"JUNQ\u3068IPOD"@ja . . . . . . . . . . . . . "JUNQ and IPOD are types of cytosolic protein inclusion bodies in eukaryotes. Neurodegenerative diseases, such as Parkinson's, Alzheimer's, and Huntington's, are associated and correlated with protein aggregation and accumulation of misfolded proteins in inclusion bodies. For many years, protein aggregation was considered a random process by which misfolded proteins stick to each other to form inclusions (imagine a bundle of hairs haphazardly piling up in a corner of a room). Moreover, protein aggregates were thought to be toxic agents and the cause for neuronal dysfunction and death. However, recent studies, using advanced methods (i.e. fluorescence microscopy), show that protein aggregation may actually be a tightly regulated, organized process, by which the cell protects itself from toxic proteins by sequestration to inclusion bodies. In 2008, Daniel Kaganovich showed that eukaryotic cells sort misfolded proteins into two distinct inclusion bodies in a well-managed cellular process: 1. \n* The JUNQ (JUxta Nuclear Quality control compartment) 2. \n* The IPOD (Insoluble Protein Deposit) JUNQ and IPOD are evolutionarily conserved, and are found in specific and defined cellular sites. Delivery of misfolded, aggregated proteins to JUNQ and IPOD require an intact cytoskeleton and specific cellular quality control components, such as Heat Shock Proteins (HSPs). The partition into the two distinct inclusion bodies is due to the different handling and processing of different kinds of misfolded proteins (e.g. ubiquitinated vs. non-ubiquitinated proteins). Segregation of toxic protein aggregates into JUNQ and IPOD inclusion bodies is a means by which mammalian cells can be rejuvenated through asymmetric division. Thus, the discovery of JUNQ and IPOD provided a new striking perspective of how cells manage misfolded aggregated proteins and gave convincing proof that protein aggregation is a non-random, well regulated and controlled cellular process. Furthermore, the discovery of JUNQ and IPOD suggested that in addition to temporal quality control (i.e. time dependent administration of damaged proteins) cells exploit homeostasis spatially: If degradation isn't available, protection of the cellular environment from a misfolded protein is accomplished by its sequestration to an aggregate inclusion."@en . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "JUNQ and IPOD"@en . . . . . . . . . . . . . . . . . . . . "Les JUNQ et IPOD constituent des types de structures d'inclusion de prot\u00E9ines cytosoliques qu'on retrouve chez les eucaryotes. Des maladies neurod\u00E9g\u00E9n\u00E9ratives, comme celles de Parkinson, Alzheimer et Huntington, sont associ\u00E9es et corr\u00E9l\u00E9es \u00E0 l'agr\u00E9gation des prot\u00E9ines et l'accumulation de prot\u00E9ines mal