. . . "Osificaci\u00F3n intramembranosa\u200B es uno de los dos procesos esenciales durante el desarrollo fetal del esqueleto de mam\u00EDferos para formar tejido \u00F3seo, y en particular huesos planos.\u200B A diferencia de la osificaci\u00F3n endocondral, que es el otro proceso, el cart\u00EDlago no est\u00E1 presente durante la osificaci\u00F3n intramembranosa, sino que ocurre dentro de una membrana de tejido conjuntivo.\u200B Tambi\u00E9n es un proceso esencial durante la curaci\u00F3n natural de las fracturas \u00F3seas\u200B y la formaci\u00F3n rudimentaria de huesos de la cabeza humana.\u200B"@es . . . . . . . . . . . "Ossifica\u00E7\u00E3o intramembranosa"@pt . "Intramembranous ossification is one of the two essential processes during fetal development of the gnathostome (excluding chondrichthyans such as sharks) skeletal system by which rudimentary bone tissue is created.Intramembranous ossification is also an essential process during the natural healing of bone fractures and the rudimentary formation of bones of the head. Unlike endochondral ossification, which is the other process by which bone tissue is created during fetal development, cartilage is not present during intramembranous ossification."@en . . . . . . "\u062A\u0639\u0638\u0645 \u063A\u0634\u0627\u0626\u064A"@ar . . . . . . "1311539"^^ . . . . . . . . . . . . . "L\u2019ossification endoconjonctive ou endomembraneuse est le processus de construction des os plats (os cr\u00E2nien, scapula\u2026). Elle permet \u00E9galement la croissance en \u00E9paisseur des os longs (f\u00E9mur, hum\u00E9rus\u2026). Le m\u00E9senchyme embryonnaire se transforme en un tissu richement vascularis\u00E9 (angiog\u00E9n\u00E8se). Les cellules m\u00E9senchymateuses de type fibroblastique, incluses dans la matrice extracellulaire riche en collag\u00E8ne, s'agr\u00E8gent. Ces cellules m\u00E9senchymateuses se diff\u00E9rencient et acqui\u00E8rent un ph\u00E9notype ost\u00E9oblastique. Elles se mettent alors \u00E0 s\u00E9cr\u00E9ter des prot\u00E9ines qui constituant la matrice osseuse . De nombreux foyers d\u2019ossification se d\u00E9veloppent, fusionnent et forment par anastomose un r\u00E9seau de trav\u00E9es, formant une structure ressemblant \u00E0 une \u00E9ponge, d\u2019o\u00F9 son nom d\u2019os spongieux. Cet os a une structure tiss\u00E9e contrastant avec l\u2019os lamellaire rencontr\u00E9 plus tard chez l\u2019adulte lors du remodelage de l\u2019os. Le phosphate de calcium sous forme de cristaux d\u2019hydroxyapatite (ou ossopan) [Ca10(PO4)6(OH)2] est le facteur essentiel de la min\u00E9ralisation des prot\u00E9ines s\u00E9cr\u00E9t\u00E9es (collag\u00E8ne de type I, ost\u00E9ocalcine, ost\u00E9opontine, ost\u00E9onectine et phosphatase alcalines) par les ost\u00E9oblastes. Cette min\u00E9ralisation conduit \u00E0 l\u2019emprisonnement des ost\u00E9oblastes en ost\u00E9ocytes et \u00E0 celles de la vascularisation qui devient un tissu h\u00E9matopo\u00EF\u00E9tique. Les ost\u00E9ocytes restent connect\u00E9s entre eux par des canalicules. Les stades finaux incluent la conversion de l\u2019os spongieux en os lamellaire ; les fibres de collag\u00E8ne nouvellement synth\u00E9tis\u00E9es s\u2019alignent en faisceaux parall\u00E8les. Ces