043D\u0442\u0430 \u0444\u043E\u0441\u0444\u043E\u043B\u0438\u043F\u0430\u0437\u044B \u0421. \u0418\u043D\u043E\u0437\u0438\u0442\u043E\u043B\u0442\u0440\u0438\u0444\u043E\u0441\u0444\u0430\u0442 \u0432\u043C\u0435\u0441\u0442\u0435 \u0441 \u0434\u0438\u0430\u0446\u0438\u043B\u0433\u043B\u0438\u0446\u0435\u0440\u0438\u043D\u043E\u043C \u043F\u0440\u0438\u043D\u0438\u043C\u0430\u0435\u0442 \u0443\u0447\u0430\u0441\u0442\u0438\u0435 \u0432 \u043F\u0435\u0440\u0435\u0434\u0430\u0447\u0435 \u0441\u0438\u0433\u043D\u0430\u043B\u0430 \u0432 \u043A\u043B\u0435\u0442\u043A\u0435. IP3 \u0432\u0437\u0430\u0438\u043C\u043E\u0434\u0435\u0439\u0441\u0442\u0432\u0443\u0435\u0442 \u0441 Ca2+-\u043A\u0430\u043D\u0430\u043B\u0430\u043C\u0438 \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u044B \u044D\u043D\u0434\u043E\u043F\u043B\u0430\u0437\u043C\u0430\u0442\u0438\u0447\u0435\u0441\u043A\u043E\u0433\u043E \u0440\u0435\u0442\u0438\u043A\u0443\u043B\u0443\u043C\u0430, \u0432 \u0440\u0435\u0437\u0443\u043B\u044C\u0442\u0430\u0442\u0435 \u0447\u0435\u0433\u043E \u043F\u0440\u043E\u0438\u0441\u0445\u043E\u0434\u0438\u0442 \u0432\u044B\u0434\u0435\u043B\u0435\u043D\u0438\u0435 \u0438\u043E\u043D\u043E\u0432 \u043A\u0430\u043B\u044C\u0446\u0438\u044F \u0438\u0437 \u042D\u041F\u0420. IP3 \u0442\u0430\u043A\u0436\u0435 \u043F\u0440\u0438\u043D\u0438\u043C\u0430\u0435\u0442 \u0443\u0447\u0430\u0441\u0442\u0438\u0435 \u0432 \u0440\u0435\u0433\u0443\u043B\u044F\u0442\u043E\u0440\u043D\u044B\u0445 \u043F\u0440\u043E\u0446\u0435\u0441\u0441\u0430\u0445, \u0441\u043E\u043F\u0440\u043E\u0432\u043E\u0436\u0434\u0430\u044E\u0449\u0438\u0445 \u043E\u043F\u043B\u043E\u0434\u043E\u0442\u0432\u043E\u0440\u0435\u043D\u0438\u0435 \u044F\u0439\u0446\u0435\u043A\u043B\u0435\u0442\u043A\u0438. \u0410\u0433\u043E\u043D\u0438\u0441\u0442 \u0440\u0435\u0446\u0435\u043F\u0442\u043E\u0440\u0430 IP3 \u2014 \u0430\u0434\u0435\u043D\u043E\u0444\u043E\u0441\u0442\u0438\u043D."@ru . "[(1R,2S,3R,4R,5S,6R)-2,3,5-trihydroxy-4,6-diphosphonooxycyclohexyl]dihydrogen phosphate"@en . . . "Inositol trisfosfato, inositol 1,4,5-trisfosfato o trifosfoinositol (abreviado InsP3 o IP3), es un segundo mensajero de la transducci\u00F3n de se\u00F1al celular. Se produce, junto con el diacilglicerol, por hidr\u00F3lisis catalizada mediante la fosfolipasa C del fosfatidilinositol 4,5-bifosfato (PIP2) , un fosfol\u00EDpido de membrana. Su efecto en el entorno celular es la movilizaci\u00F3n del Ca2+, almacenado en org\u00E1nulos como el ret\u00EDculo endoplasm\u00E1tico y en el aparato de Golgi.\u200B"@es . . . . "L'inositol 1,4,5\u2010trisfosfat o trifosfoinositol (abreujat insp\u2083 o IP\u2083), \u00E9s un segon missatger de la transducci\u00F3 de senyal cel\u00B7lular. Es produeix, juntament amb el diacilglicerol, per hidr\u00F2lisi catalitzada mitjan\u00E7ant la fosfolipasa C del (PIP 2 ), un fosfol\u00EDpid de membrana. El seu efecte en l'entorn cel\u00B7lular \u00E9s la mobilitzaci\u00F3 del Ca 2 + , emmagatzemat en org\u00E0nuls com el reticle endoplasm\u00E0tic."@ca . .