repli\u00E9es dans ces structures d'inclusion. Pendant de nombreuses ann\u00E9es, l'agr\u00E9gation prot\u00E9ique \u00E9tait consid\u00E9r\u00E9e comme un processus al\u00E9atoire par lequel les prot\u00E9ines mal repli\u00E9es se collent entre elles pour former des inclusions (s'imaginer un paquet de cheveux qui s'empilent de fa\u00E7on d\u00E9sordonn\u00E9e dans le coin d'une pi\u00E8ce). De plus, on pensait que les agr\u00E9gats prot\u00E9iques \u00E9taient des agents toxiques ainsi que la cause d'un dysfonctionnement neuronal pouvant conduire \u00E0 la mort. Cependant, des \u00E9"@fr . . . . . . . . . "JUNQ and IPOD are types of cytosolic protein inclusion bodies in eukaryotes. Neurodegenerative diseases, such as Parkinson's, Alzheimer's, and Huntington's, are associated and correlated with protein aggregation and accumulation of misfolded proteins in inclusion bodies. For many years, protein aggregation was considered a random process by which misfolded proteins stick to each other to form inclusions (imagine a bundle of hairs haphazardly piling up in a corner of a room). Moreover, protein aggregates were thought to be toxic agents and the cause for neuronal dysfunction and death. However, recent studies, using advanced methods (i.e. fluorescence microscopy), show that protein aggregation may actually be a tightly regulated, organized process, by which the cell protects itself from toxi"@en . "JUNQ\u3068IPOD\u306F\u3001\u771F\u6838\u751F\u7269\u306E\u7D30\u80DE\u8CEA\u306B\u898B\u3089\u308C\u308B\u30BF\u30F3\u30D1\u30AF\u8CEA\u306E\u5C01\u5165\u4F53\u3067\u3042\u308B\u3002 \u30D1\u30FC\u30AD\u30F3\u30BD\u30F3\u75C5\u3001\u30A2\u30EB\u30C4\u30CF\u30A4\u30DE\u30FC\u75C5\u3001\u30CF\u30F3\u30C1\u30F3\u30C8\u30F3\u75C5\u306A\u3069\u306E\u75BE\u60A3\u306F\u795E\u7D4C\u5909\u6027\u75BE\u60A3\u3068\u7DCF\u79F0\u3055\u308C\u3001\u30BF\u30F3\u30D1\u30AF\u8CEA\u51DD\u96C6\u3084\u30DF\u30B9\u30D5\u30A9\u30FC\u30EB\u30C9\u30BF\u30F3\u30D1\u30AF\u8CEA\u306E\u5C01\u5165\u4F53\u3078\u306E\u84C4\u7A4D\u3092\u4F34\u3046\u3002\u304B\u3064\u3066\u3088\u308A\u30BF\u30F3\u30D1\u30AF\u8CEA\u306E\u51DD\u96C6\u306F\u3001\u30DF\u30B9\u30D5\u30A9\u30FC\u30EB\u30C9\u3057\u305F\u30BF\u30F3\u30D1\u30AF\u8CEA\u304C\u304A\u4E92\u3044\u306B\u7D50\u5408\u3057\u3066\u5C01\u5165\u4F53\u3092\u5F62\u6210\u3059\u308B\u30E9\u30F3\u30C0\u30E0\u306A\u904E\u7A0B\u3068\u8003\u3048\u3089\u308C\u3066\u304D\u305F\u3002\u307E\u305F\u3001\u30BF\u30F3\u30D1\u30AF\u8CEA\u306E\u51DD\u96C6\u4F53\u306F\u6BD2\u6027\u3092\u6301\u3064\u7269\u8CEA\u3068\u3057\u3066\u3001\u795E\u7D4C\u7D30\u80DE\u306E\u6A5F\u80FD\u969C\u5BB3\u3084\u7D30\u80DE\u6B7B\u3092\u5F15\u304D\u8D77\u3053\u3059\u3082\u306E\u3068\u8003\u3048\u3089\u308C\u3066\u304D\u305F\u3002\u3057\u304B\u3057\u8FD1\u5E74\u3001\u86CD\u5149\u9855\u5FAE\u93E1\u306A\u3069\u306E\u5148\u7AEF\u6280\u8853\u