lamelles s\u2019organisent de mani\u00E8re concentrique autour d\u2019un vaisseau central log\u00E9 dans le canal de Havers et forment des ost\u00E9ones ou syst\u00E8me haversien. Les os membranaires (ou dermiques) gardent leur structure spongieuse au centre, le diplo\u00E9 compris entre les deux lames d\u2019os lamellaire de la bo\u00EEte cr\u00E2nienne. Le p\u00E9rioste et l\u2019endoste r\u00E9sultent de la min\u00E9ralisation des couches de tissus conjonctifs des couches externes et internes."@fr . "Intramembranous ossification is one of the two essential processes during fetal development of the gnathostome (excluding chondrichthyans such as sharks) skeletal system by which rudimentary bone tissue is created.Intramembranous ossification is also an essential process during the natural healing of bone fractures and the rudimentary formation of bones of the head. Unlike endochondral ossification, which is the other process by which bone tissue is created during fetal development, cartilage is not present during intramembranous ossification."@en . "1081250504"^^ . "A ossifica\u00E7\u00E3o intramembranosa \u00E9 um dos dois tipos de forma\u00E7\u00E3o \u00F3ssea existentes e \u00E9 respons\u00E1vel pelo desenvolvimento dos ossos chatos ou laminados, especialmente aqueles que se encontram no cr\u00E2nio. Esse tipo de ossifica\u00E7\u00E3o acontece no interior das membranas do tecido conjuntivo, o chamado centro de ossifica\u00E7\u00E3o prim\u00E1ria. As c\u00E9lulas mesenquim\u00E1ticas se diferenciam em osteoblastos. Estes, por sua vez, sintetizam osteoides (matriz \u00F3ssea rec\u00E9m-sintetizada), que se mineralizam, dando origem aos oste\u00F3citos. V\u00E1rios desses centros de ossifica\u00E7\u00E3o acontecem simultaneamente dentro de uma membrana de tecido conjuntivo. Desse modo, as traves \u00F3sseas formadas d\u00E3o aspecto esponjoso ao osso, propiciando a penetra\u00E7\u00E3o de vasos sangu\u00EDneos nessas cavidades formadas, originando a medula \u00F3ssea. A parte da membrana conjuntiva que n\u00E3o sofre ossifica\u00E7\u00E3o passa a constituir o end\u00F3steo e o peri\u00F3steo, para dentro e para fora. Enquanto na ossifica\u00E7\u00E3o endocondral ocorre o desenvolvimento \u00F3sseo do centro para as extremidades, na intramembranosa ocorre de forma diferente, partindo de n\u00FAcleos de ossifica\u00E7\u00E3o, que se expandem e se juntam ao longo do tempo. O cr\u00E2nio, por exemplo, ossifica desta maneira. Por esse motivo, deve-se tomar cuidado ao pegar na cabe\u00E7a dos rec\u00E9m-nascidos (fontanelas) para n\u00E3o afetar o enc\u00E9falo que ainda n\u00E3o est\u00E1 totalmente protegido."@pt . "\u0627\u0644\u062A\u0639\u0638\u0645 \u0627\u0644\u063A\u0634\u0627\u0626\u064A (\u0628\u0627\u0644\u0625\u0646\u062C\u0644\u064A\u0632\u064A\u0629: Intramembranous ossification)\u200F\u060C \u0647\u0648 \u0648\u0627\u062D\u062F \u0645\u0646 \u0639\u0645\u0644\u064A\u062A\u064A\u0646 \u0623\u0633\u0627\u0633\u064A\u062A\u064A\u0646 \u062A\u062D\u062F\u062B\u0627\u0646 \u0623\u062B\u0646\u0627\u0621 \u0627\u0644\u062A\u0637\u0648\u0631 \u0627\u0644\u062C\u0646\u064A\u0646\u064A \u0644 ganthostome (\u0628\u0627\u0633\u062A\u062B\u0646\u0627\u0621 chondrichthyans \u0645\u062B\u0644 \u0623\u0633\u0645\u0627\u0643 \u0627\u0644\u0642\u0631\u0634)\u060C \u0648\u0627\u0644\u062C\u0647\u0627\u0632 \u0627\u0644\u0647\u064A\u0643\u0644\u064A \u062D\u064A\u062B \u0628\u0648\u0627\u0633\u0637\u062A\u0647 \u062A\u062A\u0643\u0648\u0646 \u0628\u0642\u0627\u064A\u0627 \u0623\u0646\u0633\u062C\u0629 \u0627\u0644\u0639\u0638\u0645. \u0627\u0644\u062A\u0639\u0638\u0645 \u0627\u0644\u063A\u0634\u0627\u0626\u064A \u0647\u0648 \u0623\u064A\u0636\u0627 \u0639\u0645\u0644\u064A\u0629 \u0636\u0631\u0648\u0631\u064A\u0629 \u0623\u062B\u0646\u0627\u0621 \u0627\u0644\u0627\u0644\u062A\u0626\u0627\u0645 \u0627\u0644\u0637\u0628\u064A\u0639\u064A \u0644\u0643\u0633\u0648\u0631 \u0627\u0644\u0639\u0638\u0627\u0645\u060C \u0648\u0627\u0644\u062A\u0634\u0643\u064A\u0644 \u0627\u0644\u0628\u062F\u0627\u0626\u064A \u0644\u0631\u0623\u0633 \u0627\u0644\u0639\u0638\u0645.\u0639\u0644\u064A \u0627\u0644\u0639\u0643\u0633 \u0645\u0646 \u0627\u0644\u062A\u0639\u0638\u0645 \u062F\u0627\u062E\u0644 \u0627\u0644\u063A\u0636\u0631\u0648\u0641\u060C \u062D\u064A\u062B \u0623\u0646\u0647\u0627 \u0639\u0645\u0644\u064A\u0629 \u064A\u062A\u0645 \u0628\u0648\u0627\u0633\u0637\u062A\u0647\u0627 \u062A\u0643\u0648\u064A\u0646 \u0623\u0646\u0633\u062C\u0629 \u0627\u0644\u0639\u0638\u0645 \u062E\u0644\u0627\u0644 \u0646\u0645\u0648 \u0627\u0644\u062C\u0646\u064A\u0646\u060C \u0627\u0644\u063A\u0636\u0631\u0648\u0641 \u063A\u064A\u0631 \u0645\u0648\u062C\u0648\u062F \u0623\u062B\u0646\u0627\u0621 \u0627\u0644\u062A\u0639\u0638\u0645 \u0627\u0644\u063A\u0634\u0627\u0626\u064A."@ar . . . . "Intramembranous ossification"@en . "\u0627\u0644\u062A\u0639\u0638\u0645 \u0627\u0644\u063A\u0634\u0627\u0626\u064A (\u0628\u0627\u0644\u0625\u0646\u062C\u0644\u064A\u0632\u064A\u0629: Intramembranous ossification)\u200F\u060C \u0647\u0648 \u0648\u0627\u062D\u062F \u0645\u0646 \u0639\u0645\u0644\u064A\u062A\u064A\u0646 \u0623\u0633\u0627\u0633\u064A\u062A\u064A\u0646 \u062A\u062D\u062F\u062B\u0627\u0646 \u0623\u062B\u0646\u0627\u0621 \u0627\u0644\u062A\u0637\u0648\u0631 \u0627\u0644\u062C\u0646\u064A\u0646\u064A \u0644 ganthostome (\u0628\u0627\u0633\u062A\u062B\u0646\u0627\u0621 chondrichthyans \u0645\u062B\u0644 \u0623\u0633\u0645\u0627\u0643 \u0627\u0644\u0642\u0631\u0634)\u060C \u0648\u0627\u0644\u062C\u0647\u0627\u0632 \u0627\u0644\u0647\u064A\u0643\u0644\u064A \u062D\u064A\u062B \u0628\u0648\u0627\u0633\u0637\u062A\u0647 \u062A\u062A\u0643\u0648\u0646 \u0628\u0642\u0627\u064A\u0627 \u0623\u0646\u0633\u062C\u0629 \u0627\u0644\u0639\u0638\u0645. \u0627\u0644\u062A\u0639\u0638\u0645 \u0627\u0644\u063A\u0634\u0627\u0626\u064A \u0647\u0648 \u0623\u064A\u0636\u0627 \u0639\u0645\u0644\u064A\u0629 \u0636\u0631\u0648\u0631\u064A\u0629 \u0623\u062B\u0646\u0627\u0621 \u0627\u0644\u0627\u0644\u062A\u0626\u0627\u0645 \u0627\u0644\u0637\u0628\u064A\u0639\u064A \u0644\u0643\u0633\u0648\u0631 \u0627\u0644\u0639\u0638\u0627\u0645\u060C \u0648\u0627\u0644\u062A\u0634\u0643\u064A\u0644 \u0627\u0644\u0628\u062F\u0627\u0626\u064A \u0644\u0631\u0623\u0633 \u0627\u0644\u0639\u0638\u0645.