3092\u7528\u3044\u305F\u7814\u7A76\u306B\u3088\u308A\u3001\u30BF\u30F3\u30D1\u30AF\u8CEA\u51DD\u96C6\u3068\u3044\u3046\u73FE\u8C61\u306F\u5B9F\u969B\u306B\u306F\u53B3\u5BC6\u306B\u5236\u5FA1\u3055\u308C\u305F\u30D7\u30ED\u30BB\u30B9\u3067\u3042\u308B\u3053\u3068\u3001\u305D\u3057\u3066\u7D30\u80DE\u306F\u6BD2\u6027\u30BF\u30F3\u30D1\u30AF\u8CEA\u3092\u5C01\u5165\u4F53\u306B\u9694\u96E2\u3059\u308B\u3053\u3068\u3067\u3001\u81EA\u3089\u3092\u4FDD\u8B77\u3057\u3066\u3044\u308B\u3053\u3068\u304C\u660E\u3089\u304B\u3068\u306A\u3063\u305F\u30022008\u5E74\u3001\u30C0\u30CB\u30A8\u30EB\u30FB\u30AB\u30AC\u30CE\u30F4\u30A3\u30C3\u30C1\u306F\u3001\u771F\u6838\u7D30\u80DE\u306F\u305D\u306E\u5DE7\u5999\u306B\u7BA1\u7406\u3055\u308C\u305F\u7D30\u80DE\u30D7\u30ED\u30BB\u30B9\u306B\u3088\u308A\u3001\u30DF\u30B9\u30D5\u30A9\u30FC\u30EB\u30C9\u3057\u305F\u30BF\u30F3\u30D1\u30AF\u8CEA\u3092\uFF08\u4EE5\u4E0B\u306B\u5217\u6319\u3059\u308B\uFF092\u7A2E\u985E\u306E\u5C01\u5165\u4F53\u3078\u4ED5\u5206\u3051\u3092\u3057\u3066\u3044\u308B\u3053\u3068\u3092\u793A\u3057\u305F\u3002 1. \n* JUNQ\uFF08JUxta Nuclear Quality control compartment\u3001\u610F\u5473\uFF1A\u6838\u8FD1\u508D\u54C1\u8CEA\u7BA1\u7406\u30B3\u30F3\u30D1\u30FC\u30C8\u30E1\u30F3\u30C8\uFF09 2. \n* IPOD\uFF08Insoluble Protein Deposit\u3001\u610F\u5473\uFF1A\u4E0D\u6EB6\u6027\u30BF\u30F3\u30D1\u30AF\u8CEA\u4FDD\u7BA1\u6240\uFF09 JUNQ\u3068IPOD\u306F\u3068\u3082\u306B\u9032\u5316\u7684\u306B\u4FDD\u5B58\u3055\u308C\u305F\u30B3\u30F3\u30D1\u30FC\u30C8\u30E1\u30F3\u30C8\u3067\u3042\u308A\u3001\u7279\u5B9A\u306E\u7D30\u80DE\u5185\u90E8\u4F4D\u306B\u89B3\u5BDF\u3055\u308C\u308B\u3002\u30DF\u30B9\u30D5\u30A9\u30FC\u30EB\u30C9\u3057\u51DD\u96C6\u3057\u305F\u86CB\u767D\u8CEA\u304CJUNQ\u3084IPOD\u306B\u8F38\u9001\u3055\u308C\u308B\u306B\u306F\u3001\u7121\u50B7\u306E\u7D30\u80DE\u9AA8\u683C\u3084\u3001\u71B1\u30B7\u30E7\u30C3\u30AF\u30BF\u30F3\u30D1\u30AF\u8CEA\u3068\u3044\u3063\u305F\u7279\u5B9A\u306E\u7D30\u80DE\u54C1\u8CEA\u7BA1\u7406\u56E0\u5B50\u304C\u5FC5\u8981\u3068\u306A\u308B\u3002\u30BF\u30F3\u30D1\u30AF\u8CEA\u306E\u8F38\u9001\u5148\u3068\u3057\u3066JUNQ\u3068IPOD\u306E\u3069\u3061\u3089\u304C\u9078\u3070\u308C\u308B\u304B\u306F\u3001\u30DF\u30B9\u30D5\u30A9\u30FC\u30EB\u30C9\u3057\u305F\u30BF\u30F3\u30D1\u30AF\u8CEA\u304C\u7D30\u80DE\u5185\u3067\u53D7\u3051\u308B\u30D7\u30ED\u30BB\u30B7\u30F3\u30B0\u306E\u69D8\u5F0F\u306B\u3088\u3063\u3066\u6C7A\u5B9A\u3055\u308C\u308B\uFF08\u30BF\u30F3\u30D1\u30AF\u8CEA\u304C\u30E6\u30D3\u30AD\u30C1\u30F3\u5316\u3055\u308C\u308B\u304B\u3069\u3046\u304B\u3001\u306A\u3069\uFF09\u3002\u54FA\u4E73\u985E\u7D30\u80DE\u3067\u306F\u3001\u6709\u6BD2\u306A\u30BF\u30F3\u30D1\u30AF\u8CEA\u51DD\u96C6\u4F53\u3092JUNQ\u53CA\u3073IPOD\u3078\u9694\u96E2\u3059\u308B\u3053\u3068\u3067\u3001\u975E\u5BFE\u79F0\u5206\u88C2\u3092\u901A\u3058\u3066\u7D30\u80DE\u306E\u82E5\u8FD4\u308A\u304C\u884C\u308F\u308C\u3066\u3044\u308B\u306E\u3067\u3042\u308B\u3002 \u5F93\u3063\u3066\u3001JUNQ\u3068IPOD\u306E\u767A\u898B\u306F\u3001\u300C\u7D30\u80DE\u304C\u30DF\u30B9\u30D5\u30A9\u30FC\u30EB\u30C9\u3057\u51DD\u96C6\u3057\u305F\u30BF\u30F3\u30D1\u30AF\u8CEA\u3092\u3044\u304B\u306B\u5BFE\u51E6\u3059\u308B\u306E\u304B\u300D\u306B\u3064\u3044\u3066\u306E\u65B0\u3057\u3044\u77E5\u898B\u3092\u3082\u305F\u3089\u3057\u3001\u307E\u305F\u300C\u30BF\u30F3\u30D1\u30AF\u8CEA\u51DD\u96C6\u304C\u30E9\u30F3\u30C0\u30E0\u306B\u9032\u3080\u30D7\u30ED\u30BB\u30B9\u3067\u306F\u306A\u304F\u3001\u5B9F\u306F\u3088\u304F\u8ABF\u7BC0\u30FB\u5236\u5FA1\u3055\u308C\u305F\u7D30\u80DE\u30D7\u30ED\u30BB\u30B9\u3067\u3042\u308B\u300D\u3053\u3068\u306E\u8AAC\u5F97\u529B\u306E\u3042\u308B\u8A3C\u660E\u3092\u4E0E\u3048\u305F\u3002\u3055\u3089\u306B\u3001JUNQ\u3068IPOD\u304C\u767A\u898B\u3055\u308C\u305F\u3053\u3068\u306B\u3088\u308A\u3001\u7D30\u80DE\u306F\u54C1\u8CEA\u7BA1\u7406\u3092\u6642\u9593\u7684\u306B\u884C\u306A\u3063\u3066\u3044\u308B\u3060\u3051\u3067\u306A\u304F\uFF08\u8A00\u3044\u63DB\u3048\u308C\u3070\u3001\u58CA\u308C\u305F\u30BF\u30F3\u30D1\u30AF\u8CEA\u3092\u6642\u9593\u4F9D\u5B58\u7684\u306B\u9664\u53BB\u3059\u308B\u3060\u3051\u3067\u306A\u304F\uFF09\u3001\u30DB\u30E1\u30AA\u30B9\u30BF\u30B7\u30B9\u6A5F\u69CB\u3092\u7A7A\u9593\u7684\u306B\u884C\u306A\u3063\u3066\u3044\u308B\u3053\u3068\u3082\u793A\u5506\u3055\u308C\u305F\u3002\u3064\u307E\u308A\u3001\u30BF\u30F3\u30D1\u30AF\u8CEA\u5206\u89E3\u304C\u884C\u3048\u306A\u3044\u3088\u3046\u306A\u72B6\u6CC1\u306B\u9665\u3063\u305F\u5834\u5408\u3001\u7D30\u80DE\u306F\u51DD\u96C6\u30BF\u30F3\u30D1\u30AF\u8CEA\u5C01\u5165\u4F53\u3092\u7A7A\u9593\u7684\u306B\u9694\u96E2\u3059\u308B\u3053\u3068\u306B\u3088\u308A\u3001\u30DF\u30B9\u30D5\u30A9\u30FC\u30EB\u30C9\u30BF\u30F3\u30D1\u30AF\u8CEA\u304B\u3089\u7D30\u80DE\u5185\u74B0\u5883\u3092\u4FDD\u8B77\u3057\u3066\u3044\u308B\u306E\u3067\u3042\u308B\u3002"@ja . . . . . . . . . "21952"^^ . "JUNQ\u3068IPOD\u306F\u3001\u771F\u6838\u751F\u7269\u306E\u7D30\u80DE\u8CEA\u306B\u898B\u3089\u308C\u308B\u30BF\u30F3\u30D1\u30AF\u8CEA\u306E\u5C01\u5165\u4F53\u3067\u3042\u308B\u3002 \u30D1\u30FC\u30AD\u30F3\u30BD\u30F3\u75C5\u3001\u30A2\u30EB\u30C4\u30CF\u30A4\u30DE\u30FC\u75C5\u3001\u30CF\u30F3\u30C1\u30F3\u30C8\u30F3\u75C5\u306A\u3069\u306E\u75BE\u60A3\u306F\u795E\u7D4C\u5909\u6027\u75BE\u60A3\u3068\u7DCF\u79F0\u3055\u308C\u3001\u30BF\u30F3\u30D1\u30AF\u8CEA\u51DD\u96C6\u3084\u30DF\u30B9\u30D5\u30A9\u30FC\u30EB\u30C9\u30BF\u30F3\u30D1\u30AF\u8CEA\u306E\u5C01\u5165\u4F53\u3078\u306E\u84C4\u7A4D\u3092\u4F34\u3046\u3002\u304B\u3064\u3066\u3088\u308A\u30BF\u30F3\u30D1\u30AF\u8CEA\u306E\u51DD\u96C6\u306F\u3001\u30DF\u30B9\u30D5\u30A9\u30FC\u30EB\u30C9\u3057\u305F\u30BF\u30F3\u30D1\u30AF\u8CEA\u304C\u304A\u4E