\u0639\u0644\u064A \u0627\u0644\u0639\u0643\u0633 \u0645\u0646 \u0627\u0644\u062A\u0639\u0638\u0645 \u062F\u0627\u062E\u0644 \u0627\u0644\u063A\u0636\u0631\u0648\u0641\u060C \u062D\u064A\u062B \u0623\u0646\u0647\u0627 \u0639\u0645\u0644\u064A\u0629 \u064A\u062A\u0645 \u0628\u0648\u0627\u0633\u0637\u062A\u0647\u0627 \u062A\u0643\u0648\u064A\u0646 \u0623\u0646\u0633\u062C\u0629 \u0627\u0644\u0639\u0638\u0645 \u062E\u0644\u0627\u0644 \u0646\u0645\u0648 \u0627\u0644\u062C\u0646\u064A\u0646\u060C \u0627\u0644\u063A\u0636\u0631\u0648\u0641 \u063A\u064A\u0631 \u0645\u0648\u062C\u0648\u062F \u0623\u062B\u0646\u0627\u0621 \u0627\u0644\u062A\u0639\u0638\u0645 \u0627\u0644\u063A\u0634\u0627\u0626\u064A."@ar . . . "L\u2019ossification endoconjonctive ou endomembraneuse est le processus de construction des os plats (os cr\u00E2nien, scapula\u2026). Elle permet \u00E9galement la croissance en \u00E9paisseur des os longs (f\u00E9mur, hum\u00E9rus\u2026). Le m\u00E9senchyme embryonnaire se transforme en un tissu richement vascularis\u00E9 (angiog\u00E9n\u00E8se). Les cellules m\u00E9senchymateuses de type fibroblastique, incluses dans la matrice extracellulaire riche en collag\u00E8ne, s'agr\u00E8gent. Ces cellules m\u00E9senchymateuses se diff\u00E9rencient et acqui\u00E8rent un ph\u00E9notype ost\u00E9oblastique. Elles se mettent alors \u00E0 s\u00E9cr\u00E9ter des prot\u00E9ines qui constituant la matrice osseuse . De nombreux foyers d\u2019ossification se d\u00E9veloppent, fusionnent et forment par anastomose un r\u00E9seau de trav\u00E9es, formant une structure ressemblant \u00E0 une \u00E9ponge, d\u2019o\u00F9 son nom d\u2019os spongieux. Cet os a une structur"@fr . . "A ossifica\u00E7\u00E3o intramembranosa \u00E9 um dos dois tipos de forma\u00E7\u00E3o \u00F3ssea existentes e \u00E9 respons\u00E1vel pelo desenvolvimento dos ossos chatos ou laminados, especialmente aqueles que se encontram no cr\u00E2nio. Esse tipo de ossifica\u00E7\u00E3o acontece no interior das membranas do tecido conjuntivo, o chamado centro de ossifica\u00E7\u00E3o prim\u00E1ria. As c\u00E9lulas mesenquim\u00E1ticas se diferenciam em osteoblastos. Estes, por sua vez, sintetizam osteoides (matriz \u00F3ssea rec\u00E9m-sintetizada), que se mineralizam, dando origem aos oste\u00F3citos. V\u00E1rios desses centros de ossifica\u00E7\u00E3o acontecem simultaneamente dentro de uma membrana de tecido conjuntivo. Desse modo, as traves \u00F3sseas formadas d\u00E3o aspecto esponjoso ao osso, propiciando a penetra\u00E7\u00E3o de vasos sangu\u00EDneos nessas cavidades formadas, originando a medula \u00F3ssea. A parte da membrana "@pt . . . "Osificaci\u00F3n intramembranosa"@es . . . . . . . . . . . . . . "9063"^^ . . . . . . . . . . . . "Ossification endoconjonctive"@fr . . . . . . . "Osificaci\u00F3n intramembranosa\u200B es uno de los dos procesos esenciales durante el desarrollo fetal del esqueleto de mam\u00EDferos para formar tejido \u00F3seo, y en particular huesos planos.\u200B A diferencia de la osificaci\u00F3n endocondral, que es el otro proceso, el cart\u00EDlago no est\u00E1 presente durante la osificaci\u00F3n intramembranosa, sino que ocurre dentro de una membrana de tejido conjuntivo.\u200B Tambi\u00E9n es un proceso esencial durante la curaci\u00F3n natural de las fracturas \u00F3seas\u200B y la formaci\u00F3n rudimentaria de huesos de la cabeza humana.\u200B"@es . . . . . . . . . . . . .