92\u3044\u306B\u7D50\u5408\u3057\u3066\u5C01\u5165\u4F53\u3092\u5F62\u6210\u3059\u308B\u30E9\u30F3\u30C0\u30E0\u306A\u904E\u7A0B\u3068\u8003\u3048\u3089\u308C\u3066\u304D\u305F\u3002\u307E\u305F\u3001\u30BF\u30F3\u30D1\u30AF\u8CEA\u306E\u51DD\u96C6\u4F53\u306F\u6BD2\u6027\u3092\u6301\u3064\u7269\u8CEA\u3068\u3057\u3066\u3001\u795E\u7D4C\u7D30\u80DE\u306E\u6A5F\u80FD\u969C\u5BB3\u3084\u7D30\u80DE\u6B7B\u3092\u5F15\u304D\u8D77\u3053\u3059\u3082\u306E\u3068\u8003\u3048\u3089\u308C\u3066\u304D\u305F\u3002\u3057\u304B\u3057\u8FD1\u5E74\u3001\u86CD\u5149\u9855\u5FAE\u93E1\u306A\u3069\u306E\u5148\u7AEF\u6280\u8853\u3092\u7528\u3044\u305F\u7814\u7A76\u306B\u3088\u308A\u3001\u30BF\u30F3\u30D1\u30AF\u8CEA\u51DD\u96C6\u3068\u3044\u3046\u73FE\u8C61\u306F\u5B9F\u969B\u306B\u306F\u53B3\u5BC6\u306B\u5236\u5FA1\u3055\u308C\u305F\u30D7\u30ED\u30BB\u30B9\u3067\u3042\u308B\u3053\u3068\u3001\u305D\u3057\u3066\u7D30\u80DE\u306F\u6BD2\u6027\u30BF\u30F3\u30D1\u30AF\u8CEA\u3092\u5C01\u5165\u4F53\u306B\u9694\u96E2\u3059\u308B\u3053\u3068\u3067\u3001\u81EA\u3089\u3092\u4FDD\u8B77\u3057\u3066\u3044\u308B\u3053\u3068\u304C\u660E\u3089\u304B\u3068\u306A\u3063\u305F\u30022008\u5E74\u3001\u30C0\u30CB\u30A8\u30EB\u30FB\u30AB\u30AC\u30CE\u30F4\u30A3\u30C3\u30C1\u306F\u3001\u771F\u6838\u7D30\u80DE\u306F\u305D\u306E\u5DE7\u5999\u306B\u7BA1\u7406\u3055\u308C\u305F\u7D30\u80DE\u30D7\u30ED\u30BB\u30B9\u306B\u3088\u308A\u3001\u30DF\u30B9\u30D5\u30A9\u30FC\u30EB\u30C9\u3057\u305F\u30BF\u30F3\u30D1\u30AF\u8CEA\u3092\uFF08\u4EE5\u4E0B\u306B\u5217\u6319\u3059\u308B\uFF092\u7A2E\u985E\u306E\u5C01\u5165\u4F53\u3078\u4ED5\u5206\u3051\u3092\u3057\u3066\u3044\u308B\u3053\u3068\u3092\u793A\u3057\u305F\u3002 1. \n* JUNQ\uFF08JUxta Nuclear Quality control compartment\u3001\u610F\u5473\uFF1A\u6838\u8FD1\u508D\u54C1\u8CEA\u7BA1\u7406\u30B3\u30F3\u30D1\u30FC\u30C8\u30E1\u30F3\u30C8\uFF09 2. \n* IPOD\uFF08Insoluble Protein Deposit\u3001\u610F\u5473\uFF1A\u4E0D\u6EB6\u6027\u30BF\u30F3\u30D1\u30AF\u8CEA\u4FDD\u7BA1\u6240\uFF09"@ja . . . . . . . . . "Les JUNQ et IPOD constituent des types de structures d'inclusion de prot\u00E9ines cytosoliques qu'on retrouve chez les eucaryotes. Des maladies neurod\u00E9g\u00E9n\u00E9ratives, comme celles de Parkinson, Alzheimer et Huntington, sont associ\u00E9es et corr\u00E9l\u00E9es \u00E0 l'agr\u00E9gation des prot\u00E9ines et l'accumulation de prot\u00E9ines mal repli\u00E9es dans ces structures d'inclusion. Pendant de nombreuses ann\u00E9es, l'agr\u00E9gation prot\u00E9ique \u00E9tait consid\u00E9r\u00E9e comme un processus al\u00E9atoire par lequel les prot\u00E9ines mal repli\u00E9es se collent entre elles pour former des inclusions (s'imaginer un paquet de cheveux qui s'empilent de fa\u00E7on d\u00E9sordonn\u00E9e dans le coin d'une pi\u00E8ce). De plus, on pensait que les agr\u00E9gats prot\u00E9iques \u00E9taient des agents toxiques ainsi que la cause d'un dysfonctionnement neuronal pouvant conduire \u00E0 la mort. Cependant, des \u00E9tudes r\u00E9centes utilisant des m\u00E9thodes modernes (comme la microscopie \u00E0 fluorescence) ont montr\u00E9 que l'agr\u00E9gation prot\u00E9ique peut en fait \u00EAtre un processus fermement r\u00E9gul\u00E9 et organis\u00E9 par lequel la cellule se prot\u00E8ge des prot\u00E9ines toxiques par s\u00E9questration des structures d'inclusion. En 2008, Daniel Kaganovich a montr\u00E9 que les cellules eucaryotes trient les prot\u00E9ines mal repli\u00E9es et les transportent vers deux structures d'inclusion distinctes via un processus cellulaire bien rod\u00E9, qui sont : 1. \n* Le JUNQ (pour JUxta Nuclear Quality control compartment en anglais, soit compartiment de contr\u00F4le qualit\u00E9 juxta-nucl\u00E9aire en fran\u00E7ais) 2. \n* L'IPOD (pour Insoluble Protein Deposit en anglais, soit d\u00E9p\u00F4t pour les prot\u00E9ines insolubles en fran\u00E7ais) Les JUNQ et IPOD sont \u00E9volutivement conserv\u00E9s et se trouvent dans des sites cellulaires sp\u00E9cifiques et d\u00E9finis. La distribution des prot\u00E9ines mal repli\u00E9es et agr\u00E9g\u00E9es au JUNQ et IPOD requiert un cytosquelette intact et des composants de contr\u00F4le qualit\u00E9 cellulaires sp\u00E9cifiques, comme les prot\u00E9ines de choc thermique (HSP en anglais). La division en deux structures d'inclusion distinctes sont dues aux diff\u00E9rents traitements et gestions des diff\u00E9rentes sortes de prot\u00E9ines mal repli\u00E9es (par exemple les prot\u00E9ines ubiquitin\u00E9es versus non ubiquitin\u00E9es). La s\u00E9gr\u00E9gation des agr\u00E9gats prot\u00E9iques toxiques vers les structures d'inclusion JUNQ et IPOD est un moyen par lequel les cellules mammaliennes peuvent \u00EAtre rajeunies par division asym\u00E9trique. Ainsi, la d\u00E9couverte des JUNQ et IPOD a fourni une nouvelle perspective saisissante de comment les cellules prennent en charge les prot\u00E9ines agr\u00E9g\u00E9es et a donn\u00E9 une preuve convaincante que l'agr\u00E9gation prot\u00E9ique est un processus cellulaire non al\u00E9atoire, bien r\u00E9gul\u00E9 et bien contr\u00F4l\u00E9. De plus, la d\u00E9couverte de JUNQ et IPOD a sugg\u00E9r\u00E9 qu'en plus d'un contr\u00F4le qualit\u00E9 temporaire (c'est-\u00E0-dire dont la dur\u00E9e d\u00E9pend de la gestion des prot\u00E9ines endommag\u00E9es), les cellules exploitent l'hom\u00E9ostasie de fa\u00E7on spatiale. Si la d\u00E9gradation n'est pas possible, la protection de l'environnement cellulaire contre une prot\u00E9ine mal repli\u00E9e est accomplie par la s\u00E9questration de celle-ci dans une structure d'inclusion pour agr\u00E9gats."@fr . . . . . "1061311385"^^ . "36066758"^^ . . . . . . . . . . . . . . "JUNQ et IPOD"@fr . . . . . . . . . . . . . .